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ISOLATION AND ACTIVITY ANTIOXIDANT TEST OF COCOA POD HUSK ETHYL ASETAT EXTRACTS (Theobroma cacao L) Binawati Ginting; Ilham Maulana; Nurdin Saidi; Syarifah Yanti Astryna
Jurnal Natural Volume 19 Number 2, June 2019
Publisher : Universitas Syiah Kuala

Isolation and testing of antioxidant activity with1,1-difenil-2-pikril hidrazil (DPPH) from ethyl acetate extract ofcocoa pod husk(Theobroma cacao L) has been carried out.Theobroma cacaoextract (TCE) showed highly strong antioxidant activity with IC50 = 8,75 ppm and vitamine C = 6,07 ppm as positive control. Isolation of the active components of TCE by column chromatography using silica gel absorbent 60 mesh ASTM (Merck 774) and the eluent n-hexane: ethyl acetate (9:1), obtained 7 fraction combined (TCE 1 to TCE 7). There are 6 combined fractions having the potential as antioxidants, namely TCE 2 to TCE 7 with a range of IC50 (6,46 ppm – 91,8 ppm). TCE 2 fraction has a very strong antioxidant activity with IC50 = 6,46 ppm. Separation of TCE 2 fraction on silica column chromatography obtained 4 combined fractions (TCE 2.1 to TCE 2.4). The test results of antioxidant activity showed that TCE 2.4 had very strong activity with IC50 = 42,7 ppm.For the TCE 2.2 fraction, preparative TLC was carried out using eluent n-hexane: ethyl acetate (9.5: 0,5) obtained by TCE 2.2.4 isolate with a melting point of 114-120 °C and was a steroid class.

ISOLATION AND ACTIVITY ANTIOXIDANT TEST OF COCOA POD HUSK ETHYL ASETAT EXTRACTS (Theobroma cacao L) Binawati Ginting; Ilham Maulana; Nurdin Saidi; Syarifah Yanti Astryna
Jurnal Natural Volume 19 Number 2, June 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v19i2.12568

Isolation and testing of antioxidant activity with1,1-difenil-2-pikril hidrazil (DPPH) from ethyl acetate extract ofcocoa pod husk(Theobroma cacao L) has been carried out.Theobroma cacaoextract (TCE) showed highly strong antioxidant activity with IC50 = 8,75 ppm and vitamine C = 6,07 ppm as positive control. Isolation of the active components of TCE by column chromatography using silica gel absorbent 60 mesh ASTM (Merck 774) and the eluent n-hexane: ethyl acetate (9:1), obtained 7 fraction combined (TCE 1 to TCE 7). There are 6 combined fractions having the potential as antioxidants, namely TCE 2 to TCE 7 with a range of IC50 (6,46 ppm – 91,8 ppm). TCE 2 fraction has a very strong antioxidant activity with IC50 = 6,46 ppm. Separation of TCE 2 fraction on silica column chromatography obtained 4 combined fractions (TCE 2.1 to TCE 2.4). The test results of antioxidant activity showed that TCE 2.4 had very strong activity with IC50 = 42,7 ppm.For the TCE 2.2 fraction, preparative TLC was carried out using eluent n-hexane: ethyl acetate (9.5: 0,5) obtained by TCE 2.2.4 isolate with a melting point of 114-120 °C and was a steroid class.

Using The TGT Learning Model to Improve Student Learning Outcomes in Colloidal Systems Material at Sman 1 Lhoknga Aceh Besar Mardhiah, Ainun; Adiska, Dessi Nur; Astryna, Syarifah Yanti; Rahmi, Rauzatur
Jurnal Pendidikan dan Pembelajaran Kimia Vol 13, No 2 (2024): Jurnal Pendidikan dan Pembelajaran Kimia
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar

