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Journal : medula

Cara-cara mempercepat penyembuhan luka takhfa nur asyifa; Syazili Mustofa; Helmi Ismunandar; Winda Trijayanthi
Medula Vol 12 No 4 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i4.531

Abstract

A wound is a disconnection of tissue continuity due to damage, or loss of tissue substance due to injury or surgery. wounds are the most common injuries found in our daily lives. there are 3 phases of wound healing process are inflammatory phase, proliferation phase and maturation phase. this process is influenced by many factors like patient factors, wound factors and local factors. in the wound healing process, there are several things that can accelerate wound healing are away from cigarettes, reducing stress, improving nutrition by adding supplements (protein, vitamins and minerals), control chronic disease, stop consume alcohol, prevent infections (wound dressings and antibiotik), and avoid medical drugs that can affect wound healing. by understanding the physiology of good wound healing, we can accelerate wound healing and minimize unwanted effects
Sindrom MELAS: Kelainan Genetik Mitokondria Muhamad Fathurrahman Zain; Kevin Jeremia Purba; Delisa Mutiara Nabila; Takhfa Nur Asyifa; Rani Himayani
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.609

Abstract

MELAS (mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes) is an inherited mitochondrial genetic disorder. Paternal mitochondria are present only in the sperm tailpiece due to a mutation in the tRNA in the mitochondrial gene MTTL1. MELAS is the most common mitochondrial disease with an incidence prevalence of 1 in 4000. MELAS syndrome is a multi-organ disease with a wide variety of manifestations including stroke-like episodes, dementia, epilepsy, lactic acidosis, myopathy, recurrent headaches, hearing loss, diabetes, and short stature. Individuals with the MELAS syndrome often present with more than one initial clinical manifestation. The diagnosis can be made with Hirano’s criteria for MELAS. The diagnostic criteria for MELAS must include the following events: (1) signs of encephalopathy, often with dementia and seizures, (2) episodes similiar to stroke (stroke-like episodes) in young age, and (3) biochemical evidence of mitochondrial dysfunction such as lactic acidosis or RRF in muscle biopsy. There is no specific treatment for MELAS syndrome, but most of the treatment for MELAS is symptomatic and involves multidiscipline such as neurologists, cardiologists, endocrinologists, audiologists, ophthalmologists, physical and occupational therapy and psychology, considering that MELAS syndrome can cause dysfunction of several organ.