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Pengembangan Inovasi Dan Branding Produk UMKM Wedang Uwuh “Sari Asih” Tri Wijayanti; Desmana Mei Yuliyanti; Fitri Melati; Maria Nona Adriana Lering; Yovi Pranata
Jurnal Mandala Pengabdian Masyarakat Vol. 4 No. 2 (2023): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

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Wedang uwuh merupakan salah satu minuman herbal yang berkhasiat untuk kesehatan. Saat ini penjualan wedang uwuh di pasaran masih dalam bentuk kemasan konvensional yaitu simplisia yang dikemas persatuan minum. Tujuan kegiatan pengabdian ini yaitu melakukan inovasi dan branding kemasan celup wedang uwuh yang bekerja sama dengan produsen Wedang uwuh “Sari Asih” untuk meningkatkan minat pembeli dan nilai jual produk. Kegiatan pengabdian ini dilakukan dengan metode observasi, persiapan, pendampingan, dan evaluasi. Hasil pengabdian berupa pembuatan desain kemasan primer dan sekunder yang lebih moderen sehingga meningkatkan minat pembeli dan meningkatkan nilai jual terhadap produk wedang uwuh “Sari Asih”.

Antibacterial and Antibiofilm Activity of Papaya Leaf Fractions (Carica Papaya L.) Against Staphylococcus Aureus ATCC 25923 Pranata, Yovi; Rahmawati, Ismi; Saptarini, Opstaria
Jurnal Multidisiplin Madani Vol. 4 No. 6 (2024): June 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/mudima.v4i6.9879

The research on papaya leaves was aimed at determining antibacterial activity, antibiofilm activity, K+ and Ca2+ metal ion parameters, as well as the morphology of S.aureus bacteria from papaya leaf fractions and extracts. The average value of the test results for the diffusion method at 50% concentration was 20.66 ± 0.57 and the test results for the dilution method for Minimum Inhibitory Concentration at a concentration of 12.5%. Antibiofilm formation inhibitor test results at a concentration of 50 mg/ml with an average value of 72.37 ± 0.65, a concentration of 25 mg/ml 64.75 ± 0.83 and a concentration of 12.5 mg/ml with an average value of IC50 of 0.975 ± 0.012. Biofilm degradation testing at a concentration of 50 mg/ml resulted in an average value of 60.43 ± 1.11, a concentration of 25 mg/ml with an average value of 50.05 ± 0.87 and a concentration of 12.5 mg/ml with an average value -mean 35.86 ± 1.05. The average EC50 value was 26.731 ± 1.1874. Tests using AAS on K+ metal ions showed ion leakage or cell contents coming out was 1,805 mg/L, Ca2+ metal ions resulting from this leak were 3,884. Morphological observations using SEM showed that the samples experienced shrinkage and reduced size from being perfectly round to oval to S.aureus bacteria in samples with water fraction

Uji Formulasi Sediaan Salep dari Ekstrak Etanol Daun Salam (Sysygium polyanthum) terhadap Bakteri Staphylococcus epidermidis Rindi Permata Sari; Yovi Pranata; Putu Nila Sari
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v5i1.8085

Acne (Acne vulgaris) is one of the most common skin problems, affecting 80–85% of adolescents aged 15–18 years, with some cases persisting into adulthood. One of the associated bacteria is Staphylococcus epidermidis, a normal skin flora that can become an opportunistic pathogen. Bay leaves (Syzygium polyanthum) are known to contain secondary metabolites such as alkaloids, flavonoids, tannins, saponins, and essential oils with antibacterial activity. This study aimed to formulate ethanol extract of bay leaves into ointments with concentrations of 10%, 20%, and 30%, test their antibacterial activity against Staphylococcus epidermidis using the disc diffusion method, and evaluate their physical quality (organoleptic properties, homogeneity, pH, adhesion, and spreadability). Results showed that the ethanol extract of bay leaves contained alkaloids, flavonoids, saponins, and tannins. The ointments met topical quality standards with pH 5.8–6.9, adhesion time 36–41 seconds, and spreadability 6.9–8.1 cm. Antibacterial activity increased with higher concentrations: 7.8 mm (10%), 12 mm (20%), and 15 mm (30%), although still lower than the positive control (clindamycin, 34 mm). In conclusion, ethanol extract of bay leaves has potential as an active ingredient in topical anti-acne ointments, but further studies with higher concentrations, in vivo testing, and optimized formulations are needed to achieve efficacy comparable to synthetic antibiotics.

Influence of Stearic Acid and Triethanolamine on the Physical Properties and Antibacterial Efficacy of Ocimum basilicum L. Anti-acne Cream against Staphylococcus epidermidis Nurcahya, Salsabila; Pranata, Yovi; Pratamarta, Meliasi Nora; Hidayati, Nurul; Setiawansyah, Arif
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25043