The learning model is one of the important things that must be prepared by an educator in learning process. One effort to achieve value in understanding concepts and learning outcomes can be done by implementing active, creative, fun and effective learning models in the classroom. The innovation that can be carried out is by implementing the Teams Games Tournaments (TGT) learning model. The purpose of this research to improve learning outcomes, determine student activities and responses to the subject of colloid systems using the teams games torunament (TGT) learning model in class XI at SMAN 1 Lhoknga Aceh Besar. The design used in this research was nonequivalent control group design. The sampling technique used was purposive sampling. The subjects of this research were class XI IA1 and class XI IA2, totaling 24 students. Research data was obtained from learning outcomes tests. observation of student activities, and provide student response questionnaires. The research results show that 1) The use of the teams games tournament (TGT) learning model can improve student learning outcomes in the Colloid System material at SMAN 1 Lhoknga Aceh Besar with an average score of 79,54%. 2) Student activity in teaching and learning activities through the use of the teams games tournament (TGT) learning model at the first meeting obtained a percentage of 75%, while at the second meeting student activity increased with a percentage of 90%. 3) Student responses to the use of the teams games tournament (TGT) learning model in the questionnaire distributed at the end of the lesson were obtained sequentially, namely strongly agree 28%, agree 58% and disagree 14%.Keywords: Teams Games Tournament (TGT) learning model, learning outcomes, colloid system DOI: 10.23960/jppk.v13i2.29811

FORMULASI SALEP EKSTRAK DAUN BIDURI (Calotropis gigantea L.) SEBAGAI ANTIBAKTERI Staphylococcus aureus Syarifah Yanti Astryna; Nora Mariska; Melizar Melizar
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 7, No 2 (2021): OKTOBER 2021
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v7i2.4195

Staphylococcus aureus merupakan patogen utama pada manusia yang menyebabkan penyakit kulit. Penyakit yang disebabkan oleh Staphylococcus aureus ditandai dengan kerusakan jaringan yang disertai abses bernanah seperti bisul, jerawat, impetigo, dan infeksi luka. Daun biduri memilki bahan aktif yaitu alkaloid, polifenol, steroid, and saponin yang diduga mempunyai efek antibakteri. Tujuan penelitian untuk mengetahui kestabilan sifat fisik ekstrak daun biduri yang diformulasikan kedalam sediaan salep dan seberapa besar efektivitas yang dihasilkan oleh formulasi salep ekstrak daun biduri (Calotropis gigantea L.) sebagai antibakteri Staphylococcus aureus. Metode penelitian ini yaitu eksperimental laboratorium dengan pengujian secara in vitro. Extrak daun biduri diperoleh dengan metode maserasi menggunakan metanol. Salep dibuat menggunakan basis hidrokarbon. Salep yang telah dihasilkan selanjutnya diuji aktivitas antibakterinya terhadap Staphylococcus aureus menggunakan metode difusi agar, kemudian diameter daya hambat diukur dengan menggunakan jangka sorong. Bakteri Staphylococcus aureus akan diuji dengan salep ekstrak daun biduri dengan konsentrasi masing-masing 12,5%, 25%, dan 50%, kelompok kontrol positif salep gentamicin dan kelompok kontrol negatif basis salep. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) masing-masing kelompok dilakukan lima kali pengulangan. Analisis data yang diperoleh secara deskriptif. Hasil penelitian menunjukkan bahwa diameter zona inhibisi untuk Staphylococcus aureus pada konsentrasi formulasi ekstrak daun biduri 12,5% (0 mm); 25% (0 mm) dan 50% (0 mm). Kontrol negatif (basis salep) (0 mm) dan kontrol positif (salep gentamicin) (14,4 mm). Hasil uji ini menunjukkan bahwa salep ekstrak daun biduri tidak menunjukkan aktivitas antibakteri terhadap Staphylococcus aureus.Kata kunci: Ekstrak Daun Biduri, Salep, Antibakteri, Staphylococcus aureus.Staphylococcus aureus is a major pathogen in humans which cause skin infections. The disease is caused by Staphylococcus aureus that characterized by tissue damage accompanied by abscesses such as ulcers, acne, impetigo, and wound infections. Calotropis gigantea leaves have an active ingredient which is alkaloid, polifenol, steroid, and saponin are believed as antibacterial effects. The main objective of the present study is to know the stability of physical properties with formulation of extract of Calotropis gigantea leaves and to determine how much effectiveness as antibacterial activity toward Staphylococcus aureus. This research was an experimental laboratory with in vitro test. The extract of Calotropis gigantea leaves obtained from maceration method using methanol. The ointment was made based of hydrocarbon. The obtained ointment then was examined on bacterial activity toward Staphylococcus aureus using agar diffusion method, then the diameter of the zone of inhibition measured by using sliding term. Staphylococcus aureus bacteria is tested with ointment containing extract of Calotropis gigantea leaves with concentrations of 12.5%, 25%, and 50%, gentamicin ointment is used as positive control and ointment base was used as negative. This study used Complete Randomized Design (CRD) each group performed five repetitions. The Analyzes were performed using descriptive study. The results showed that the diameter of the zone of inhibition for Staphylococcus aureus at a concentration of 12,5% (0 mm); 25% (0 mm) and 50% (0 mm). Negative control (0 mm) and positive control (14.4 mm). The results of this test indicate that ointment containing Extract of Calotropis gigantea leaves did not show antibacterial activity against Staphylococcus aureus.Keywords : Extract of Calotropis gigantea Leaves, Ointment, Antibacterial, Staphylococcus aureus.

