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All Journal JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Dunia Farmasi Jurnal Inkofar Jurnal Pengabdian Inovasi dan Teknologi Kepada Masyarakat JIKA
Fernenda, Larysa
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Uji Toksisitas Ekstrak Etanol 96% Daun Mahkota Dewa (Phaleria Macrocarpa) dengan Metode Brine Shrimpe Lethality Test (BSLT) Fernenda, Larysa; Putriani, Kony; Apriliani, Oksi
Jurnal Ilmu Kesehatan Abdurrab Vol 2 No 1 (2024): Volume 2 Nomor 1 Maret 2024
Publisher : LPPM Universitas Abdurrab

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Mahkota dewa (Phaleria macrocarpa) is a plant from the Thymelaeceae family. This plant contains several active compounds such as alkaloids, flavonoids, steroids, saponins, and tannins, so it has potential as a herbal medicine in Indonesia. This study aims to determine the toxicity of the leaves of the god crown using the Brine Shrimp Lethality Test (BSLT) method. Extraction of the god crown leaves using 96% ethanol solvent with the maceration method was then carried out a phytochemical screening which showed that the sample of the crown god leaf contained alkaloids, flavonoids, steroids, saponins and tannins. Toxicity testing of the ethanol extract of Mahkota Dewa leaves on Artemia salina Leach larvae was divided into 5 test groups, namely 4 treatment groups (concentrations of 250 ppm, 500 ppm, 750 ppm, and 1000 ppm) and 1 control or comparison group (seawater). Each concentration was made in 3 vials including 10 Artemia salina Leach larvae. Observations were made by looking at the death of Artemia salina Leach larvae after 24 hours of treatment. The research results can be seen through probit analysis by calculating the LC50 value. The LC50 value of the ethanol extract of Mahkota Dewa leaves was 7,7090 /mL. This shows that the ethanol extract of Mahkota Dewa leaves has a toxic effect on Artemia salina Leach larvae because the LC50 value is <1000 ppm.
Penetapan Kadar Asam Salisilat Pada Cream Anti Jerawat Yang Dijual Secara Online Shop Dan Di Apotek Menggunakan Metode Spektrofotometri UV-Vis Dan Alkalimetri Bali, Subardi; Fernenda, Larysa
Jurnal Ilmu Kesehatan Abdurrab Vol 2 No 1 (2024): Volume 2 Nomor 1 Maret 2024
Publisher : LPPM Universitas Abdurrab

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Cream is a semi-solid preparation, using an emulsion containing not less than 60% water. Salicylic acid, an anti-acne and keratolic agent, is commonly administered topically. This study aims to analyze salicylic acid levels in anti-acne creams sold online and in pharmacies. Quantitative Testing uses UV -Vis Spectrophotometry and Alkalimetry. Quantitative testing using UV-Vis Spectrophotometry, there were 3 samples sold in pharmacies containing salicylic acid with sample levels A 1.568%, B 1.755%, C 0.895%, and samples sold online contained salicylic acid with sample levels D 0.151%. Alkalimetric quantitative testing, 3 samples sold in pharmacies contained salicylic acid with sample levels A 0.71%, B 0.36%, C 0.48%, and samples sold online contained salicylic acid with sample levels D 0, 42 %. Based on BPOM requirements, the permitted level of salicylic acid in cosmetics does not exceed 2%, so the anti-acne cream product meets BPOM requirements. The salicylic acid level was tested using Uv-Vis spectrophotometry and analyzed using Kruskal Wallis with a significance value of 0.00 (P0.05). It was said that the spectrophotometric method influenced determining the salicylic acid level from samples A – D. The salicylic acid level used alkalimetry. Homogeneity test with the Homogeneity of Variances test with a significance value of P (0.104 - 0.05) homogeneous data. Data were analyzed using ANOVA. The results of the One Way Anova test analysis show a significance value of 0.00 (P 0.05), so the salicylic acid levels of samples A – D carried out using alkalimetry show a significant difference between the 4 samples tested.
Co-Authors Apriliani, Oksi Fitri Ayu Hasan, Nurmaliza Nasution, Azlaini Yus Octariany Putri, Angelina Putriani, Kony Ramadhani, Arba Pramundita Siregar, Sepridawati Subardi Bali Utama, Vonny Kurnia Yandi Syukri