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All Journal Acta Biochimica Indonesiana Jurnal Respirologi Indonesia Respiratory Science Eduvest - Journal of Universal Studies Jurnal Farmasi Indonesia Neurona
Raden Rara Diah Handayani
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, West Java, Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Medicine & Pharmacology Neuroscience Social Sciences

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Corona Virus Disease 2019 Diah Handayani; Dwi Rendra Hadi; Fathiyah Isbaniah; Erlina Burhan; Heidy Agustin
Jurnal Respirologi Indonesia Vol 40, No 2 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i2.101

Abstract

Corona virus disease 2019 (COVID-19) is a new name given by World Health Organization (WHO) of 2019 novel corona virus infection, reported at the end of 2019 from Wuhan, Cina. The spread of infection occurs rapidly and creates a new pandemic threat. Etiology of COVID-19 was identified in 10 January 2020, a betacorona virus, similar with severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS CoV). The clue diagnosis pathway of COVID-19 were history of travel from Wuhan or others infected countries within 14 days prior, and symptoms of acute respiratory illness (ARI) or lower respiratory infection (pneumonia) with the result of real time polymerase chain reaction (RT-PCR) specific for COVID-19. The WHO classified COVID-19 into suspect case, probable case and confirmed case. Indonesia Ministry of Health classified the case into in monitoring (ODP), patient under surveillance (PDP), people without symptom (OTG) and confirmed case. Specimens for detection COVID-19 could be acquired from nasal and nasopharynx swab, sputum and another lower respiratory aspirate including broncoalveolar lavage (BAL). Management of COVID-19 consist of isolation and infection control, supportive treatment according to the disease severity which could be mild (acute respiratory infection) to severe pneumonia or acute respiratory distress syndrome (ARDS). Disease transmission is via droplets and contact with droplets. Currently, there is no antiviral and vaccine. Prevention is very important for this disease by limitation of transmission, identification and isolate patients. Prognosis is determined by severity of the disease and patient comorbidity. Information about this novel disease remains very few, studies are still ongoing and is needing further research to fight with this new virus. (J Respir Indo. 2020; 40(2): 120-30)
Pulmonary Mycoses in Indonesia: Current Situations and Future Challenges Anna Rozaliyani; Anwar Jusuf; Priyanti ZS; Erlina Burhan; Diah Handayani; Henie Widowati; Satria Pratama; Findra Setianingrum
Jurnal Respirologi Indonesia Vol 39, No 3 (2019)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (900.239 KB) | DOI: 10.36497/jri.v39i3.69

Abstract

Cases of pulmonary mycosis or pulmonary fungal diseases continues to increase in frequency along with the expanding population with impaired immune systems, including patients with pre-existing pulmonary diseases. Changing profile of underlying diseases might cause altering diseases profile as well. In previous decades, Pneumocystis pneumonia was the most common pulmonary mycosis in HIV-infected patients. As the increasing number of TB cases, pulmonary malignancy, chronic obstructive pulmonary disease (COPD) and certain chronic diseases, other pulmonary mycoses also increase such as chronic pulmonary aspergillosis, cryptococcosis, histoplasmosis, and other filamentous fungal infection. Furthermore, the airborne fungal particles of Aspergillus and other fungi could seriously worsen asthma or allergic respiratory diseases. In low- and middle-income countries, including Indonesia, lack of diagnostic facilities may lead to inadequate treatment. It will contribute to poor clinical outcomes with high mortality rates. The awareness among clinicians and other health workers of this epidemiology changes is the important step in early diagnosis and better managemenet of pulmonary mycosis in the future. (J Respir Indo. 2019; 39(3): 210-4)
The Role of Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte Ratio (PLR), and D-Dimer in Predicting the Outcome of Confirmed COVID-19 patients Fathiyah Isbaniah; Tomu Juliani; Triya Damayanti; Dewi Yenita; Faisal Yunus; Budhi Antariksa; Wahyu Aniwidyaningsih; Sita Laksmi Andarini; Diah Handayani
Jurnal Respirologi Indonesia Vol 41, No 4 (2021)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v41i4.215

