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Lactoferrin as a Potential Immune Biomarker in Breast Milk Exposed to Secondhand Smoke: A Literature Review Sarah Angelica W. Simamora; Artika Sri Wahyuni; Elffisa Eriani; Ario Sucipto; Nayla Khairani; Yadi Oktariansyah
BIOVALENTIA: Biological Research Journal Vol. 12 No. 1 (2026)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24233/biov.12.1.2026.568

Abstract

Smoking remains prevalent in Indonesia and poses health risks to mothers and infants. Data from the Maternal and Perinatal Death Notification (MPDN) system indicate that maternal mortality increased to 4,129 cases in 2023 from 4,005 cases in the previous year. Although maternal mortality is multifactorial, this highlights the importance of reducing environmental risks such as secondhand smoke (SHS) exposure. SHS is common in household environments and may affect breastfeeding mothers and infants. Breast milk is the main source of infant nutrition and supports early immune protection. Lactoferrin, an iron-binding glycoprotein in breast milk, has antimicrobial, anti-inflammatory, and immunomodulatory functions. SHS-induced oxidative stress may damage the structural integrity of glycoproteins in breast milk, including lactoferrin, which can impair their immunological functions. This literature review aims to examine the potential role of lactoferrin as an immune biomarker in breast milk from mothers exposed to SHS. This study used a literature review approach by identifying, selecting, and synthesizing relevant scientific articles on SHS exposure, breast milk composition, lactoferrin, and infant immune protection based on predetermined inclusion criteria. The reviewed literature indicates that SHS exposure is associated with oxidative stress and inflammatory responses, which may interfere with lactation quality and alter immune-related glycoproteins in breast milk. Lactoferrin is considered a potential biomarker because it is related to antimicrobial activity, immune regulation, and infant protection against infection. This review concludes that reducing household SHS exposure is important to protect breastfeeding mothers and maintain breast milk immunological quality. Further empirical studies are recommended to examine the direct relationship between SHS exposure intensity and lactoferrin levels by considering lactation stage, maternal nutritional status, infant age, infection history, and breastfeeding patterns.
Pelatihan Pemanfaatan Bioteknologi untuk Produk Sabun Alami Ramah Lingkungan Masyarakat Laila Hanum; Hary Widjajanti; Elisa Nurnawati; Mustafa Kamal; Yuniar Harvianti; Yadi Oktariansyah
Jurnal Medika: Medika Vol. 4 No. 4 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/8qyxsp08

Abstract

Pemanfaatan tanaman obat keluarga menjadi alternatif penting untuk meningkatkan kesehatan masyarakat secara alami dan berkelanjutan. Meski banyak tanaman seperti jeruk, manggis, rambutan, dan lidah buaya tersedia di sekitar rumah, pengetahuan masyarakat tentang penggunaannya sebagai bahan antiseptik masih terbatas. Padahal, bahan alami tersebut dapat diolah menjadi produk ramah lingkungan seperti sabun herbal, yang lebih aman dibandingkan sabun berbahan kimia yang berpotensi menimbulkan dampak negatif pada kulit dan lingkungan. Program pengabdian ini memperkenalkan bioteknologi sederhana melalui pemanfaatan ekstrak tanaman obat sebagai bahan pembuatan sabun antiseptik herbal. Kegiatan difokuskan pada edukasi dan pelatihan bagi ibu-ibu dan remaja putri di Desa Tanjung Atap Barat, Kecamatan Tanjung Batu, Kabupaten Ogan Ilir, desa binaan Universitas Sriwijaya. Metode pelaksanaan meliputi observasi, pelatihan, pendampingan, dan evaluasi. Program ini meningkatkan pengetahuan dan keterampilan masyarakat dalam memanfaatkan sumber daya lokal untuk mendukung pola hidup bersih dan sehat, sekaligus membuka peluang usaha berbasis produk herbal serta mendukung upaya pelestarian lingkungan.
Edukasi Biologi Sebagai Ilmu Hayati Terapan dalam Meningkatkan Pemahaman dan Minat Siswa Sma IT Raudhatul Ulum Ogan Ilir Laila Hanum Hanum; Hary Widjajanti; Indra Yustian; Arum Setiawan; Elisa Nurnawati; Singgih Tri Wardhana; Endri Junaidi; Yadi Oktariansyah; Yuniar Harvianti
Jurnal Medika: Medika in progres
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/8stcek83