Characterization of Thermophilic Novel-Rare Actinobacteria from Hot Springs and Compost as an Unique Secondary Metabolite Producer Maghfirah, Ruhul; Kemala, Pati; Astryna, Syarifah Yanti
Journal of Carbazon Vol 2, No 2 (2024): December 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jocarbazon.v2i2.42883

This review aims to explain in more detail about the Actinobacteria and it secondary metabolites. Some species of Actinobacteria can live in extreme environments such as high acid, high base, high salt and even high temperatures. Actinobacteria mainly of the genus Streptomyces sp. has been known to produce bioactive compounds such as antibacterial, antifungal, anticancer, antitumor, anticytotoxic, anti-inflammatory, anti-parasitic, anti-malarial, antiviral and antioxidant. This study reviews various research findings on Actinobacteria species and their ability to thrive in extreme environments. It also reviews the findings of bioactive compounds isolated from Actinobacteria and their potential applications. Some species in the genera Streptomyces, Thermonospora, and Thermoactinomyces have optimal growth temperatures above 55C and are categorized as thermophilic. More than 30,000 bioactive compounds that have been isolated are derived from Actinobacteria and 80% are from the genus Streptomyces sp. Benzastatin C and 3-Chloro-Tetrahidroquinolon are new antivirals isolated from Streptomyces nitrosporeus. Essramycin is a novel antibiotic that shows activity against Gram positive and Gram negative bacteria. Chandrananimycin A isolated from Actinomadura sp. and N-(2-hydroxyphenyl)-2-Phenazinamin (NHP) isolated from Nocardia dassonvillei are novel antibiotics that can be used as antifungals, antialgas, antibacterials and anticancer. The potential of Actinobacteria in producing bioactive compounds can advance the field of science and technology in the future and become an alternative to overcome the problem of resistance to pathogenic microorganisms are increasing.

HUBUNGAN TINGKAT PENGETAHUAN IBU TENTANG GIZI DENGAN ANGKA KEJADIAN STUNTING PADA BALITA USIA 24-59 BULAN DI DESA PAWOH KECAMATAN LABUHAN HAJI KABUPATEN ACEH SELATAN Dhirah, Ulfa Husna; Asyura, Finaul; Astryna, Syarifah Yanti; Nurhayati, Nurhayati
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 10, No 2 (2024): OKTOBER 2024
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v10i2.4366

