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UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL, FRAKSI POLAR, SEMI POLAR DAN NONPOLAR DAUN SIRIH CINA (PEPEROMIA PELLUCIDA (L.) KUNTH) DENGAN METODE DPPH Nurliansyah, Nurliansyah; Ridwanto, Ridwanto; Dalimunthe , Gabena Indrayani; Yuniarti , Rafita
Seroja Husada: Jurnal Kesehatan Masyarakat Vol. 1 No. 7 (2024): Seroja Husada: Jurnal Kesehatan Masyarakat
Publisher : Seroja Husada: Jurnal Kesehatan Masyarakat

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Chinlelsel beltell lelavels (Pelpelromia pelllucida (L.) Kunlth) arel traditionlally useld as a meldicinlel for relducel thel painl of rhelumatism anld gout. Chinlelsel beltell has selconldary meltabolitel compounlds, nlamelly alkaloids, flavonloids, saponlinls, tanlnlinls anld stelroids. activitiels. Thelrel arel anltioxidanlt compounlds that funlctionl as anltidotels anld canl stabilizel frelel radicals. Anltioxidanlts work by protelctinlg againlst damagel causeld by frelel radicals. NLatural anltioxidanlt compounlds arel oftelnl founld inl planlt parts such as lelavels, flowelrs anld fruit. Thel melthod most oftelnl useld to telst thel anltioxidanlt activity of meldicinlal planlts is thel telst melthod usinlg DPPH radicals. This relselarch aims to deltelrminlel thel potelnltial anltioxidanlt activity of elthanlol elxtract anld polar, selmi-polar anld nlonl-polar fractionls of Chinlelsel beltell lelavels (Pelpelromia pelllucida (L.) Kunlth) usinlg thel Dpph melthod. This relselarch inlcludeld macelrationl of Chinlelsel beltell lelavels with 96% melthanlol for 5 days anld relmacelrationl for 2 days. Thel thick elxtract was fractionlateld usinlg nl-helxanlel anld elthyl aceltatel solvelnlts. Thel anltioxidanlt activity telst useld DPPH (1,1-diphelnlyl-2-picrylhydrazyl) by melasurinlg thel anltioxidanlt activity againlst Dpph frelel radicals qualitativelly anld quanltitativelly. Thel relsults of thel anltioxidanlt activity telst of thel Chinlelsel beltell lelaf fractionl usinlg thel dpph melthod havel a velry stronlg catelgory with anl IC50 activity valuel inl thel watelr fractionl of 40.71525µg/ml, thel elthyl aceltatel fractionl has a velry stronlg strelnlgth with a catelgory of 6.17085µg/ml, anld thel nl-Helxanlel fractionl has velry stronlg strelnlgth with a catelgory of 23.8421 µg/ml. Thel selconldary meltabolitel compounlds conltainleld inl Chinlelsel beltell lelavels (Pelpelromia pelllucida (L.) Kunlth) originlatinlg from Meldanl City sub-district arel flavonloids, alkaloids, saponlinls, tanlnlinls, glycosidels anld stelroids/telrpelnloids

Pembuatan dan Aktivitas Anti-Acne Nano Essence Sheet Mask Ekstrak Bonggol Nanas (Ananas comosus (L.) Merr) Ritonga , Nur Sakina; Lubis, Minda Sari; Yuniarti , Rafita; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.852

