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All Journal The Journal of Society Medicine (JSOCMED) Jurnal Kedokteran Hewan
Berlian, Guntur
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Veterinary

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Patch Test Analysis of Channa Striata Extract Biopolymer Dalimunthe, Dina A; Lubis, Flora Marita; Hazlianda, Cut Putri; Sinaga, Riana Miranda; Dhillon, Jesryn; Hutagalung, Patricia; Berlian, Guntur
Journal of Society Medicine Vol. 4 No. 6 (2025): June
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i6.217

Abstract

Introduction: Wound healing involves complex interactions between cells and mediators that occur immediately after the wound occurs and depends on nutritional factors and wound closure. Snakehead murrel fish (Channa striata) extract has been extensively researched to speed up the wound healing process because of its high amino acid content. Patch tests were carried out to assess the allergen potential of the Channa striata extract biopolymer in the form of wound dressings. Methods: Experimental study of 40 subjects who had admit patch test with various consentration of Channa striata extract biopolymer. The patch test materials divided of 5 grups. They were aquadest solution, Eucheuma cottonii biopolymer, Channa striata extract biopolymer concentrations of 5.4 g/mL, 10.8 g/mL, and 21.6 g/mL. All subjects had been assessed for skin reactions that occured after 48 hours, 72 hours, and 96 hours. Results: A total of 40 subjects met the inclusion criteria and completed informed consent.  There was minimum allergen reaction (+) in slight subject in all grups except aquadest grup after 48 hours. The allergic reaction dissolve in 72 and 96 hours. An irritant reaction (IR) occurred in among all grups but indicated to the  hypafix plaster. Conclusion: Patch test containing biopolymer Channa striata extract showed a minimal allergic reaction
THE EFFECTIVENESS OF COMBINATION OF SNAKEHEAD FISH, TEMULAWAK, AND MENIRAN EXTRACTS ON POST OVARIOHYSTERECTOMY WOUND HEALING IN CATS Bermani, Fadeli; Soehartono, Raden Harry; Berlian, Guntur; Siswandi, Riki
Jurnal Kedokteran Hewan Vol 18, No 1 (2024): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v18i1.34542

Abstract

This study aims to determine the effectiveness of combination of snakehead fish, ginger and meniran extract (GTM) on healing wounds after ovariohysterectomy (OH) in cats. Twenty healthy female cats aged 1-4 years, weighed 2-4 kg were divided into three groups with different doses of GTM and compared with the group without treatment (n= 5 cats/group). The GTM dose was extrapolated from the human dose using allometric scaling, with the basal dose for G:T:M were 40:3.2:4.8 mg/kg BW (group 1, GTM1x). Treatment groups 2 (GTM2x) and 3 (GTM4x) were given a dose of GTM that was multiplied by 2 and 4 of the basal doses, respectively. OH was performed via a flank approach with the same operator and anesthesia. Discharge, swelling and erythema scores were significantly lower on days 3, 4 and 5 post-operativeamong all GTM groups compared with control. Pain evaluation using Baseline Tactile Semmes Monofilaments showed significantly lower in GTM2x and GTM4x compared to GTM1x and control. The 4A-vet pain scale showed lower pain in GTM2x from 1 to 5 days postoperative. The number of leukocytes, erythrocytes and platelets was in the normal range indicates the absence of postoperative infection. Postoperative albumin levels showed a significantly higher difference in GTM2x compared to control. The treatment given GTM2x showed the fastest healing interval (3.20.44 days). The combination of GTM can reduce pain, reduce wound scores and accelerate post-OH wound healing with the most effective dose was GTM2x. ________________________________________________________________
Co-Authors Bermani, Fadeli Cut Putri Hazlianda Dalimunthe, Dina A Dhillon, Jesryn Hutagalung, Patricia Lubis, Flora Marita Riki Siswandi Sinaga, Riana Miranda