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All Journal ACTA VETERINARIA INDONESIANA Current Biomedicine al Kimiya : Jurnal Ilmu Kimia dan Terapan
Aryani Satyaningtijas
Division Of Physiology, School Of Veterinary Medicine And Biomedical Sciences, IPB University, Bogor, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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The Potential of Ciplukan Leaf Extract (Physalis Angulata L.) to Improve Kidney Function Tampie, Bella; Damiana R Astuti; I Ketut M Adnyane; Aryani S Satyaningtijas
Acta VETERINARIA Indonesiana Vol. 11 No. 1 (2023): Maret 2023
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.11.1.9-16

Abstract

Gagal ginjal merupakan penyakit tidak menular namun dapat mengancam nyawa manusia. Penyakit ini dapat dialami dari berbagai macam usia mulai dari anak-anak hingga lansia. Salah satu tanaman yang biasanya dijadikan sebagai obat herbal ialah tanaman ciplukan (Physalis angulata L.). Gagal ginjal merupakan penyakit tidak menular namun dapat mengancam nyawa manusia. Penyakit ini dapat dialami dari berbagai macam usia mulai dari anak-anak hingga lansia. Salah satu tanaman yang biasanya dijadikan sebagai obat herbal ialah tanaman ciplukan (Physalis angulata L.). Penelitian ini bertujuan untuk mengetahui potensi dari daun tanaman ciplukan dalam memperbaiki fungsi ginjal. Penelitian ini dilakukan di Kampus IPB Dramaga, IPB University, Bogor. Tikus putih digunakan sebanyak 24 ekor dan dibagi menjadi 8 kelompok dengan perlakuan dosis 150mg/kg BB dan 300mg/kg BB. Perlakuan dilakukan selama 14 hari dan 28 hari.Etilen glikol digunakan sebagai agen nefrotoksik. Pemberian kombinasi etilen glikol 1 ml/100g BW secara oral dan ekstrak ciplukan dosis 300mg/kg BB secara bersamaan mampu menormalkan kadar ureum dalam darah. Hasil histologi juga menunjukkan adanya perbaikan pada glomerulus ginjal. Ekstrak daun ciplukan memiliki kandungan flavonoid yang berpotensi memperbaiki fungsi dan morfologi ginjal.
Performa Reproduksi Ayam IPB-D1 Betina pada Konsentrasi IgY Berbeda Hayu Fitriyani; Niken Ulupi; Aryani Sismin Satyaningtijas
Acta VETERINARIA Indonesiana Vol. 11 No. 2 (2023): Juli 2023
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.11.2.156-159

Abstract

Ayam IPB-D1 merupakan hasil persilangan antara jantan F1 pelung-sentul dengan betina F1 kampung-broiler parent stock. Keunggulan yang dimiliki ayam IPB-D1 yaitu pertumbuhan yang cepat dan mencapai bobot potong (jantan 1.18 kg dan betina 1.04 kg) pada umur 10-12 minggu. Salah satu indikator ketahanan tubuh terhadap penyakit yakni konsentrasi Immonoglobulin Yolk (IgY) pada serum. Induk ayam yang memiliki konsentrasi IgY serum tinggi menghasilkan kuning telur dengan konsentrasi IgY yang tinggi . Tujuan dari penelitian ini adalah untuk mengevaluasi konsentrasi IgY yang berbeda terhadap reproduksi pada ayam IPB-D1 betina. Penelitian ini menggunakan 20 ekor ayam IPB-D1 7 bulan, terdiri dari 10 ekor dengan konsentrasi IgY tinggi dan 10 ekor dengan konsentrasi IgY rendah. Variabel yang diamati reproduksi meliputi fertilitas, daya tetas, dan bobot DOC ayam IPB D-1. Hasil penelitian mengenai performa reproduksi ayam IPB -D1 yang memiliki IgY rendah pada kondisi normal menghasilkan persentase fertilitas yang lebih tinggi dibandingkan ayam IPB-D1 IgY tinggi. Daya tetas dan bobot tetas pada telur ayam IPB-D1 yang menunjukkan data persentase daya tetas dan bobot DOC ayam IgY tinggi lebih rendah dibandingkan ayam IgY rendah. Bobot tetas pada penelitian dapat dikatakan kurang maksimal. Hal ini kemungkinan disebabkan karena adanya peningkatan suhu panas dan penurunan kelembaban pada mesin tetas yang menyebabkan daya tetas pada telur kurang maksimal. Dapat disimpulkan bahwa induk Ayam IPB-D1 yang memiliki IgY tinggi pada kondisi normal menghasilkan performa reproduksi yang lebih rendah dibandingkan ayam IPB-D1 IgY rendah.
Studi of In Vivo Antidiabetic Activity of Namnam Leaves (Cynometra cauliflora) Extract in Sprague Dawley Rat La Ode Sumarlin; Agik Suprayogi; Min Rahminiwati; Aryani Satyaningtijas; Hajar Hajar; Meyliana Wulandari
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 10, No 1 (2023): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v10i1.23406

