The purpose of this study is to determine whether or not the use of anagram technique can improve the students' English vocabulary mastery in science class A SMA Negeri 1 Paguyaman eleventh-grade students. This study used a pre-experimental design with one group pre-test and post-test, with the difference between the pre-test and post-test score indicating the effects of treatments. The data sample consisted of eleventh grade students from Science class A at SMA Negeri 1 Paguyaman. Twenty-five students were chosen as the sample by the researcher. The data was collected by the researcher using an instrument test that included a pre- and post-test. The T-test is being used to analyze the data in this study. The pre-test mean score of the students is (45.6). By the end of the study, the students' mean score is (75.2). The t-test result tcount 2.747 was higher than ttable 1.711. The outcome indicates that the alternative hypothesis (Ha) has been accepted and the null hypothesis (Ho) has been rejected. As a result, it is possible to conclude that the anagram technique can help students improve their vocabulary mastery.