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All Journal Acta Pharmaceutica Indonesia Jurnal Sains Teknologi dan Lingkungan (JSTL) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis BIO-SAINS | Jurnal Ilmiah Biologi
Hidayat, Lalu Husnul
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Immunology & microbiology Materials Science & Nanotechnology Physics Public Health

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UJI EFEKTIVITAS ANTIDEPRESAN OBAT HERBAL KAPSUL EKSTRAK DAUN PEGAGAN (Centella asiatica L.) PADA MENCIT DENGAN METODE FORCED SWIMMING TEST Ramadhan, Muhammad Arif; Rini, Gina Hanindya; Azhahra, Rizka Dwi; Zahra, Nisrina; Raissa, Talitha Hasna; Meizora, Berlian Caterine; Hidayat, Lalu Husnul
BIO-SAINS : Jurnal Ilmiah Biologi Vol 3 No 2 (2023): Bio-Sains Vol 3 No 2, Agustus 2023
Publisher : Fakultas Sains dan Teknologi, Universitas Islam As-Syafi'iyah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34005/bio-sains.v3i1.2684

Abstract

Depresi adalah gangguan mental yang ditandai dengan beberapa gangguan seperti perasaan sedih hingga berujung pada bunuh diri. Obat antidepresan yang digunakan secara berkepanjangan memiliki efek samping. Sehingga pengembangan dan penemuan obat antidepresan yang memiliki efektivitas lebih tinggi dan efek samping rendah sangat penting untuk dilakukan. Salah satu tumbuhan yang memiliki aktivitas antidepresan adalah pegagan. Saat ini, banyak produk obat herbal ekstrak daun pegagan beredar dipasaran diantaranya dalam bentuk kapsul dengan klaim yang sama sebagai antidepresan. Penelitian ini bertujuan untuk menguji efektivitas antidepresan obat herbal kapsul ekstrak daun pegagan. Metode yang digunakan adalah Forced Swimming Test (FST) yang dimodifikasi. 9 mencit dibagi ke dalam 3 kelompok dan masing-masing kelompok diberi tiga macam perlakuan yaitu amitriptilin sebagai kontrol positif, Na-CMC 0,5% sebagai kontrol negatif, dan obat herbal kapsul ekstrak daun pegagan sebagai sampel uji. Data yang didapatkan yaitu berupa data durasi immobility, struggling, dan swimming yang kemudian dianalisis menggunakan aplikasi SPSS 25 dengan uji One-way ANOVA dan dilanjutkan dengan post hoc LSD sebagai uji lanjutan untuk membandingkan tiap perlakuan. Hasil yang didapatkan yaitu durasi immobility, struggling, dan swimming pada perlakuan kontrol negatif, kontrol positif, dan obat herbal ekstrak daun pegagan berturut-turut kontrol negatif (87,00 detik; 25,33 detik; 127,667 detik), kontrol positif (17,66 detik; 36,33 detik; 186,00 detik), dan sampel uji (74,00 detik; 25,00 detik;140,66 detik). Hal tersebut menunjukkan bahwa obat herbal kapsul ekstrak daun pegagan memiliki efek antidepresan yang secara signifikan menurunkan durasi immobility dan meningkatkan durasi swimming pada mencit, tetapi tidak mempengaruhi durasi struggling.
Potential of Therapeutic Ethanolic Extract of Flavonoids Mutingia Calabura on Alloxan-induced Diabetic Male Mus musculus Rahayu, Zilfia; Rahmayanti, Wulan Desi; Tanjaya, Steve Pratama; Aziz, Nanda Putri Utami; Christian, Samuel Erza; Ridwan, Sucilawaty; Hidayat, Lalu Husnul
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.7733

Abstract

One alternative treatment for diabetes mellitus is herbal therapy. One example of herbal therapy that can be used to treat diabetes mellitus is cherry. Cherry (Muntingia calabura L.) is a plant that is widespread in Indonesia, including NTB. In West Nusa Tenggara, cherry plants are very abundant and can often be found on roadsides and in house yards. One of the compounds contained in cherry leaves which has antidiabetic and antioxidant activity is flavonoids. The aim of this research was to determine the potential of ethanol flavonoid extract to reduce blood sugar levels in mice induced by alloxan. The manufacture of cherry leaf ethanol extract was carried out using the sonication method, with the testing process including qualitative tests, quantitative tests, evaluation of cherry leaf ethanol extract suspension preparations, and measurement of fasting blood sugar. The results of blood sugar measurements showed that administering a dose of 300 mg/kg showed the best results which were almost the same as the positive control (metformin).
Evaluasi Kadar Antosianin Beras Merah dan Hitam Serta Formulasi Sediaan Masker Peel-Off Yogaswara, I Gusti; Wirasisya, Dyke Gita; Juliantoni, Yohanes; Hidayat, Lalu Husnul
JURNAL SAINS TEKNOLOGI & LINGKUNGAN Vol. 10 No. 1 (2024): JURNAL SAINS TEKNOLOGI & LINGKUNGAN
Publisher : LPPM Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jstl.v10i1.614

