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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Respirasi (JR) Jurnal Kesehatan Tambusai MAHESA : Malahayati Health Student Journal Bandung Conference Series : Medical Science Jurnal Pandu Husada Jurnal Medis Umum Proceeding UMSurabaya
Laitupa , Afrita Amalia
Universitas Muhammadiyah Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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HUBUNGAN ANTARA KEJADIAN BENCANA KEBAKARAN HUTAN DENGAN JUMLAH PENYAKIT PERNAPASAN DI KALIMANTAN TENGAH PADA TAHUN 2019 Wikananda, Naza Naratama; Subkhan, Mohammad; Levani, Yelvi; Laitupa, Afrita Amalia
Syifa'Medika Vol 12, No 1 (2021): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v12i1.2773

Abstract

Kebakaran hutan telah menjadi bencana alam yang rutin di Kalimantan. Hal ini meningkatkan dampak polusi yang berkepanjangan. Salah satu dampak polusi yang paling utama adalah pengaruhnya terhadap kesehatan pernapasan. Tujuan dari studi ini adalaha untuk mencari hubungan antara kebakaran hutan dengan penyakit pernapasan. Mencari hubungan antara kebakaran hutan dengan penyakit pernapasan PPOK, Asma dan ISPA. Metode studi ini menggunakan cohort retrospective dengan total sampel. Data polusi yang diambil pada bulan september hingga november terdapat di dua tempat yaitu Kota Palangkaraya dan Kabupaten kotawaringin Timur. Penelitian dilakukan di RSUD Dr. Doris Sylvanus Palangkaraya dan RSUD Dr. Murjani Sampit. Uji statistik menggunakan korelasi Spearmen dan tes Kruskal-Wallis. Hasil dari 277 responden didapatkan tidak ada korelasi antara peningkatan polusi dengan ketiga penyakit. Untuk antar penyakit dengan tingkat polusi signifikansinya adalah p=0,058 (PPOK), p=0,759 (Asma) dan p=0,594 (ISPA). Sebagai kesimpulan, tidak ada hubungan antara tiga penyakit pernapasan dengan peningkatan tingkat polusi yang diakibatkan oleh kebakaran hutan. Tetapi pada polusi tingkat berbahaya terdapat lonjakan yang berarti jika dilihat secara diagram. Diperlukan penelitian lebih lanjut dalam waktu yang lebih  lama untuk mendapatkan hasil yang lebih akurat.
The Level of Effectiveness Use of Quinoline Drugs in COVID-19: A Literature Review M.Dedi Dermawan Dermawan; Afrita Amalia Laitupa; Muslim Andala Putra; Nenny Triastuti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 2 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i2.4998

Abstract

ABSTRACT          Chloroquine is the first line of medicine in the treatment of malaria. Besides being antimalaria, the chloroquine also can be used as the anti-inflammation in the medicine of arthritis rheumatoid arthritis and lupus erythematosus discoid. Hydroxychloroquine sulfate is 4-aminoquinolin with hydroxylated chloroquine analog, having the same pharmacokinetic as chloroquine which is given orally in hydroxychloroquine sulfate form, processed by gastrointestinal absorption and very faster kidney elimination. The effectiveness of chloroquine and hydroxychloroquine towards COVID-19 in the in vitro experiment showed it could inhibit the duplication of the SARS-CoV-2 virus. The chloroquine function is to stop COVID-19 infection with (EC50) 1,13 μM and (CC50) larger than 100 μM. Meanwhile, the hydroxychloroquine function is to inhibit the attachment and entry of the virus into the host’s cell by enzymatic activation which is the lysosome acidification disorder and antigen presentation as the result of pH increase. Based on the clinical study, the 10 of 12 patients who have lopinavir/ritonavir therapy by virology, the chloroquine group showed RT-PCR negative on day 7, 10, and 14 in compare to lopinavir/ritonavir that showed RT-PCR negative on day 14. On the 9th day, 60% of the patients of chloroquine group showed the CT scan of Lungs image normal instead of the lopinavir/ritonavir at 25%. In the day 14 based on the CT test result, the pulmonary improvement increased twice rather than chloroquine group (Rate Ratio 2.21). It proved that the chloroquine role showed the result of the medicine has a significant effect by cleaning the virus or other clinical matters. The purpose of this literature review is to know the effectiveness quinoline class of drugs which is chloroquine and hydroxychloroquine in COVID-19 disease.Keywords: effectiveness, chloroquine, COVID-19Correspondence: dedydermawan555@gmail.com
The difference in severity and management between children and adult's cases of COVID-19 Mohammad Husin; Gina Noor Djalilah; R A Kaniraras; Afrita Amalia Laitupa
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 1 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i1.6229

