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All Journal Jurnal Konseling dan Pendidikan Damianus Journal of Medicine Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Journal of Community Empowerment for Health Jurnal Abdi Masyarakat Indonesia Jurnal Penelitian Inovatif JURNAL BIOLOGI PAPUA
Elisa Nugraha Haryadi Salakay
Medical Education Unit, Faculty Of Medicine, Cenderawasih University, Jayapura, Papua
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Enhancing Antimalarial Treatment Adherence: A Systematic Review of Multifaceted Intervention Strategies Elisa Nugraha Haryadi Salakay; Grace Novylian Tandialo; Ricky Lazarus Rumboirusi; Grace Fitriana Primasari Hau Mahu
Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) Vol 8, No 2 (2025): July
Publisher : Faculty of Medicine, Public Health, and Nursing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/rpcpe.109709

Abstract

Background: Despite the availability of effective antimalarial medications, poor adherence remains a significant obstacle in malaria control, particularly in endemic areas. Numerous interventions have sought to enhance adherence; however, a clear understanding of their effectiveness is lacking. Objective: This systematic review aimed to evaluate the effectiveness of intervention strategies to improve adherence to antimalarial treatments and identify the contextual factors that influence them. Method: Following the PRISMA guidelines, studies published between 2020 and 2025 were systematically retrieved from PubMed, ScienceDirect, and Google Scholar databases. Ten studies that met the predefined inclusion criteria were analyzed using narrative thematic synthesis. The interventions were categorized into five groups: health education, digital reminders (mHealth), directly observed therapy (DOT), home visits, and family/community involvement. Results: Structured health education and mHealth strategies (e.g., SMS reminders) consistently improve medication adherence across diverse contexts. Directly observed therapy, particularly involving family supervision, significantly enhances adherence in community settings. Home visits and active community involvement promote adherence by addressing the sociocultural barriers. Multicomponent strategies that integrated educational, technological, and social elements had the highest and most sustained adherence rate. Key challenges include adverse drug reactions (ADRs), medication supply issues, complex treatment regimens, and limited health literacy. Discussion and conclusion: Improving antimalarial treatment adherence requires context-specific, multifaceted interventions that integrate education, technology, and community engagement while addressing systemic health challenges in the region. These findings provide valuable insights into the design of culturally sensitive and sustainable interventions for eliminating malaria.
Deteksi molekuler High Risk Human Papillomavirus (HR-HPV) pada Wanita Risiko Tinggi di Kota Jayapura, Papua, 2025 Eka Dian Ayu Agustina Fatem; Grace Fitriana Primasari Hau Mahu; Elisa Nugraha Haryadi Salakay; Dais Iswanto; Nuraliah Rusman
Bahasa Indonesia Vol 25 No 2 (2026): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v25i2.7725

Abstract

Pendahuluan: Infeksi high-risk human papillomavirus (HR-HPV) merupakan penyebab utama kanker serviks. Data molekuler lokal pada populasi kunci di Indonesia bagian timur masih terbatas. Penelitian ini bertujuan mendeteksi DNA HR-HPV dan mendeskripsikan distribusi HPV 16, HPV 18, dan HR-HPV non-16/18 pada wanita pekerja seks (WPS) di Kota Jayapura. Metode: Studi potong lintang ini melibatkan 30 WPS. Swab serviks diperiksa dengan real-time polymerase chain reaction (qPCR) menggunakan assay yang mendeteksi HPV 16 dan HPV 18 secara terpisah serta melaporkan 12 genotipe HR-HPV lain sebagai kelompok gabungan non-16/18. Karakteristik responden dianalisis secara deskriptif. Hasil: DNA HR-HPV terdeteksi pada 10 dari 30 responden (33,3%). Seluruh hasil positif berada pada kelompok non-16/18, sedangkan HPV 16 dan HPV 18 tidak terdeteksi. Sebanyak 25 responden (83,3%) belum pernah menerima vaksin HPV dan 15 responden (50,0%) melaporkan tidak pernah menggunakan kondom. Kesimpulan: HR-HPV terdeteksi pada sepertiga responden dan seluruh hasil positif termasuk kelompok non-16/18. Temuan ini mendukung penggunaan skrining DNA HPV yang mampu mendeteksi spektrum HR-HPV secara luas dan layanan pencegahan terintegrasi. Interpretasi temuan dibatasi oleh ukuran sampel purposif yang kecil serta keterbatasan uji dalam mengidentifikasi genotipe individual non-16/18.
Co-Authors Agnes Supraptiwi Rahayu Andoy , Morris GJ. Astawa, Gregorius Adista Enrico Astuti Tamher Dais Iswanto Dais Iswanto Dais Iswanto Doni Widyandana Eka Dian Ayu Agustina Fatem Eka Dian Ayu Agustina Fatem Elieser Elieser Grace Fitriana Primasari Hau Mahu Grace Fitriana Primasari Hau Mahu Grace Fitriana Primasari Hau Mahu Grace Fitriana Primasari Hau Mahu Grace Fitriana Primasari Hau Mahu Grace Fitriana Primasari Hau Mahu Grace Novylian Tandialo Gregorius Adista Enrico Astawa Hawryanto, Yogi Kaida Irma Setyarini Labobar, Maryam Kathrien Labobran, Maryam Khrien Mahu , Grace F.P.H. Mahu, Grace Fitriana Primatasari Hau Maryam Kathrien Labobar Mendrofa, Hendry K. Merrandan, Novianto Nuraliah Rusman Nuraliah Rusman Purwanto Purwanto Rahayu , Agnes S. Ricky Lazarus Rumboirusi Rumbino, Samdei Carolina Rumbino, Samdei Carollina Samdei Carolina Rumbino Samdei Carolina Rumbino Samdei Carolina Rumbino Samdei Carolina Rumbino Samuel Octovianus Dimara Setyarini, Kaida Irma Shrivastava, Saurabh RamBihariLal Sidabutar , Astrina R.I. Sitanggang, Prysta Aderlia Tamher, Astuti Titi Savitri Prihatiningsih