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All Journal Pharmacy Reports Jurnal Pengabdian Masyarakat Bangsa
Arrafi, Muhammad Zhafran
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Pelatihan Pembuatan Suplemen Organik dari Olahan Rumput Laut Merah asal Desa Ruguk, Kec. Ketapang, Lampung Selatan Putri, Refsya Azanti; Saputra, Muhammad Yogi; Ayuwulanda, Aditya; Nareswari, Tantri Liris; Windari, Nurul Irna; Saeli, Pinka Mustika; A.L, Ihza Adzkiya Mubarak; Arrafi, Muhammad Zhafran; N.S, Yonatan Adi; Cahyadi, Dzaky Raihan
Jurnal Pengabdian Masyarakat Bangsa Vol. 1 No. 9 (2023): November
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v1i9.428

Abstract

Provinsi Lampung merupakan salah satu sentra penghasil rumput laut kering di Indonesia. Rumput laut dikenal dengan berbagai kandungan gizi yang berkhasiat untuk mengobati penyakit dan memenuhi kebutuhan nutrisi tubuh. Jenis rumput laut yang banyak dibudidaya yaitu rumput laut merah (Eucheuma cottoni). Namun, pemanfaatan rumput laut merah untuk dijadikan produk olahan yang sehat dan bernilai ekonomis masih belum dilakukan. Oleh karena itu, kegiatan pengabdian masyarakat ini dilakukan untuk membantu dan mengedukasi Masyarakat agar bisa mengoptimalkan potensi rumput laut merah menjadi produk suplemen herbal berupa serbuk dan gel yang dikombinasi dengan empon-empon sehingga bermanfaat untuk kesehatan dan bernilai ekonomis  tinggi. Kegiatan pelatihan ini diikuti oleh 21 orang masyarakat desa dan anggota kelompok tani Putra Laut. Bentuk kegiatan yang dilakukan yaitu penyuluhan, pendampingan  pembuatan produk, dan pelatihan kewirausahaan rumput laut merah kepada masyarakat Desa Ruguk, Lampung Selatan. Evaluasi dilakukan menggunakan penilaian kuisioner pre dan post tes yang menunjukkan bahwa terdapat peningkatan pengetahuan pada semua peserta mengenai materi dan pengolahan rumput laut menjadi produk herbal.
Molecular docking analysis of guaiacin and chalcone from nutmeg (Myristica fragrans) as novel HSP90A inhibitors for skin cancer treatment Arrafi, Muhammad Zhafran; Cahyani, Ayu Sukma; Sitohang, Nada Nikita; Ulya, Salsa Nabila Ahlika; Anggraeni, Inggrid; Amalia, Miranti; Putri, Gladys Ellnora; Rajwa, Raihan M Dhiya; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 3 No. 3 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.73

Abstract

Skin cancer represents one of the most prevalent malignancies globally, with Indonesia reporting the third highest incidence among cancer types. Despite advances in treatment, there remains a critical need for novel therapeutic agents. Heat Shock Protein 90 Alpha (HSP90A) has emerged as a promising target for cancer therapy due to its critical role in stabilizing oncogenic proteins. This study aimed to evaluate the potential of guaiacin and chalcone from nutmeg (Myristica fragrans) as HSP90A inhibitors for skin cancer treatment through computational analysis. Molecular docking was performed using AutoDock Tools with the HSP90A crystal structure (PDB ID: 2VCJ). The compounds were assessed for binding affinity, molecular interactions, and drug-likeness properties according to Lipinski's Rule of Five. Redocking validation yielded an RMSD of 1.24 Å, confirming protocol reliability. Guaiacin demonstrated promising binding affinity (-7.40 kcal/mol) with key hydrogen bonds to Asp93 and Lys58, while chalcone showed moderate affinity (-5.99 kcal/mol) with a single hydrogen bond to Thr184. Both compounds exhibited favorable drug-like properties with high predicted gastrointestinal absorption. Guaiacin emerges as a promising natural HSP90A inhibitor candidate with binding energy exceeding the stability threshold (-7.00 kcal/mol) and interactions with critical residues in the ATP-binding pocket, providing a foundation for further development of nutmeg-derived compounds as potential anticancer agents.
Co-Authors A.L, Ihza Adzkiya Mubarak Amalia, Miranti Anggraeni, Inggrid Anjar Hermadi Saputro Ayuwulanda, Aditya Cahyadi, Dzaky Raihan Cahyani, Ayu Sukma Muhammad Yogi Saputra N.S, Yonatan Adi Putri, Gladys Ellnora Rajwa, Raihan M Dhiya Refsya Azanti Putri Saeli, Pinka Mustika Sitohang, Nada Nikita Tantri Liris Nareswari Ulya, Salsa Nabila Ahlika Windari, Nurul Irna Winni Nur Auli