Abstract

Brown rice and black rice have high levels of anthocyanins so they have the potential to be developed as peel-off masks. This study aims to determine the anthocyanin levels of brown rice and black rice ethanol extracts and carry out formulations and evaluations of the physical properties of the peel-off mask formula with the highest anthocyanin levels. The anthocyanin levels of the two samples were determined using the pH difference method. Black rice samples produced the highest anthocyanin levels. Peel-off mask preparations are formulated from samples with the highest anthocyanin levels. Evaluation of the preparation includes organoleptic testing, homogeneity, dispersal power, pH and the time the preparation dries. Anthocyanin levels of black and red rice were 123.2±6,312 and 24.9±4,117 mg/100 gr, respectively. The maske r peel-off preparation was successfully formulated from black rice with a content of 1%. The evaluation results showed that the peel-off mask was purple, gel shape, distinctively scented, homogeneous, spreading power was 6.0 cm, pH 5.0 and the preparation time dried 20.33 ± 0.15 minutes. Based on research, it can be concluded that the formula of the peel-off mask of 1% black rice ethanol extract has met the physical requirements of the preparation.
STUDI FARMAKOGNOSTIK SERBUK JUS KULIT NANAS (Ananas comosus (L.) Merr) Farobbi, Muhammad Iqbal; Pratama, Iman Surya; Hidayat, Lalu Husnul
Acta Pharmaceutica Indonesia Vol. 50 No. 1 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i1.24955

Abstract

Pineapple (Ananas comosus (L.) Merr) is plant that can be utilized as traditional medicine. Pineapple is used as remedy for constipation, nausea, hemorrhoids, flu, anemia, urinary tract disorders, and various skin diseases. In addition, pineapple peels are used as anthelmintic. Pineapple peel has many therapeutic effects, but there is no pharmacognostic standardization related to pineapple peel to verify its validity and effectiveness.  Purpose of this research is to evaluate various pharmacognostic parameters, such as organoleptic, botanical, and physical aspects of pineapple peel. This research conducted organoleptic, microscopic, specific gravity, pH, water-soluble and ethanol-soluble extract content, acid number, and fluorescence tests. This research produced organoleptic profile pineapple peel solution with brownish-yellow color,  characteristic pineapple aroma, and  sour taste. Microscopic observations revealed parenchyma, vascular bundles, meristematic cells, raphide calcium oxalate crystals, epidermis, stone cells, phloem, and fibers. Specific gravity of pineapple peel powder is 1.04 g/mL. pH of  extract at 1% and 10% concentrations is 5 and 4. Water-soluble and ethanol-soluble content is 7.4 ± 0.23% and 5.3 ± 0.17%. Acid number of pineapple peel juice powder is 26.37 mg KOH/g. Pineapple peel juice powder fluoresces upon the addition of DMSO, ether, water, glacial acetic acid, petroleum ether, chloroform, toluene, acetic acid, dichloromethane, and ethyl acetate reagents
The Effect of Propolis Trigona sp. Water Extract from North Lombok on Blood Sugar Levels in Vivo Ananta, Muhammad Naufal Farras; Nuralyza, Imasayu; Humaira, Ani Fatin; Sausan, Salwa; Hidayat, Lalu Husnul; Hasina, Raisya; Pratama, Iman Surya; Andayani, Yayuk; Aini, Siti Rahmatul
Jurnal Penelitian Pendidikan IPA Vol 10 No 8 (2024): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i8.7459

Abstract

Propolis has been touted for its ability to regulate blood sugar levels in diabetes, but the effectiveness can vary depending on the region. A study was conducted to investigate the effect of propolis Trigona sp. water extract on blood sugar levels in vivo. The mice were divided into three groups, with four mice in each group. The positive control group received a 5 mg/kgBW glibenclamide suspension, the negative control group was given a 0.25% CMC-Na suspension, and the treatment group was administered with water extract of propolis at a dose of 300 mg/kgBW. All groups were induced with a 20% D-glucose solution intraperitoneally, and blood sugar levels were measured at 15, 30, 60, 90, and 120 minutes via the tail vein. The blood sugar data was analyzed and presented descriptively. The Mann-Whitney statistical analysis was used to determine the results, revealing that the water extract of propolis at 300 mg/kgBW did not have a significant effect on reducing blood sugar levels in animals induced by a 20% D-glucose solution, with a significance value (p < 0.05).
Co-Authors Aini, Siti Rahmatul Ananta, Muhammad Naufal Farras Azhahra, Rizka Dwi Aziz, Nanda Putri Utami Christian, Samuel Erza Farobbi, Muhammad Iqbal Hasina, Raisya Humaira, Ani Fatin Meizora, Berlian Caterine Nuralyza, Imasayu Pratama, Iman Surya Rahayu, Zilfia Rahmayanti, Wulan Desi Raissa, Talitha Hasna Ramadhan, Muhammad Arif Ridwan, Sucilawaty Rini, Gina Hanindya Sausan, Salwa Tanjaya, Steve Pratama Wirasisya, Dyke Gita Yayuk Andayani Yogaswara, I Gusti Yohanes Juliantoni, Yohanes Zahra, Nisrina