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All Journal Nusantara Medical Science Journal Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Innovative: Journal Of Social Science Research
Achmad, Djumadi
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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EKSPRESI HYPOXIA INDUCIBLE FACTOR 1 ALPHA (HIF 1a) PADA PROSTATIC INTRAEPITHELIAL NEOPLASIA (PIN) DAN BENIGN PROSTATIC HIPERPLASIA (BPH) Sudin, Asmirani; Cangara, Muhammad Husni; Djimahit, Tarsisia Truly; Miskad, Upik Anderiani; Achmad, Djumadi; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 2 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i2.1125

Abstract

Prostatic Intraepithelial Neoplasia (PIN) adalah lesi premaligna yang merupakan prekusor kanker prostat. Benign Prostatic Hyperplasia (BPH) adalah salah satu penyakit kronik yang paling umum yang terjadi pada laki-laki. Tujuan penelitian ini adalah untuk mengetahui pola ekspresi Hypoxia Inducible Factor 1 Alpha (HIF 1a) pada PIN dan BPH. Penelitian ini merupakan suatu penelitian observasi analitik dengan desain cross sectional yang dilakukan di Laboratorium Patologi Anatomik Rumah Sakit Universitas Hasanuddin dan Rumah Sakit Umum Pusat Dr. Wahidin Sudirohusodo Makassar mulai bulan April 2023 sampai Agustus 2023. Kami mengumpulkan dan mengelompokkan seluruh sampel yang memenuhi syarat berdasarkan pemeriksaan histopatologi PIN dan BPH dan kemudian dilakukan pemeriksaan imunohistokimia untuk menilai protein HIF 1a. Hasil penelitian ini adalah protein HIF 1a terekspresi kuat pada PIN dan terekspresi negatif sampai lemah pada BPH
HUBUNGAN TUMOR BUDDING DENGAN KEJADIAN METASTASIS KELENJAR GETAH BENING PADA PENDERITA ADENOKARSINOMA KOLOREKTAL: HUBUNGAN TUMOR BUDDING DENGAN KEJADIAN METASTASIS KELENJAR GETAH BENING ADENOKARSINOMA KOLOREKTAL Hutasoit, Gina Andyka; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Wahid, Syarifuddin; Achmad, Djumadi; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 3 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i3.1324

Abstract

ABSTRAK Adenokarsinoma kolorektal adalah karsinoma yang ditemukan pada kolon dan/atau rektum. Salah satu gambaran histopatologi yang penting pada adenokarsinoma kolorektal adalah tumor budding. Tumor budding adalah adanya sel tumor tunggal atau kelompok kecil hingga empat sel dalam stroma tumor. Keberadaan entitas tumor budding terkait dengan invasi limfovaskular dan metastasis pada kelenjar getah bening. Tujuan penelitian untuk mengetahui hubungan tumor budding dengan kejadian metastasis kelenjar getah bening pada penderita adenokarsinoma kolorektal di Makassar tahun 2021-2023. Metode penelitian adalah observasi analitik dengan desain cross sectional. Enam puluh empat sampel diperiksa menggunakan mikroskop cahaya Olympus CX-43 dan dianalisis statistik dengan uji Chi-square menggunakan SPSS 27. Dari 64 sampel, terdapat sampel low grade tumor budding tanpa metastasis kelenjar getah bening sebanyak 10 sampel (90,9%) dan dengan metastasis kelenjar getah bening sebanyak 1 sampel (9,1%). Sampel intermediate grade tumor budding tanpa metastasis kelenjar getah bening sebanyak 18 sampel (75,0%) dan dengan metastasis kelenjar getah bening sebanyak 6 sampel (25,0%). Sedangkan sampel high grade tumor budding tanpa metastasis kelenjar getah bening sebanyak 13 sampel (44,8%) dan positif metastasis kelenjar getah bening sebanyak 16 sampel (55,2%). Terdapat hubungan yang bermakna antara tumor budding dengan kejadian metastasis kelenjar getah bening pada adenokarsinoma kolorektal (p=0,009).
Analisis Forensik Terhadap Kekerasan Benda Tajam Pada Korban Hidup Hadytiaz, Muhammad Farhan; Achmad, Djumadi; Mathius, Denny
Innovative: Journal Of Social Science Research Vol. 4 No. 6 (2024): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v4i6.15771