Abstract

AbstractCOVID-19 (Coronavirus Disease 2019) has been started in Wuhan, China, and spread worldwide and resulting in many cases of death. COVID-19 attacks the respiratory tract acutely and infected both children and adults. The number of cases in children is less than in adults. By seeing from the clinical aspect, the COVID-19 case in children is milder. There are differences in immunology responses in children and adults where children have higher immunology response of COVID-19 than adults. Meanwhile, if the immunology response is slow in adults, it may cause them infected by COVID-19 with severe symptoms. There are some relations between immunization with immunology response to SARS-CoV-2 where children who already have BCG vaccination has lower infection rates of acute respiratory tract case. This study aims to know the difference between COVID-19 cases that infected adults and children seen in various aspects.Keywords                     : COVID-19,SARS-CoV-2, children, adult, severity, managementCorrespondence         : mohammad_husin@yahoo.com
Risk Factors for Diabetes Mellitus Patients Against Covid-19 Jasmin Ananda Wulan; Afrita Amalia Laitupa; Kartika Prahasanti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.4999

Abstract

ABSTRACTCovid-19 patients with Diabetes mellitus (DM) ranked third after hypertension and cardiovascular disease with an estimated 36% of all Covid-19 cases. These patients have a risk of experiencing a higher complication possibility since their metabolic disorder can cause hyperglycemia to the patient. It is showed that the number of deaths reached 7,3%, which is higher than non-diabetes. The increase of DM patients caused by stress factors may trigger the onset of glucose in blood sugar, and the glucose variability became abnormal. This circumstance may cause a glycemic increase that causes the predisposition intensification of susceptible affected by Covid-19. Good management is truly needed for DM patients affected by Covid-19. It is hoped to reduce the risk factor, such as preventing complications and increasing life quality by regular medical check to have a good prognosis. Some research showed that Covid-19 patients with DM are essential in ICU and need more treatment attention as they may experience Acute Respiratory Distress Syndrome (ARDS). Diabetes mellitus patients' treatment strategy is to manage the blood glucose level, especially in post-prandial glucose. This literature aims to know the degree of serious illness of Covid-19 patients by the comorbidity of DM in this pandemic event. Keywords: Covid-19, Sars-Cov-2, Diabetes Mellitus, risk factors,Correspondence: jasminananda@gmail.com
Ventilasi dan Perfusi, serta Hubungan antara Ventilasi dan Perfusi: [Ventilation, Perfusion, and Its Correlation in Pulmonary Diagnostic] Afrita Amalia Laitupa; Muhammad Amin
Jurnal Respirasi Vol. 2 No. 1 (2016): Januari 2016
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.338 KB) | DOI: 10.20473/jr.v2-I.1.2016.29-34

Abstract

Lung is a place for gas exchange where ventilation and perfusion occurs. Ventilation is the first step where sequential process of inhalation and exhalation take place. Meanwhile perfusion as the other step facilitates the gas exchange and tissue supply need. Blood flows through the lungs are equals as the amount of cardiac output where the factors that control cardiac output are mainly peripheral factors, also control pulmonary blood flow. In general condition, pulmonary blood vessels act as a passive tube, which can be increased with the increasing pressure and narrowed the pressure drop. Oxygen absorption level from lungs into bloodstream is a critical determinant for functional capacity, and an important factor wheter in normal conditions (including exercise) or even in illness state. Lung diffusion capacity is influenced by several geometric and functional factors. Gravitation influence systematic gradient in ventilation and perfusion distribution. Ventilation and blood flow variations at horizontal level also occur due to intrinsic anatomic variations and vascular geometry, as well as the differences in airway and vascular smooth muscle response which modifies the distribution. The change of integrity intrapleural chamber, hydrostatic pressure and osmotic imbalance, malfunction of surfactants, other intrinsic weakness of the branching system in the form of a progressive airway, and all the things that could potentially damage the structure of the lung can cause ventilation and diffusion dysfunction.
Hubungan Antara Kebiasaan Merokok terhadap Tingkat Keparahan Penyakit Paru Obstruktif Kronis Nanda Sinya Dwi Putri; Afrita Amalia Laitupa; Syafarinah Nur Hidayah; Anik Purnawati
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.7023