Stunting adalah kondisi gagal tumbuh pada tubuh dan otak akibat kekurangan gizi dalam waktu yang lama sehingga anak lebih pendek dari anak normal seusianya dan memiliki keterlambatan dalam berfikir. Stunting pada anak disebabkan asupan gizi balita, adanya penyakit infeksi, faktor ibu dengan nutrisi buruk selama prekonsepsi, kehamilan dan laktasi, faktor genetik, pemberian ASI eksklusif, ketersediaan pangan, faktor sosial ekonomi, faktor tingkat pendidikan ibu, pengetahuan gizi ibu dan faktor lingkungan. Salah satu upaya untuk meningkatkan perilaku ibu balita yaitu melalui pendidikan kesehatan. Â Penelitian ini bertujuan mengetahui hubungan tingkat pengetahuan ibu tentang gizi dengan angka kejadian stunting pada balita di Desa Pawoh Kecamatan Labuhan Haji Kabupaten Aceh Selatan. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan desain survey analitik dan metode pendekatan cross sectional. Populasi pada penelitian ini yaitu ibu yang mempunyai balita di Desa Pawoh Kecamatan Labuhan Haji Kabupaten Aceh Selatan. Pengambilan sampel dalam penelitian ini menggunakan teknik purposive sampling. Analisis data mengguankan uji statistik chi square. Hasil uji stastistik didapatkan (Ï‡Â²) sebesar 75,602 dengan sig. 0,000 < 0,05 artinya bahwa terdapat hubungan antara pengetahuan ibu tentang gizi dengan kejadian stunting pada balita di Desa Pawoh Kecamatan Labuhan Haji Kabupaten Aceh Selatan. Diharapkan bagi ibu yang memiliki anak. perlu menyadari pentingnya peranan gizi bagi balita dan segera memperhatikan asupan gizi yang dibutuhkan oleh anak.Kata Kunci : Balita, Gizi, Pengetahuan Ibu, StuntingÂ Stunting is a condition of failure to grow in the body and brain due to lack of nutrition for a long time so that children are shorter than normal children of their age and have delays in thinking. Stunting in children is caused by nutritional intake of toddlers, the presence of infectious diseases, maternal factors with poor nutrition during preconception, pregnancy and lactation, genetic factors, exclusive breastfeeding, food availability, socio-economic factors, maternal education level, maternal nutritional knowledge and environmental factors. One effort to improve the behavior of mothers of toddlers is through health education.Â This research aims to determine the relationship between the level of maternal knowledge about nutrition and the incidence of stunting among toddlers in Pawoh Village, Labuhan Haji District, South Aceh Regency. This research is a quantitative study using an analytical survey design and a cross-sectional approach method. The population in this study were mothers who had toddlers in Pawoh Village, Labuhan Haji District, South Aceh Regency. Sampling in this research used purposive sampling technique. Data analysis used the chi square statistical test. The statistical test results obtained (Ï‡Â²) were 75.602 with sig. 0.000 < 0.05 means that there is a relationship between maternal knowledge about nutrition and the incidence of stunting in toddlers in Pawoh Village, Labuhan Haji District, South Aceh Regency. It is expected for mothers who have children. need to be aware of the important role of nutrition for toddlers and immediately pay attention to the nutritional intake needed by children.Keywords: Toddlers, Nutrition, Mother's Knowledge, Stunting

FORMULASI DAN EVALUASI SEDIAAN ROLL-ON AROMATERAPI MINYAK ATSIRI PALA (Myristica fragrans houtt.) DAN SERAI (Cybopongon citratus) SEBAGAI ANTIEMETIK Meilina, Rulia; Hafizhathifa, Fathin; Astryna, Syarifah Yanti; Safitri, Faradilla; Syafriadi, Syafriadi; Rezeki, Sahbainur; Ningsih, Yustika Wirda; Lestari, Widya; Alvionida, Fitra
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 10, No 2 (2024): OKTOBER 2024
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v10i2.4758

