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Purwoningsih, Emni
Universitas Muhammadiyah Sumatera Utara
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Pemberdayaan Ibu Pengajian Sebagai Upaya Pencegahan Kanker Serviks di Kota Medan Siti Mirhalina; Humairah Medina Liza Lubis; Emni Purwoningsih
ABDI SABHA (Jurnal Pengabdian kepada Masyarakat) Vol. 1 No. 1 (2020): Oktober
Publisher : CERED Indonesia Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53695/jas.v1i1.68

Abstract

According to Riskesdas data in 2013 in Indonesia, it is estimated that 40,000 new cases of cervical cancer are found each year. The incidence of cancer sufferers continues to increase and requires immediate treatment to prevent the continued increase in cancer death rates. This can be achieved, one of which is the right detection of cancer, both diagnosis and prognosis. The objectives of this community service are: (1) Finding cervical cancer cases that become an iceberg phenomenon and undetectable at an early stage, (2) Providing debriefing about Pap smear screening programs in Medan that do not run routinely or are not even carried out (3 ) Providing information on the importance of Pap smears in women of reproductive age,  (4) Empowering cadres in this case the members of the Istiqomah Mosque study in each neighborhood in Pahlawan Village as a system of coordination in treating cervical cancer in their respective work areas. Of the 30 people who had Pap smear tests, none of them found suspicious results, only in the form of inflammation of the cervix which could be treated with antibiotics. Keywords: members of Istiqomah mosque, prevention, cervical cancer  
Anti-Cervical Cancer Study of a Labdane-type Diterpene Obtained from Legundi Fruit (Vitex triolia L.) Targeting the Bcl-2 Gene Humairah Medina Liza Lubis; Emni Purwoningsih; Nurfadly Nurfadly
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11728

Abstract

Abstract: The development and induction of cervical cancer carcinogenesis are linked to sexually transmitted Human Papillomavirus (HPV) infection, and can affect human genes, particularly those involved in the apoptotic process, one of which is the Bcl-2 gene. Several synthetic compounds, including pyrimidineylpiperazine, phenylpyrazole, kendomycin, and navitoclax, have been shown to be effective in inhibiting the antiapoptotic activity of Bcl-2, but it is the labdane-type diterpene content of the natural legundi fruit plant (Vitex trifolia L.) that has anticancer bioactivity, particularly in the process of genetic mutations, Apoptotic inhibition and therapeutic failure have yet to be discovered, particularly in cervical cancer. The study's goal was to investigate the mechanism of interaction (molecular docking) of labdane type-diterpene compounds with the antiapoptotic protein Bcl-2. In silico (docking molecular) research was used to determine the interaction between legundi fruit ligands and the Bcl-2 target protein in cervical cancer. The docking analysis results will then be visualized with the Discovery Studio 4.1, LigPlot+, and Ligand Scout 3.1 software. The interaction of proteins and ligands was studied to determine the number and type of bonds formed, such as hydrogen and hydrophobic bonds. The results were as follows: Gibbs energy -7.8, pKi 1.91 m, 10 hydrophobic bonds, and hydrophobic residues Leu80, Leu82, Thr83, Thr86, Ala87, Cys90, Met118, Glu121, Ser122, and Leu130. The findings presented here suggest that labdane-type diterpenes are powerful anticancer agents capable of inducing apoptosis and inhibiting the antiapoptotic action of the Bcl-2 gene, which should be investigated further in (pre)clinical studies.
Mechanism of Action of Tumorigenesis of Anticancer Molecules of Palm Oil Tocotrienols (Elaeis Guieensis Jacq.): A Systematic Review Humairah Medina Liza Lubis; Emni Purwoningsih; Annissa Ambaravista Nasution; Qatrunnada Medina Salim
Eduvest - Journal of Universal Studies Vol. 2 No. 2 (2022): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2479.722 KB) | DOI: 10.59188/eduvest.v2i2.379