Abstract

Abstract. Chronic obstructive pulmonary disease is a disease caused by exposure to exposure and causes airway limitations to enter and leave the lungs. In 2019, WHO reported 3.23 million COPD deaths and is the third leading cause of death in the world. Chronic obstructive pulmonary disease in Indonesia is quite high which is caused by smoking activities, this is a problem in the surrounding environment. assume is one of the main risk factors for COPD and smoking activation is a habit in Indonesia. Writing this literature review uses databases from Pubmed, Google Scholar, Science Direct in the form of full text articles and journals in English and Indonesian with the year of publication 2012-2022. Writing this literature review aims to determine whether there is a relationship between smoking habits and the severity of COPD. Based on scientific articles that have been reviewed, there are signs of a relationship between smoking and the severity of COPD disease. is thought to affect reduced oxygen levels in the body caused by harmful substances contained in cigarettes. The relationship between smoking and COPD is a dose response that is related to the duration of smoking and the number of cigarettes consumed each day, which in turn will affect the severity of COPD. Abstrak. Penyakit paru obstruktif kronis merupakan penyakit yang disebabkan oleh paparan pajanan dan menyebabkan keterbatasan saluran napas untuk masuk dan keluar dari paru. Pada tahun 2019, WHO melaporkan 3,23 juta kasus kematian PPOK dan merupakan penyebab kematian nomer tiga di dunia. Penyakit paru obstruktif kronis di Indonesia cukup tinggi yang disebabakan oleh aktivitas merokok hal ini menjadi permasalahan di lingkungan sekitar. Merokok merupakan salah satu faktor risiko utama terjadinya PPOK dan aktivatas merokok menjadi kebiasaan di Indonesia. Penulisan literature review ini menggunakan database dari Pubmed, Google Scholar, Science Direct berupa artikel dan jurnal full text bahasa Inggris dan bahasa Indonesia dengan tahun penerbitan 2012-2022. Penulisan literature review ini bertujuan untuk mengetahui apakah terdapat hubungan kebiasaan merokok terhadap tingkat keparahan penyakit PPOK. Berdasarkan artikel-artikel ilmiah yang sudah di telaah menunjukan terdapat hubungan merokok dengan tingkat keparahan penyakit PPOK. Merokok dapat mempengaruhi berkurangnya kadar oksigen di dalam tubuh yang disebabkan oleh zat-zat berbahaya yang terkandung di dalam rokok. Hubungan merokok dengan penyakit PPOK adalah dose response yang berhubungan dengan durasi lama merokok dengan jumlah batang rokok yang dikomsumsi setiap hari sehingga nantinya akan mempengaruhi derajat keparahan penyakit PPOK.
PERBEDAAN EFEK NIKOTIN PADA ROKOK DAN VAPE TERHADAP PENINGKATAN TEKANAN DARAH : LITERATURE REVIEW Fahreza Albar Mulyadi; Afrita Amalia Laitupa; Muslim Andala Putra; Irma Kartikasari
Jurnal Kesehatan Tambusai Vol. 4 No. 2 (2023): JUNI 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v4i2.14713

