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All Journal Dental Journal (Majalah Kedokteran Gigi) Medical and Health Journal
Andini, Restian Febi
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Dentistry Medicine & Pharmacology

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AKTIVITAS ANTIBAKTERI EKSTRAK TANGKAI Begonia multangula Blume TERHADAP PERTUMBUHAN Aggregatibacter actinomycetemcomitans Sari, Dwi Nur Indah; Prihastuti, Christiana Cahyani; Andini, Restian Febi; Gusri, Aldina; Ghani, Muhammad Hisyam; Nabila, Haidy Lailatun
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8594

Abstract

Periodontitis adalah penyakit gigi dan mulut yang paling sering ditemukan pada masyarakat dan dapat menyebabkan tanggalnya gigi. Salah satu bakteri penyebab periodontitis adalah Aggregatibacter actinomycetemcomitans. Perawatan periodontitis dilakukan dengan terapi mekanik (scaling and root planning) disertai terapi kimiawi (antibiotik dan obat kumur). Penggunaan terapi kimiawi yang berkepanjangan dapat menyebabkan resistensi bakteri, gangguan pengecapan dan perubahan warna gigi. Alternatifnya dapat digunakan bahan herbal yang memiliki daya antibakteri Tangkai Begonia multangula Blume di beberapa wilayah digunakan sebagai tanaman obat serta memiliki aktivitas antibakteri. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak tangkai Begonia multangula Blume terhadap pertumbuhan A. actinomycetemcomitans secara in vitro. Penelitian dilakukan secara eksperimental laboratoris dengan sampel A. actinomycetemcomitans ATCC 43718. Tangkai Begonia multangula Blume diekstraksi menggunakan metode maserasi dan dibuat 5 seri konsentrasi (3,12%, 6,25%, 12,5%, 25%, dan 50%). Uji antibakteri dilakukan metode difusi kertas cakram dengan kontrol positif Chlorhexidine gluconate 2% serta kontrol negatif DMSO 1%. Diameter zona hambat selanjutnya dianalisis statistic. Hasil penelitian menunjukkan bahwa aktivitas antibakteri ekstrak tangkai Begonia multangula Blume meningkat seiring peningkatan konsentrasi dengan aktivitas tertinggi pada konsentrasi 50% dengan zona hambat sebesar 20,33 mm (p<0,05). Simpulan dalam penelitian ini bahwa ekstrak etanol tangkai Begonia multangula Blume memiliki aktivitas sebagai antibakteri A. actinomycetemcomitans.
POTENTIAL OF RED ONION PEEL ETHANOL EXTRACT (Allium cepa L.) TO DEGRADATION OF Staphylococcus aureus BIOFILM Sari, Dwi Nur Indah; Rosyada, Alya Ghina; Laksitasari, Anindita; Djati, Fanni Kusuma; Andini, Restian Febi
Medical and Health Journal Vol 3 No 2 (2024): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.3.2.11371

Abstract

Dental biofilm is a bacterial colonization adhering to the tooth surface, enveloped by an extracellular matrix. This biofilm shields bacteria from the body's defense and antibacterial systems, potentially leading to various dental and oral diseases.Staphylococcus aureus is among the bacteria forming dental biofilm. Red onion peel is known to contain flavonoids, saponins, tannins, steroids and alkaloids which have antibacterial and anti-biofilm activity. This study aimed to determine the potential of shallot peel extract in degrading S. aureus biofilms. This study was conducted with a posttest-only control group design. Red onion peel extraction is carried out using the maceration method. A total of 5 groups of extracts (50%, 25%, 12.5%, 6.25%, and 3.12%), positive control (chlorhexidine gluconate 0.2%), and negative control (DMSO 1%) were tested for their activity in S. aureus biofilm degradation at 24 and 48 hours of incubation. The biofilm degradation was assessed using the microtiter plate assay method with crystal violet staining read at a wavelength of 595 nm. Percent biofilm degradation was statistically analyzed using Two way ANOVA and LSD. The results indicated significant differences based on treatment, incubation time, and the interaction between the two. The highest activity was observed at a concentration of 25%, although it was still lower than that of positive control. Conclusion: the ethanol extract of red onion peel has the potential to degrade S. aureus biofilms, with the highest activity at a concentration of 25% and an incubation time of 48 hours.
Effect of Ganoderma lucidum extract on tumor necrosis factor-alpha and prostaglandin E2 levels in periodontitis model Sprague Dawley rats Andini, Restian Febi; Novrial, Dody; Widodo, Haris Budi
Dental Journal Vol. 57 No. 3 (2024): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i3.p195-200

Abstract

Background: Periodontitis is a chronic multifactorial disease caused by microorganisms such as G-anaerobes in the periodontal tissues. It activates host defense cells and releases inflammatory mediators such as tumor necrosis factor-alpha (TNF-α) and prostaglandin E2 (PGE2). Ganoderma lucidum is a traditional medicinal mushroom with anti-inflammatory effects against various diseases. Biologically, different levels of its active constituents, such as triterpenoids and phenolic compounds, reduce inflammation with various pathways. Furthermore, the constituents inhibit toll-like receptor 4, MyD88 receptors, and the activities of nuclear factor-kappa B, which synthesize TNF-α and PGE2. Purpose: This study aimed to analyze the extent to which G. lucidum extract can reduce TNF-α and PGE2 levels in periodontitis model Sprague Dawley rats. Methods: Thirty Sprague Dawley rats were randomly divided into six groups of five rats. Periodontitis inflammation was induced by the injection of Porphyromonas gingivalis bacteria into intrasulcular gingival incisors in the lower jaw labial section. Grouping was as follows: Group K1 (healthy control); Group K2 (negative control); Group K3 (positive control with doxycycline dose 0.27 mg/kg BW); Group P1 (G. lucidum extract dose 5 mg/kg BW); Group P2 (G. lucidum extract dose 10 mg/kg BW); and Group P3 (G. lucidum extract dose 20 mg/kg BW). Samples were taken from rat gingival tissue and the levels of TNF-α and PGE2 were examined using the enzyme-linked immunosorbent assay method. Data analysis was performed using one-way analysis of variance (ANOVA) with a confidence level of 95% (p < 0.05). Results: The levels of TNF-α and PGE2 were the highest in the K2 group and the lowest in the K1 group. One-way ANOVA showed no significant difference in TNF-α and PGE2 levels between P3 and K1 group. Conclusion: G. lucidum extract can reduce TNF-α and PGE2 levels in Sprague Dawley rats with periodontitis.
Co-Authors Dody Novrial, Dody Dwi Nur Indah Sari Fanni Kusuma Djati Ghani, Muhammad Hisyam Gusri, Aldina Haris Budi Widodo Laksitasari, Anindita Nabila, Haidy Lailatun Prihastuti, Christiana Cahyani Rosyada, Alya Ghina