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Aktivitas Anti Trombotik dari Genus Curcuma : Kajian Sistematik Sandhori, Fajar Jamaluddin; Kusumawati, Idha; Samirah, Samirah; Rullyansyah, Subhan; Ramadhani, Firmansyah Ardian; Prasetyawan, Hanif Rifqi; Warsito, Mega Ferdina
Journal of Islamic Medicine Vol 8, No 2 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI SEPTEMBER 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i2.25929

Background : The Curcuma genus has various pharmacological activities, one of these is antithrombotic activity by preventing thrombus formation. Some of its chemical contents are also known to inhibit thrombus formation including curcumin, bisdemethoxycurcumin, ar-turmerone, and xanthorrizhol compounds. Antithrombotic drugs are used for the prevention and treatment of thrombosis whose mechanisms are divided into anticoagulants, thrombolytics, and antiplatelets. Objective: This review article discusses the potential of Curcuma genus as antithrombotic, including anticoagulant, antiplatelet, and thrombolytic, Methods: This study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method using four databases : PubMed, ScienceDirect, Scopus, and Google Scholar from July to December 2023. The inclusion criteria used were articles on antithrombotic activity, including anticoagulants, antiplatelets, and thrombolytics from the genus Curcuma. Results: The number of articles obtained from four databases was 3413 articles. Furthermore, based on the results of filtering duplicate articles from all databases, 2771 articles were selected and then continued with screening based on inclusion and exclusion criteria until 15 articles were selected as material for systematic review. Conclusion: Curcuma species that have potential as antithrombotic are Curcuma longa, Curcuma zedoaria Rosc., Curcuma amada, Curcuma caesia, Curcuma aeruginosa, Curcuma latifolia, Curcuma aromatica Salisb, Curcuma wenyujin, and Curcuma xanthorrhiza

SKRINING FITOKIMIA DAUN TEH HIJAU (CAMELLIA SINENSIS L.) DAN BIJI LADA HITAM (PIPER NIGRUM L.) Sandhori, Fajar Jamaluddin; Hanif Rifqi Prasetyawan; Farida Istiqamah; Ilham Robbynoor Sulistiyono; Rizkiyatul Hasanah
Jurnal Medicare Vol. 4 No. 3: JULY 2025
Publisher : Rena Cipta Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62354/jurnalmedicare.v4i3.233

Plants are the main source of secondary metabolites that have important biological potential. This study aims to screen the phytochemicals of green tea leaves and black pepper to identify the classes of active compounds contained within them. Extraction was performed using the maceration method with 96% ethanol over three days, followed by qualitative phytochemical testing (alkaloids, flavonoids, saponins, tannins, triterpenoids, steroids, polyphenols, and anthraquinones). Green tea leaves contain alkaloids, triterpenoids, flavonoids, polyphenols, and anthraquinones. Black pepper contains alkaloids, saponins, triterpenoids, steroids, and flavonoids, but does not contain polyphenols, tannins, or anthraquinones. The differences in the composition of active compounds indicate distinct therapeutic potentials in the two plants and support their use as natural medicinal ingredients.

UJI KARAKTERISTIK DAN AKTIVITAS ANTIBAKTERI DEODORAN SPRAY EKSTRAK DAUN ANTING-ANTING (Acalypha indica L.) TERHADAP Staphylococcus epidermis Rahmah, Corry' Nanda Nabilla; Ambarwati, Nadya; Sandhori, Fajar Jamaluddin
Jurnal Analis Farmasi Vol 10, No 2 (2025): JURNAL ANALIS FARMASI
Publisher : Program Studi Analisis Farmasi dan Makanan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v10i2.22239