Pineapple tubers, which are often considered waste, contain chemical compounds such as flavonoids, alkaloids, aPineapple tubers, which are often considered waste, contain chemical compounds such as flavonoids, alkaloids, saponins, tannins, and glycosides. This compound has antibacterial effects, especially against Propionibacterium acnes, which are gram-positive bacteria that cause acne. Anti-acne masks effectively prevent acne by disrupting the growth or killing bacteria through inhibiting microbial metabolism. This research is experimental in nature with Independent Variables: Extract, pineapple tuber simplicia, essence preparation, and nano essence sheet mask. Dependent variables include the physical characteristics of the preparation, as well as anti-acne activity. The extract was made using the maceration method, and then the antibacterial test of the extract was conducted. The preparations were subjected to physical quality tests, irritation tests, and antibacterial tests using the disc method. Orientation test results for the antibacterial activity of pineapple tuber extract against Propionibacterium acne s using the agar diffusion method with disc paper, namely, 3.25% (4.1 mm), 6.25% (4.9 mm), 12.5% (6.4 mm), 25% (7.5 mm), 50% (7.8 mm). The concentration of the preparation was obtained at 12.5% and then tested by PSA ( Particle Size Analyzer ). All particles were below 1000 nm, meeting the requirements. The results of the antibacterial activity test of the preparation showed the following inhibition zones: Blank (0 mm), Essence (9.5 mm), Nano Essence (11.13 mm), Comparator (25.3 mm), Clindamycin (32.3 mm). Good physical quality and can be used as an anti-acne.saponins, tannins and glycosides. This compound has antibacterial effects, especially against Propionibacterium acne s, gram-positive bacteria that cause acne. Anti- acne masks are effective in preventing acne by disrupting the growth or killing bacteria through inhibiting microbial metabolism. This research is experimental in nature with Independent Variables: Extract, pineapple tuber simplicia, essence preparation and nano essence sheet mask. Dependent variables include the physical characteristics of the preparation, as well as anti- acne activity . The extract was made using the maceration method, then the antibacterial test of the extract was oriented.The preparations were subjected to physical quality tests and irritation tests, as well as antibacterial tests using the disc method. Orientation test results for the antibacterial activity of pineapple tuber extract against Propionibacterium acne s using the agar diffusion method with disc paper, namely, 3.25% (4.1 mm), 6.25% (4.9 mm), 12.5% (6.4 mm), 25% (7.5 mm), 50% (7.8 mm). The concentration of the preparation was obtained at 12.5% and then tested by PSA ( Particle Size Analyzer ). All particles were below 1000 nm, meeting the requirements. The results of the antibacterial activity test of the preparation showed the following inhibition zones: Blank (0 mm), Essence (9.5 mm), Nano Essence (11.13 mm), Comparator (25.3 mm), Clindamycin (32.3 mm). Good physical quality and can be used as an anti -acne.

Analisis Kadar Protein Pada Beberapa Jenis Susu Tinggi Protein Dengan Metode Kjeldahl dan Spektrofotometri Visible Syahfitri , Adelya; Daulay, Anny Sartika; Ridwanto, Ridwanto; Yuniarti , Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.865

Introduction: Protein is an essential nutrient that serves as an energy source and plays a crucial role in tissue formation. Protein deficiency can lead to various health disorders, ranging from hair loss to serious conditions such as death. High-protein milk serves as an ideal protein source as it contains essential amino acids and complete nutrients, though its consumption should be adjusted to individual needs to avoid side effects. Research Objectives: This study aims to: (1) analyze protein content in high-protein milk (Whey, Casein, and Gainer) using the Kjeldahl and Visible Spectrophotometry methods, and (2) verify the consistency between analysis results and protein content claims on product packaging. Research Methods: Analysis was conducted using two methods: the Kjeldahl method as a high-precision standard method and Visible Spectrophotometry using Biuret reagent which is more sensitive. Each sample was analyzed with six repetitions to ensure data accuracy. Samples were selected purposively based on best-selling products. Results: The results showed the highest protein content in Whey (525.87 mg/g with Kjeldahl; 873.75 mg/g with Spectrophotometry), followed by Casein (316.87 mg/g; 720.83 mg/g), and the lowest in Gainer (227.5 mg/g; 570.5 mg/g). This consistent pattern indicates conformity with packaging claims, although there were value differences between the two methods. Conclusion: The findings emphasize the importance of verifying protein content in supplement products to ensure nutritional information accuracy for consumers. The differences between the two analysis methods are presumably due to their different analytical principles. This study contributes to developing accurate protein analysis methods for high-protein milk products.

