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All Journal Nusantara Medical Science Journal Jurnal Biologi Tropis Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat JOURNAL LA MEDIHEALTICO Wal'afiat Hospital Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Innovative: Journal Of Social Science Research WAL'AFIAT HOSPITAL JOURNAL Jurnal Kesehatan
Syarifuddin Wahid
Department of Pathology and Anatomy, Hasanuddin University, Makassar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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HUBUNGAN TUMOR BUDDING DENGAN KEJADIAN METASTASIS KELENJAR GETAH BENING PADA PENDERITA ADENOKARSINOMA KOLOREKTAL: HUBUNGAN TUMOR BUDDING DENGAN KEJADIAN METASTASIS KELENJAR GETAH BENING ADENOKARSINOMA KOLOREKTAL Hutasoit, Gina Andyka; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Wahid, Syarifuddin; Achmad, Djumadi; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 3 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i3.1324

Abstract

ABSTRAK Adenokarsinoma kolorektal adalah karsinoma yang ditemukan pada kolon dan/atau rektum. Salah satu gambaran histopatologi yang penting pada adenokarsinoma kolorektal adalah tumor budding. Tumor budding adalah adanya sel tumor tunggal atau kelompok kecil hingga empat sel dalam stroma tumor. Keberadaan entitas tumor budding terkait dengan invasi limfovaskular dan metastasis pada kelenjar getah bening. Tujuan penelitian untuk mengetahui hubungan tumor budding dengan kejadian metastasis kelenjar getah bening pada penderita adenokarsinoma kolorektal di Makassar tahun 2021-2023. Metode penelitian adalah observasi analitik dengan desain cross sectional. Enam puluh empat sampel diperiksa menggunakan mikroskop cahaya Olympus CX-43 dan dianalisis statistik dengan uji Chi-square menggunakan SPSS 27. Dari 64 sampel, terdapat sampel low grade tumor budding tanpa metastasis kelenjar getah bening sebanyak 10 sampel (90,9%) dan dengan metastasis kelenjar getah bening sebanyak 1 sampel (9,1%). Sampel intermediate grade tumor budding tanpa metastasis kelenjar getah bening sebanyak 18 sampel (75,0%) dan dengan metastasis kelenjar getah bening sebanyak 6 sampel (25,0%). Sedangkan sampel high grade tumor budding tanpa metastasis kelenjar getah bening sebanyak 13 sampel (44,8%) dan positif metastasis kelenjar getah bening sebanyak 16 sampel (55,2%). Terdapat hubungan yang bermakna antara tumor budding dengan kejadian metastasis kelenjar getah bening pada adenokarsinoma kolorektal (p=0,009).
Effectiveness of Chronic Disease Management Program in Lowering Blood Pressure in Hypertensive Patients: Literature Review Akbar, Muhammad Alief; Wahid, Syarifuddin; Lestari, Indah; Adnan, Endy; Indarwati, Rezky Putri
Journal La Medihealtico Vol. 5 No. 4 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i4.1606

Abstract

Chronic illnesses are a global health issue that kills people. Hypertension is a blood vessel disorder that compromises the body's tissues' oxygen and nutrient supply. In 2025, 1.5 billion people will have hypertension, and 9.4 million will die from it. This research review evaluates the Chronic Disease Management Program's blood pressure-lowering effects in hypertensive patients. A PRISMA Flow Diagram-based literature review. Downloading scientific papers from PubMed, Portal Garuda, and Google Scholar follows SINTA IV and V criteria. This article searches for Prolanis, blood pressure, and hypertension. Search results yielded 103 articles. Using inclusion criteria, 11 research publications were chosen for review. The study found that the chronic disease management program, which included medical consultations, Prolanis participant education, SMS gateway reminders, home visits, club activities (exercise), and health status monitoring, effectively lowered blood pressure in hypertension patients.
FAKTOR RISIKO YANG MEMENGARUHI KEJADIAN HIV (Human Immunodeficiency Virus) PADA LAKI-LAKI DI RSUP DR. WAHIDIN SUDIROHUSODO MAKASSAR TAHUN 2020-2021 Mokhtar, Shulhana; Wahid, Syarifuddin; Kanang, Indah Lestari Daeng; Iskandar, Darariani; Yuniarizka, Sekila
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 7 No. 3 (2023): DESEMBER 2023
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v7i3.22245