Abstract

Merokok dengan kandungan nikotin merupakan penyebab kematian dini di seluruh dunia. Nikotin berperan sebagai obat sympathomimetic dan meningkatan aktivitas simpatik yang berkorelasi peningkatan tekanan darah dan risiko penyakit jantung. Tujuan review studi ini adalah untuk mengidentifikasi dan membuat kesimpulan berdasarkan temuan riset yang membahas tentang perbedaan efek nikotin pada rokok dan vape terhadap peningkatan tekanan darah. Metode menggunakan literature review dari hasil penelitian tahun 2012-2022 yang sudah terpublikasi di media elektronik seperti PubMed. 20 artikel yang memenuhi kriteria inklusi dan eksklusi. Rokok dan vape dapat meningkatkan tekanan darah sistolik dan diastolik. Terdapat perbedaan peningkatan tekanan darah yang signifikan atau tidak signifikan pada rokok dan vape antar studi, masih belum diketahui secara pasti bagaimana hal tersebut bisa terjadi walaupun keduanya mengandung nikotin. Simpulannya yaitu peningkatan tekanan darah akibat rokok ditemukan lebih tinggi dibanding vape pada 12 dari 20 literatur, dengan 8 literatur yang hanya membahas peningkatan tekanan darah khusus vape. Hasil analisis penulis berpendapat ada beberapa penyebab yang memungkinkan terjadinya peningkatan tekanan darah yang lebih tinggi pada rokok dibanding vape, antara lain, konstituen non-nikotin lain pada rokok, farmakokinetik rokok yang berbeda dengan vape sehingga retensi nikotin lebih rendah pada vape, metode intervensi hisapan yang berbeda, populasi, dan jenis vape atau rokok yang digunakan.  
Gambaran Faktor Risiko Lanjut Usia Terhadap Kematian Pasien COVID-19 Yoga Eko Saputra; Kartika Prahasanti; Afrita Amalia Laitupa; Detti Nur Irawati
JURNAL PANDU HUSADA Vol 2, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v2i2.6402

Abstract

Dunia saat ini dikejutkan dengan wabah virus baru COVID-19 yang bermulai dari Wuhan, Provinsi Hubei yang menyebar dengan cepat hingga berbagai negara. Menanggapi masalah ini WHO menetapkan COVID-19 sebagai pandemi global. Virus ini dapat ditularkan dari manusia ke manusia dan telah menyebar secara luas di China dan lebih dari 190 negara dan teritori lainnya. Sampai tanggal 29 Maret 2020, terdapat 634.835 kasus dan 33.106 jumlah kematian di seluruh dunia. Sementara di Indonesia dilaporkan ditemukan sejumlah 2 kasus pada tanggal 2 Maret 2020 dan merupakan tingkat kematian tertinggi di Asia Tenggara. Kematian akibat COVID-19 dapat terjadi pada bayi hingga lanjut usia. Lanjut usia tetap menjadi faktor risiko kematian utama dibandingkan dengan usia yang lain dikarenakan beberapa faktor seperti gangguan kognitif, gangguan perilaku, dan sebagainya. Lanjut usia juga sering dikaitkan dengan penyakit komorbid seperti hipertensi dan diabetes. Tujuan penulisan ini untuk mengetahui gambaran faktor risiko lanjut usia terhadap kematian pasien dengan COVID-19 .
Pemberian Terapi Vitamin C pada COVID-19 Mohammad hasan; Yelvi Levani; Afrita Amalia Laitupa; Nenny Triastuti
JURNAL PANDU HUSADA Vol 2, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v2i2.5754

