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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Judika (Jurnal Nusantara Medika) ZAHRA: JOURNAL OF HEALTH AND MEDICAL RESEARCH Biocaster : Jurnal Kajian Biologi
Danny Meganingdyah Primartati
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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COMPARISON OF HOMOGENEITY BETWEEN LYOPHILISED CONTROL MATERIAL AND IN-HOUSE CONTROL MATERIAL FOR GLUCOSE EXAMINATION Aulia Risqi Fatmariza; Angga Eka Kurnia; Danny Meganingdyah Primartati
ZAHRA: JOURNAL OF HEALTH AND MEDICAL RESEARCH Vol. 4 No. 2 (2024): APRIL
Publisher : CV. ADIBA ADISHA AMIRA

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Abstract

Background: Internal Quality Assurance (IQA) is a continuous monitoring activity by the laboratory to reduce or prevent errors in examination results using control materials. Homogeneity of the control material is very important because homogeneity shows that the control material is the same. Objective: To find out whether there is a difference in homogeneity between the lyophilized control material and the in-house control material for glucose examination. Research method: The type of research used was a quasi experiment with a simple random sampling technique at the SMC Clinical Laboratory, Telogorejo Hospital, Semarang. Data analysis uses the homogeneity calculation formula. Results: Based on the results of homogeneity calculations, it is known that the Fcount for the lyophilized control material is 0.9538 while the in-house control material is 2.1883, where both are <Ftable (3.02) which means homogeneous. Conclusion: There is no difference in homogeneity between lyophilized control material and in-house control material for glucose examination.
The Role of Interleukin-7 in T Cell Acute Lymphoblastic Leukemia: A Systematic Literature Review Primartati, Danny Meganingdyah; Hernaningsih, Yetti; Nunki, Nastasya
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2500

Abstract

This study aims to provide a comprehensive review of the genetic characteristics of acute lymphoblastic leukemia that has relapsed, discuss the relationship between interleukins and the disease, and explore targeted therapy. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines were followed in the development of the current study on acute lymphoblastic leukemia and the role of interleukins in hemato-oncology. The results reveal that relapse rates remain high and the prognosis for individuals who experience a relapse is inferior. Currently, innovative targeted medicines are employed to supplement traditional cancer treatment. The novel strategies are put into practice to lessen the load of toxicity and enhance results. From these findings, it can be concluded that combating refractory T-ALL requires the discovery of innovative medicines that directly target pathways driving Leukemia-Initiating Cell (LIC) activity.
Analisis Korelasi Neutrophil-Lymphocyte Ratio (NLR) dengan Indikator Komplikasi Makrovaskular dan Mikrovaskular pada Diabetes Melitus Tipe 2 Hasanah, Fathul Hidayatul; Wahyuni, Sri; Primartati, Danny Meganingdyah; Fatmariza, Aulia Risqi; Sari, Fita
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.501

Abstract

Type 2 Diabetes Mellitus (DM type 2) is associated with low-grade systemic inflammation. Neutrophil-Lymphocyte Ratio (NLR) is a pro-inflammatory and oxidative stress biomarker in cardiometabolic diseases such as T2DM. This study aims to analyze the relationship of NLR with leukocyte count, random blood glucose, creatinine, total cholesterol, Serum Glutamic Pyruvic Transaminase (SGPT), and Serum Glutamic Oxaloacetic Transaminase (SGOT). The study design is a retrospective analysis with respondents of 162 uncomplicated T2DM patients treated at Mojowarno Christian General Hospital, Jombang. The results of the study showed that the average number of leukocytes was 12,688 cells/µl, neutrophils 75.3%, lymphocytes 17.2%, NLR 8.5, blood glucose 273.2 mg/dl, SGOT 40.88 U/l, SGPT 54.64 U/l, total cholesterol 196.3 mg/dl (<200), and creatinine 1.13 mg/dl. Correlation tests showed that NLR was significantly associated with leukocyte count (p = 0.000 < 0.05) and total cholesterol (p = 0.000 < 0.05), but not significantly correlated with random blood glucose (p = 0.064 > 0.05), SGOT (p = 0.089 > 0.05), SGPT (p = 0.929 > 0.05), or creatinine (p = 0.625 > 0.05). In conclusion, in patients with type 2 diabetes, NLR was significantly correlated with leukocyte count and total cholesterol, but not with random blood glucose, SGOT, SGPT, or creatinine.
Pengaruh Siklus Freeze-thaw Terhadap Akurasi dan Presisi Pooled sera Glukosa Fatmariza, Aulia Risqi; Primartati, Danny Meganingdyah; Danny Meganingdyah Primartati
Judika (Jurnal Nusantara Medika) Vol 9 No 2 (2025): Judika Volume 9 No. 2 Oktober 2025
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/judika.v9i2.27073

