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All Journal Scientia Psychiatrica Eureka Herba Indonesia Sriwijaya Journal of Forensic and Medicolegal Scientific Journal of Pediatrics Sriwijaya Journal of Otorhinolaryngology
Febria Suryani
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Scientia Psychiatrica

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Preventing Cognitive Decline in Late-Life Depression: A Longitudinal Study on the Efficacy of Omega-3 Fatty Acid Supplementation in Older Adults in Palembang, Indonesia Sony Sanjaya; Febria Suryani; Pham Uyen; Maria Rodriguez; Muhammad Yoshandi
Scientia Psychiatrica Vol. 6 No. 4 (2025): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v6i2.190

Abstract

Introduction: Late-life depression (LLD) is a prevalent condition in older adults and a significant risk factor for cognitive decline and dementia. In Indonesia, with its aging population and specific dietary patterns, understanding interventions for LLD-associated cognitive impairment is crucial. Omega-3 polyunsaturated fatty acids (PUFAs) offer potential neuroprotective benefits. This study aimed to assess the efficacy of long-term omega-3 PUFA supplementation in mitigating cognitive decline among older adults with LLD in Palembang, Indonesia. Methods: This 24-month, randomized, double-blind, placebo-controlled trial was conducted in Palembang. Three hundred sixty older adults (aged ≥60 years) with a current DSM-5 diagnosis of Major Depressive Disorder (MDD) and subjective cognitive complaints were randomized (1:1) to receive either daily oral supplementation of 2.2 grams of omega-3 PUFAs (containing 1320 mg eicosapentaenoic acid [EPA] and 880 mg docosahexaenoic acid [DHA]) or a matched placebo (corn oil). The primary outcome was the change in the Indonesian version of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog-INA) score over 24 months. Secondary outcomes included changes in the Montreal Cognitive Assessment-Indonesian version (MoCA-INA), Geriatric Depression Scale (GDS-30), Instrumental Activities of Daily Living (IADL), serum Brain-Derived Neurotrophic Factor (BDNF), and high-sensitivity C-Reactive Protein (hs-CRP). Results: Over 24 months, the omega-3 group exhibited significantly less decline on the ADAS-Cog-INA compared to the placebo group (mean difference: -2.1 points; 95% CI: -3.8 to -0.4; p=0.018). Statistically significant benefits for the omega-3 group were also observed in MoCA-INA scores (mean difference: 1.5 points; p=0.025) and GDS-30 scores (mean difference: -2.5 points; p=0.011). BDNF levels increased significantly in the omega-3 group relative to placebo (p=0.008), while hs-CRP levels showed a non-significant trend towards reduction (p=0.072). Conclusion: Long-term supplementation with 2.2 g/day of EPA-rich omega-3 PUFAs resulted in a modest but statistically significant attenuation of cognitive decline and improvement in depressive symptoms in older adults with LLD in Palembang. These findings suggest that omega-3 PUFAs could be a valuable adjunctive therapeutic strategy in this specific Southeast Asian population.
Quantifying the Boiling Point: A Distributed Lag Non-Linear Analysis of Heatwave Intensity and the 'Thermal Distress' Threshold for Psychiatric Morbidity in an Indonesian Metropolis Taufiq Indera Jayadi; Eva Naritawati; Nurul Hanifah; Maximillian Wilson; Khairiel Anwar; Febria Suryani; Zaki Ahmad
Scientia Psychiatrica Vol. 6 No. 3 (2025): Scientia Psychiatrica
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v6i3.198

Abstract

Introduction: The Indonesian archipelago sits at the forefront of the climate crisis, yet the intersection of heat stress and mental health in this equatorial region remains under-researched. Unlike temperate climates, where heatwaves are sporadic, Indonesian cities face a chronic thermal load exacerbated by the Urban Heat Island effect. Methods: We conducted a retrospective ecological time-series analysis in Jakarta, Indonesia, spanning the period from January 1st, 2014, to December 31st, 2024. Daily psychiatric Emergency Department admissions (Total N = 48,210) were aggregated from three referral hospitals. We utilized a Distributed Lag Non-linear Model combined with a quasi-Poisson regression to correlate admissions with meteorological data from the Indonesian Agency for Meteorology, Climatology, and Geophysics, adjusting for holidays, day of the week, and particulate matter 2.5. Results: The Thermal Distress Threshold was identified at a Wet Bulb Globe Temperature of 29.8°C, reflecting a high degree of physiological acclimatization. Beyond this tipping point, the cumulative Relative Risk for acute psychiatric episodes rose to 1.21 (95% Confidence Interval: 1.14–1.29) at lag 0–3 days. Schizophrenia spectrum disorders showed the highest vulnerability (Relative Risk = 1.26) during the transition season heat spikes. Conclusion: The study establishes a localized thermal threshold for psychiatric emergencies in Indonesia. The findings suggest that high ambient humidity, characteristic of the Indonesian climate, significantly amplifies the psychiatric risk of heat. These results necessitate the integration of psychiatric protocols into the BPJS Kesehatan national health strategy for climate adaptation.
Co-Authors Ahmad Erza Aisyah Andina Rasyid Bjorka Alma Bryan Helsey Desiree Montesinos Eduardo Michael Perez Eva Naritawati Fifia Ardinanti Franklin Shane Irna Nettles Karina Chandra Khairiel Anwar Leonardo Simanjuntak Linda Purnama Lisha Sandrina Maria Rodriguez Maximillian Wilson Muhammad Yoshandi Mustafa Mahmud Nurul Hanifah Pham Uyen Rinna Azrida Sony Sanjaya Taufiq Indera Jayadi Vania Delma Zaki Ahmad