Abstract

Penyakit Human Immunodeficiency Virus (HIV) menyebabkan penurunan sistem kekebalan tubuh dan dapat berakibat fatal. Pada tahun 2017, terdapat 35 juta penderita HIV dengan 940.000 jiwa meninggal dunia. Kasus HIV telah mencapai 50.282 pada tahun 2019. Faktor risiko meliputi perilaku seksual berisiko, penggunaan jarum suntik terkontaminasi, dan tingkat pendidikan rendah. Oleh karena banyaknya faktor risiko HIV, peneliti tertarik untuk meneliti faktor risiko yang memengaruhi kejadian HIV pada laki-laki di RSUP Dr. Wahidin Sudirohusodo Makassar Tahun 2020-2021. Tujuan penelitian adalah mengetahui faktor risiko kejadian pada laki-laki di RSUP Dr. Wahidin Sudirohusodo Makassar tahun 2020-2021. Metode penelitian yaitu deskriptif dilakukan pendekatan retrospektif. Penelitian ini dilakukan pada bulan September sampai dengan November Tahun 2023 di RSUP Dr. Wahidin Sudirohusodo Makassar. Sampel merupakan pasien laki-laki yang terdiagnosa HIV di RSUP Dr. Wahidin Sudirohusodo Makassar Tahun 2020-2021. Variabel dalam penelitian ini adalah faktor-faktor risiko HIV dan angka kejadian HIV pada laki-laki. Pengumpulan data diperoleh dari data sekunder yaitu rekam medik. Analisis data menggunakan uji univariat. Hasil penelitian diperoleh 39 pasien laki-laki yang menderita HIV dengan faktor risiko utama yaitu penggunaan jarum tidak steril (33,3%), homoseksual (51,3%), heteroseksual (berganti-ganti pasangan) (41%), tingkat pendidikan rendah (66,7%), serta kombinasi faktor risiko yang paling memengaruhi kejadian HIV yaitu kombinasi homoseksual dan tingkat pendidikan rendah (28,20%). Faktor risiko utama yang memengaruhi kejadian HIV pada laki-laki adalah homoseksual dan tingkat pendidikan yang rendah.  
PERBANDINGAN KARAKTERISTIK KLINIKOPATOLOGIS ANTARA ADENOKARSINOMA KOLOREKTAL MUCINOUS DAN NON-MUCINOUS DI MAKASSAR TAHUN 2021-2023 Rasyid, Nur Rahmah; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Wahid, Syarifuddin; Achmad, Djumadi; Tawali, Suryani; Mardiati, Mardiati
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 3 (2024): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i3.248

Abstract

ABSTRAK Adenokarsinoma kolorektal terdiri dari dua subtipe utama, yaitu mucinous dan non-mucinous, dengan karakteristik klinikopatologis yang berbeda. Memahami perbedaan ini penting untuk menentukan prognosis dan pendekatan terapi yang tepat. Penelitian ini bertujuan mengevaluasi perbedaan klinikopatologis, termasuk grading Tumor Infiltrating Lymphocytes (TILs), antara adenokarsinoma mucinous dan non-mucinous. Studi cross-sectional ini melibatkan 24 pasien adenokarsinoma kolorektal di Rumah Sakit Dr. Wahidin Sudirohusodo, Makassar (2021-2023). Sebanyak 12 pasien dengan adenokarsinoma mucinous dan 12 pasien dengan adenokarsinoma non-mucinous dianalisis. Uji Chi-square digunakan untuk menilai perbedaan grading TILs dan variabel klinikopatologis lainnya, dengan p < 0,05 dianggap signifikan. Grading TILs secara signifikan lebih tinggi pada adenokarsinoma non-mucinous dibandingkan mucinous (p = 0,002). Tidak terdapat perbedaan signifikan pada usia (p = 0,640), jenis kelamin (p = 0,667), invasi limfovaskular (p = 1,000), metastasis nodus limfatik (p = 0,372), tumor budding (p = 0,372), pT (p = 0,457), dan lokasi tumor (p = 0,148). Grading TILs yang lebih tinggi pada adenokarsinoma non-mucinous menunjukkan respons imun yang lebih kuat. Hasil ini dapat membantu personalisasi strategi terapi pada adenokarsinoma kolorektal. Kata Kunci: Adenokarsinoma kolorektal, mucinous, non-mucinous, Tumor Infiltrating Lymphocytes (TILs), klinikopatologi. ABSTRACT Colorectal adenocarcinoma consists of two main subtypes: mucinous and non-mucinous, with distinct clinicopathological characteristics. Understanding these differences is important for determining prognosis and appropriate therapeutic approaches. This study aims to evaluate the clinicopathological differences, including Tumor Infiltrating Lymphocytes (TILs) grading, between mucinous and non-mucinous colorectal adenocarcinoma. This cross-sectional study involved 24 colorectal adenocarcinoma patients at Dr. Wahidin Sudirohusodo Hospital, Makassar (2021-2023). Twelve patients with mucinous adenocarcinoma and 12 with non-mucinous adenocarcinoma were analyzed. Chi-square tests were used to assess differences in TILs grading and other clinicopathological variables, with p < 0.05 considered significant. TILs grading was significantly higher in non-mucinous adenocarcinoma compared to mucinous (p = 0.002). No significant differences were found in age (p = 0.640), gender (p = 0.667), lymphovascular invasion (p = 1.000), lymph node metastasis (p = 0.372), tumor budding (p = 0.372), pT classification (p = 0.457), and tumor location (p = 0.148). Higher TILs grading in non-mucinous adenocarcinoma indicates a stronger immune response. These findings may assist in personalizing therapeutic strategies for colorectal adenocarcinoma patients. Keywords: Colorectal adenocarcinoma, mucinous, non-mucinous, Tumor Infiltrating Lymphocytes (TILs), clinicopathological analysis.
Immunohistochemical Diagnostic value of Calretinin in Hirschprung Disease Azis, Zainab; Cangara, M. Husni; Zainuddin, Andi Alfian; Wahid, Syarifuddin; Mariana, Nita; Miskad, Upik A.
Nusantara Medical Science Journal Volume 8 Issue 2, July - December 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.20000

