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All Journal MAHESA : Malahayati Health Student Journal Eduvest - Journal of Universal Studies Indonesian Journal of Biomedicine and Clinical Sciences
Sutiawan, Indry Salonika
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Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Serpentine supravenous hyperpigmentation (SSH) in nasopharyngeal carcinoma patient on docetaxel and carboplatin chemotherapy: a case report Sutiawan, Indry Salonika; Puspawati, Ni Made Dwi; Martalova AJ, Adelia; Setyono, Alfred; Devi, Putu Akopita; Setyawati, Ni Kadek
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 2 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i2.13006

Abstract

Serpentine supravenous hyperpigmentation (SSH) is a rare but unique side effect of intravenous anticancer. It manifests as linear hyperpigmentation eruption on the skin that radiates along the superficial vein accompanied by mild pain and/or itch. This SSH does not cause systemic alterations, however, most patients complained about its cosmetic effects. The diagnosis of SSH can be made clinically, although histopathological examinations can aid in excluding differential diagnoses. We reported a case of SSH found in a nasopharyngeal cancer patient during docetaxel and carboplatin chemotherapy. It is a potentially alarming interface dermatitis that is not lot reported in the literature. It was reported, the patient tolerated the second and third cycles well with less severe side effects when premedicated with 250 mL NaCl 0.9% bolus intravenously before and after chemotherapy sessions, 10 mg cetirizine every 24 hr orally, and desoximetasone cream 0.25% every 12 hr topically added.
Profile of Psoriatic Arthritis Patients in the Dermatology and Venereology Clinic at RSUP Prof. I.G.N.G. Ngoerah Denpasar for the Period of 2021-2023 Setyono, Alfred; Sudarsa, Prima Sanjiwani Saraswati; Martalova, Adelia; Sutiawan, Indry Salonika; Setyawati, Ni Kadek; Devi, Putu Akopita
Eduvest - Journal of Universal Studies Vol. 4 No. 12 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i12.1528

Abstract

Psoriatic arthritis (PsA) presents a significant challenge due to its high prevalence and morbidity rates. Psoriasis vulgaris affects an estimated 0.19-2% of the global population, with approximately 30% of these individuals progressing to experience psoriatic arthritis. Methods: This is a retrospective study using medical records of psoriatic arthritis patients at the Dermatology and Venereology Clinic. Result and Discussion: A total of 168 psoriasis patients were assessed at the Dermatology and Venereology Clinic of Prof. I.G.N.G Ngoerah Hospital from 2021 to 2023. Among them, 58 cases were also diagnosed with Psoriatic Arthritis (PsA), accounting for 35.1% of the sample. Of these, 33 patients were male (67.3%) and 16 were female (32.7%). The highest prevalence was observed in the 40-59 age group (51%). Additionally, 77.5% of patients had a Body Surface Area (BSA) greater than 10%, 61.2% had a Psoriasis Area Severity Index (PASI) score of severe psoriasis (>10), and 49.0% had a Dermatology Life Quality Index (DLQI) score indicating moderate impact (6-10). Similarly, 49.0% of patients had a moderate Disease Activity Index for Psoriatic Arthritis (DAPSA) score (>4-14). The study revealed a PsA prevalence of 35.1%, which surpasses global averages, likely due to the hospital's role as a tertiary referral center for severe psoriasis cases. Conclusion: The prevalence of Psoriatic Arthritis (PsA) among patients treated is still high, particularly among male patients aged 40-59 years who have severe psoriasis based on BSA (Body Surface Area), PASI (Psoriasis Area Severity Index), and DLQI (Dermatology Life Quality Index) criteria.
Low Serum Vitamin E Levels Positively Correlate with the Severity of Acne Vulgaris Sutiawan, Indry Salonika; Winaya, Ketut Kwartantaya; Suryawati, Nyoman; Rusyati, Luh Made Mas; Karmila, I Gusti Ayu Agung Dwi; Puspawati, Ni Made Dwi
MAHESA : Malahayati Health Student Journal Vol 4, No 10 (2024): Volume 4 Nomor 10 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i10.15882

Abstract

ABSTRACT Acne vulgaris (AV) is a common disorder of the pilosebaceous, especially prevalent in adolescents. Acne vulgaris ranks among the top ten most prevalent diseases globally. Although AV may resolve spontaneously, sequelae such as scar formation can persist, causing aesthetic and psychological disturbances. There is an antioxidant to counteract acne-causing oxidative stress, vitamin E, which is an important antioxidant in the human body. Therefore, vitamin E in the skin can reduce the formation of squalene peroxide and prevent the occurrence of AV. This is an analytical observational study using a cross-sectional design. The investigation was conducted at the Dermatology and Venereology Clinic of Prof. Dr. I.G.N.G. Ngoerah Denpasar Hospital and the laboratory of the Faculty of Medicine, Udayana University, from February 2024 until the sample size was fulfilled. The sample consisted of patients aged 12-45 years with acne vulgaris who visited the clinic and were then selected through consecutive sampling according to the inclusion and exclusion criteria. In the non-AV group, the mean serum vitamin E level was 19.3 ± 0.99 µg/ml, whereas in the AV group, it was 4.49 ± 19.1 µg/ml, indicating a significant variance. There was a positive correlation between low vitamin E levels and the severity of AV. The linearity graph shows the direction of the relationship between serum vitamin E levels and the severity of AV, which leads to the lower right, indicating that the higher the severity of AV, the lower the serum vitamin E levels. The mean levels differed significantly between the non-AV and AV groups. A favorable association was found between low vitamin E levels and the severity of AV. Keywords: Acne Vulgaris, Severity, Serum Vitamin E, Reactive Oxygen Species (ROS)
Co-Authors Devi, Putu Akopita I Gusti Ayu Agung Dwi Karmila Luh Made Mas Rusyati Martalova AJ, Adelia Martalova, Adelia Ni Kadek Setyawati, Ni Kadek Ni Made Dwi Puspawati Nyoman Suryawati Prima Saraswati Sanjiwani Sudarsa Setyono, Alfred Winaya, Ketut Kwartantaya