Abstract

Sharp object violence on living victims is a problem that requires comprehensive medical and legal treatment. Forensic analysis of sharp object wounds plays an important role in determining the type of weapon used, the direction of the attack, and the dynamics of the incident involving the victim. This study aims to provide an in-depth understanding of the role of forensic science in analyzing sharp object wounds, with a focus on the physical and psychological aspects of the victim. The research method used is a literature review, in which various studies and case reports on sharp object violence on living victims are reviewed in depth. This approach provides a comprehensive picture of the characteristics of the wound, forensic examination methods, and the impact of physical and emotional trauma experienced by the victim. The results of this study indicate that forensic analysis of sharp object violence on living victims is very important for health aspects. Through wound examination, forensic experts can identify the type of weapon and estimate the strength and direction of the attack, which are crucial for determining the right medical treatment. Wound management must be carried out quickly to prevent complications, while attention to the psychological impact is also needed to support the holistic recovery process.
PERBANDINGAN KARAKTERISTIK KLINIKOPATOLOGIS ANTARA ADENOKARSINOMA KOLOREKTAL MUCINOUS DAN NON-MUCINOUS DI MAKASSAR TAHUN 2021-2023 Rasyid, Nur Rahmah; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Wahid, Syarifuddin; Achmad, Djumadi; Tawali, Suryani; Mardiati, Mardiati
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 3 (2024): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i3.248

Abstract

ABSTRAK Adenokarsinoma kolorektal terdiri dari dua subtipe utama, yaitu mucinous dan non-mucinous, dengan karakteristik klinikopatologis yang berbeda. Memahami perbedaan ini penting untuk menentukan prognosis dan pendekatan terapi yang tepat. Penelitian ini bertujuan mengevaluasi perbedaan klinikopatologis, termasuk grading Tumor Infiltrating Lymphocytes (TILs), antara adenokarsinoma mucinous dan non-mucinous. Studi cross-sectional ini melibatkan 24 pasien adenokarsinoma kolorektal di Rumah Sakit Dr. Wahidin Sudirohusodo, Makassar (2021-2023). Sebanyak 12 pasien dengan adenokarsinoma mucinous dan 12 pasien dengan adenokarsinoma non-mucinous dianalisis. Uji Chi-square digunakan untuk menilai perbedaan grading TILs dan variabel klinikopatologis lainnya, dengan p < 0,05 dianggap signifikan. Grading TILs secara signifikan lebih tinggi pada adenokarsinoma non-mucinous dibandingkan mucinous (p = 0,002). Tidak terdapat perbedaan signifikan pada usia (p = 0,640), jenis kelamin (p = 0,667), invasi limfovaskular (p = 1,000), metastasis nodus limfatik (p = 0,372), tumor budding (p = 0,372), pT (p = 0,457), dan lokasi tumor (p = 0,148). Grading TILs yang lebih tinggi pada adenokarsinoma non-mucinous menunjukkan respons imun yang lebih kuat. Hasil ini dapat membantu personalisasi strategi terapi pada adenokarsinoma kolorektal. Kata Kunci: Adenokarsinoma kolorektal, mucinous, non-mucinous, Tumor Infiltrating Lymphocytes (TILs), klinikopatologi. ABSTRACT Colorectal adenocarcinoma consists of two main subtypes: mucinous and non-mucinous, with distinct clinicopathological characteristics. Understanding these differences is important for determining prognosis and appropriate therapeutic approaches. This study aims to evaluate the clinicopathological differences, including Tumor Infiltrating Lymphocytes (TILs) grading, between mucinous and non-mucinous colorectal adenocarcinoma. This cross-sectional study involved 24 colorectal adenocarcinoma patients at Dr. Wahidin Sudirohusodo Hospital, Makassar (2021-2023). Twelve patients with mucinous adenocarcinoma and 12 with non-mucinous adenocarcinoma were analyzed. Chi-square tests were used to assess differences in TILs grading and other clinicopathological variables, with p < 0.05 considered significant. TILs grading was significantly higher in non-mucinous adenocarcinoma compared to mucinous (p = 0.002). No significant differences were found in age (p = 0.640), gender (p = 0.667), lymphovascular invasion (p = 1.000), lymph node metastasis (p = 0.372), tumor budding (p = 0.372), pT classification (p = 0.457), and tumor location (p = 0.148). Higher TILs grading in non-mucinous adenocarcinoma indicates a stronger immune response. These findings may assist in personalizing therapeutic strategies for colorectal adenocarcinoma patients. Keywords: Colorectal adenocarcinoma, mucinous, non-mucinous, Tumor Infiltrating Lymphocytes (TILs), clinicopathological analysis.
Significance of HBsAg Expression in Placental Tissue with Serum Positivity in Hepatitis B Virus-infected Mother Kalatiku, Jane Magdalena; J Nelwan, Berti; Zainuddin, Andi Alfian; Kaelan, Cahyono; Achmad, Djumadi; Masadah, Rina
Nusantara Medical Science Journal Volume 8 Issue 2, July - December 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.20242