Abstract

Background: Cytokine storm or hyperinflammation condition in COVID-19 patients could result in fatal outcomes. Inflammation could also result in coagulation disorders. The Neutrophil-Lymphocyte Ratio (NLR) and Platelet-lymphocyte ratio (PLR) have been known as inflammation markers in several diseases. D-dimer value can be used to assess a patient's coagulation status. Further study on thromboinflammation biomarkers in COVID-19 patients is needed. Therefore, we conducted a study to assess the association between NLR, PLR, and d-dimer on the clinical outcome of confirmed COVID-19 patients at Persahabatan Central Hospital.Methods: Observational cohort retrospective analysis was conducted on 214 medical records of confirmed COVID-19 patients who meet the inclusion criteria in Persahabatan Central Hospital from March to July 2020.Results: The mean patient’s age in this study is 54.35 years, dominated by male patients (60.7%). Most of the patients had normal nutritional status (54.7%). The proportion of patients with comorbidities is 65.4%. The most common comorbid is hypertension, followed by diabetes mellitus. 76.1% of patients have severe-critically ill disease, followed by moderate (20.1%) and mild disease (3.7%) The length of hospitalization median were 12 days. Sixty patients (28%) have died during hospitalization. The median of initial value of NLR, PLR, and d-dimer is 5.75 (0.68–81.5), 243.5 (44.7–1607), and 1140 (190–141300) respectively. We found significant associations between NLR (p = 0.000), PLR (p=0.013) and d-dimer (p = 0.032) on clinical outcome. Conclusion: Initial value of NLR, PLR, and D-dimer of confirmed COVID-19 patients at Persahabatan Central Hospital were associated with clinical outcome. 
Two-years Biannual Evaluation of Drug-resistant Tuberculosis Patients Completing Their Treatment at Persahabatan General Hospital Jakarta Murniati Murniati; Diah Handayani; Fathiyah Isbaniah
Respiratory Science Vol. 1 No. 1 (2020): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i1.4

Abstract

Background: Drug-resistant tuberculosis (DR-TB) is a worldwide threat, including in Indonesia, which course of treatments are time consuming and are expensive. Recent findings suggest trends in recurrence of DR-TB, while no data is available to summarize the recurrence of DR-TB in Indonesia. Objective: This study aimed to evaluate DR-TB patients which was biannually performed for two-years (e.g. at the 6th, 12th, 18th, and 24th mos) after treatment completion. Methods: This cross-sectional study involved DR-TB patients completing their treatment at Persahabatan General Hospital Jakarta, Indonesia, between April and December 2017. The post-treatment evaluation during the 6th, 12th, 18th, and 24th mos included clinical, chest x-ray (CXR) and sputum culture examination. Results: Sixty patients were observed in this study, 31 (51.7%) were males and 29 (48.3%) were females. The mean age was 42.3+12.5 yo and the mean body mass index was 21.75+4.34. Fourty nine (81.7%) patients showed extensive lesions per CXR and none of the patient showed Mycobacterium tuberculosis growth per sputum culture. Conclusion: There was no recurrence of DR-TB from patients completing their treatment at Persahabatan General Hospital Jakarta, Indonesia during two-years post-treatment evaluation.
KEJADIAN STROKE ISKEMIK PADA PASIEN POSITIF COVID-19 TERKONFIRMASI DI RUMAH SAKIT UNIVERSITAS INDONESIA Rakhmad Hidayat; Gemia Clarisa Fathi; Ramdinal Aviesena Zairinal; Raden Rara Diah Handayani; Mohammad Kurniawan; Taufik Mesiano; Al Rasyid; Salim Harris
NEURONA Vol 38 No 2 (2021)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Coronavirus disease 2019 (COVID-19) is not only disrupts the respiratory system, it can disrupt various organ systems, one of which is the central nervous system. Indonesia still has a little literature that discusses COVID-19 and its relation to ischemic stroke. This study aims to report the course of ischemic stroke cases in patients who have been confirmed positive for COVID-19. A 56 year old man presented with confirmed COVID-19, the patient had a history of type 2 diabetes mellitus and also a history of dyslipidemia. At initial presentation the patient did not complain of neurological symptoms, but after 12 days of treatment the patient complained of weakness in the left side of the upper leg. The CT scan of the head with contrast revealed an infarction in the peripheral area, perfusion CT found that the patient was hypoperfused in the right cerebral hemisphere area without the presence of a large core infarction or a clear perfusion mismatch defect. CT angiography did not reveal stenosis or occlusion of the large vessels. It can be concluded that ischemic stroke in COVID-19 patients can occur due to various underlying factors, one of which is hypercoagulability. Keywords: COVID-19, Stroke, Universitas Indonesia Hospital
The Factor Affecting Medication Adherence in Tuberculosis Patients: A Literature Review Daimah Wirdatus Sanaun Harahap; Retnosari Andrajati; Santi Purna Sari; Diah Handayani
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.1541