Abstract

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pemahaman dan minat siswa Sekolah Menengah Atas (SMA) terhadap bidang Biologi melalui pendekatan berbasis konservasi dan bioteknologi. Permasalahan yang dihadapi adalah rendahnya pemahaman siswa terhadap ruang lingkup keilmuan Biologi serta terbatasnya informasi mengenai prospek karier lulusan Biologi. Kegiatan dilaksanakan di SMA IT Pondok Pesantren Raudhatul Ulum, Kabupaten Ogan Ilir, dengan metode sosialisasi, pemaparan materi, serta diskusi interaktif. Evaluasi dilakukan menggunakan pre-test dan post-test untuk mengukur peningkatan pemahaman siswa. Hasil kegiatan menunjukkan adanya peningkatan signifikan pada seluruh parameter yang diukur, meliputi pengetahuan tentang jurusan Biologi, pemahaman ruang lingkup kajian, serta pemahaman peluang kerja lulusan. Selain itu, ketertarikan siswa untuk melanjutkan studi di bidang Biologi juga mengalami peningkatan setelah kegiatan berlangsung. Kegiatan ini tidak hanya meningkatkan aspek kognitif, tetapi juga mengubah persepsi siswa terhadap Biologi menjadi lebih aplikatif dan relevan dengan kehidupan sehari-hari. Dengan demikian, kegiatan sosialisasi berbasis konservasi dan bioteknologi ini efektif dalam meningkatkan literasi sains serta minat siswa terhadap Biologi, sehingga berpotensi mendukung pengembangan sumber daya manusia yang peduli terhadap lingkungan dan berorientasi pada pemanfaatan sumber daya hayati secara berkelanjutan.
Secondary metabolites from Lansium domesticum as potential anti-inflammatory iNOS inhibitors: An in silico study Yadi Oktariansyah; Laila Hanum; Muhammad Habiburrahman
Jurnal Biolokus : Jurnal Penelitian Pendidikan Biologi dan Biologi Vol 8, No 2 (2025): December
Publisher : Universitas Islam Negeri Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30821/biolokus.v8i2.4731

Abstract

Inflammation is a crucial mechanism by which the immune system combats disease. However, when it becomes uncontrolled, it can result in acute inflammatory disorders. Although non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for treatment, their associated side effects have prompted the search for safer, natural alternatives. One of the enzymes central to the progression of acute inflammation is inducible nitric oxide synthase (iNOS), particularly its active site, plays a key role in the progression of acute inflammation. Lansium domesticum Corrêa, 1807 have been reported to contain secondary metabolites with anti-inflammatory potential, but their interaction with iNOS has not been systematically explored. This study is the first to comprehensively evaluate these secondary metabolites against iNOS using an in silico approach combing biological activity prediction, physicochemical and pharmacokinetic profiling, and molecular docking simulations. From 53 screened metabolites, nine compounds met drug-likeness and pharmacokinetic criteria and were further analyzed through molecular docking.  Ellagic Acid, (+)-Spathulenol, α-Cadinene, and τ-Muurolol showed substantial binding affinities at the iNOS active site, which suggests that they could be good anti-inflammatory agents. These results establish a basis for subsequent in vitro and in vivo validation aimed at creating safe, natural iNOS inhibitors as herbal-based for the alternative anti-inflammatory medicines.
Kelimpahan mikroplastik pada saluran pencernaan ikan Sapu-sapu (Pterygoplichthys pardalis Castelnau, 1855) di Hulu dan Hilir Sungai Musi kota Palembang Doni Setiawan; Nur Fatimah Vita Sari; Yadi Oktariansyah; Enggar Patriono; Mustafa Kamal
Sriwijaya Bioscientia Vol 6 No 3 (2025)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24233/sribios.6.3.2025.544