Indonesia merupakan negara beriklim tropis dengan suhu tinggi dan kelembapan rendah, yang menyebabkan tubuh mengeluarkan keringat. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi ekstrak daun anting-anting (10%, 20%, 30%) terhadap karakteristik fisik sediaan deodoran spray, meliputi organoleptik, pH, homogenitas, pola semprot, waktu kering, stabilitas, viskositas, uji hedonik, dan aktivitas antibakteri terhadap Staphylococcus epidermidis. Penelitian menggunakan desain eksperimental dengan tiga formula: F1 (10%), F2 (20%), dan F3 (30%). Hasil menunjukkan bahwa seluruh sediaan berbentuk cair dengan warna dan aroma yang bervariasi: F1 berwarna coklat muda beraroma lavender, F2 coklat beraroma lavender, dan F3 coklat tua dengan aroma khas anting-anting. Semua formula memiliki pH 5, sesuai standar, dan terdapat perbedaan signifikan (p = 0.010). Sediaan homogen, tanpa partikel kasar atau endapan. Pola semprot rata-rata 6 cm, waktu kering 47 detik, dan stabilitas baik. Viskositas memenuhi kriteria (56,30 ± 1,51 cps; p = 0.015). Uji hedonik menunjukkan formula F2 paling disukai oleh 30 responden berdasarkan aroma, warna, dan tekstur. Sementara itu, F3 (30%) menunjukkan aktivitas antibakteri yang paling kuat terhadap S. epidermidis.

UJI KARAKTERISTIK DAN AKTIVITAS ANTIBAKTERI DEODORAN SPRAY EKSTRAK DAUN ANTING-ANTING (Acalypha indica L.) TERHADAP Staphylococcus epidermis Rahmah, Corry' Nanda Nabilla; Ambarwati, Nadya; Sandhori, Fajar Jamaluddin
Jurnal Analis Farmasi Vol 10, No 2 (2025): JURNAL ANALIS FARMASI
Publisher : Program Studi Analisis Farmasi dan Makanan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v10i2.22239

Indonesia merupakan negara beriklim tropis dengan suhu tinggi dan kelembapan rendah, yang menyebabkan tubuh mengeluarkan keringat. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi ekstrak daun anting-anting (10%, 20%, 30%) terhadap karakteristik fisik sediaan deodoran spray, meliputi organoleptik, pH, homogenitas, pola semprot, waktu kering, stabilitas, viskositas, uji hedonik, dan aktivitas antibakteri terhadap Staphylococcus epidermidis. Penelitian menggunakan desain eksperimental dengan tiga formula: F1 (10%), F2 (20%), dan F3 (30%). Hasil menunjukkan bahwa seluruh sediaan berbentuk cair dengan warna dan aroma yang bervariasi: F1 berwarna coklat muda beraroma lavender, F2 coklat beraroma lavender, dan F3 coklat tua dengan aroma khas anting-anting. Semua formula memiliki pH 5, sesuai standar, dan terdapat perbedaan signifikan (p = 0.010). Sediaan homogen, tanpa partikel kasar atau endapan. Pola semprot rata-rata 6 cm, waktu kering 47 detik, dan stabilitas baik. Viskositas memenuhi kriteria (56,30 ± 1,51 cps; p = 0.015). Uji hedonik menunjukkan formula F2 paling disukai oleh 30 responden berdasarkan aroma, warna, dan tekstur. Sementara itu, F3 (30%) menunjukkan aktivitas antibakteri yang paling kuat terhadap S. epidermidis.

Training on Hand Soap Formulation Using Caesalpinia sappan (Sappanwood) Ambarwati, Nadya; Indriani , Novamei; Vibrianita Nidom, reviany; Marfuatin Nur, Fikria; Jamaluddin Sandhori, Fajar; Purbosari, ira; Rahayu, asti; Wido Mukti, asri; Pramushinta, iak; Rifqi Prasetyawan, Hanif; rismawati
JURNAL PENGABDIAN TEKNOLOGI TEPAT GUNA Vol 6 No 3 (2025): Teknologi Tepat Guna (TTG)
Publisher : Universitas Sahid Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

: This community service aims to increase the capacity of community skills in utilizing local biological resources, especially secang wood (Caesalpinia sappan L.), as an active ingredient in making natural-based handsoap with bioactive compounds such as brazilin, tannins, and flavonoids that have antibacterial, antioxidant, and anti-inflammatory properties, as environmentally friendly hygiene products. The training will be carried out through a theoretical and practical approach, which includes the introduction of the chemical characteristics of sappang wood, active ingredient extraction techniques, natural soap formulation, production process, and equipped with basic materials for product packaging and marketing strategies, especially in the context of micro business development and promotion through digital media. From the results of the community service program about education on Handsoap Making Training Using Secang Wood, it can increase the insight and knowledge of the residents of RT Wage Sidoarjo and can improve the community's economy.

