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All Journal Jurnal Inovasi Farmasi Indonesia PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Komunita: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Kesehatan Metro Sai Wawai Jurnal Mahasiswa Kesehatan Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM)
Kadir, Mujtahid Bin Abd
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Potensi Kombinasi Pemberian Ekstrak Rosella dan Pare Menurunkan Kadar Glukosa Darah dan Meningkatkan Kolesterol-HDL pada Tikus Model Sindrom Metabolik Kasimo, Elfred Rinaldo; Savitri, Lisa; Kadir, Mujtahid Bin Abd; Alimansur, Moh; Antoro, Ester Lianawati
Jurnal Kesehatan Metro Sai Wawai Vol. 15 No. 2 (2022): Jurnal Kesehatan Metro Sai Wawai
Publisher : Poltekkes Kemenkes Tanjung Karang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jkmsaw.v15i2.3598

Abstract

Latar Belakang: Sindrom metabolik merupakan salah satu masalah kesehatan yang meningkat saat ini. Sindrome metabolik akan meningkatkan risiko diabetes melitus tipe 2 dan kardiovaskuler. Penyakit ini menjadi ancaman kesehatan sehingga dibutuhkan kombinasi obat dalam menangani berbagai gangguan disfungsi. Terapi obat kimia tidak cukup menyembuhkan atau menghentikan perkembangan penyakit. Tanaman Rosella dan pare memiliki aktifitas sebagai hipoglikemik dan antilipidemik. Tujuan: Untuk mengetahui efek kombinasi ekstrak rosella dan pare dalam menurunkan kadar glukosa darah puasa dan meningkatkan kadar HDL terhadap tikus model sindrom metabolik. Metode: Rancangan penelitian yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan sampel penelitian dibagi dalam 5 kelompok perlakuan. Analisis data dengan uji paired T Test. Tahapan pelaksanaannya yaitu pengkondisian tikus sindrom metabolik. Hasil: Pada kelompok PII didapatkan penurunanan kadar glukosa darah puasa yang signifikan setelah intervensi sebesar 37,43 % (p value = 0,001). Pada kelompok PII didapatkan peningkatan kadar HDL yang signifikan setelah interveni 48,95 % (p value = 0,005) Simpulan: Potensi kombinasi pemberian ekstrak rosella dan pare mampu menurunkan kadar glukosa darah puasa dan meningkatkan kadar HDL tikus model sindrom metabolik. Simpulan: Kadar glukosa darah puasa tikus model sindrom metabolik menurun dan kadar HDL meningkat setelah diberikan intervensi kombinasi ekstrak rosella dan pare. Tahap lanjutan studi adalah untuk mengetahui uji toksisitas akut penggunaan rosella dan pare. Abstract: The potency of Combination of Rosella and Bitter Gourd Extracts to Reduce Blood Glucose Levels and Increase HDL-Cholesterol in Metabolic Syndrome Model Rats. Background: Metabolic syndrome is one of the increasing health problems today. The metabolic syndrome will increase the risk of type 2 diabetes mellitus and cardiovascular disease. This disease is a health threat that requires a combination of drugs to treat various dysfunction disorders. Chemical drug therapy is not enough to cure or stop the progression of the disease. Rosella and bitter melon plants have activities as hypoglycemic and antilipidemic. Purposes: To determine the effect of a combination of rosella and bitter melon extracts in reducing fasting blood glucose levels and increasing HDL levels in metabolic syndrome model rats. Methods: The research design used was a completely randomized design (CRD) with the research sample divided into 5 treatment groups. Data analysis with paired T-test. The stages of implementation are conditioning of metabolic syndrome rats. Result: In group PII, there was a significant decrease in fasting blood glucose levels after intervention by 37.43% (p-value = 0.001). In group PII, there was a significant increase in HDL levels after the intervention of 48.95% (p-value = 0.005) Conclusion: After receiving a mixture of rosella and bitter melon extracts, rats with the metabolic syndrome model had lower fasting blood glucose levels and higher levels of HDL. The next stage of the study was to determine the acute toxicity test of using rosella and bitter melon.
Uji Aktivitas Antibakteri Fraksi Etil Asetat Daun Pare (Momordica charantia L.) Terhadap Bakteri Pseudomonas aeruginosa: Antibacterial Activity of Ethyl Acetate Fraction of Bitter Gourd Leaves (Momordica charantia L.) in Pseudomonas aeruginosa Bacteria Putri Larasati, Julyana; Yuniarto, Prayoga Fery; Sukmawati, Datin An Nisa; Kadir, Mujtahid Bin Abd; Sulistyowati , Yuni
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 5 No. 2 (2024): Volume 5 Nomor 2 Juni 2024
Publisher : Universitas Kadiri

