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All Journal Indonesian Journal of Medicine Jurnal Prima Medika Sains
Daulay, Agus Husein
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Health Professions Medicine & Pharmacology Nursing Public Health

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Effectiveness of Ethanol Extract and Ethyl Acetate Fraction of Breadfruit Leaves (Artocarpus altilis) as Antihyperglycemia Daulay, Agus Husein; Siahaan , Jekson Martiar; Syahrir, Lesmana; Tambunan, Ronald Tunggul Hotmarojahan
Indonesian Journal of Medicine Vol. 9 No. 3 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2024.09.03.01

Abstract

Background: The rising diabetes mellitus (DM) population is a public health concern. Pharmaco­therapy for DM can cause side effects and is often inaccessible, necessitating alternative therapies like medicinal plants. Breadfruit leaves (Artocarpus altilis) have antidiabetic effects. This study aimed to examine the antihyperglycemic effect of ethanol extract and ethyl acetate fraction of bread­fruit leaves on alloxan-induced diabetic male white rats (Rattus norvegicus). Subjects and Method: This was a randomized controlled trial. Sample was 35 male white Wistar rats (Rattus norvegicus sp.) divided into 7 groups. The study was conducted at the Phytochemical Laboratory and Animal House, Faculty of Medicine, Indonesian Methodist University, from April to May 2023. The dependent variables were body weight, blood glucose levels, and diameter of the islets of Langerhans. The independent variables were variations in the dose of ethanol extract and ethyl acetate fraction of breadfruit leaves. Body weight was measured by scales. Blood glucose was measured using glucometer. Diameter of the islets of Langerhans was measured using computer-based image analysis system. Data were analyzed using Anova and Kruskal-Wallis tests. Results: Weight loss was better in the group given the ethyl acetate fraction at a dose of 200 mg/kgBW compared to the other groups. Administration of ethanol extract at a dose of 200 mg/kgBW showed a better reduction in blood glucose levels compared to the other groups, where P < 0.05 between K4 and K3, K5, and K7 on day 5. Ethanol extract at a dose of 200 mg/kgBW was able to improve the diameter of the islets of Langerhans induced by alloxan. Conclusion: A 200 mg/kg BW dose of ethyl acetate fraction reduces body weight. A 200 mg/kg BW dose of ethanol extract reduces blood glucose and improves pancreatic islet diameter.
Factors associated with uric acid levels in elderly: A cross-sectional study Sinurat, Suryati; Simanjuntak, Maestro Bina Utama; Siahaan, Jekson Martiar; Hutagalung, Mangatas Halomoan Parluhutan; Daulay, Agus Husein; Tarigan, Leonardo; Sihotang, Ruth Wydia Wati; Sembiring, Bob Agustinus; Nababan, Titus Imanuel; Tampubolon, Ruth Septianna Br.; Salamon, Yuda Monang; Ainun, Nur Azizah; Nainggolan, Serevina
Jurnal Prima Medika Sains Vol. 7 No. 1 (2025): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v7i1.6809

Abstract

Sustained elevated blood uric acid levels can lead to gout, a chronic inflammatory disease characterized by the deposition of uric acid crystals in the joints. Factors contributing to hyperuricemia include insufficient knowledge of risk factors and management, consumption of high-purine diets, and inadequate uric acid monitoring. Overweight and obesity are also frequently associated with increased uric acid production and reduced renal excretion. The aging process contributes to declining renal function, essential for uric acid elimination. This observational analytic cross-sectional study investigated the relationships between knowledge, nutritional status, and physical activity with blood uric acid levels in 30 elderly individuals at Hamparan Perak Health Center from March 5-19, 2025. Data were collected via questionnaires and analyzed using Chi-Square or Fisher Exact tests. The majority of respondents were female (73.3%) and aged 60-69 years (63.3%). Most had poor knowledge (56.7%) and high uric acid levels (63.3%). A significant relationship was found between knowledge (p=0.002) and nutritional status (p=0.000) with blood uric acid levels. However, no significant relationship was observed between physical activity levels and uric acid levels (p=0.125).
Co-Authors Ainun, Nur Azizah Hutagalung, Mangatas Halomoan Parluhutan Lesmana Syahrir, Lesmana Nababan, Titus Imanuel Nainggolan, Serevina Salamon, Yuda Monang Sembiring, Bob Agustinus Siahaan, Jekson Martiar Sihotang, Ruth Wydia Wati Simanjuntak, Maestro Bina Utama Sinurat, Suryati Tambunan, Ronald Tunggul Hotmarojahan Tampubolon, Ruth Septianna Br. Tarigan, Leonardo