Abstract

Sungai Musi di Kota Palembang memiliki peranan penting bagi masyarakat, namun tingginya aktivitas antropogenik seperti transportasi, pemukiman, dan kegiatan industri berpotensi  meningkatkan pencemaran plastic yang terdegradasi menjadi mikroplastik. Penelitian ini bertujuan untuk mengidentifikasi jenis dan persentase kelimpahan mikroplastik pada saluran pencernaan  ikan sapu-sapu (Pterygoplichthys pardalis) serta membandingkan kelimpahannya antara bagian hulu dan hilir Sungai Musi. Pengambilan sampel dilakukan menggunakan metode purposive random sampling, diikuti dengan analisis laboratorium. Hasil penelitian menunjukkan adanya lima jenis mikroplastik yaitu fiber, fragmen, film, pellet, foam, dengan dominasi fiber sebesar 85,87%. Total  mikroplastik  yang ditemukan mencapai 977 partikel, di bagian hulu (525 partikel) dan hilir (452 partikel) dengan rata-rata kelimpahan 32,56 partikel per individu. Persentase kelimpahan mikroplastik menunjukkan lokasi  hulu sedikit lebih tinggi dibanding hilir yang mengindikasikan adanya variasi tingkat pencemaran mikroplastik yang lebih tinggi dibagian hulu Sungai Musi bagian Kota Palembang.
Light source effects on egg production and performance modeling of kub chickens Yadi Oktariansyah; Afni Salhsa Billa; Masito Masito
JPBIO (Jurnal Pendidikan Biologi) Vol 11, No 1 (2026): April 2026
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v11i1.5742

Abstract

Lighting intensity strongly influences reproductive physiology and productivity in laying hens. This study examined the effects of different light intensities and lamp types on egg production traits in KUB chickens and modeled production dynamics using nonlinear regression. Four treatments were tested: control, 5-watt blue LED, 5-watt incandescent, and 5-watt white LED. Daily egg count, Hen Day Production (HDP), total egg weight, and average egg weight were analyzed using one-way ANOVA and Tukey’s HSD. Results showed that higher light intensities significantly increased egg count, HDP, and total egg weight (p < 0.05), while average egg weight remained unchanged. Logistic models best fit incandescent and white LED groups, whereas blue LED data aligned with an Exponential model. White LEDs offer an energy-efficient option for improving productivity.
Culture optimization for keratinase production by thermophilic bacillus licheniformis AAL3 in keratin waste biodegradation Muharni Muharni; Khairatul Hasanah; Yuniar Harvianti; Yadi Oktariansyah
JPBIO (Jurnal Pendidikan Biologi) Vol 11, No 1 (2026): April 2026
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v11i1.6243

Abstract

Keratin waste is highly recalcitrant due to its complex protein structure, requiring efficient biodegradation strategies. This study aimed to evaluate and optimize keratinase production of thermophilic Bacillus licheniformis AAL3 isolated from the Air Putih hot spring, Lebong, Bengkulu. Qualitative keratinolytic activity was determined using feather meal agar, while quantitative enzyme activity was measured spectrophotometrically based on tyrosine release. The isolate exhibited a higher keratinolytic index (5.0) compared to B. licheniformis SCL2 (1.5). Quantitative analysis showed that AAL3 produced higher cell density (8.9 × 10? CFU/mL) and keratinase activity (1.0074 U/mL). Optimization studies revealed that maximum keratinase production occurred at 60 °C and pH 9. Among the tested carbon sources, 1% glucose resulted in the highest cell growth and enzyme activity, whereas 0.4% peptone was the most effective nitrogen source. The results demonstrate a strong positive correlation between bacterial growth and keratinase production. These findings indicate that B. licheniformis AAL3 has significant potential as a thermophilic keratinase producer for biotechnological applications, particularly in keratin waste biodegradation.
Lansium domesticum metabolites interfere with digestive enzyme function in the rice weevil sitophilus oryzae Yadi Oktariansyah; Ferta Liza Putri; Yuniar Harvianti; Eva Musifa
JPBIO (Jurnal Pendidikan Biologi) Vol 11, No 1 (2026): April 2026
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v11i1.6212

Abstract

Pectin methylesterase (PME) plays a key role in polysaccharide digestion in the rice weevil Sitophilus oryzae, making it a potential molecular target for pest control. This study employed structure-based in silico analysis to evaluate selected metabolites of Lansium domesticum as PME inhibitors. Representative compounds were chosen according to predicted interference mechanisms and docked into the validated catalytic site. All complexes showed structural stability, while interaction patterns revealed six inhibition modes: competitive mimicry, catalytic disruption, orientation interference, channel blocking, polymer mimicry, and interfacial modulation, whereas polyphenols and glycosides produced the strongest interference. The findings indicate that L. domesticum metabolites can disrupt digestive enzymatic processes through multiple complementary pathways, supporting their potential development as biologically derived pest management agents.
Genetic diversity and phylogenetic analysis of matoa (Pometia pinnata) from South Sumatra, Indonesia based on ITS rDNA LAILA HANUM; SALWA GHANIYU USMAN; YADI OKTARIANSYAH
Biodiversitas Journal of Biological Diversity Vol. 26 No. 11 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d261113