Abstract

Medication adherence is crucial for the successful treatment of tuberculosis (TB), a persistent global health issue that demands prolonged and rigorous therapy to achieve cure, prevent drug resistance, and reduce transmission rates within communities. Recent studies highlight predictors of effective treatment outcomes such as being a new TB case and being HIV-negative. There is a significant relationship between various psychosocial factors that influence treatment adherence, particularly among elderly TB patients, where adherence is characterized by complexity and multidimensionality. Factors like depression, anxiety, income levels, social support, patient status, and TB classification play critical roles in adherence. Understanding these factors is essential for optimizing treatment strategies and improving outcomes in TB management.
Challenges of Monitoring Blood Levels of Bedaquiline in Drug-Resistant Tuberculosis: A Narrative Review Nur Isra; Santi Purna Sari; Yahdiana Harahap; Raden Rara Diah Handayani
Eduvest - Journal of Universal Studies Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i3.50267

Abstract

Bedaquiline, a second-line drug for drug-resistant tuberculosis (MDR-TB), is one of the latest generation drugs in the treatment of tuberculosis (TB). However, the challenge in determining the optimal dose and individual pharmacokinetic variability requires the implementation of Therapeutic Drug Monitoring (TDM). This article aims to evaluate the challenges of TDM bedaquiline through a narrative review of the current literature. Relevant articles were identified through computerized searches on PubMed and Google Scholar using a combination of keywords related to bedaquiline, pharmacokinetics, and TDM. Limited clinical data indicate a lack of standard exposure targets and reliable efficacy thresholds. Pharmacokinetic variability is influenced by factors such as age, weight, gender, genetics, comorbidities, and serum albumin. Technical challenges include the need for precise analytical methods and the accessibility of technology in clinical practice. The use of TDM for bedaquiline offers the potential to improve the efficacy of MDR-TB treatment, but more research is needed to address pharmacokinetic variability and develop standardized guidelines.
Profile of Drug-Resistant Tuberculosis Patients at Rumah Sakit Universitas Indonesia Depok Period October 2024 Suci Rizki Dumiarsih; Santi Purna Sari; Retnosari Andrajati; Diah Handayani
Eduvest - Journal of Universal Studies Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i3.50269

Abstract

Indonesia has been one of the three countries in Asia that contributes to the highest case of Tuberculosis (TB) in the world. Tuberculosis itself counted as the top ten cause of death globally. Two of the challenges in controlling TB cases are the occurrence of drug-resistance strain and patients’ adherence. Drug-resistant TB has to be treated with the second line drugs of TB with higher risk of adverse events. Linezolid as one of the suggested drugs by WHO in the treatment may increase patients’ risk of cytopenia events. This study was conducted to represent the profile of drug-resistant TB obtained from Rumah Sakit Universitas Indonesia (RSUI) Depok period October 2024. Design of this study is a quantitative-descriptive where the data of patients obtained from the patients’ medical records in the period of October 2024. The findings of this study showed the total number of drug-resistant TB was 104 with 3 cases of HIV and 70 patients having Linezolid in their regimen. Most of the patients are male with mean of age 41.3 years. New cases and RR/MDR TB level are dominated while on the other hand there’s 9 cases of After Failure and 4 others are After Loss to Follow-up. Median values obtained for patients’ leukocytes, hemoglobin, and platelets are 7818.0, 11.9, 279.5 respectively.
A Pemantauan Kadar Obat Dalam Darah Bedaquilin dan Linezolid Pada Pasien Tuberculosis Resistensi Obat : Literatur Review Ai Yeni Herlinawati Yeni; Santi Purnasari; Retnosari Andrajati; Raden Rara Diah Handayani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 17 No 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.320