Formulasi, Evaluasi dan Penentuan Nilai SPF Serta Uji Kelembaban Perona Pipi Stik Ekstrak Etanol Bawang Dayak (Eleutherine bulbosa (Mill.) Urb Hutagalung , Septi Ratna Cempaka; Yuniarti , Rafita; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.886

Background: Blush is traditionally used to add color to cheeks, but UV exposure poses significant skin damage risks. Dayak onion (Eleutherine palmifolia), containing anthocyanins as natural pigments and photoprotective compounds, shows potential as a multifunctional blush ingredient. Objectives: The aim of this study is to determine whether Bawang Dayak can be formulated as a natural colorant for blushers, whether Bawang Dayak extract possesses sun protection properties, and whether the ethanol extract of Bawang Dayak blusher has sun protection and skin moisturizing abilities. Methods: An experimental study employing quantitative and qualitative approaches was conducted. The research stages included material characterization, phytochemical screening, SPF testing of extract and formulations, physical quality evaluation (homogeneity, stability, adhesiveness), and in vivo skin hydration testing. Ethanolic Dayak onion extract samples were prepared at varying concentrations (100-1000 ppm). Results: The ethanolic extract was successfully formulated into stick blush meeting standard physical quality criteria. The extract demonstrated ultra SPF ratings (1000 ppm: SPF 32; 700 ppm: SPF 25; 500 ppm: SPF 21) to minimal protection (100 ppm: SPF 4). The 1000 ppm blush formulation showed ultra SPF 29, while the 700 ppm formula (F2) exhibited the highest skin moisturizing capacity. Conclusion: Dayak onion shows promise as both a natural colorant and active sunscreen agent in blush formulations. The developed product meets physical quality standards while offering dual functionality as a color cosmetic with UV protection.

Isolasi Gelatin dari Tulang Ikan Gulamah (Johnius trachycephalus) dan Aplikasinya Pada Permen Jelly Sindi, Sindi; Yuniarti , Rafita; Lubis , Minda Sari; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.936

Background: Gelatin, as a product of partial collagen hydrolysis, is typically derived from pig bones or skin, creating halal compliance issues for Indonesia's Muslim population. Objective: This study aimed to isolate halal gelatin from gulamah fish bones (Johnius trachycephalus) and apply it as a gelling agent in jelly candy production. Methods: The gelatin isolation process involved: (1) degreasing through immersion in boiling water, (2) demineralization using 5% acetic acid for 48 hours, (3) extraction at 60-75°C for 12 hours, and (4) oven drying at 50°C. Gelatin was characterized using FTIR and tested for quality parameters (yield, moisture content, ash content, pH) according to SNI standards. Jelly candies were formulated with two gelatin concentrations (F1=5g; F2=10g) and evaluated for physical properties and hedonic quality. Results: The study achieved a gelatin yield of 7.32% with SNI 06-3735 compliant characteristics: 10.2% moisture content, 1.24% ash content, pH 6.28, and FTIR identification of characteristic functional groups (-OH, C=O, N-H, C-H, and C-N). Formula F2 (10g gelatin) received the highest preference scores for texture (2.93), aroma (2.93), and taste (4.63). Conclusion: Gulamah fish bones show potential as a halal gelatin source meeting quality standards, with optimal application at a 10g concentration in jelly candy formulations

Perbandingan Kandungan Fenolik dan Aktivitas Antioksidan pada Varian Seduhan Teh dan Varian Teh Kombucha Secara Spektrofotometri Visible Maghfirah , Dini; Pulungan , Ainil Fithri; Ridwanto, Ridwanto; Yuniarti , Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.952

One of the most widely consumed aromatic beverages in the world is tea. Tea shoots are rich in polyphenolic compounds that function as antioxidants. Not many people know that tea can be fermented with a type of bacteria and yeast culture that can be consumed as a drink for health known as kombucha tea. The health benefits of consuming kombucha tea as anti-carcinogenic, anti-diabetic, detoxification, increased immune response, treating stomach ulcers and lowering cholesterol levels as well as high blood pressure. The purpose of this study was to determine the total phenolic content and antioxidant activity as well as the comparison of total phenolic content and antioxidant activity in tea brewing variations with kombucha tea variations. The methods carried out include testing the total phenolic content and antioxidant activity using the DPPH method on tea brewing variants and kombucha tea variants by visible spectrophotometry.mThe results of total phenolic content in black tea, green tea, and oolong tea were 24,480 mgGAE/g, 26,538 mgGAE/g, and 38,427 mgGAE/g, respectively, while kombucha black tea, green tea, and oolong tea were 39,264 mgGAE/g, 58,581 mgGAE/g, and 64,299 mgGAE/g, respectively. Brewed black tea, green tea, and oolong tea have antioxidant activity with IC50 values of 105,68 ppm in teh moderate category, 81,59 ppm in teh strong category, and 56,25 ppm in the strong category, respectively. In kombucha black tea, green tea, and oolong tea have antioxidant activity with IC50 values respectively 101,60 ppm with moderate category, 55,82 ppm with strong category, and 39,69 ppm with very strong category. While teh vitamin C comparator has antioxidant activity with an IC50 value of 3,22 ppm with a very strong category.

