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All Journal Jurnal Biologi Tropis Sasambo Journal of Pharmacy SALUT: Journal of Social and Education
Tanjaya, Steve Pratama
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences Other

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Artikel review : validasi metode penentuan kadar asam retinoat pada sediaan kosmetik dalam bentuk krim dengan menggunakan berbagai instrumen Tanjaya, Steve Pratama; Rosyada, Sabila; Octavia, Ditha Zanetti; Putri, Dewi Angelita; Nadiya, Aisya; Pratiwi, Eskarani Tri
Sasambo Journal of Pharmacy Vol. 6 No. 1 (2025): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i1.505

Abstract

Whitening cream cosmetics are widely used to treat skin and are often employed to lighten the complexion of skin and reduce marking. Unfortunately, these products mostly contain hazardous ingredients like retinoic acid, effective yet capable of causing harm with its side effects in terms of skin inflammation, desiccation, and teratogenicity. This review will discuss the evaluation and comparison of the validity of the analytic method in the determination of retinoic acid in cosmetic cream formulations with different instruments; High-Performance Liquid Chromatography, Chromatography-Photodiode Array Detector, and UV-Vis Spectrophotometry methods were discussed. The conducted review used a literature review method wherein various national and international relevant studies of these analytic techniques had been analyzed. Results indicate that HPLC, especially with UV detection, presents the highest accuracy, precision, and sensitivity for quantifying retinoic acid, although it requires a longer analysis time. UV-Vis Spectrophotometry, on the other hand, though less sensitive, offers advantages in terms of simplicity, cost, and shorter duration of the analysis. Among the methods reviewed here, HPLC provides comprehensive validation parameters, demonstrating a linearity of 0.9999, an RSD of 0.99%, an accuracy of 114.3%, an LOD of 0.0165 ppm, and an LOQ of 0.0495 ppm.. Therefore, in order to ensure the safety and regulatory compliance of cosmetic products, the validation of the analytical methodologies for the detection of retinoic acid becomes indispensable, and hence the selection of the most optimal technique is highly relevant.
Potential of Therapeutic Ethanolic Extract of Flavonoids Mutingia Calabura on Alloxan-induced Diabetic Male Mus musculus Rahayu, Zilfia; Rahmayanti, Wulan Desi; Tanjaya, Steve Pratama; Aziz, Nanda Putri Utami; Christian, Samuel Erza; Ridwan, Sucilawaty; Hidayat, Lalu Husnul
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.7733

Abstract

One alternative treatment for diabetes mellitus is herbal therapy. One example of herbal therapy that can be used to treat diabetes mellitus is cherry. Cherry (Muntingia calabura L.) is a plant that is widespread in Indonesia, including NTB. In West Nusa Tenggara, cherry plants are very abundant and can often be found on roadsides and in house yards. One of the compounds contained in cherry leaves which has antidiabetic and antioxidant activity is flavonoids. The aim of this research was to determine the potential of ethanol flavonoid extract to reduce blood sugar levels in mice induced by alloxan. The manufacture of cherry leaf ethanol extract was carried out using the sonication method, with the testing process including qualitative tests, quantitative tests, evaluation of cherry leaf ethanol extract suspension preparations, and measurement of fasting blood sugar. The results of blood sugar measurements showed that administering a dose of 300 mg/kg showed the best results which were almost the same as the positive control (metformin).
Urgensi Penegakan Hukum Yang Berkeadilan Dalam Mewujudkan Demokrasi  Berkualitas Melalui Pendidikan Pancasila Tanjaya, Steve Pratama; Ahmad, Dzakiyyah Sulthanah; Ramadhani, Aliza Salsabila; Inggit, Baiq Putri Maharani Bine; Salsabiella, Baiq Rani; Nabila, Baiq Aisya Adinda
Journal of Social and Education Vol. 2 No. 1 (2025): Journal of Social and Education
Publisher : Lembaga Riset dan Publikasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/6nar7t23

Abstract

Penegakan hukum yang berkeadilan menjadi pondasi utama dalam mewujudkan demokrasi yang berkualitas di Indonesia. Namun, berbagai tantangan seperti ketimpangan hukum, diskriminasi, dan rendahnya akuntabilitas aparat penegak hukum masih menghambat terwujudnya keadilan substantif bagi seluruh warga negara. Artikel ini bertujuan mengkaji urgensi penegakan hukum yang berkeadilan dalam konteks demokrasi serta menganalisis kontribusi pendidikan Pancasila dalam membentuk kesadaran hukum dan demokrasi masyarakat. Penelitian ini menggunakan metode studi literatur dengan pendekatan kualitatif melalui telaah berbagai sumber ilmiah yang relevan dalam kurun waktu sepuluh tahun terakhir. Hasil kajian menunjukkan bahwa sinergi antara penegakan hukum yang adil, sistem demokrasi yang inklusif, dan pendidikan Pancasila yang berorientasi pada pembentukan karakter berperan strategis dalam menciptakan tatanan hukum yang menjunjung hak asasi manusia dan keadilan sosial. Pendidikan Pancasila dinilai krusial dalam menanamkan nilai-nilai kemanusiaan, keadilan, dan tanggung jawab warga negara sejak dini, sehingga mampu membangun budaya demokrasi yang menghargai hukum dan menjadikan hukum sebagai alat kontrol terhadap kekuasaan, bukan alat represi. Dengan demikian, integrasi nilai-nilai Pancasila dalam sistem pendidikan dan penegakan hukum menjadi kunci dalam membangun demokrasi substantif yang berkeadilan dan beradab. 
Co-Authors Ahmad, Dzakiyyah Sulthanah Aziz, Nanda Putri Utami Christian, Samuel Erza Hidayat, Lalu Husnul Inggit, Baiq Putri Maharani Bine Nabila, Baiq Aisya Adinda Nadiya, Aisya Octavia, Ditha Zanetti Pratiwi, Eskarani Tri Putri, Dewi Angelita Rahayu, Zilfia Rahmayanti, Wulan Desi Ramadhani, Aliza Salsabila Ridwan, Sucilawaty Rosyada, Sabila Salsabiella, Baiq Rani