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Abstract

Pseudomonas aeruginosa dapat menjadi penyebab infeksi. Infeksi yang dapat disebabkan oleh Pseudomonas aeruginosa salah satunya yaitu infeksi saluran kemih (ISK). ISK yang disebabkan oleh bakteri Pseudomonas aeruginosa dapat diatasi dengan antibiotik. Antibiotik merupakan obat untuk mengatasi atau mencegah infeksi bakteri. Salah satu tanaman yang bisa dimanfaatkan sebagai antibakteri yaitu daun Pare (Momordica charantia L.). Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri fraksi etil asetat daun Pare (Momordica charantia L.) terhadap bakteri Pseudomonas aeruginosa. Pengujian aktivitas antibakteri pada penelitian ini dilakukan dengan metode difusi kertas cakram. Uji aktivitas antibakteri fraksi etil asetat daun Pare menggunakan konsentrasi 5%, 10% dan 15%. Diameter zona hambat yang dihasilkan yaitu fraksi etil asetat 5% (8,50 mm), fraksi etil asetat 10% (10,16 mm), fraksi etil asetat 15% (12,11 mm). Hasil analisa data menggunakan uji one way anova didapatkan nilai sig 0,000 (p<0,05). Dapat disimpulkan bahwa fraksi etil asetat daun Pare yang memiliki aktivitas paling bagus dalam menghambat pertumbuhan bakteri Pseudomonas aeruginosa adalah konsentrasi 15%.
Education on the Use of Vitamin A (Retinol) for the Prevention of Myopia in Adolescents in Gembleb Trenggalek: Edukasi Penggunaan Obat Vitamin A (Retinol) Untuk Pencegahan Penyakit Miopi Pada Remaja di Dusun Gembleb Trenggalek Prasetyawan, Fendy; Saristiana, Yuneka; Salmasfattah, Novyananda; Savitri, Lisa; Herman; Kadir, Mujtahid Bin Abd
KOMUNITA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol 4 No 2 (2025): Mei
Publisher : PELITA NUSA TENGGARA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60004/komunita.v4i2.177

Abstract

This community service program aimed to increase adolescents' awareness and knowledge regarding the role of Vitamin A (Retinol) in preventing myopia, particularly in rural areas such as Gembleb Village, Trenggalek. The activity was conducted on Saturday, May 3, 2025, in collaboration with the Government of Gembleb Village and supported by the Institute for Research, Community Service, and Publication (LP3M) of Universitas Kadiri. A total of 15 adolescents participated in the educational intervention, which included a pre-test, a lecture session, and a post-test evaluation. The results showed a significant improvement in participants’ knowledge about myopia and the importance of Vitamin A for eye health. Pre-test scores averaged lower compared to post-test results, with an average increase of 20–25 points. This finding suggests that structured education can effectively enhance health literacy among youth, particularly regarding nutritional prevention of visual disorders. These outcomes underscore the importance of continued community-based health education programs, especially in underserved areas, as a strategic effort to reduce the prevalence of preventable eye diseases
PENGARUH PEMBERIAN KOMBINASI METFORMIN DENGAN EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) TERHADAP KADAR GLUKOSA DARAH MENCIT DIABETES Khotimah, Khusnul; Kadir, Mujtahid Bin Abd; Kasimo, Elfred Rinaldo; Sanjaya, Rochmad Kris
Jurnal Mahasiswa Kesehatan Vol. 2 No. 2 (2021): MARET 2021
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jumakes.v2i2.1216