Abstract

Introduction: Hirschsprung's disease (HD) is characterized by the absence of ganglion cells in Meissner's plexus and Auerbach's plexus which used to be assessed by histopathological examination using Hematoxylin and Eosin (H&E).  In some cases is difficult to assess ganglion cells, thus requiring additional examination in the form of calretinin immunohistochemistry to detect the presence of ganglion. Methods: The 59 samples of suspected HD  were analyzed by H&E staining followed by calretinin immunohistochemical staining. This study aimed to assess the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of calretinin in HD diagnostics. Results:  The immunohistochemistry of calretinin showed a good diagnostic value in detecting aganglionosis in patients with suspected HD with a sensitivity value = 97.7%; Specificity = 100%; Positive Presumptive Value (PPV) = 100%; Negative Presumptive Value (NPV) = 93.7%; Accuracy= 98.3%. Thus, calretinin immunohistochemistry can be relied upon as an additional method in the diagnosis of HD
Faktor yang Berhubungan dengan Lokasi Osteoarthritis Genue pada Pasien Usia Lanjut di RS Ibnu Sina Tahun 2021-2024 Adnan, Syahrul; Wahid, Syarifuddin; Hasbi, Berry Erida; Putra, Fadil Mula; Nur, Muh Jabal
Wal'afiat Hospital Journal Vol 6 No 1 (2025): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/whj.v6i1.150

Abstract

Factors Associated with the Location of Osteoarthritis Genue in Elderly Patients at Ibnu Sina Hospital in 2021-2024. Osteoarthritis is a common form of arthritis in geriatric populations that can cause damage to the bones and their surroundings. There are several things that are risk factors for Osteoarthritis. This study aims to make observations related to factors that can affect the occurrence of Osteoarthritis in the elderly, the data used is the patient's medical records recorded in the hospital. This study uses the cross-sectional study method. Univariate or characteristic analysis uses frequency distribution analysis and bivariate analysis or analysis of relationships between variables using the chi-square test. The results of the study showed that there was an effect of disease history on the risk of osteoarthritis in the elderly. Hypertension is one of the risk factors that can increase the incidence of osteoarthritis, especially in men, this is related to the activity of endogenous receptors (AR) in the Renin-angiotensin-aldosterone system.
Faktor yang Berhubungan dengan Lokasi Osteoarthritis Genue pada Pasien Usia Lanjut di RS Ibnu Sina Tahun 2021-2024 Adnan, Syahrul; Wahid, Syarifuddin; Hasbi, Berry Erida; Putra, Fadil Mula; Nur, Muh Jabal
Wal'afiat Hospital Journal Vol 6 No 1 (2025): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/whj.v6i1.150

