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All Journal Science Midwifery Narra J
Afief, Arief R.
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Science Midwifery

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The role of honey, curcuma, and black cumin supplements in overcoming stunting on the adaptive immune system Sabarudin, Cecep; Hasimun, Patonah; Kusriani, Herni; Zuniarto, Ahmad Azrul; Pandanwangi, Siti; Fatmawati, Eva; Afief, Arief R.; Sodik, Jajang Japar
Science Midwifery Vol 13 No 5 (2025): Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i5.2185

Abstract

Stunting is strongly associated with impaired immune function, as chronically malnourished children tend to have weaker immunity and are more vulnerable to infection. This study aimed to examine the effect of temulawak–black cumin herbal honey on the adaptive immune system in stunted children. A quasi-experimental one-group pre-test and post-test design was used. The findings showed that the intervention significantly increased height-for-age (TB/U) in the treatment group compared to the control group (p = 0.014). Weight-for-age (BB/U) also rose significantly within the treatment group (p = 0.013), but no significant difference was found relative to the control group (p = 0.192). The supplement significantly elevated IgM levels in the treatment group (p = 0.001), though again without a significant difference from the control (p = 0.546). CD4 concentration decreased in the treatment group (p = 0.003), but the change was not significantly different from the control (p = 0.682). In conclusion, temulawak–black cumin herbal honey can improve nutritional status and enhance adaptive immunity by increasing IgM levels, although it does not raise CD4 levels and instead slows CD4 decline. However, its effectiveness in increasing IgM and CD4 concentrations compared to controls is not significant.
Co-Authors Darmawi Darmawi Fatmawati, Eva Hasimun, Patonah Irham, Lalu M. Kemal, Rahmat A. Maya Savira Nurfi Pratiwi, Nurfi Rachmadina, Rachmadina Rangkuti, Ina F. Sabarudin, Cecep Siti Pandanwangi TW Sodik, Jajang Japar Ulfah, Aida J. Wirawan Adikusuma Zuniarto, Ahmad Azrul