Abstract

People with diabetes mellitus extremely increase every year. Management of diabetes mellitus disease requires appropriate therapy to prevent serious increasing and progressing the disease to be serious complication then the achievement of therapy goals. This study aims to determine the effect of giving a combination of metformin and red dragon fruit peel extract (Hylocereus polyrhizus) on blood glucose levels of diabetic mice.This type of research is an experimental study with a pre-test and post-test design with a control group. As the test animal, Swiss webster male white mice were used. They were grouped into 6 groups, each with 4 tails for each group. As the treatment group by giving of a combination of metformin and red dragon fruit peel extract with various doses of 75 mg/kg body weight for mice, 150 mg/kg body weight for mice, 300 mg/kg body weight for mice, positive control for metformin 65 mg/kg BW for mice, comparative control extracts red dragon fruit peel 150 mg/kg BW of mice and negative control 0.5% Na CMC was given orally once a day for 14 days. Data analysis used the One Way Anova method followed by the Last Significant Difference (LSD) method.The results showed that the percentage of the highest reduction in blood glucose levels was 81% in the combination group with an extract dose of 300 mg/kg BW of mice which was significantly different from the negative control group and the comparison control group.
Identification of Active Compounds from Sambung Nyawa Leaves (Gynura procumbens (Lour.) Merr) as Potential Natural Antioxidant and Anti-inflammatory Agents Saristiana, Yuneka; Salmasfattah, Novyananda; Prasetyawan, Fendy; Savitri, Lisa; Kadir, Mujtahid Bin Abd
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 4 No. 3 (2025): JULY
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v4i3.1865

Abstract

Diseases caused by oxidative stress and inflammation are global health problems that encourage the search for alternative treatments from natural materials. Grapevine leaves (Gynura procumbens (Lour.) Merr.) have long been empirically used, but scientific validation of their potential is still limited. The objective of this research is to identify and describe the active substances in sambung nyawa leaves and assess their effectiveness as natural antioxidants and anti-inflammatory agents. The study involves conducting laboratory experiments, starting with the extraction of sambung nyawa leaves using 96% ethanol solvent through a maceration process. The extract obtained is then analysed for its phytochemical composition. The antioxidant activity is evaluated using the DPPH method to determine the IC₅₀ value. On the other hand, the anti-inflammatory properties are tested in male Wistar rats following the induction of rat hind paw edema with 1% carrageenan, using extract doses of 75, 150, and 300 mg/kgBW. The findings indicate a 13.4% yield from the extraction process. The phytochemical analysis reveals the presence of flavonoids, alkaloids, saponins, tannins, phenols, and steroids/triterpenoids. The antioxidant test results show a moderate level of activity with an IC₅₀ value of 89.26 µg/mL. In the anti-inflammatory test, the 150 mg/kgBW dose demonstrates the highest efficacy with a 52.00% reduction in edema, comparable to the positive control triamcinolone (55.00%). In summary, the ethanol extract of sambung nyawa leaves exhibits promising potential as an antioxidant and anti-inflammatory agent, indicating its suitability for further development as a botanical pharmaceutical ingredient.
Interactive Discussion Related to the Preparation of Pharmacy Professional Work Practice at the Health Center and Health Office Saristiana, Yuneka; Prasetyawan, Fendy; Mildawati, Ratna; Marhenta, Yogi Bhakti; Kadir, Mujtahid Bin Abd; Arifin, Chandra; Rofiq, Abd; Astutik, Widhi; Rohmah, Eka Hayati
Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM) Vol. 1 No. 1 (2025): Maret
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mjpmm.v1.i1.3

Abstract

The Professional Pharmacy Practice Experience (PKPA) at Community Health Centers and Health Offices plays a crucial role in developing the professional competence of pharmacy students before they enter the actual workforce. To facilitate this preparation, an interactive discussion activity has been conducted as a means of training and collective reflection among students, supervising lecturers, and resource persons from the Health Office and community health centers. This discussion aims to enhance students' understanding of the roles and responsibilities of pharmacists within primary healthcare facilities (FKTP), while also identifying the challenges and solutions involved in the implementation of PKPA. The execution of the discussion demonstrated a high level of enthusiasm among students in exploring both the technical and non-technical aspects of the pharmacy profession, including the integration of clinical and managerial roles. The evaluation of the questionnaire reveals that over 85% of participants believe this activity significantly aids in preparing them to confront the PKPA with greater confidence. Group discussions highlight the significance of interpersonal communication skills, professional ethics, and teamwork collaboration as essential factors for the success of practice. A representative from the Health Department assessed that this activity is effective in aligning the perspectives between educational institutions and practical venues, thereby fostering ongoing synergy.
Co-Authors Alimansur, Moh Antoro, Ester Lianawati Astutik, Widhi Chandra Arifin Datin An Nisa Sukmawati Elfred Rinaldo Kasimo, Elfred Rinaldo Fendy Prasetyawan Herman khusnul khotimah Marhenta, Yogi Bhakti Mildawati, Ratna Putri Larasati, Julyana Rofiq, Abd Rohmah, Eka Hayati Salmasfattah, Novyananda Sanjaya, Rochmad Kris savitri, Lisa Sulistyowati , Yuni Yuneka Saristiana Yuniarto, Prayoga Fery