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All Journal Alotrop Jurnal Pendidikan dan Ilmu Kimia International Journal of Mechanics, Energy Engineering and Applied Science (IJMEAS)
Muhammad Arif Fadilah
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Automotive Engineering Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Education Electrical & Electronics Engineering Industrial & Manufacturing Engineering

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ANTIDIABETIC POTENTIAL OF SOLID LIPID NANOPARTICLES (SLNS) FROM KABAU SEED (ARCHIDENDRON BUBALINUM (JACK) I.C. NIELSEN) EXTRACT COATED WITH TRIMYRISTIN Balqis, Solina; Diah Miftahul Aini; Muhammad Arif Fadilah; Nurkayah; Mu'awiyatu Al-Laitsi; Lia Aseptin Murdini; Elva Febriyanti
ALOTROP Vol. 9 No. 1 (2025): Jurnal Pendidikan dan Ilmu Kimia
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/alo.v9i1.42075

Abstract

Type 2 diabetes mellitus is a global health problem that continues to increase. One alternative approach in managing diabetes is using natural materials with antihyperglycemic activity. This study aims to evaluate the effectiveness of solid lipid nanoparticles (SLN) containing Kabau seed extract (Archidendron bubalinum (Jack) I.C. Nielsen) coated with trimyristin in reducing blood glucose levels in hyperglycemic rats. Extraction was carried out by maceration using 96% ethanol, while SLN was synthesized by high-speed homogenization and ultrasonication methods. Particle size analysis showed an average diameter of 262.61 nm with a polydispersity index (PDI) of 0.144, indicating a homogeneous formulation. Phytochemical testing showed that Kabau seed extract contains alkaloids, flavonoids, tannins, and saponins contributing to antihyperglycemic activity. In vivo tests on Mus musculus showed that 20 % concentration of Kabau SLN reduced blood glucose levels by up to 97 mg/dL, approaching the effectiveness of metformin (104 mg/dL). Statistical analysis of ANOVA and BNT test showed significant differences between treatments. These results indicate that Kabau SLN has the potential as a candidate for phytopharmaceuticals in managing type 2 diabetes mellitus. Keywords: Diabetes mellitus; Kabau; solid lipid nanoparticles; trimyristin; flavonoids
Design Simulation of Upper Arm on Welding Table Arifin, Fatahul; Azharuddin; Arnoldi, Dwi; Effendi, Sairul; Herlambang, Yusuf Dewantoro; Yahya; Muhammad Arif Fadilah; Radjiq, Akhmad
International Journal of Mechanics, Energy Engineering and Applied Science (IJMEAS) Vol. 1 No. 1 (2023): IJMEAS - October
Publisher : Yayasan Ghalih Pelopor Pendidikan (Ghalih Foundation)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53893/ijmeas.v1i1.215

Abstract

Welding process is the joining of two metals by heating. There are two types of welding that are often applied in the field, namely gas welding (OAW) and electric welding (SMAW). Both of them have their advantages as metal connectors. This research originated from a problem that occurred in the upper arm on the welding table which experienced bending as a result of carrying the load when holding the welding disc. Therefore, CAD/CAE design is carried out. In this case, the strength and tension that occur in the upper arm are analyzed. This research aims to reveal the value of the stress that occurs in the upper arm and the safety value. Where in the design the planned force capacity is 300 newtons using the finite element method or also known as Finite Element Analysis (FEA). And the material used is ASTM A36. The results of the simulation and also the analysis that has been carried out show that the upper arm frame structure on the welding table has a stress, deformation, and safety factor of 311.987 MPa, 2.28286 mm, and 0.663488 ul.
Co-Authors Arnoldi, Dwi Azharuddin Balqis, Solina Diah Miftahul Aini Effendi, Sairul Elva Febriyanti Fatahul Arifin, Fatahul Lia Aseptin Murdini Mu'awiyatu Al-Laitsi Nurkayah Radjiq, Akhmad Yahya Yusuf Dewantoro Herlambang