Abstract

Various treatments for Type 2 Diabetes Mellitus (T2DM) aim to alleviate hyperglycemia. Although natural products have been extensively utilized, their mechanism of action and efficacy as antidiabetic agents, particularly for T2DM, has not been extensively assessed in vivo. In this research, the leaves of the Namnam (Cynometra cauliflora) were extracted and tested for their activity as an antidiabetic agent. Sprague Dawley rats aged 3.5-4 months, weighing 200-250 g, were used as the experimental model, with a total of 30 individuals. The rats were induced with a high-fat diet and 30% sucrose until their blood glucose concentration reached ≥ 120 mg/dL. Subsequently, the rats were divided into four groups (groups 1, 2, 3, and 4). Over 21 days, changes in blood glucose, triacylglycerol, glycogen, and blood plasma insulin levels were assessed. The results demonstrated that the methanol extract of Namnam leaves (NLME) effectively reduced blood glucose levels by 23-34%, decreased plasma triglyceride levels by 13-30%, and increased liver glycogen levels by 68-96% compared to the control group (Diabetes). Among all the parameters assessed, NLME exhibited similar performance to metformin, a commonly prescribed diabetes medication (p<0.05). Furthermore, the study revealed that NLME exerted antidiabetic effects, particularly for T2DM, by promoting liver glycogen formation, enhancing insulin secretion control, facilitating glucose absorption by muscles, and restricting fat metabolism in the blood
Canine monocytic Ehrlichiosis in Alaskan Malamute dog in GloriaVet Pet Health Solution, Bandung, Indonesia Aqila Zata Amani; Kinanti Dwi Rahma; Aryani Sismin Satyaningtijas; Ivan Satriawan; Nurul Nadelia; Sus Derthi Widhyari
Current Biomedicine Vol. 4 No. 1 (2026): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.4.1.24

Abstract

Background Ehrlichiosis is an infection caused by the bacterium Ehrlichia canis, which attacks monocytes. Ehrlichiosis is characterized by anemia, lethargy, lameness, pancytopenia, hemorrhage, and weight loss. Objective This study aimed to describe the clinical findings and treatment of a dog diagnosed with Ehrlichia canis infection. Case A 5-year-old female Alaskan Malamute dog named Salt was brought to the clinic of GloriaVet Pet Health Solution, Bandung, Indonesia, with lameness and weakness, accompanied by high fever and very pale mucous membranes (pallor). Examination and treatments Dog was examined using a general examination, hematology test, biochemistry test, native smear, and IDExx SNAP© 4dx test kit. The examinations showed a positive result for Ehrlichia canis infection, along with severe pancytopenia, hyperglobulinemia, and thrombocytopenia. Diagnosis heavily relied on serology and clinical manifestation, and further PCR testing was not performed. The treatment consisted of doxycycline 10 mg/kg/day for 28 days, a 0.75% ketamine drip infusion, darbepoetin alfa, and a blood transfusion. Conclusion Dog was infected with chronic ehrlichiosis with several clinical symptoms including severe anemia. Treatment with doxycycline as the treatment of choice for ehrlichiosis infection and a blood transfusion for treating severe anemia showed signs of improvement, but were ultimately ineffective due to the poor prognosis associated with chronic ehrlichiosis and severe pancytopenia.
Co-Authors Agik Suprayogi Aqila Zata Amani Chairun Nisa Damiana R Astuti Damiana Rita Ekastuti Hajar Hajar Hayu Fitriyani I Ketut M Adnyane Ivan Satriawan Kinanti Dwi Rahma La Jumadin La Ode Sumarlin Meyliana Wulandari Mohamad Yogie Hendrawan Niken Ulupi Nurul Nadelia Rahminiwati, Min Resi Milna Sus Derthi Widhyari Tampie, Bella Wasmen Manalu Yuvensius Yuvensius