Acne vulgaris represents a significant dermatological concern, with Staphylococcus epidermidis identified as a key pathogenic contributor. While Ocimum basilicum L. (basil) leaves contain bioactive compounds including flavonoids, eugenol, and tannins that demonstrate promising antibacterial properties, the successful translation of these natural antimicrobials into effective topical formulations remains critically dependent on appropriate excipient selection. Despite the growing interest in botanical-based acne treatments, there exists a significant knowledge gap regarding how emulsifying agents, particularly stearic acid and triethanolamine (TEA), influence both the physical stability and therapeutic efficacy of herbal cream formulations. This study investigated the effects of varying concentrations of stearic acid and TEA on the physical characteristics, stability, and antibacterial activity of basil leaf extract cream formulations against S. epidermidis ATCC-12228. Extracts obtained via maceration in 96% ethanol were incorporated into cream formulations (F0–F4), which were subsequently evaluated for organoleptic properties, homogeneity, spreadability, adhesion, pH, stability using a thermal cycling test, and antibacterial activity via disc diffusion. Stability assessment revealed notable differences across formulations. Although all formulations maintained consistent pH values and exhibited uniform microscopic homogeneity after cycling, variations in spreadability and adhesion indicated differing degrees of structural stability. Formulations F3 and F4 showed minimal changes across cycles, demonstrating superior resistance to thermal stress, whereas F0 exhibited significant instability in both spreadability and adhesion. Antibacterial testing showed that the formulation containing 20% basil extract (F4) produced the largest inhibition zone (11.83 ± 0.77 mm). Beyond its higher extract content, F4’s superior antibacterial performance is attributed to its more stable structural matrix, which likely enhanced the release and bioavailability of active phytochemicals such as eugenol and flavonoids, thereby promoting more efficient diffusion into the agar medium. Overall, the findings demonstrate that stearic acid and TEA concentrations substantially influence both the physical stability and antibacterial efficacy of basil-based cream formulations. The optimal stability and enhanced antimicrobial activity observed in F3 underscore their potential as promising candidates for topical anti-acne product development.

Influence of Stearic Acid and Triethanolamine on the Physical Properties and Antibacterial Efficacy of Ocimum basilicum L. Anti-acne Cream against Staphylococcus epidermidis Nurcahya, Salsabila; Pranata, Yovi; Pratamarta, Meliasi Nora; Hidayati, Nurul; Setiawansyah, Arif
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25043

Acne vulgaris represents a significant dermatological concern, with Staphylococcus epidermidis identified as a key pathogenic contributor. While Ocimum basilicum L. (basil) leaves contain bioactive compounds including flavonoids, eugenol, and tannins that demonstrate promising antibacterial properties, the successful translation of these natural antimicrobials into effective topical formulations remains critically dependent on appropriate excipient selection. Despite the growing interest in botanical-based acne treatments, there exists a significant knowledge gap regarding how emulsifying agents, particularly stearic acid and triethanolamine (TEA), influence both the physical stability and therapeutic efficacy of herbal cream formulations. This study investigated the effects of varying concentrations of stearic acid and TEA on the physical characteristics, stability, and antibacterial activity of basil leaf extract cream formulations against S. epidermidis ATCC-12228. Extracts obtained via maceration in 96% ethanol were incorporated into cream formulations (F0–F4), which were subsequently evaluated for organoleptic properties, homogeneity, spreadability, adhesion, pH, stability using a thermal cycling test, and antibacterial activity via disc diffusion. Stability assessment revealed notable differences across formulations. Although all formulations maintained consistent pH values and exhibited uniform microscopic homogeneity after cycling, variations in spreadability and adhesion indicated differing degrees of structural stability. Formulations F3 and F4 showed minimal changes across cycles, demonstrating superior resistance to thermal stress, whereas F0 exhibited significant instability in both spreadability and adhesion. Antibacterial testing showed that the formulation containing 20% basil extract (F4) produced the largest inhibition zone (11.83 ± 0.77 mm). Beyond its higher extract content, F4’s superior antibacterial performance is attributed to its more stable structural matrix, which likely enhanced the release and bioavailability of active phytochemicals such as eugenol and flavonoids, thereby promoting more efficient diffusion into the agar medium. Overall, the findings demonstrate that stearic acid and TEA concentrations substantially influence both the physical stability and antibacterial efficacy of basil-based cream formulations. The optimal stability and enhanced antimicrobial activity observed in F3 underscore their potential as promising candidates for topical anti-acne product development.

Analysis of Community Knowledge, Practices, and Perceptions Regarding the Management of Leftover, Damaged, and Expired Medicines in Tegal Sari Village Azzahra, Nia; Wati, Indhika Tyas; Pranata, Yovi; Muliana, Hilda; Sabda Wahab
JUKEJ : Jurnal Kesehatan Jompa Vol 4 No 4 (2025): JUKEJ: Jurnal Kesehatan Jompa
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jkj.Vol4.Iss4.2023

Medicines play an important role in maintaining and restoring public health. However, limited knowledge and improper management can cause various problems, such as the accumulation of leftover medicines, the use of expired medicines, and the disposal of medicines that does not comply with regulations. This study aims to evaluate the level of knowledge, actions, and perceptions of the community regarding the management of leftover, damaged, and expired medicines in Tegal Sari Village, Belitang II District, East Ogan Komering Ulu Regency in 2025. This study used a quantitative analytical design with a cross-sectional approach. A total of 86 respondents were selected using purposive sampling. The research instrument was a structured questionnaire that assessed the level of knowledge, actions, and perceptions of the community. Data analysis was performed descriptively and analytically using Partial Least Squares Structural Equation Modeling (PLS-SEM) to test the relationship between variables. The study showed a significant relationship between the variables of knowledge, actions, and perceptions of the community regarding the management of leftover, damaged, and expired medicines in Tegal Sari Village in 2025 with a p-value <0.05. Conclusion there is a significant relationship between knowledge, actions, and public perception and the management of leftover, damaged, and expired medicines in Tegal Sari Village. Although the respondents' knowledge and actions were in the good category, medicine management practices were still not fully in accordance with standards. Educational interventions and the provision of medicine disposal facilities are needed to improve safe medicine management behavior.

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