Minyak Atsiri merupakan salah satu metabolit sekunder yang banyak dimanfaat sebagai aromaterapi untuk mengatasi mual dan muntah. Tumbuhan Pala (Myristica fragrans houtt.) dan Serai (Cymbopogon citratus) berpotensi besar sebagai sumber minyak atsiri karena mengandung komponen utama minyak atsiri. Tumbuhan Pala mengandung senyawa seperti myristicin, elemicin, safrole, sedangkan tumbuhan Serai memiliki sitronelal, sitronelol dan geraniol yang merupakan komponen utama minyak atsiri. Tujuan penelitian ini adalah untuk mengetahui formulasi sediaan roll-on aromaterapi dan konsentrasi optimal dari Minyak Atsiri Pala dan Serai sebagai antiemetik. Penelitian ini bersifat eksperimental laboratorium. Roll-on diformulasikan dengan konsentrasi sediaan F1 (20%-10%), F2 (15%-15%), F3 (10%-20%). Kemudian tahap evaluasi formulasi sediaan roll-on dilakukan dengan uji organoleptik, uji homogenitas, pH, uji daya sebar dan uji hedonik dianalisis menggunakan metode statistik berupa uji one way anova. Hasil penelitian dari uji pH (5), daya sebar baik, sediaan homogen, nilai uji hedonik keterangan rata-rata suka dan analisis anova menyatakan formula diperoleh nilai signifikan p value <0,05 terhadap aspek penilaian (warna, wangi alami, tekstur, kesegaran, antiemetik, kesukaan keseluruhan)maka diketahui bahwa ada pengaruh formula terhadap ke 6 (enam) aspek penilaian sediaan tersebut, sedangkan kehangatan diperoleh nilai signifikan p value >0,05 maka diketahui bahwa tidak ada pengaruh formula terhadap kehangatan sediaan. Minyak Atsiri Pala dan Serai dapat diformulasikan dalam bentuk sediaan roll-on aromaterapi sebagai antiemetek. Konsentrasi minyak atsiri pala dan serai yang optimal dan paling efektif sebagai aromaterapi antiemetik yaitu konsentrasi F3 (10%-20%).

UJI SKRINING FITOKIMIA EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L. ) Astryna, Syarifah Yanti; Samaniyah, Siti; Nurhayati, Nurhayati; Asyura, Syarifah; Maghfirah, Ruhul
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 10, No 2 (2024): OKTOBER 2024
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v10i2.4718

Bunga telang (Clitoria ternatea L.) merupakan tanaman yang dikenal memiliki berbagai manfaat dalam pengobatan tradisional. Tanaman ini mengandung berbagai senyawa fitokimia yang diduga memiliki aktivitas farmakologis yang bermanfaat untuk kesehatan. Penelitian ini bertujuan untuk mengidentifikasi kandungan senyawa fitokimia pada ekstrak etanol bunga telang melalui uji skrining fitokimia. Ekstraksi dilakukan menggunakan pelarut etanol 70%, dan hasil ekstrak diuji terhadap senyawa alkaloid, flavonoid, saponin, tanin, dan terpenoid menggunakan metode reaksi kimia spesifik. Hasil penelitian menunjukkan bahwa ekstrak etanol bunga telang mengandung senyawa flavonoid, saponin, dan terpenoid, yang memiliki potensi sebagai bahan baku obat alami. Namun, alkaloid dan tanin tidak terdeteksi dalam ekstrak. Temuan ini menunjukkan pentingnya bunga telang sebagai sumber fitokimia dengan potensi terapeutik.

UJI EFEKTIVITAS GEL EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L. ) TERHADAP PENYEMBUHAN LUKA BAKAR PADA HEWAN UJI KELINCI (Oryctolagus cuniculus) Astryna, Syarifah Yanti; Samaniyah, Siti; Ridjna, Hilal Zulikram; Rosdiana, Eva; Maghfirah, Ruhul
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 10, No 2 (2024): OKTOBER 2024
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v10i2.4765