Training on Hand Soap Formulation Using Caesalpinia sappan (Sappanwood) Ambarwati, Nadya; Indriani , Novamei; Vibrianita Nidom, reviany; Marfuatin Nur, Fikria; Jamaluddin Sandhori, Fajar; Purbosari, ira; Rahayu, asti; Wido Mukti, asri; Pramushinta, iak; Rifqi Prasetyawan, Hanif; rismawati
JURNAL PENGABDIAN TEKNOLOGI TEPAT GUNA Vol 6 No 3 (2025): Teknologi Tepat Guna (TTG)
Publisher : Universitas Sahid Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47942/jpttg.v6i3.2155

: This community service aims to increase the capacity of community skills in utilizing local biological resources, especially secang wood (Caesalpinia sappan L.), as an active ingredient in making natural-based handsoap with bioactive compounds such as brazilin, tannins, and flavonoids that have antibacterial, antioxidant, and anti-inflammatory properties, as environmentally friendly hygiene products. The training will be carried out through a theoretical and practical approach, which includes the introduction of the chemical characteristics of sappang wood, active ingredient extraction techniques, natural soap formulation, production process, and equipped with basic materials for product packaging and marketing strategies, especially in the context of micro business development and promotion through digital media. From the results of the community service program about education on Handsoap Making Training Using Secang Wood, it can increase the insight and knowledge of the residents of RT Wage Sidoarjo and can improve the community's economy.

PENGARUH EKSTRAK BATANG AKAR KUNING (Arcangelisia flava (L.) Merr.) TERHADAP AKTIVITAS SEKSUAL MENCIT JANTAN (Mus musculus) SECARA IN VIVO Istiqamah, Farida; Sandhori, Fajar Jamaluddin; Ainah, Nur; Amalia, Senya Puteri; Lestari, Desy Ayu
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2799

Disfungsi seksual merupakan masalah umum di kalangan banyak orang dewasa dan dapat diobati dengan mengonsumsi obat herbal. Salah satu tanaman yang berpotensi sebagai afrodisiak adalah Akar Kuning (Arcangelisia flava (L.) Merr.). Penelitian ini bertujuan untuk menentukan aktivitas afrodisiak ekstrak etanol 70% dari Akar Kuning (Arcangelisia flava (L.) Merr.) menggunakan uji in vivo. Penelitian ini menggunakan uji perilaku seksual mencit jantan pendekatan, menunggangi , dan kawin. Jumlah mencit percobaan adalah 25 pasang (25 mencit jantan dan 25 mencit betina) yang dibagi menjadi lima kelompok. Kelompok I (suspensi CMC-Na), kelompok II, III, dan IV masing-masing menggunakan ekstrak etanol 70% akar kuning (150 mg/kgBB, 200 mg/kgBB, dan 250 mg/kgBB), dan kelompok V (sildenafil 0,13 mg/20g BB tikus). Pengamatan dilakukan selama satu hari menggunakan kotak libidometer yang dilengkapi dengan CCTV, kipas angin, dan lampu merah. Data dianalisis menggunakan SPSS versi 25. Berdasarkan hasil, kelompok IV (250 mg/kgBB) merupakan dosis paling optimal karena menghasilkan efek afrodisiak tertinggi pada semua parameter dibandingkan dengan kelompok II (150 mg/kgBB) dan kelompok III (200 mg/kgBB). Berdasarkan hasil penelitian ini, dapat disimpulkan bahwa ekstrak etanol 70% akar kuning (Arcangelisia flava (L.) Merr.) dapat meningkatkan efek afrodisiak.

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