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All Journal Usadha Indonesian Journal of Pharmacology and Therapy
Handani, Dewa Ayu Sri
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Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pengaruh Polimorfisme Gen terhadap Risiko Penyakit Gagal Ginjal Kronis: Narrative Review Handani, Dewa Ayu Sri; Megawati, Fitria
Usadha Vol 3 No 3 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i3.10956

Abstract

Chronic Kidney Disease (CKD) is an escalating global health issue, particularly in Indonesia. CKD is characterized by a progressive and irreversible decline in renal function, with diabetes mellitus and hypertension as primary risk factors. Genetic polymorphisms, variations in DNA sequences that affect gene function and protein expression, play a critical role in CKD risk and progression. This narrative review examines the role of genetic polymorphisms in CKD risk based on available literature. Scientific articles were sourced from PubMed, ScienceDirect, Google Scholar, and Scopus using keywords related to genetic polymorphisms and CKD. From the 441 articles identified, selection was based on relevance, sample size, and article completeness. Several genetic polymorphisms were found to have significant associations with increased CKD risk, including Renalase (rs2296545), GSTO1 (rs2164624), GSTO2, MMP3 (rs35068180), and MGP (rs4236), among others such as CYP24A1, GPX1, UMOD, CYP2C8, CYP4A11, EPHX2, SPP1, and BGLAP. These polymorphisms influence mechanisms such as blood pressure regulation, oxidative stress, inflammation, and tissue calcification, all contributing to CKD progression. In conclusion, genetic polymorphisms are crucial in CKD risk, offering insights for more personalized approaches in diagnosing, preventing, and treating this condition. These findings support the development of more effective, genetics-based treatment strategies in the future.
Identifikasi Senyawa Fitokimia dan Uji Aktivitas Antioksidan pada Cascara (Coffea arabica L.) Sasadara, Maria Malida Vernandes; Cahyaningsih, Erna; Yuda, Putu Era Sandhi Kusuma; Handani, Dewa Ayu Sri; Dewi, Ni Luh Kade Arman Anita; Megawati, Fitria; Tirtayasa, Gede Agus Ari
Usadha Vol 4 No 1 (2025): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i1.12181

Abstract

Cascara refers to the dried husk of coffee cherries. It has garnered significant attention in recent research due to its phytochemical composition and potential health benefits. Several studies have highlighted the presence of bioactive compounds and the antioxidant activity exhibited by cascara. This study aims to investigate the phytochemical content and antioxidant potential of cascara. The cascara was extracted using the maceration method with 96% ethanol, followed by phytochemical screening for alkaloids, flavonoids, tannins, saponins, terpenoids, steroids, and quinones using standard color reactions in test tubes. Antioxidant activity was assessed via the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, with ascorbic acid as a reference compound. The phytochemical profile of the extract was identified using gas chromatography-mass spectrometry (GC-MS). The findings indicated that cascara contains alkaloids, flavonoids, tannins, saponins, and triterpenoids. GC-MS analysis identified caffeine, hexadecanoic acid (methyl ester), and hexadecanoic acid (ethyl ester) as the predominant compounds in cascara. The antioxidant activity test using the DPPH method demonstrated that the ethanol extract of cascara possesses moderate antioxidant potential, with an average IC50 value of 108.49 ± 1.28 ppm. Ascorbic acid, the reference compound used in this study, yielded an IC50 of 2.53 ppm, categorized as very strong. This research underscores cascara’s potential as a valuable source of antioxidants with significant health benefits, influenced by geographic factors affecting its bioactive compound profile. Consequently, cascara holds promise for further development as a raw material for functional health-promoting products.
Co-Authors Adam Hermawan Erna Cahyaningsih Megawati, Fitria Ni Luh Kade Arman Anita Dewi Putu Era Sandhi Kusuma Yuda Sasadara, Maria Malida Vernandes Tirtayasa, Gede Agus Ari