Abstract

Factors Associated with the Location of Osteoarthritis Genue in Elderly Patients at Ibnu Sina Hospital in 2021-2024. Osteoarthritis is a common form of arthritis in geriatric populations that can cause damage to the bones and their surroundings. There are several things that are risk factors for Osteoarthritis. This study aims to make observations related to factors that can affect the occurrence of Osteoarthritis in the elderly, the data used is the patient's medical records recorded in the hospital. This study uses the cross-sectional study method. Univariate or characteristic analysis uses frequency distribution analysis and bivariate analysis or analysis of relationships between variables using the chi-square test. The results of the study showed that there was an effect of disease history on the risk of osteoarthritis in the elderly. Hypertension is one of the risk factors that can increase the incidence of osteoarthritis, especially in men, this is related to the activity of endogenous receptors (AR) in the Renin-angiotensin-aldosterone system.
The Role of Tumor Budding as a Prognostic Factor in Colorectal Adenocarcinoma Rianti, Andi Marcha; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Wahid, Syarifuddin; Achmad, Djumadi; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i1.1586

Abstract

Background: Colorectal cancer is one of the most prevalent malignancies worldwide. Tumor budding has emerged as a potential prognostic indicator in colorectal adenocarcinoma. Objective: This study aimed to analyze the relationship between tumor budding and histopathological grade, lymphovascular invasion, and lymph node metastasis in colorectal adenocarcinoma, and to assess the potential of tumor budding as a prognostic factor. Methods: A cross-sectional study was conducted using 93 colorectal adenocarcinoma samples. The association between tumor budding and histopathological grade, lymphovascular invasion, and lymph node metastasis was evaluated using the Chi-square and Mann-Whitney tests. Results: Among the 93 samples, a significant difference in tumor budding scores was found between cases with and without lymphovascular invasion (p = 0.003). However, no significant association was observed between tumor budding scores and histopathological grade (p = 0.685) or lymph node metastasis (p = 0.092). Additionally, a significant correlation was found between lymphovascular invasion and lymph node metastasis (p < 0.001). Conclusion: Tumor budding may serve as an important prognostic factor in colorectal adenocarcinoma, particularly in its association with lymphovascular invasion
Relationship Between Eosinophil Levels and Histopathological Grading of Colorectal Carcinoma Mubdi, Abdul; Muthma'innah, Gadista Mayssi; Wahid, Syarifuddin
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2103

Abstract

Colorectal cancer (CRC) is a multifactorial disease and a leading cause of cancer-related mortality. CRC ranks as the second most common cancer globally and the third most frequently diagnosed malignancy worldwide. Several studies have suggested that elevated eosinophil levels in peripheral blood correlate with poor prognosis in colorectal cancer cases. This study aims to analyze the relationship between eosinophil levels and histopathological grading of colorectal carcinoma by evaluating peripheral blood eosinophil counts in correlation with CRC histopathology grading. This research employs a descriptive-correlational approach, utilizing univariate and bivariate analyses. The study findings indicate a significant correlation between eosinophil levels and histopathological grading of colorectal carcinoma at Wahidin Sudirohusodo General Hospital, Makassar.
The Effect of Mango Leaf Extract Administration on Fasting Blood Sugar Levels in Deksametason-Induced Mice Tola, Aqilah Faizah; Wahid, Syarifuddin; Kanang, Indah Lestari Daeng; Hidayati, Prema Hapsari; Dirgahayu L, Andi Millaty
Jurnal Kesehatan Vol 18, No 2 (2025): Jurnal Kesehatan
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jk.v18i2.7244