Abstract

Palm oil contains vitamin E which comprises two structurally similar compounds namely tocopherols and tocotrienols. For many years tocopherols considered the best therapy in curing disease, but in recent research advances, tocotrienol has been widely used as a powerful therapy in several diseases, including cancer. We prepared this article to review and analyze the role of tocotrienols from palm oil as anticancer molecules and their mechanism of action in the process of tumorigenesis based on the literature from PubMed, Scopus, Science Direct, and ProQuest databases published from 2011 to 2020, and according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Nineteen English articles and abstracts according to the inclusion criteria, systematically reviewed and compiled. The results showed that tocotrienol acts on intracellular and extracellular targets involved in cell signaling pathways and suppresses the growth of various malignancies, including breast, lung, prostate, ovarian, liver, brain, colon, pancreatic, and myeloma cancers. This literature review shows that the molecular mechanism of action of tocotrienols has several advantages, namely a positive effect on cell proliferation, apoptosis, angiogenesis, metastasis, and inflammation, which when working together can function as effective agents in cancer therapy. The tocotrienol-mediated therapeutic action mechanism could help clinicians to design new strategies for cancer treatment.
Tuberculous Lymphadenitis with Dark Specks Cytomorphology: Focus on the Presence of Eosinophils and History of Atopy in Children Humairah Medina Liza Lubis; Nurcahaya Sinaga; Emni Purwoningsih; Qatrunnada Medina Salim; Muhammad Fathurridha Arabia Salim
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (830.895 KB) | DOI: 10.30604/jika.v8i2.1790

Abstract

Background. Research on eosinophils in lymph node cytology in tuberculous lymphadenitis (TBLN) patients with dark specks cytomorphology and its association with a history of atopies are still very little. Although neutrophils have been reported as predominant phagocytic cells in TB patients, eosinophils are also abundant in blood and lung tissue, but their role and pathogenesis are still unclear. Objective. To analyze the relationship between TBLN and eosinophils, dark specks, and history of atopy in pediatric TBLN patients. Methods. This study is a cross-sectional study of 35 indicative cytology results of patients with TBLN stained with May Grunwald Giemsa. Data on atopy history were measured by filling out the standard questionnaire of The International Study of Asthma and Allergies in Childhood (ISAAC). Results. Based on the cytological examination, 22 samples (62.9%) were found with positive eosinophils, and 13 samples (37.1%) with negative eosinophils. A total of 23 samples (65.7%) had a history of atopy. The Fisher's Exact Test results showed that TBLN with dark specks cytomorphology tends to find eosinophils with a test value of p=0.001, indicating a relationship between the two cytomorphological features. The results also showed a relationship between TBLN with dark specks cytomorphology with a history of allergies (p=0.038), and there was a relationship between the presence of eosinophils and a history of allergies (p=0.001). Conclusion.  Tuberculous lymphadenitis with dark specks cytomorphology was significantly associated with eosinophils and a history of atopy.Abstrak: Latar Belakang. Penelitian eosinofil pada sitologi kelenjar getah bening pada pasien limfadenitis tuberkulosis (LNTB) dengan sitomorfologi bintik gelap dan kaitannya dengan riwayat atopi masih terbatas. Meskipun neutrofil telah dilaporkan sebagai sel fagosit dominan pada pasien TB, eosinofil juga banyak ditemukan pada darah dan jaringan paru tetapi peran dan patogenesisnya masih belum jelas. Tujuan. Menganalisis hubungan antara LNTB dengan eosinofil, bintik gelap dan riwayat atopi pada pasien limfadenitis TB anak. Metode. Studi dilakukan secara cross-sectional dengan sampel 35 hasil sitologi indikatif pasien LNTB yang diwarnai dengan May Grunwald Giemsa. Data riwayat atopi diukur dengan pengisian kuesioner standar The International Study of Asthma and Allergies in Childhood (ISAAC). Hasil. Berdasarkan pemeriksaan sitologi didapatkan 22 sampel (62,9%) dengan eosinofil positif dan 13 sampel (37,1%) dengan eosinofil negatif. Sebanyak 23 sampel (65,7%) memiliki riwayat atopi. Hasil uji Fisher’s Exact menunjukkan bahwa LNTB dengan sitomorfologi bintik gelap cenderung ditemukan eosinofil dengan nilai uji p=0,001, menunjukkan adanya hubungan antara kedua gambaran sitomorfologi. Hasil penelitian juga menunjukkan adanya hubungan sitomorfologi LNTB dengan sitomorfologi bintik gelap dengan riwayat alergi (p=0,038), dan ada hubungan antara adanya eosinofil dengan riwayat alergi (p=0,001). Simpulan. Limfadenitis tuberkulosis dengan sitomorfologi bintik gelap berhubungan secara signifikan dengan eosinofil dan riwayat atopi. 
Penyuluhan Perilaku Hidup Bersih dan Sehat Anak-Anak Sekolah Dasar Desa Bagan Kuala Dalam Upaya Peningkatan Kualitas Kesehatan Purwoningsih, Emni; Utami, Ratih Yulistika; Lubis, Humaira Medina Liza
JURNAL PANDU HUSADA Vol 5, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v5i2.18972