Abstract

Tuberculosis remains a leading cause of global mortality and morbidity. Current TB elimination programs have not yet met their targets. Drug resistance poses a significant challenge, necessitating effective alternative treatments for drug-resistant TB patients. Bedaquiline and Linezolid are primary drugs (Category A) used to combat drug-resistant TB. However, they come with side effects and toxicity, have narrow therapeutic window, and exhibit pharmacokinetic variability. Therefore, therapeutic drug monitoring (TDM) is recommended to achieve desired treatment outcomes and prevent or minimize potential side effects or toxicity. The objective of this study is to assess the urgency of TDM implementation to address these issues. This research is a literature review involving the synthesis of data from six studies that met inclusion and exclusion criteria. Data sources include Science Direct, PubMed, and Nature. The results indicate that Bedaquiline and Linezolid exhibit pharmacokinetic variability and the occurrence of side effects. Therefore, TDM is recommended for Bedaquiline and Linezolid to achieve desired therapeutic effects and avoid the onset of side effects or toxicity
Detection of latent tuberculosis infection in household contacts of drug-resistant tuberculosis patients using interferon-gamma release assay: a study at Universitas Indonesia Hospital Muhammad Faris Indratmo; Diah Handayani; Ardiana Kusumaningrum; Febriana Catur Iswanti; Mohamad Sadikin
Acta Biochimica Indonesiana Vol. 8 No. 2 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.214

Abstract

Background: Drug-resistant tuberculosis (DR-TB) poses significant public health challenges in Indonesia. Household contacts of DR-TB patients face elevated risk of Mycobacterium tuberculosis infection, which may remain latent and asymptomatic. Objective: This study aimed to assess the prevalence of latent tuberculosis infection (LTBI) among household contacts of DR-TB patients using interferon-gamma release assay (IGRA). Methods: This cross-sectional study was conducted at Universitas Indonesia Hospital from February to May 2023. Eighteen asymptomatic household contacts from six confirmed DR-TB index cases were enrolled. Participants underwent clinical evaluation, chest radiography, and LTBI screening using the QuantiFERON-TB Gold Plus (QFT-Plus) assay. Results: Among 18 participants (mean age 33.3 years; 55.6% female), 8 (44.4%) tested positive for LTBI, while 10 (55.6%) tested negative. The highest IGRA positivity rates were observed in adolescents aged 12–16 years (66.7%) and young adults aged 17–25 years (60.0%). All participants were clinically asymptomatic with normal chest radiographs. Conclusion: This study demonstrates substantial LTBI prevalence among household contacts of DR-TB patients. The findings underscore the importance of systematic contact tracing, IGRA-based screening, and timely tuberculosis preventive therapy to reduce disease transmission and progression in high-risk populations.
Co-Authors Agustin, Heidy Ai Yeni Herlinawati Yeni Al Rasyid Anna Rozaliyani Anwar Jusuf Ardiana Kusumaningrum Budhi Antariksa Daimah Wirdatus Sanaun Harahap Damayanti, Triya Dewi Yenita Dwi Rendra Hadi Erlina Burhan Faisal Yunus Febriana Catur Iswanti Gemia Clarisa Fathi Henie Widowati Isbaniah, Fathiyah Kurniawan, Mohammad Mohamad Sadikin Muhammad Faris Indratmo Murniati Murniati Nur Isra Priyanti ZS Rakhmad Hidayat Ramdinal Aviesena Zairinal Retnosari Andrajati Retnosari Andrajati Retnosari Andrajati Salim Harris Santi Purna Sari Santi Purnasari Satria Pratama Setianingrum, Findra Sita Laksmi Andarini Suci Rizki Dumiarsih Taufik Mesiano Tomu Juliani Wahyu Aniwidyaningsih Yahdiana Harahap