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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Current Biochemistry QARDHUL HASAN: MEDIA PENGABDIAN KEPADA MASYARAKAT Halal Studies and Society
Dwicesaria, Maheswari Alfira
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Economics, Econometrics & Finance Education Languange, Linguistic, Communication & Media Social Sciences Other

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Bioactive Properties of Commercially Cultivated Spirulina platensis in Indonesia: Evaluation of Anticancer and Antioxidant Potentials Tarman, Kustiariyah; Safithri, Mega; Saputra, Rahadita Maura Amanda; Silitonga, Ria Gusharani; Dwicesaria, Maheswari Alfira; Wong, Chen Wai; Setyaningsih, Iriani
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 30, No 2 (2025): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.30.2.301-310

Abstract

Spirulina platensis is a commercially cultivated cyanobacterium known for its rich bioactive compounds, including phenolics, flavonoids, and phycocyanin, which contribute to its antioxidant and anticancer properties. While previous studies focused on laboratory-grown strains, this study evaluates the total flavonoid and phenolic content, antioxidant activity, and in vitro anticancer effects of ethanol extracts from two commercial manufacturers (MA and MB). The antioxidant potential was assessed using DPPH and FRAP assays, while cytotoxicity against A549 lung and HeLa cervical cancer cells was determined via MTT assays. Results indicated that MB exhibited higher flavonoid (12.52 ± 0.23 mg QE.g-1 DW) and phenolic content (19.10 ± 0.66 mg GAE.g-1 DW) than MA, correlating with stronger antioxidant activity (FRAP: 16.55 ± 0.1 µmol TE.g-1 DW vs. 11.1 ± 0.29 µmol TE.g-1 DW). DPPH inhibition reached 80.33% (MA) and 77.77% (MB). MB also demonstrated greater anticancer activity, with 28.31% inhibition in A549 cells at 100 ppm, compared to MA’s 20.6%, and 33.85% inhibition in HeLa cells at 50 ppm. Both extracts displayed preferential toxicity toward cancer cells over normal Chang cells, supporting their potential as safer alternatives to chemotherapy. This study confirms the dual therapeutic potential of commercially cultivated S. platensis as an antioxidant and anticancer agent, highlighting its applications in pharmaceutical and nutraceutical industries. Further research is recommended to isolate and identify the bioactive compounds responsible for its cytotoxic effects.
Peningkatan Kesehatan Melalui Pengolahan Sumber Daya Herbal Menjadi Minuman Fungsional SIJAKA Safithri, Mega; Andrianto, Dimas; Fitrilia, Tiana; Rosyidah, Rara Annisaur; Purwanto, Ukhradiya Magharaniq Safira; Kurniasih, Rini; Hudayanti, Martini; Achyar, Catellia Auliany; Febrina, Adella; Dwicesaria, Maheswari Alfira; Gholam, Gusnia Meilin; Nusyarah, Ayu Tri
Qardhul Hasan: Media Pengabdian kepada Masyarakat Vol. 11 No. 2 (2025): Qardhul Hasan: Media Pengabdian kepada Masyarakat
Publisher : Universitas Djuanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/qh.v11i2.18127

Abstract

Program pelatihan dan sosialisasi mengenai pemanfaatan SIJAKA (sirih merah, jahe merah, dan kayu manis) sebagai minuman fungsional antidiabetes bertujuan untuk meningkatkan pemahaman dan praktik masyarakat dalam mengelola diabetes secara alami. Desa Sukamaju yang terletak di Kecamatan Cigudeg, Kabupaten Bogor memiliki peluang untuk mengembangkan produksi minuman fungsional berbahan dasar SIJAKA, namun potensi ini belum dimanfaatkan secara optimal. Program ini dirancang untuk meningkatkan taraf kesehatan masyarakat serta mendorong pertumbuhan ekonomi lokal melalui pendirian fasilitas produksi minuman fungsional SIJAKA. Pelaksanaan kegiatan melibatkan kader Posyandu dan PKK melalui kegiatan penyuluhan dan pelatihan. Metode yang digunakan mencakup pengisian kuisioner pre-test dan post-test guna mengevaluasi tingkat pengetahuan peserta sebelum dan sesudah pelatihan. Hasil pelatihan menunjukkan adanya peningkatan pemahaman masyarakat terkait minuman fungsional SIJAKA, meskipun sebelumnya pengetahuan mereka masih terbatas. Pelatihan ini juga mengungkapkan bahwa 79,31% peserta mengenal sirih merah dan jahe merah sebagai herbal potensial, sedangkan 72,41% mengetahui manfaat kayu manis. Hasil ini menunjukkan adanya peningkatan kesadaran akan potensi herbal dalam mengelola diabetes. Selain itu, mayoritas peserta (92,11%) menunjukkan ketertarikan yang tinggi terhadap pelatihan dan ingin lebih memahami manfaat serta cara pembuatan SIJAKA. Program ini terbukti mampu meningkatkan antusiasme dan wawasan masyarakat terhadap SIJAKA, serta memiliki potensi untuk dijadikan sebagai contoh bagi desa-desa lainnya. Secara keseluruhan, program ini memberikan dua manfaat utama, yaitu peningkatan kualitas kesehatan masyarakat dan penguatan ekonomi lokal, meskipun masih terdapat kendala dalam mendorong masyarakat untuk memproduksi dan mengonsumsi SIJAKA secara mandiri.
Halal enzymatic cosmetic ingredients: The role of enzymes in ingredients selection Dwicesaria, Maheswari Alfira; Safithri, Mega; Andrianto, Dimas; Purwanto, Ukhradiya Magharaniq Safira
Halal Studies and Society Vol. 1 No. 1 (2024): January 2024
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/hass.1.1.16-19

