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All Journal Science Midwifery Narra J
Afief, Arief R.
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Promising candidate drug target genes for repurposing in cervical cancer: A bioinformatics-based approach Pratiwi, Nurfi; Ulfah, Aida J.; Rachmadina, Rachmadina; Irham, Lalu M.; Afief, Arief R.; Adikusuma, Wirawan; Darmawi, Darmawi; Kemal, Rahmat A.; Rangkuti, Ina F.; Savira, Maya
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.938

Abstract

Cervical cancer is the fourth most common cancer among women globally, and studies have shown that genetic variants play a significant role in its development. A variety of germline and somatic mutations are associated with cervical cancer. However, genomic data derived from these mutations have not been extensively utilized for the development of repurposed drugs for cervical cancer. The objective of this study was to identify novel potential drugs that could be repurposed for cervical cancer treatment through a bioinformatics approach. A comprehensive genomic and bioinformatics database integration strategy was employed to identify potential drug target genes for cervical cancer. Using the GWAS and PheWAS databases, a total of 232 genes associated with cervical cancer were identified. These pharmacological target genes were further refined by applying a biological threshold of six functional annotations. The drug target genes were then cross-referenced with cancer treatment candidates using the DrugBank database. Among the identified genes, LTA, TNFRSF1A, PRKCZ, PDE4B, and PARP were highlighted as promising targets for repurposed drugs. Notably, these five target genes overlapped with 12 drugs that could potentially be repurposed for cervical cancer treatment. Among these, talazoparib, a potent PARP inhibitor, emerged as a particularly promising candidate. Talazoparib is currently being investigated for safety and tolerability in other cancers but has not yet been studied in the context of cervical cancer. Further clinical trials are necessary to validate this finding and explore its potential as a repurposed drug for cervical cancer.
The role of honey, curcuma, and black cumin supplements in overcoming stunting on the adaptive immune system Sabarudin, Cecep; Hasimun, Patonah; Kusriani, Herni; Zuniarto, Ahmad Azrul; Pandanwangi, Siti; Fatmawati, Eva; Afief, Arief R.; Sodik, Jajang Japar
Science Midwifery Vol 13 No 5 (2025): Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i5.2185

Abstract

Stunting is strongly associated with impaired immune function, as chronically malnourished children tend to have weaker immunity and are more vulnerable to infection. This study aimed to examine the effect of temulawak–black cumin herbal honey on the adaptive immune system in stunted children. A quasi-experimental one-group pre-test and post-test design was used. The findings showed that the intervention significantly increased height-for-age (TB/U) in the treatment group compared to the control group (p = 0.014). Weight-for-age (BB/U) also rose significantly within the treatment group (p = 0.013), but no significant difference was found relative to the control group (p = 0.192). The supplement significantly elevated IgM levels in the treatment group (p = 0.001), though again without a significant difference from the control (p = 0.546). CD4 concentration decreased in the treatment group (p = 0.003), but the change was not significantly different from the control (p = 0.682). In conclusion, temulawak–black cumin herbal honey can improve nutritional status and enhance adaptive immunity by increasing IgM levels, although it does not raise CD4 levels and instead slows CD4 decline. However, its effectiveness in increasing IgM and CD4 concentrations compared to controls is not significant.
Co-Authors Darmawi Darmawi Fatmawati, Eva Hasimun, Patonah Irham, Lalu M. Kemal, Rahmat A. Maya Savira Nurfi Pratiwi, Nurfi Rachmadina, Rachmadina Rangkuti, Ina F. Sabarudin, Cecep Siti Pandanwangi TW Sodik, Jajang Japar Ulfah, Aida J. Wirawan Adikusuma Zuniarto, Ahmad Azrul