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All Journal Academia Open Indonesian Journal of Cultural and Community Development Proceedings of The ICECRS Eduvest - Journal of Universal Studies Journal of Empowerment and Community Service Journal of Social Comunity Services Journal of Global Research in Public Health
Anis Khoirin Hayati
Universitas Muhammadiyah Sidoarjo, Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Academia Open

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Inhibition of Propolis on the Growth of Aggregatibacter Actinomycetemcomitans Pratiwi, Novita; Hayati, Anis Khoirin; Maulidah, Nurul
Academia Open Vol 10 No 1 (2025): June (In Progress)
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/acopen.10.2025.10589

Abstract

General Background: Periodontitis, a chronic inflammatory disease, leads to tooth loss, with Aggregatibacter actinomycetemcomitans playing a key role in its pathogenesis. Specific Background: The rise of antibiotic resistance necessitates alternative treatments. Propolis, a bee-derived resin, has shown antimicrobial properties. Knowledge Gap: Limited research exists on the inhibitory effects of propolis against A. actinomycetemcomitans at varying concentrations. Aims: This study evaluates the antibacterial activity of propolis extract on A. actinomycetemcomitans in vitro. Results: Propolis exhibited significant antibacterial effects, with a minimum inhibitory concentration of 12.5% (125 mg/mL), attributed to flavonoids and apigenin. Statistical analysis confirmed significant differences across concentrations (p < 0.05). Novelty: This study highlights the concentration-dependent antibacterial efficacy of propolis against A. actinomycetemcomitans, suggesting its potential as a natural therapeutic. Implications: Propolis may serve as a complementary antimicrobial in periodontal therapy, reducing antibiotic reliance and resistance. Highlights: Effective Antibacterial Agent – Propolis inhibits A. actinomycetemcomitans growth at a minimum concentration of 12.5% (125 mg/mL). Bioactive Components – Flavonoids and apigenin in propolis disrupt bacterial membranes and biofilm formation. Clinical Potential – Propolis may serve as a natural alternative to antibiotics in periodontal therapy. Keywords: Periodontitist, Propolis, Aggregatibacter Actinomycetemcomitans, Antimicroba
Co-Authors Adi, Ali Agus Hayatal Falah Amelia, Ananda Firly Amri, Rangga Nur Zaifatul Davinaiella R G Prameswari Dedi Fardiaz Febrianti , Sofi Intan Hasan, Salma Tsaniyah El Hidayah, Pratiwi Nur Imaniah, Anissa Alifia Indrawati, Dwi Wahyu Joni Haryanto Kartika, Mas Aldrin Zagna Rania Manurung, Rizky Briliant Syah Maulidah, Nurul Nihayah, Durrotun Ornando, Muhammad Athallah Hazel Pratiwi, Novita Rahayu, A. Retno Pudji Ratna Wardhani Rosyidah, Rafhani Rosyidah Salma Tsaniyah Sandu Siyoto, Sandu Sandy, Rizky Rahmahdian Sari, Ervina Fatika Setyawatie, Ernie Maduratna Silmi , Dewi Nurus Yunita Wulandari