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All Journal Biogenesis: Jurnal Ilmiah Biologi Jurnal Biologi Tropis Jurnal Biolokus: Jurnal Penelitian Pendidikan Biologi dan Biologi Jurnal AbdiMas Nusa Mandiri Journal of Natural Sciences Sriwijaya Bioscientia BIOVALENTIA: Biological Research Journal Jurnal Sylva Lestari Jurnal Medika: Medika
Yadi Oktariansyah
Sriwijaya University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Lactoferrin as a Potential Immune Biomarker in Breast Milk Exposed to Secondhand Smoke: A Literature Review Sarah Angelica W. Simamora; Artika Sri Wahyuni; Elffisa Eriani; Ario Sucipto; Nayla Khairani; Yadi Oktariansyah
BIOVALENTIA: Biological Research Journal Vol. 12 No. 1 (2026)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24233/biov.12.1.2026.568

Abstract

Smoking remains prevalent in Indonesia and poses health risks to mothers and infants. Data from the Maternal and Perinatal Death Notification (MPDN) system indicate that maternal mortality increased to 4,129 cases in 2023 from 4,005 cases in the previous year. Although maternal mortality is multifactorial, this highlights the importance of reducing environmental risks such as secondhand smoke (SHS) exposure. SHS is common in household environments and may affect breastfeeding mothers and infants. Breast milk is the main source of infant nutrition and supports early immune protection. Lactoferrin, an iron-binding glycoprotein in breast milk, has antimicrobial, anti-inflammatory, and immunomodulatory functions. SHS-induced oxidative stress may damage the structural integrity of glycoproteins in breast milk, including lactoferrin, which can impair their immunological functions. This literature review aims to examine the potential role of lactoferrin as an immune biomarker in breast milk from mothers exposed to SHS. This study used a literature review approach by identifying, selecting, and synthesizing relevant scientific articles on SHS exposure, breast milk composition, lactoferrin, and infant immune protection based on predetermined inclusion criteria. The reviewed literature indicates that SHS exposure is associated with oxidative stress and inflammatory responses, which may interfere with lactation quality and alter immune-related glycoproteins in breast milk. Lactoferrin is considered a potential biomarker because it is related to antimicrobial activity, immune regulation, and infant protection against infection. This review concludes that reducing household SHS exposure is important to protect breastfeeding mothers and maintain breast milk immunological quality. Further empirical studies are recommended to examine the direct relationship between SHS exposure intensity and lactoferrin levels by considering lactation stage, maternal nutritional status, infant age, infection history, and breastfeeding patterns.
Secondary metabolites from Lansium domesticum as potential anti-inflammatory iNOS inhibitors: An in silico study Yadi Oktariansyah; Laila Hanum; Muhammad Habiburrahman
Jurnal Biolokus : Jurnal Penelitian Pendidikan Biologi dan Biologi Vol 8, No 2 (2025): December
Publisher : Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/biolokus.v8i2.4731

Abstract

Inflammation is a crucial mechanism by which the immune system combats disease. However, when it becomes uncontrolled, it can result in acute inflammatory disorders. Although non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for treatment, their associated side effects have prompted the search for safer, natural alternatives. One of the enzymes central to the progression of acute inflammation is inducible nitric oxide synthase (iNOS), particularly its active site, plays a key role in the progression of acute inflammation. Lansium domesticum Corrêa, 1807 have been reported to contain secondary metabolites with anti-inflammatory potential, but their interaction with iNOS has not been systematically explored. This study is the first to comprehensively evaluate these secondary metabolites against iNOS using an in silico approach combing biological activity prediction, physicochemical and pharmacokinetic profiling, and molecular docking simulations. From 53 screened metabolites, nine compounds met drug-likeness and pharmacokinetic criteria and were further analyzed through molecular docking.  Ellagic Acid, (+)-Spathulenol, α-Cadinene, and τ-Muurolol showed substantial binding affinities at the iNOS active site, which suggests that they could be good anti-inflammatory agents. These results establish a basis for subsequent in vitro and in vivo validation aimed at creating safe, natural iNOS inhibitors as herbal-based for the alternative anti-inflammatory medicines.
Analisis In Silico Metabolit Sekunder Lansium domesticum sebagai Agen Antimalaria Potensial yang Menargetkan Enzim Laktat Dehidrogenase (PfLDH) pada Plasmodium falciparum Hanum, Laila; Nirwana, Rahma Julia; Oktariansyah, Yadi; Harvianti, Yuniar
Biogenesis: Jurnal Ilmiah Biologi Vol 14 No 1 (2026)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v14i1.62225