Abstract

Abstrak: Vitamin C merupakan salah satu nutrisi yang tidak bisa disintesis oleh manusia. Fungsi Vitamin C dalam tubuh sangat banyak, salah satunya sebagai antioksidan dan efek pada sistem imun. Vitamin C terbukti dapat melawan virus karena sebagai imunomodulasi, sehingga dapat meningkatkan produksi interferon dan mengatur sintesis sitokin proinflamasi. Vitamin C berhasil mencegah dan mengurangi pasien ICU pada ISPA. Vitamin C juga mepercepat kesembuhan pada penyakit flu. Pemberian terapi vitamin C diharapkan membantu dalam menurunkan morbiditas dan mortalitas pada COVID-19. Vitamin C pada tubuh pasien COVID-19 juga menurun, sehingga sangat dibutuhkan terapi vitamin C. Vitamin C dapat sebagai imunosupresan yang akan menghambat cytokin storm pada pasien COVID-19. Vitamin C dalam pasien yang terinfeksi virus dapat menghambat ROS. Pemberian vitamin C dengan dosis tinggi dapat membantu penyembuhan dalam dengan sepsis. Dokter di China melaporkan 50 pasien COVID-19 dengan pemberian vitamin C berhasil sembuh. Hal ini dapat membuktikan vitamin C dapat dijadikan terapi pada pasien COVID-19. Tujuan pembuatan literature review ini untuk mengatahui efektivitas vitamin C pada pasien COVID-19.Kata kunci: Vitamin C, Terapi, COVID-19Abstract: Vitamin C is one of the nutrition that cannot be synthesized by human. There are so many function of Vitamin C for our body, one of them is become an antioxidant and affects immune system. Vitamin C has been proofed can against virus as immunomodulation, so that can increase the production of interferon and arrange the synthesis of proinflammatory cytokines. Vitamin C is succeeded in preventing and reducing ISPA patient from ICU. It also fasten the flu disease recovery. The Vitamin C therapy administration is expected can help decreasing morbidity and mortality of COVID-19 patient. The amount of Vitamin C in patient's body is also decreasing. For the reason, the Vitamin C therapy is needed. Vitamin C can also be immunosuppressants than will inhibit cytokin storm of COVID-19's patient. The Vitamin C present's in COVID-19's patient body is to inhibit ROS. The high dose of Vitamin C administration can help the inside recovery by sepsis. Some
Differences in Chest X-Ray Imaging in Pulmonary Tuberculosis across Various Comorbidities Subkhan, Mohammad; Rezacharawa, Meltritania Arief; Putra, Muslim Andala; Laitupa, Afrita Amalia; Permana, Putu Bagus Dharma; Irfana, Laily
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.169-180

Abstract

Background:  Tuberculosis (TB) remains a significant public health concern in Indonesia, with a high prevalence of cases, particularly in patients with comorbidities such as HIV infection, chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), and chronic kidney disease (CKD). Evidence suggested radiological variations in chest X-ray findings among these complex condition, which may pose significant challenges in accurately diagnosing pulmonary TB in clinical practice.Objective:  This study aimed to provide a comprehensive understanding of the variations in chest X-ray imaging in pulmonary TB patients with specific comorbidities, focusing on DM, CKD, and COPD.Methods: A cross-sectional study was conducted at Siti Khodijah Muhammadiyah Sepanjang Hospital by utilizing standardized medical records and chest X-ray results of 50 pulmonary patients with comorbidities.Results: The most prevalent comorbidity was DM, with radiological findings including fibroinfiltrates, consolidations, and cavities. CKD patients exhibited radiological features such as infiltrates, cavitations, and pleural effusion, while COPD patients presented with infiltrates and consolidations. Conclusion: The study provides valuable insights into the radiological manifestations of pulmonary TB and its comorbidities, offering a basis for improved management and treatment strategies for patients with pulmonary TB and comorbidities. Further research employing longitudinal designs and balanced representation of comorbid conditions is recommended to enhance the understanding of the interplay between TB and associated health conditions.
Co-Authors Absor, Sholihul Anik Purnawati Detti Nur Irawati Djalillah, Gina Noor Fahreza Albar Mulyadi Gina Noor Djajilah Gina Noor Djalilah Irma Kartikasari Jasmin Ananda Wulan Kartika Prahasanti Kusumaningrum, Aliffia Ayu Laily Irfana, Laily M.Dedi Dermawan Dermawan Mochtar , Nur Mujadiddah Mohammad hasan Mohammad Husin Mohammad Subkhan Muhammad Amin Muhammad Daffa Akbar Alamsyah Nanda Sinya Dwi Putri Nenny Triastuti Nova Primadina Permana, Putu Bagus Dharma Putra, Muslim Andala R A Kaniraras Rezacharawa, Meltritania Arief Septian, Mir'atul Faroha Syafarinah Nur Hidayah Ummu Khonsa Wikananda, Naza Naratama Yelvi Levani Yoga Eko Saputra