Abstract

Abstract. Hanum L, Usman SG, Oktariansyah Y. 2025. Genetic diversity and phylogenetic analysis of matoa (Pometia pinnata) from South Sumatra, Indonesia based on ITS rDNA. Biodiversitas 26: 5515-5524. Matoa (Pometia pinnata) is an ecologically and economically significant tropical fruit tree, however, its genetic variation in South Sumatra, Indonesia remains poorly characterized. This study aimed to examine the genetic diversity and phylogenetic relationships of four matoa variants, i.e., red, yellow, green, and forest types using ITS rDNA sequences. PCR amplification yielded sequences of 681 bp for cultivated and 478 bp for forest matoa, revealing two InDel haplotypes, 141 InDel sites, and three InDel events with moderate haplotype diversity (Hd = 0.50) and low InDel diversity per site (?i = 0.001). These findings indicate limited but informative structural variation linked to insertion-deletion mutation events, supporting the ITS region’s dual role as both a conserved barcode and a marker for intraspecific differentiation. Phylogenetic and AMOVA analyses showed clear separation between cultivated and forest variants, with almost all genetic variation (99.9997%) partitioned among populations (Fst = 0.999997), suggesting restricted gene flow and possible ecological divergence. Despite high sequence similarity of 99.85% to 100% confirming conspecificity, forest matoa formed a distinct clade and grouped separately, highlighting its potential as a unique genetic reservoir. These results provide foundational molecular insights for conservation, breeding, and germplasm authentication strategies for matoa in Indonesia.
Genetic diversity of pigmented rice landraces (Oryza sativa) from South Sumatra, Indonesia revealed by SSR markers LAILA HANUM; TUTIK WAHYUNI; YADI OKTARIANSYAH
Biodiversitas Journal of Biological Diversity Vol. 27 No. 1 (2026)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d270130

Abstract

Abstract. Hanum L, Wahyuni T, Oktariansyah Y. 2026. Genetic diversity of pigmented rice landraces (Oryza sativa) from South Sumatra, Indonesia revealed by SSR markers. Biodiversitas 27 (1): d270130. https://doi.org/10.13057/biodiv/d270130. Pigmented rice landraces constitute an important component of Indonesia’s rice genetic resources, yet information on their molecular diversity in South Sumatra remains limited. This study tested the hypothesis that pigmented rice landraces from South Sumatra exhibit SSR-detectable genetic variation among accessions, whereas genome-wide differentiation between pigmentation groups (red and black rice) is weak or non-significant. This study assessed the genetic diversity and relatedness of ten local pigmented rice (Oryza sativa) landraces, comprising seven red and three black rice accessions, using 11 Simple Sequence Repeat (SSR) markers. All markers produced clear and reproducible amplification profiles, generating fragments ranging from 127 to 480 bp, with six to twelve alleles per locus. Marker informativeness was consistently high, with PIC values of 0.790-0.917 (mean = 0.878), indicating strong discriminatory power for accession differentiation. SSR profiles were predominantly homozygous, reflecting the autogamous reproductive system of rice, although limited heterozygosity was detected at a few loci in specific accessions. Multilocus comparison revealed moderate divergence among landraces, supported by Jaccard similarity coefficients ranging from 0.769 to 1.000. UPGMA clustering resolved a structured pattern consisting of a closely related core group of accessions, an intermediate subgroup represented by Linggau and Tanjung Agung, and a more divergent subgroup comprising Sumber Jaya and Teluk Tenggirik. However, AMOVA indicated that molecular variation was predominantly distributed within populations (100%) rather than among populations (0%), with a non-significant differentiation between red and black rice groups (Fst = -0.038; p = 0.769). These findings provide baseline molecular evidence supporting conservation prioritization and highlight genetically distinct landraces as potential donors for future pigmented rice breeding programs. This study represents one of the few SSR-based molecular assessments focusing specifically on pigmented rice landraces from South Sumatra, Indonesia.