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PUTRIANA SARI SIRAIT
Universitas Riau
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Public Health Social Sciences Other

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Journal : Jurnal Pengolahan Hasil Perikanan Indonesia

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Anticancer Activity of Spirulina Cultivated in Walne and Organic Media Putriana Sari Sirait; Iriani Setyaningsih; Kustiariyah Tarman
Jurnal Pengolahan Hasil Perikanan Indonesia Vol 22 No 1 (2019): Jurnal Pengolahan Hasil Perikanan
Publisher : Masyarakat Pengolahan Hasil Perikanan Indonesia (MPHPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (365.088 KB) | DOI: 10.17844/jphpi.v22i1.25876

Abstract

Spirulina is Cyanobacteria containing active components which is potentially showing anticancer activity. The purposes of this study were to determine anticancer activity and selectivity of crude extractsof Spirulina cultured using Walne and organic media, and to detect the apoptosis. The stages of this study included cultivation and harvesting of Spirulina, active components extraction, anticancer test and apoptosisdetection. Anticancer activity was determined using MTT assay. The crude extracts of Spirulina from Walne and organic cultures contained active components of alkaloids, flavonoids, steroids, and saponins. Theseextracts were not toxic to normal breast cells (MCF-12a), but showed cytotoxic activity in breast cancer cells (MCF-7). The crude extract of Spirulina from Walne culture had IC50 value of 36.23 ppm and selectivity index 30.07, while the IC50 of organic culture was 117.78 ppm and selectivity index 7.17. Detection of apoptosis with Hoechst dye 33342 showed the apoptotic activity of Spirulina crude extract against MCF-7 cells.
Co-Authors Agustin, Uci Andarini Diharmi Andri Hendrizal Aninta, Zia Nasywa Arta , Aryon Asmika H Simarmata Azmi, Heriza Br. Siagian, Eirene Junita Budijono, Budijono Chicka Willy Yanti Hutabarat, Putri Natalia Irfandi, Rahmat Iriani Setyaningsih Isma Mulyani Kustiariyah Tarman Mery Sukmiwati Muhammad Zakiyul Fikri Nofri Sandria Nugroho , Rio Prayoga, Putri Regina Rahmayani, Anggita Amaliyah Rina D'rita Sibagariang Santhy Wisuda Sidauruk Sari, Syafira Permata Septiana Sulistiawati Singo , Lloyd Shodiq Sinta, Laras Siregar, Rizky Febriansyah Suhendra, Rahmad Sumarto Suparmi Syafdina, Intan Wiradharma, Putra Agung Zebua, Putra Sutrisman