Luka bakar disebabkan oleh perpindahan energi dari sumber panas ke tubuh melalui konduksi atau radiasi elektromagnetik. Data dari Riset Kesehatan Dasar Kementrian Kesehatan tahun 2019 menyatakan angka luka bakar di Indonesia menempati peringkat kedua pada golongan proporsi jenis cidera luka bakar dengan besar 1,3% setelah cedera lainnya dengan presentase sebesar 2,6%. Bunga telang merupakan salah satu tanaman yang memiliki senyawa antioksidan yang dapat memberikan perlindungan tubuh dari serangan radikal bebas yang dapat menyebabkan luka bakar. Senyawa pada bunga telang dapat berperan dalam penyembuhan luka bakar antara lain flavonoid dan saponin. Tujuan Penelitian untuk mengetahui ekstrak etanol bunga telang berpengaruh terhadap penyembuhan luka bakar pada kelinci dan untuk mengetahui tingkat konsentrasi paling efektif pada ekstrak etanol bunga telang yang terbaik memberikan efek penyembuhan luka bakar. Metode Penelitian berupa ekstrak yang diformulasikan menjadi sediaan gel dengan konsentrasi 5%, 10% dan 15%. Pengujian yang dilakukan meliputi standarisasi simplisia, skrinning fitokimia, evaluasi sediaan, uji efektivitas luka bakar pada kelinci dan uji statistik One Way ANOVA. Hasil penelitian menunjukkan bahwa ekstrak etanol bunga telang memiliki pengaruh terhadap penyembuhan luka bakar pada kelinci.

Aktivitas Antibakteri Ekstrak Gel Topikal Daun Beluntas (Pluchea indica (L.) Astryna, Syarifah Yanti; Alvionida, Fitra; Nurhayati, Nurhayati; Sulistyani, Nanik; Sugihartini, Nining
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 10, No 1 (2024): April 2024
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v10i1.4108

Indonesia merupakan Negara yang terkenal akan sumber kekayaan hayatinya, salah satunya adalah daun beluntas. Daun beluntas berpotensi sebagai antibakteri sehingga tepat untuk diformulasi dalam bentuk sediaan obat terutama gel. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak daun beluntas terhadap aktivitas antibakteri. Gel dibuat dalam empat variasi basis gel yaitu F0 (0,5% karbopol, 1% HPMC), FI (1% karbopol, 1,5% HPMC), FII (1,5% karbopol, 2,5% HPMC), dan FIII (2% karbopol, 3% HPMC). Kemudian gel diuji aktivitas antibakteri terhadap bakteri Staphylococcus aureus dengan metode Kirby bauer. Data yang diperoleh dianalisis dengan One Way Anova dengan taraf kepercayaan 95%. Berdasarkan hasil uji yang telah dilakukan dengan beberapa parameter di atas variasi karbopol 940 dan HPMC yang paling optimal dalam gel ekstrak daun beluntas adalah FIII (2% karbopol dan 3% HPMC). Namun yang mempunyai aktivitas antibakteri paling tinggi terhadap Staphylococcus aureus adalah FI (1% karbopol dan 1,5% HPMC) yang ditunjukkan dengan terbentuknya diameter zona bening di sekitar lubang sumuran termasuk dalam katagori daya hambat kuat.Kata Kunci: Antibakteri, Formulasi, Gel, Pluchea indica (L.)), Staphylococcus aureusÂ Indonesia is a country famous for its natural resources, one of which is beluntas leaves. Beluntas leaves have the potential as antibacterial so they are suitable to be formulated in the form of drug preparations, especially gels. This study aims to determine the effect of beluntas leaf extract on antibacterial activity. The gel was made in four variations of gel bases, namely F0 (0.5% carbopol, 1% HPMC), FI (1% carbopol, 1.5% HPMC), FII (1.5% carbopol, 2.5% HPMC), and FIII (2% carbopol, 3% HPMC). Then the gel was tested for antibacterial activity against Staphylococcus aureus bacteria using the Kirby Bauer method. The data obtained were analyzed by One Way Anova with a confidence level of 95%. Based on the results of the tests that have been carried out with several parameters above, the most optimal variation of carbopol 940 and HPMC in beluntas leaf extract gel is FIII (2% carbopol and 3% HPMC). However, the one with the highest antibacterial activity against Staphylococcus aureus is FI (1% carbopol and 1.5% HPMC) which is indicated by the formation of a clear zone diameter around the well hole, which is included in the strong inhibitory power category.Keywords: antibacterial, formulation, gel, (Pluchea indica (L.)), Staphylococcus aureus

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