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All Journal KOVALEN: Jurnal Riset Kimia IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) IJEMS (Indonesian Journal of Environmental Management and Sustainability) JPBIO (Jurnal Pendidikan Biologi) Journal of Natural Sciences Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Indonesian Journal of Chemical Science
Musifa, Eva
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Energy Environmental Science Languange, Linguistic, Communication & Media Nursing Physics Public Health Social Sciences

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Lansium domesticum metabolites interfere with digestive enzyme function in the rice weevil sitophilus oryzae Oktariansyah, Yadi; Putri, Ferta Liza; Harvianti, Yuniar; Musifa, Eva
JPBIO (Jurnal Pendidikan Biologi) Vol 11, No 1 (2026): April 2026
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v11i1.6212

Abstract

Pectin methylesterase (PME) plays a key role in polysaccharide digestion in the rice weevil Sitophilus oryzae, making it a potential molecular target for pest control. This study employed structure-based in silico analysis to evaluate selected metabolites of Lansium domesticum as PME inhibitors. Representative compounds were chosen according to predicted interference mechanisms and docked into the validated catalytic site. All complexes showed structural stability, while interaction patterns revealed six inhibition modes: competitive mimicry, catalytic disruption, orientation interference, channel blocking, polymer mimicry, and interfacial modulation, whereas polyphenols and glycosides produced the strongest interference. The findings indicate that L. domesticum metabolites can disrupt digestive enzymatic processes through multiple complementary pathways, supporting their potential development as biologically derived pest management agents.
Co-Authors Abdi Dharma Addy Rachmat Ady Mara, Ady Afreni Hamidah Ananda, Dea Bijak Riyandi Ahadito Desnelli Desnelli Elida Mardiah Fahma Riyanti Fatma Harvianti, Yuniar Huzaifah, Huzaifah Indah Indah Julinar Julinar MUHAMMAD SAID Muharni Muharni Naimah , Miftahun Nova Yuliasari Nugraheni, Titah Maharti Pratama, Nisa Manora Putra, M. Bagus Kurnia Putri, Ferta Liza Robiatul Adawiyah Safitri, Siska Suheyanto Suheryanto Talib, Ramanisa Muliani Tania, Alinda Uswati, Dinii Warni, Mega Yadi Oktariansyah