Abstract

Desa Bagan Kuala terletak di Kecamatan Tanjung Beringin, Serdang Bedagai. Desa ini berada di daerah pesisir, dan kerap mengalami banjir akibat pasang air laut. Kondisi tersebut menyebabkan lingkungan menjadi lembab dan tidak sehat. Masalah mitra adalah rendahnya kesadaran masyarakat tentang budaya hidup bersih dan sehat, dan kualitas kebersihan lingkungan yang buruk. Metode pelaksanaan kegiatan dengan pendekatan participatory rural appraisal, yaitu melibatkan masyarakat sebagai agen perubahan dalam menerapkan perilaku hidup bersih dan sehat (PHBS). Kegiatan yang dilakukan adalah pemeriksaan kebersihan kuku, kemudian dilanjutkan dengan edukasi PHBS, cara mencuci tangan yang baik dan benar, dan jajanan bergizi. Edukasi menggunakan media poster, video interaktif dan praktik langsung.  Peserta kegiatan ini adalah siswa sekolah dasar 102052 kelas 3, 4, 5 dan 6, dengan jumlah 60 siswa, dan kegiatan dilaksanakan pada 30 Maret 2019). Para siswa dan guru terlibat aktif pada kegiatan tersebut. Kesimpulan: perilaku hidup bersih dan sehat dapat menjadi kebiasaan jika dilakukan edukasi PHBS yang berkelanjutan dan terus menerus, dan guru berperan aktif dalam monitoring dan evaluasi pelaksanaan PHBS.
PENINGKATAN PENGETAHUAN TENTANG MAKRO DAN MIKRONUTRIEN PADA REMAJA DI LEMBAGA KESEJAHTERAAN SOSIAL ANAK MELATI AISYIYAH DELI SERDANG Purwoningsih, Emni; Lubis, Humairah Medina Liza; Malini, Fitri Nur; Salsabila, Salsabila; Noviardy, Arya; Fadillah, Akram
Jurnal Salingka Abdimas Vol 4, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31869/jsam.v4i2.5867

Abstract

Masa remaja adalah peralihan dari masa remaja ke dewasa yang merupakan periode pertumbuhan dan perkembangan yang dinamis dan pesat secara fisik, psikologis, intelektual, sosial, tingkah laku, dan seksual yang dikaitkan dengan pubertas. Salah satu masalah nutrisi utama remaja adalah kekurangan mikronutrien, terutama anemia dan kekurangan zat besi, masalah malnutrisi, seperti kekurangan gizi, perawakan pendek, dan kekurangan gizi hingga obesitas. Masalah gizi pada remaja memiliki dampak yang signifikan pada kesehatan generasi muda, serta ekonomi dan kesehatan negara. Tujuan pengabdian masyarakat ini adalah untuk meningkatkan pengetahuan remaja tentang makro dan mikronutrien. Pengabdian masyarakat ini dilaksanakan melalui edukasi tentang cara mengukur pengetahuan remaja tentang kebutuhan gizinya. Remaja yang diberikan edukasi merupakan siswa di Lembaga Kesejahteraan Sosial Anak Melati Aisyiyah Deli Serdang diberi pertanyaan untuk mengukur pengetahuan mereka tentang gizi. Sebelum intervensi pendidikan gizi, skor rata-rata pengetahuan siswa sebesar 5,89 ± 1,711, tetapi setelah intervensi skor rata-rata siswa meningkat sebesar 6,44 ± 1,977, yang menunjukkan peningkatan pengetahuan siswa tentang gizi terutama untuk makro dan mikronutrien.Kata kunci: makronutrien, mikronutrien, pengetahuan, remaja
Co-Authors Ance Roslina Annissa Ambaravista Nasution Fadillah, Akram Fani Ade Irma Fitri Nur Malini Fujiati, Isti Ilmiati Gultom, Dapot Parulian Humairah Medina Liza Lubis LITA SEPTINA Lubis, Humaira Medina Liza Malini, Fitri Nur Muhammad Al Anas MUHAMMAD EGGA ACHYAR RAHMAN Muhammad Fathurridha Arabia Salim Noviardy, Arya Nst, Muhammad Solih Nurcahaya Sinaga Nurfadly, Nurfadly Purnama, Melfi Qatrunnada Medina Salim Qatrunnada Medina Salim Ratih Yulistika Utami Robitah Asfur Salsabila, Salsabila SITI MIRHALINA USWATUL KHOIROT Utami, Ratih Yulistika Zulfadly, -