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All Journal HAYATI Journal of Biosciences Jurnal Penelitian Sains Jurnal Pengabdian West Science Life Science and Biotechnology
Farhan, Abdillah Maulana
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Immunology & microbiology Mathematics Physics Public Health Social Sciences

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Journal : Life Science and Biotechnology

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Growth and physiological adaptation of Ageratum conyzoides L. under salinity stress Putri, Yusi Ananda; Dwinianti, Edia Fitri; Inayah, Ulfatul; Farhan, Abdillah Maulana
Life Science and Biotechnology Vol. 2 No. 1 (2024): May 2024
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/lsb.v2i1.49086

Abstract

Physiological stress affects all plants, including salinity stress, which poses significant challenges. Ageratum conyzoides L. was selected as the subject of this study due to its reputed ability to thrive under various stress conditions, owing to its excellent adaptive capacity. The study employed salt solutions at concentrations of 1000 ppm, 3000 ppm, and 5000 ppm, administered as a single treatment over four weeks. The aim was to assess the impact of salinity stress on the growth, stomatal density, and chlorophyll content of A. conyzoides. Results indicate that salt treatment adversely affected the height of A. conyzoides. Stomatal density was highest at the 5000 ppm concentration, attributed to intensified transpiration in response to stress compared to lower concentrations. Chlorophyll content also showed an reduced at higher salt concentrations. These findings highlight the physiological responses of A. conyzoides to salinity stress, providing insights into its adaptation mechanisms under adverse environmental conditions.
In Silico Study of Genus Marchantia using matK loci for DNA Barcoding Farhan, Abdillah Maulana; Ulum, Fuad Bahrul
Life Science and Biotechnology Vol. 2 No. 2 (2024): November 2024
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/lsb.v2i2.53527

Abstract

Marchantia is a genus of liverworts that can be found in the Asia-Europe Region. Some of the types that can be found are Marchantia polymorpha subsp. montivagans, Marchantia polymorpha subsp. ruderalis, Marchantia paleacea subsp. diptera. All of these species have different levels of kinship, this is due to differences in their nucleotide structure. The purpose of this study was to identify the intolerance between Marchantia species in genomic studies using the NCBI Database. The method used in this research is the collection of nucleotides on NCBI and then construction with Mega 11 software. The marker used in this study is Maturase K (matK), this is because the marker is very optimal in the identification of a molecular-based species. The results of this study are Marchantia paleacea subsp. diptera matK (MP 58 and MP 54) has the highest level of kinship with a score of 99 (Neighbor-Joining Tree) and 100 (Maximum Likelihood Tree) and the outgroup of this phylogenetic is Dumortiera hirsuta. Keywords: Marchantia, matK, NCBI, Phylogenetic.
In Silico Biological Activity Prediction of Bioactive Compounds from Dumortiera hirsuta (Sw.) Nees. Using Way2Drug PASS Online Farhan, Abdillah Maulana; Rosida, Waki'atil; Ulum, Fuad Bahrul
Life Science and Biotechnology Vol. 3 No. 1 (2025): May 2025
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

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Abstract

The liverwort Dumortiera hirsuta (Sw.) Nees. is recognized as a potential source of pharmacologically active metabolites. Bioactive compounds from D. hirsuta have been previously reported through in vitro metabolomic analyses using gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–mass spectrometry (LC–MS). In this study, the biological activities of the GC-MS-identified metabolites were evaluated in silico using the Way2Drug PASS Online platform. The results indicated that ten metabolites from D. hirsuta exhibit medicinal potential, with Pa values greater than 0.7, suggesting a high probability of biological activity. Among these compounds, stigmasterol (Pa = 0.970) and lathosterol (Pa = 0.960) demonstrated the strongest antihypercholesterolemic potential, indicating their role as natural agents for reducing cholesterol levels. These findings highlight the pharmacological potential of D. hirsuta metabolites and warrant further validation through in vitro cholesterol-lowering assays to confirm their predicted activities.
Chemical Profiling of Locally Grown Zingiber officinale Roscoe (Ginger) Rhizomes using GC-MS and Biological Activities Farhan, Abdillah Maulana; Ilmiah , Ika iffah; Mufidi, Farah Fakhirah; Perkasa, Excel Taruna Reksa; Shodiq, Muhammad Husein; Shodiq, Abdulloh Hasan
Life Science and Biotechnology Vol. 3 No. 1 (2025): May 2025
Publisher : Department of Biology, Faculty Mahematics and Natural Sciences, University of Jember

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Abstract

Ginger (Zingiber officinale Roscoe), a widely used rhizomatous species of the family Zingiberaceae, possesses extensive medicinal value owing to its diverse phytochemical composition. This study aimed to characterize the bioactive constituents of locally grown ginger rhizomes using Gas Chromatography–Mass Spectrometry (GC–MS) to elucidate their potential pharmacological activities. GC–MS analysis enabled the detection of volatile and semi-volatile compounds based on retention time and molecular ion fragmentation patterns, providing a comprehensive chemical profile of the extract. A total of 39 compounds were identified, of which 14 exhibited relative abundances exceeding 3%. Major constituents included sesquiterpenes and phenolic derivatives known for their antioxidant, antimicrobial, anti-inflammatory, and anticancer properties. The presence of these bioactive metabolites confirms the therapeutic potential of Z. officinale as a natural source of bioactive agents and supports its continued exploration for pharmaceutical and nutraceutical applications
Co-Authors Aulasya, Ulfie Sakha Azizah, Alya Najwa Dexa Sya’ban, Sabaquna Biliman Dwi Setyati Dwinianti, Edia Fitri Febiani, Tika Fuad Bahrul Ulum Gilani, Noor Azizah Ilmiah , Ika iffah Inayah, Ulfatul Masayu, Muhammad Zulfikar Arian Maulana Farhan, Abdillah Mufidi, Farah Fakhirah Perkasa, Excel Taruna Reksa Putri, Yusi Ananda Risqi, Alexandria Zazila Rosida, Waki'atil Shodiq, Abdulloh Hasan Shodiq, Muhammad Husein Su’udi, Mukhamad