Formulasi dan Evaluasi Mutu Fisik Serta Uji Aktivitas Antiinflamasi Sediaan Balsem Stik Ekstrak Etanol Daun Bakung (Crinum asiaticum L.) Ramadhan , Yusril; Yuniarti , Rafita; Lubis , Minda Sari; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.892

Background: Spider lily leaves (Crinum asiaticum L.) contain bioactive compounds, such as flavonoids, which are known for their anti-inflammatory properties. Developing a convenient topical formulation like a stick balm could provide an effective and practical alternative for treating inflammation. Objective: This study aimed to formulate a stick balm containing ethanol extract of spider lily leaves (EESL) and evaluate its physical quality and anti-inflammatory activity. Methods: The extract was obtained by macerating the leaves in 96% ethanol. Stick balm formulations were prepared with varying concentrations of EESL: F0 (base), F1 (1%), F2 (3%), and F3 (5%). The physical quality of the formulations (homogeneity, pH, spreadability, melting point) was evaluated. Anti-inflammatory activity was tested on 24 male white rats induced with carrageenan. The rats were divided into six groups: negative control (induced only), positive control (commercial Geliga balm), F0, F1, F2, and F3. Paw edema volume was measured every hour for 6 hours. Results: All stick balm formulations met the physical quality standards. The anti-inflammatory test showed that the F3 formulation (5% EESL) exhibited the highest activity, with an edema reduction of 0.007 mm, which was equivalent to the positive control group (0.007 mm). The anti-inflammatory effect was concentration-dependent, with lower efficacy observed in the F2 and F1 groups. Conclusion: The ethanol extract of Crinum asiaticum L. leaves can be successfully formulated into a stable stick balm. The 5% EESL stick balm demonstrated significant anti-inflammatory activity that was comparable to a commercial product, making it a promising natural alternative for topical anti-inflammatory therapy.

Evaluasi Mutu Fisik, Uji Kelembapan dan Potensi Aktivitas Tabir Surya Pelembab Bibir Ekstrak Etanol Daun Pucuk Merah (Syzygium myrtifolium Walp.) Safitri , Nurhaliza; Yuniarti , Rafita; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1052

Background: Lip balm is a cosmetic preparation containing key components such as waxes, fats, and oils—derived from either natural or synthetic extracts—to prevent lip dryness by enhancing moisture and protecting against harmful environmental factors. The red shoot plant (Syzygium myrtifolium Walp.) is commonly known as an ornamental plant but also contains beneficial chemical compounds. Objective: This study aims to formulate red shoot leaf ethanol extract into a lip balm with good physical quality, sun protection capability, and moisturizing effects. Methods: This research uses an experimental method with quantitative and qualitative data collection. The stages include simplicia characterization, secondary metabolite identification, extract preparation through maceration, lip balm formulation, and evaluation of physical quality (organoleptic test, homogeneity, pH, stability, irritation, melting point, and hedonic test), moisture test, and Sun Protection Factor (SPF) value determination. Results: The red shoot leaf extract was successfully formulated into a stick lip balm at concentrations of 5%, 7%, and 10%. The formulas demonstrated good physical quality in all tests, increased lip moisture and oil content (especially at 10% concentration), and high SPF values with ultra protection at the 10% concentration. Conclusion: Red shoot leaf extract (Syzygium myrtifolium Walp.) can be used as an active ingredient in lip balm, providing optimal physical quality, moisturizing effects, and UV radiation protection.

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