Abstract

Malaria continues to be a significant global infectious illness, with Plasmodium falciparum primarily responsible for the most severe and lethal cases, including cerebral malaria. P. falciparum lactate dehydrogenase (PfLDH), an essential enzyme in the parasite's glycolytic cycle, is a viable molecular target for the development of antimalarial drugs. The deficiencies in existing therapeutics underscore the necessity for novel candidate alternative drugs. Lansium domesticum, a native Indonesian plant, possesses bioactive compounds with potential antimalarial effects. This work sought to assess L. domesticum secondary metabolites as potential antimalarial agents using an in silico methodology. A total of 47 compounds were evaluated to forecast antimalarial efficacy, thereafter, assessing their physicochemical attributes, pharmacokinetic features, and toxicity profiles. Molecular docking was used to examine the interactions between potential drugs and the PfLDH target enzyme. Four compounds—is-3-Hexen-1-ol, Aromadendrene, Isoledene, and Hexadecanoic acid—fulfilled the necessary physicochemical, pharmacokinetic, and toxicological standards. Hexadecanoic acid demonstrated the most robust interaction with PfLDH, establishing three critical amino acid connections at the active site (GLY29, THR97, and HIS195) and exhibiting a superior binding affinity compared to control and natural ligands. The data indicate that hexadecanoic acid is a promising antimalarial candidate sourced from L. domesticum. Additional molecular dynamics simulations, together with in vitro and in vivo investigations, are required to validate its therapeutic efficacy.
From Illumination to Biological Regulation: A Biological Reappraisal of Lighting Management in Chickens – A Review Yadi Oktariansyah; Ferta Liza Putri
Jurnal Biologi Tropis Vol. 26 No. 1 (2026): Januari-Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11515

Abstract

Lighting management is a fundamental component of chicken production systems and has traditionally been applied as a technical tool to enhance activity, feeding behavior, and productivity. Increasing evidence, however, indicates that light functions not merely as illumination, but as a key biological signal regulating circadian rhythms, neuroendocrine pathways, behavior, welfare, and long-term production performance. This review provides a biological reappraisal of lighting management in chickens by synthesizing current evidence on how different lighting characteristics influence biological regulation and practical outcomes. A systematic literature review was conducted following PRISMA guidelines, with a qualitative synthesis approach adopted due to heterogeneity in study designs, lighting protocols, and outcome measures. Evidence was integrated across major lighting domains, including photoperiod duration, timing consistency, light intensity, spatial distribution, spectral composition, lighting technology, and stage-specific implementation. Emphasis was placed on identifying primary biological targets, expected production benefits, risks of mismanagement, and relevant monitoring indicators. The synthesized findings demonstrate that lighting management acts primarily through alignment with endogenous circadian and endocrine systems rather than isolated technical parameters. Lighting regimes that preserve circadian stability support sustainable productivity and animal welfare, whereas biologically inappropriate strategies may induce cumulative physiological stress and compromise long-term performance. This review highlights the need to reframe lighting management as a form of biological regulation to support data-driven and biologically informed production systems.
PENINGKATAN SKILL SISWA TUNARUNGU MELALUI PELATIHAN PATCHWORK DAN QUILTING BERBASIS APLIKASI SIGN TALK DI SLB-B YPAC PALEMBANG Anita Desiani; Bambang Suprihatin; Ali Amran; Yadi Oktariansyah; Siti Rusdiana Puspa Dewi; Jonatan Jonatan; Slamet Prayogo; Lonamonika Sinabutar
Jurnal AbdiMas Nusa Mandiri Vol. 8 No. 2 (2026): Periode April 2026
Publisher : LPPM Universitas Nusa Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33480/abdimas.v8i2.7965

Abstract

Skill development for deaf students at SLB-B YPAC Palembang still faces significant challenges, particularly due to communication barriers between teachers and students that hinder knowledge transfer. This community service program aims to enhance hard skills (technical sewing skills in patchwork and quilting) as well as soft skills (communication, teamwork, and independence) through the integration of an Artificial Intelligence (AI)-based application called Sign Talk. The implementation method was carried out through a workshop and intensive mentoring scheme over 4 months, which included 3 main training sessions, each lasting 120 minutes, for 15 deaf students. Evaluation was conducted using pre-test and post-test instruments analyzed descriptively. The results of the activity showed an increase in students’ soft skills of 40.5%. For hard skills, specifically sewing competencies, there was a 23.31% increase. Although 90% of participants rated the Sign Talk application as very helpful in understanding instructions during the activity, further development of the Sign Talk vocabulary is needed. Additionally, this activity can be expanded to include other hard skill trainings with Sign Talk serving as the communication medium.
Co-Authors Ali Amran Amrillah Nugrasyah Anita Desiani Ario Sucipto Artika Sri Wahyuni Arum Setiawan Arum Setiawan Ayu Safitri Bambang Suprihatin Cahyani, Riski Desitarani Doni Setiawan Elffisa Eriani Febrian Hadinata Ferta Liza Putri Harvianti, Yuniar Huda, Muhammad Komarul Indra Yustian Iqbar, Muhammad Jonatan Jonatan Laila Hanum Lonamonika Sinabutar Masito, Masito Muhammad Habiburrahman Muhammad Ikhsan Mustafa Kamal Nayla Khairani Nirwana, Rahma Julia Novira, Sandra Patricia, Margareth Pragustiandi, Guntur Pranoto, Aidil Fitra Putri, Cyntia Sabarani Ramadhani, Audya Rahma Sarah Angelica W. Simamora Sarno . Siti Rusdiana Puspa Dewi Slamet Prayogo Zainal Fanani