Abstract

Latar Belakang: Daun mangga memiliki efek anti-diabetes karena kandungan mangiferin yang tinggi. Mangiferin memberikan efek anti-diabetes dengan meningkatkan ekspresi GLUT4 dan translokasinya di dalam sel otot. Tujuannya adalah untuk mengetahui pengaruh ekstrak daun mangga (Mangifera foetida) terhadap kadar gula darah puasa pada mencit yang sebelumnya diinduksi deksametason untuk meningkatkan kadar gula darah puasa. Metode: Penelitian eksperimental dengan rancangan pre-test dan post-test group control design. Besar sampel ditentukan menggunakan pendekatan resource equation, dengan total 25 ekor mencit yang dibagi menjadi lima kelompok. Hiperglikemia diinduksi menggunakan deksametason dosis 1 mg/kgBB per hari selama 7 hari, kemudian dilanjutkan dengan pemberian ekstrak daun mangga per oral (dosis 150, 250, dan 350 mg/kgBB per hari) selama 10 hari. Kadar gula darah puasa diukur sebelum dan sesudah induksi, serta pada hari ke-3, ke-7, dan ke-10 setelah pemberian perlakuan. Analisis statistik dilakukan menggunakan metode multivariat. Data dianalisis dengan ANOVA, Post Hoc LSD, dan Paired Sample T-Test. Hasil: Terdapat penurunan signifikan kadar gula darah puasa pada mencit sebelum dan sesudah pemberian ekstrak daun mangga pada kelompok 2 (ekstrak daun mangga 150 mg/kgBB) dengan p = 0,002, kelompok 4 (deksametason 1 mg/kgBB + ekstrak daun mangga 250 mg/kgBB) dengan p = 0,001, dan kelompok 5 (deksametason 1 mg/kgBB + ekstrak daun mangga 350 mg/kgBB) dengan p < 0,001. Kesimpulan: Ekstrak daun mangga (Mangifera foetida) dapat menurunkan kadar gula darah puasa pada mencit yang telah diinduksi.   Background: Mango leaves have anti-diabetic effects due to their high content of mangiferin. Mangiferin exerts its anti-diabetic effects by increasing the expression of GLUT4 and its translocation within muscle cells. The aim is to determine the effect of mango leaf extract (Mangifera foetida) on fasting blood glucose levels in mice previously induced with dexamethasone to elevate fasting blood glucose levels. Method: An experimental method with a pre-test and post-test group control design. The sample size was determined using the resource equation approach, with a total of 25 mice divided into five groups. Hyperglycemia was induced with dexamethasone at 1 mg/kg body weight per day for 7 days, followed by oral administration of mango leaf extract (150, 250, 350 mg/kg body weight per day) for 10 days. Fasting blood glucose levels were measured before and after induction, as well as on days 3, 7, and 10 of treatment. Statistical analysis was performed using multivariate methods. Data were analyzed using ANOVA, Post Hoc LSD, and Paired Sample T-Test. Results: There was a significant decrease in fasting blood glucose levels in mice before and after administration of mango leaf extract in group 2 (Mango leaf extract 150 mg/kg BW) with a p-value of 0.002, group 4 (Dexamethasone 1 mg/kg BW + Mango leaf extract 250 mg/kg BW) with a p-value of 0.001, and group 5 (Dexamethasone 1 mg/kg BW + Mango leaf extract 350 mg/kg BW) with a p-value of <0.001. Conclusion: Mango leaf extract (Mangifera foetida) can reduce fasting blood sugar levels in mice that have been induced.
Co-Authors Achmad, Djumadi Adnan, Endy Adnan, Syahrul Agus Sulaeman Akbar, Muhammad Alief Ali Sulaiman Amiruddin Aliah, Amiruddin Andi Alfian Zainuddin Andi Mappaware, Nasrudin Arfah, Arni Isnaini As'ad, Suryani Azis, Zainab Budhianto Suhadi Cahyono Kaelan, Cahyono Cangara, Husni Cangara, M. Husni Dirgahayu L, Andi Millaty Eka J. Wahjoepramono Gatot Susilo Lawrence Gina Andyka Hutasoit Hasbi, Berry Erida Ilham J. Patellongi, Ilham J. Ilhamjaya Patellongi Indah Lestari, Indah Indarwati, Rezky Putri Irmasanty, Irmasanty Iskandar, Darariani Jan S. Purba, Jan S. Kanang, Indah Lestari Daeng Khaerina, Ilma Mardiati Mardiati Mokhtar, Shulhana Mubdi, Abdul Muthma'innah, Gadista Mayssi mutiara mutiara Nita Mariana Nur Intan, Nur Nur, Muh Jabal Nurfauziah Nurfauziah, Nurfauziah Prema Hapsari Putra, Fadil Mula Rasyid, Nur Rahmah Rianti, Andi Marcha Rocksy F.V. Situmeang, Rocksy F.V. Sari Dewi, Anna Tawali, Suryani Tola, Aqilah Faizah Upik A. Miskad, Upik A. UPIK ANDERIANI MISKAD, UPIK ANDERIANI Vivien Puspitasari, Vivien Yuniarizka, Sekila