Abstract

Introduction:  Hepatitis B virus infection in fetal and newborn may result from the intrauterine vertical transmission. The purpose of our study is to determine the association between HBsAg expression in the placental and HBsAg serum in pregnant women. Methods: Total 67 placental tissues and serum were obtained from HBV-infected mothers. This study was conducted in various hospitals in Makassar, Indonesia from December 2017 until August 2018. Maternal serum and placental tissues were tested by ELISA and Immunohistochemistry staining. Results: 67 samples from placental tissues and serum were categorized into two different levels of serum titer and staining positivity. Twenty nine samples (43.3%) were categorized in low titer of HBsAg positive serum and 38 samples (56.7%) in high titer of  HBsAg positive serum. From the total of 67 placental samples, 43 (64.2%) samples had positive expression of HBsAg immunohistochemistry staining and 24 (34.8%) samples had negative expressions. Conclusions: There was a significant correlation between the expressions of HBsAg in the placental tissues and serum titers of HBV-infected mothers that is important in predicting the risk of transplacental transmission. The results of this study can be used as guidelines for the prevention and therapeutic approach of mother-to-child HBV infection.
The Role of Tumor Budding as a Prognostic Factor in Colorectal Adenocarcinoma Rianti, Andi Marcha; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Wahid, Syarifuddin; Achmad, Djumadi; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i1.1586

Abstract

Background: Colorectal cancer is one of the most prevalent malignancies worldwide. Tumor budding has emerged as a potential prognostic indicator in colorectal adenocarcinoma. Objective: This study aimed to analyze the relationship between tumor budding and histopathological grade, lymphovascular invasion, and lymph node metastasis in colorectal adenocarcinoma, and to assess the potential of tumor budding as a prognostic factor. Methods: A cross-sectional study was conducted using 93 colorectal adenocarcinoma samples. The association between tumor budding and histopathological grade, lymphovascular invasion, and lymph node metastasis was evaluated using the Chi-square and Mann-Whitney tests. Results: Among the 93 samples, a significant difference in tumor budding scores was found between cases with and without lymphovascular invasion (p = 0.003). However, no significant association was observed between tumor budding scores and histopathological grade (p = 0.685) or lymph node metastasis (p = 0.092). Additionally, a significant correlation was found between lymphovascular invasion and lymph node metastasis (p < 0.001). Conclusion: Tumor budding may serve as an important prognostic factor in colorectal adenocarcinoma, particularly in its association with lymphovascular invasion
GAMBARAN LUKA AKIBAT KEKERASAN TUMPUL DAN TAJAM PADA KORBAN PENGANIAYAAN DI RS BHAYANGKARA KOTA MAKASSAR TAHUN 2023 Azizah, Ghina; Achmad, Djumadi; Indarwati, Rezky Putri; Mathius, Denny; Sam, Dhedie Prasatia
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.31159

Abstract

Penganiayaan merupakan salah satu masalah kesehatan masyarakat yang utama di seluruh dunia. Gambaran perlukaan pada korban penganiayaan bervariasi menurut penyebab traumanya. Cedera akibat kekerasan tumpul dapat berupa luka memar, luka lecet, luka robek, patah tulang dan perdarahan atau robekan pada alat-alat didalamnya. Tercatat mulai dari tahun 2000 hingga 2020, diperkirakan terdapat peningkatan sebanyak 83% dan pada tahun 2002, terdapat 5 juta orang meninggal akibat trauma, diantaranya 90% terjadi di negara berkembang.Penelitian ini bertujuan untuk mengetahui gambaran luka akibat kekerasan tumpul dan tajam pada korban penganiayaan di RS Bhayangkara kota Makassar tahun 2023. Metode yang digunakan dalam penelitian ini adalah metode deskriptif, dengan jenis studi korelasional. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kuantitatif. Penelitian ini dilakukan pada Juni 2024. Berdasarkan hasil penelitian di Sentra Visum dan Medikolegal RS Bhayangkara Kota Makassar tahun 2023 diperoleh dari 120 sampel data distribusi kasus penganiayaan berdasarkan usia, kelompok paling banyak yaitu pada usia dewasa.
Co-Authors Andi Alfian Zainuddin Azizah, Ghina Cahyono Kaelan, Cahyono Cangara, Husni Djimahit, Tarsisia Truly Gina Andyka Hutasoit Hadytiaz, Muhammad Farhan Indarwati, Rezky Putri J Nelwan, Berti Kalatiku, Jane Magdalena Mardiati Mardiati Mathius, Denny Rasyid, Nur Rahmah Rianti, Andi Marcha Rina Masadah Sam, Dhedie Prasatia Sudin, Asmirani Syarifuddin Wahid Tawali, Suryani UPIK ANDERIANI MISKAD, UPIK ANDERIANI