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APAKAH PATAH TULANG DISERTAI PEMBENGKAKAN JARINGAN LUNAK DAPAT MENYEBABKAN PNEUMONIA YANG BERUJUNG KEMATIAN? : CAN A FRACTURE ACCOMPANIED BY SOFT TISSUE SWELLING LEAD TO PNEUMONIA AND DEATH? Indrayana, Mohammad Tegar; Alparisi, Bima Diokta; Arenja, Regina Trisya; Khairussyifa, Najmi; Marbun, Patricia Dean Ully; Amanda, Shalsabila Ghaasani; Harahap, Fadhlina Murhami
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 24 No. 2 (2025): Juli 2025
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v24i2.876

Abstract

Pneumonia merupakan penyakit infeksi paru dengan tingkat morbiditas dan mortalitas yang tinggi. Pneumonia dapat menyebabkan kegagalan pernapasan yang berujung pada kematian mendadak jika tidak terdeteksi dan ditatalaksana dengan tepat. Seorang anak laki-laki berusia 14 tahun ditemukan meninggal dunia di kamar tidurnya dengan dugaan awal kematian yang disebabkan karena cedera akibat perundungan. Pemeriksaan luar menunjukkan pembengkakan jaringan lunak dan fraktur tipis pada os ulna proksimal dekstra. Hasil autopsi mengungkap adanya cairan eksudatif di rongga pleura serta infiltrasi sel inflamasi pada jaringan paru. Analisis histopatologi dan laboratorium mendukung diagnosis pneumonia bakterialis sebagai penyebab utama kematian, serta tidak ditemukan cedera fatal yang berkontribusi langsung terhadap kematian. Kasus ini menegaskan pentingnya autopsi dalam menentukan penyebab pasti kematian, terutama pada kasus kematian mendadak tanpa riwayat medis yang jelas. Pemeriksaan forensik secara menyeluruh sangat diperlukan untuk menghindari kesalahan interpretasi yang berimplikasi pada aspek medis dan hukum.
INFEKSI KUSTA PASCA INFEKSI COVID-19 : ANCAMAN PENYAKIT TROPIS TERABAIKAN PASCA PANDEMI BAGI INDONESIA Simanjuntak, Arya Marganda; Marbun, Patricia Dean Ully; Anggraini, Yuni Eka
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 10 No 1 (2023): JIMKI (Jurnal Ilmiah Mahasiswa Kedokteran Indonesia) Volume 10 Nomor 1 Periode M
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v10i1.513

Abstract

Background: Leprosy is still a health problem in Indonesia and as the third world largest contributor the number of cases ranging from 8% world’s cases. Leprosy has various challenges in Indonesia, such as negative stigma, public reluctance to seek medical treatment and comply with medication and the pandemic. Pandemic COVID-19 seems to cover up leprosy cases in Indonesia. A Population-based study in Brazil showed that the impact of pandemic as increasing the diagnosis of multibacillary leprosy. Correlation studies COVID-19 and Leprosy is still unknown. No article identified about leprosy and COVID-19 related in Indonesia. Researchers are trying to explore more about leprosy infection and COVID-19 mechanisms that may occur and also probable condition that would happen in Indonesia. Methods: This literature review sourced from Pubmed, Science Direct and Google Scholar according to the inclusion criteria and evaluated and studied. Discussion: Patient would had Lymphopenia after COVID-19. This supports growth of leprosy in the patient’s body as the patient contact with other leprosy patient. The growth will be progressive due to decreased immunity in COVID-19 patients that would persist for a certain period of time. Increasing severity of COVID-19, the greater the susceptibility of the patient to be infected with leprosy. This allows for a sudden spike in leprosy cases after the pandemic. Solution that can be carried out by the government, such as education to eradicate stigma, to serological examination of IgM PGL-1 are needed to find leprosy case as early as possible, especially in patients with sublclinical phase. Finding cases of leprosy as early as possible is needed so that it can be treated before the occurrence of disability in the patient. Conclusion: Infection of COVID-19 would make patient more susceptible for leprosy infection to growth progressively hence increasing case of leprosy after the pandemic if the case is not found as early as possible especially in subclinical phase of Leprosy infection.
Penggunaan SGLT2-i Sebagai Inovasi Terapi Preventif Stroke Pada Pasien Diabetes Mellitus Tipe 2 Simanjuntak, Arya Marganda; Marbun, Patricia Dean Ully; Patresia, Putri Leony
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 1 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i1.8347

Abstract

Diabetes merupakan faktor resiko stroke iskemik sebesar 2,5 kali dan 1,5 kali lipat menderita stroke hemoragik. Hal ini memicu meningkatnya angka mortalitas baik yang disebabkan oleh diabetes, stroke maupun diabetes yang berkomplikasi pada stroke. Sodium Glucose cotransporter 2 inhibitor (SGLT2-i) diketahui dapat mengurangi permasalahan kardiovaskular pada diabetes sehingga penulis akan menelaah lebih lanjut mengenai mekanisme SGLT2-i terhadap vaskular yang dihubungkan terhadap stroke. Literature Review ini dilakukan dengan menelusuri artikel penelitian yang terdapat pada mesin pencarian. Mesin pencarian jurnal yang digunakan berupa PubMed dan Science Direct. Dari 551 artikel diidentifikasi berdasarkan judul, duplikasi, abstrak dan kesesuaian dengan kriteria inklusi dan dilaksanakan review untuk artikel terpilih. SGLT2-i memiliki mekanisme untuk menghambat progresivitas atheroma. Mekanisme yang terjadi berupa penurunan reaksi inflamasi sistemik, penurunan stress oksidatif, pengurangan ukuran ateroma hingga menjaga kestabilan plak ateroma. Oleh karena itu SGLT2-i merupakan kandidat terapi yang potensial dalam mengurangi risiko stroke pada pasien DMT2. SGLT2-i dapat digunakan sebagai inovasi terapi preventif untuk stroke pada pasien DMT2.
COVID-19 dan Tuberkulosis Paru, Antara Koinfeksi dan Reaktivasi dari Laten Tuberkulosis: Sebuah Kajian Sistematis Simanjuntak, Arya Marganda; Yovi, Indra; Marbun, Patricia Dean Ully; Elisabet, Adinda
Majalah Kedokteran Indonesia Vol 73 No 2 (2023): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.73.2-2023-1006

Abstract

Introduction: Globally, cases of pulmonary tuberculosis (PTB) are rising by 4%, while new cases have declined in many nations, most notably by 14% in Indonesia. During the COVID-19 pandemic, the number of undiagnosed and untreated PTB patients could rise and infect more people. In particular, CD8+ lymphocytes were decreased in COVID-19. Perhaps this is the cause of the rise in cases, but there is no data to show it. Aim: Determine current data about the PTB with COVID-19 coinfection and possible reactivation of PTB after COVID-19 infection in LTB patient. Methods: This systematic review is based on PRISMA statements using Pubmed, EBSCOHost, Science Direct and Cochrane from December 2019 to July 2022. Inclusion and exclusion criteria were set to select studies that included. We analyze risk of bias of all included studies with JBI critical appraisal tools. Results: This study had 107,425 patients in total from 20 studies. All studies were deemed to have low overall author bias risks. A critical component of PTB defense is CD8+. By reducing lymphocytes, COVID-19 can encourage the growth of PTB, which might therefore result in coinfection or the reactivation of existing PTB. Conclusion: COVID-19 possibly increase case of PTB in form of co-infection or reactivation of PTB in LTB patients. This needs special attention for patients that have infected by COVID-19 to followed up for risk developing PTB.