Abstract

The rising demand for halal products, especially within the cosmetics industry, has increased the need for cosmetic products to comply with Islamic laws. One of the challenges in achieving halal certification is the determination of the source of the active ingredients used in cosmetic products, such as enzymes. According to Islamic laws, enzymes derived from pigs or other animals that are not slaughtered are not considered halal. To ensure that the enzymes used in cosmetics are derived from halal sources, it is necessary to use enzymes generated from microorganisms through fermentation, provided that the raw materials and growth medium comply with Islamic laws. Additionally, halal cosmetics must meet regional and international standards, including the Indonesian Ulema Council’s Fatwa and the Malaysian Cosmetic and Personal Care Standards. This research provides a comprehensive review of the role of enzymes in selecting halal compliance cosmetic ingredients, focusing on the source of enzymes as a means of assessing the halalness of cosmetic products. It is essential to utilize halal enzymes such as those derived from plants to provide Muslim consumers with assurance when using cosmetic products.
Kandungan Nutrisi dan Daya Inhibisi α-glukosidase Ekstrak Daging Buah Salak Sidempuan (Salacca sumatrana) Safithri, Mega; Ritonga, Aprilita Putri Defan; Indariani, Susi; Dwicesaria, Maheswari Alfira; Sulistiyani; Hasim
Current Biochemistry Vol. 11 No. 1 (2024)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.11.1.1

Abstract

Penelitian terhadap pemanfaatan salak khususnya salak Sidempuan sebagai inhibitor α-glukosidase belum dilakukan. Penelitian ini bertujuan mengukur kadar proksimat (air, abu, protein kasar, lemak kasar, serat kasar, dan karbohidrat), menganalisis komponen fitokimia, kandungan total fenolik dan aktivitas penghambatan α-glukosidase pada ekstrak air dan etanol daging buah salak Sidempuan. Kadar total fenol diukur menggunakan metode Folin Ciocalteu. Aktivitas penghambatan α-glukosidase diukur menggunakan substrat pNPG. Kadar karbohidrat, air, abu, lemak kasar, protein kasar, dan serat kasar berturut-turut sebesar 86.35%, 6.57%, 3.60%, 1.44%, 1.24%, dan 0.82%. Kedua ekstrak mengandung senyawa flavonoid dan saponin. Ekstrak etanol 70% daging buah salak Sidempuan memiliki kandungan total fenol sebesar 10.6 mg GAE/g ekstrak, lebih tinggi dibandingkan ekstrak air sebesar 5.55 mg GAE/g esktrak. Ekstrak etanol daging buah salak Sidempuan memiliki konsentrasi inhibisi (IC50) sebesar 13.69 mg/L. Konsentrasi ini lebih kecil dibandingkan ekstrak air yaitu 4160.56 mg/L, namun masih lebih besar dibandingkan akarbosa yaitu 1.15x10-3 mg/L sebagai kontrol positif.
Antibacterial Activity of Hermetia illucens (Black Soldier Fly) Maggot Extract Against Salmonella typhi Andrianto, Dimas; Hasim; Muhammad, Zulfikar; Dwicesaria, Maheswari Alfira
Current Biochemistry Vol. 12 No. 2 (2025)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.12.2.1

Abstract

Typhus is an acute fever caused by Salmonella typhi bacterial infection. This research aims to test the efficacy of BSF maggot extract as an antibacterial against Escherichia coli and Salmonella typhi. The stages in this research are the preparation of maggot samples, determination of water content of samples, extraction of maggot BSF, screening of antibacterial activity of maggot BSF against Escherichia coli and Salmonella typhi, fractionation from the best results of antibacterial activity of maggot extract BSF and the test of antibacterial activity of maggot BSF fraction against Escherichia coli and Salmonella typhi, fractionation of the best results of antibacterial activity of maggot extract BSF and the test of antibacterial activity of maggot BSF fraction against Escherichia coli and Salmonella typhi. Extraction was carried out by a multi-level maceration method using acetone, methanol and water solvents, then the extract was tested for antibacterial activity against Salmonella typhi using the disc diffusion method with the best results, acetone extract with an inhibition zone of 8.13 mm ± 0.153. Then, acetone extract was fractionated according to its polarity, namely n-hexane, dichloromethane, ethyl acetate, and water. The results of the fractionation were tested for antibacterial activity against Escherichia coli and Salmonella typhi using the disc method with the best fraction was the n-hexane fraction, at a concentration of 2500 ppm with inhibition zones 8.37 mm ± 0.32 (Escherichia coli) and 9.00 mm ± 0.00 (Salmonella typhi)
Co-Authors Achyar, Catellia Auliany DIMAS ANDRIANTO Febrina, Adella Fitrilia, Tiana Gholam, Gusnia Meilin Hasim Hudayanti, Martini Indariani, Susi Kustiariyah Tarman Mega Safithri Nusyarah, Ayu Tri Purwanto, Ukhradiya Magharaniq Safira Rini Kurniasih, Rini Ritonga, Aprilita Putri Defan Rosyidah, Rara Annisaur Saputra, Rahadita Maura Amanda Silitonga, Ria Gusharani Sulistiyani Wong, Chen Wai Zulfikar Muhammad, Zulfikar