Abstract

Siklus pembekuan dan pencairan (freeze–thaw) berulang sering kali tidak dapat dihindari dalam pengelolaan bahan kontrol laboratorium, terutama pada laboratorium dengan keterbatasan sumber daya. Glukosa merupakan salah satu parameter kimia klinik yang banyak diperiksa, sehingga penting untuk mengevaluasi stabilitasnya terhadap proses freeze–thaw. Tujuan: Penelitian ini bertujuan untuk menilai pengaruh siklus freeze–thaw terhadap akurasi dan presisi pooled sera glukosa. Metode: Penelitian eksperimental dilakukan menggunakan pooled sera dengan kadar glukosa tinggi yang dibagi menjadi aliquot dan melalui sepuluh kali siklus freeze–thaw. Pemeriksaan kadar glukosa dilakukan secara duplo pada setiap siklus. Analisis dilakukan dengan menghitung bias (%) terhadap nilai target awal, koefisien variasi (CV%), serta distribusi data (mean, median, minimum, maksimum). Hasil: Kadar glukosa rata-rata menunjukkan rentang 231,5–236 mg/dL dengan nilai mean 233,75 mg/dL, median 233,5 mg/dL, minimum 231,5 mg/dL, dan maksimum 236 mg/dL. Bias maksimum yang diperoleh adalah -1,91% dan nilai CV% ≤0,30%, yang keduanya masih memenuhi standar akurasi dan presisi berdasarkan ISO 15189 dan CLSI EP15-A3. Kesimpulan: Pooled sera glukosa terbukti stabil terhadap sepuluh kali siklus freeze–thaw tanpa penurunan signifikan pada akurasi maupun presisi, sehingga berpotensi digunakan sebagai alternatif bahan kontrol internal level tinggi yang efektif dan efisien di laboratorium klinik.
Pengaruh Siklus Freeze-thaw Terhadap Akurasi dan Presisi Pooled sera Glukosa Fatmariza, Aulia Risqi; Primartati, Danny Meganingdyah; Danny Meganingdyah Primartati
Judika (Jurnal Nusantara Medika) Vol 9 No 2 (2025): Judika Volume 9 No. 2 Oktober 2025
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/judika.v9i2.27073

Abstract

Siklus pembekuan dan pencairan (freeze–thaw) berulang sering kali tidak dapat dihindari dalam pengelolaan bahan kontrol laboratorium, terutama pada laboratorium dengan keterbatasan sumber daya. Glukosa merupakan salah satu parameter kimia klinik yang banyak diperiksa, sehingga penting untuk mengevaluasi stabilitasnya terhadap proses freeze–thaw. Tujuan: Penelitian ini bertujuan untuk menilai pengaruh siklus freeze–thaw terhadap akurasi dan presisi pooled sera glukosa. Metode: Penelitian eksperimental dilakukan menggunakan pooled sera dengan kadar glukosa tinggi yang dibagi menjadi aliquot dan melalui sepuluh kali siklus freeze–thaw. Pemeriksaan kadar glukosa dilakukan secara duplo pada setiap siklus. Analisis dilakukan dengan menghitung bias (%) terhadap nilai target awal, koefisien variasi (CV%), serta distribusi data (mean, median, minimum, maksimum). Hasil: Kadar glukosa rata-rata menunjukkan rentang 231,5–236 mg/dL dengan nilai mean 233,75 mg/dL, median 233,5 mg/dL, minimum 231,5 mg/dL, dan maksimum 236 mg/dL. Bias maksimum yang diperoleh adalah -1,91% dan nilai CV% ≤0,30%, yang keduanya masih memenuhi standar akurasi dan presisi berdasarkan ISO 15189 dan CLSI EP15-A3. Kesimpulan: Pooled sera glukosa terbukti stabil terhadap sepuluh kali siklus freeze–thaw tanpa penurunan signifikan pada akurasi maupun presisi, sehingga berpotensi digunakan sebagai alternatif bahan kontrol internal level tinggi yang efektif dan efisien di laboratorium klinik.
Co-Authors Aulia Risqi Fatmariza Fathul Hidayatul Hasanah, Fathul Hidayatul Fita Sari, Fita Kurniawan, Angga Eka Nunki, Nastasya Sri Wahyuni Yetti Hernaningsih