Claim Missing Document
Check
Articles

Found 14 Documents
Search

Uji Anti Hiperglikemik Ekstrak Etanol Daun Salam (Syzygium Polyanthum (Wight.) Walp) Dan Daun Cepcepan (Castanopsis Costata (Blume) A. Dc.) Terhadap Tikus Putih Devortivo Hartono Putra; Erida Novriani; Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3399

Abstract

Hyperglycemia, characterized by elevated blood glucose levels, is a key clinical feature of diabetes mellitus. In recent years, medicinal plants have gained attention as alternative therapies due to their relatively minimal side effects. This study aimed to explore the potential of acombined ethanol extract of bay leaf (Syzgium polyanthum) and cepcepan leaf (castanopsis costata) in lowering blood flucose leveles in white rats (Rattus norvegicus) induced with alloxan. The extraction process was carried out using the maceration methos with 96% ethanol. Phytochemical screening revealed the presence of active compounds such as flavonoids, alkoloids, tannins, saponins, and steroid. The rats were divided into six groups: a normal group. A negative control group (alloxan only), a positive control group (glibenclamide 0.45 mg/kgBB), and three treatment groups receiving the combined extract at doses of 120 mg/kgBW, 250mg/kgBW, and 500mg/kgBW. Blood glucose levels were monitored from day 0 to day 15. ANOVA analysis showed a reduction in glucose levels among the treatment groups, althought the results were not statistically significant (p > 0.05). nevertheless, a consistent downward trend was observed, particularyl in the group receiving 250mg/kgBW. These findings suggest that the ethanol extract combination of bay and cepcepan leaves holds promise as an antihyperlycemic agent. However, frurther research is necessary to confirm its efficacy and fully understand its mechanism of action.
Perbandingan Efektivitas Penggunaan Obat Oral Antiabetik Tunggal dan Kombinasi pada Pasien Diabetes Mellitus Tipe 2 di Rumah Sakit Umum Royal Prima Medan Ega Yos Sanda; Muhammad Yunus; Erida Novriani
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6857

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, with a high prevalence in Indonesia. Pharmacological therapy using oral antidiabetic medications (OAD), either singly or in combination, is a primary approach to managing type 2 DM. Evaluating the effectiveness of therapy is essential to ensure the achievement of glycemic targets and to prevent complications. This study aims to compare the effectiveness of using single and combination oral antidiabetic medications in reducing blood glucose levels in patients with type 2 Diabetes Mellitus at Royal Prima General Hospital Medan. This study is a non-experimental observational study, utilizing a retrospective descriptive design with a cross-sectional approach. A sample of 60 patients with type 2 DM who were hospitalized between January - June 2024, consisted of 30 patients on single therapy and 30 patients on combination therapy. Data was taken from medical records, and the effectiveness was assessed based on the decrease in blood sugar levels over six days of treatment. The results of this study show that the average percentage decrease in blood sugar levels over 6 days for single oral antidiabetics was 28.87%, and the average reduction in blood sugar levels for combination antidiabetics was 31.34%. Combination therapy shows higher effectiveness in reducing blood sugar levels compared to single therapy. There is a difference in effectiveness between single OAD therapy and combination therapy in patients with T2DM. Combination therapy tends to be more effective and can be a rational alternative for patients who do not reach glycemic targets with monotherapy.
Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Kunyit Putih (Curcuma Zedoaria Rosc.) Rika Mai Dinasari Br Sembiring; Razoki Razoki; Erida Novriani; Hariyadi Dharmawan Syahputra
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7054

Abstract

This test aims to evaluate the formulation of floating microcapsule preparations containing ethanol extract of white turmeric (Curcuma zedoaria Rosc.), using chitosan, sodium alginate, and calcium chloride polymers as crosslinking agents. The preparation was formulated using the crosslinking method and tested based on its physical properties, which include moisture content, physical stability through cycle tests, resistance to the gastric and intestinal mucosa. The results showed that the microcapsule formulation was able to maintain the color and texture during the storage period well. The microcapsule durability test showed that the particles could survive in the gastric and intestinal mucosa for two hours. In addition, the water content is within the range that is in accordance with the requirements, namely, at a concentration of 0.25% there is (22%), a concentration of 0.5% there is (38.75%), a concentration of 0.75% there is (22.5%), and the blank has 20.5% water content. Based on previous research by Mardikasari et al., (2020) which used chitosan and alginate polymers. Through this method, this formulation shows the possibility as a technology-based drug delivery system that survives effectively in increasing the bioavailability of active substances from white turmeric.
Studi Kualitatif : Analisis Faktor-Faktor yang Mempengaruhi Pengobatan Pasien TB di Puskesmas Sentosa Baru Veronika Bertua Simanjuntak; Erida Novriani; Razoki Razoki
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v4i1.4751

Abstract

Tuberculosis (TB) is a global health problem, with Indonesia having the second highest number of cases in the world. Although morbidity and mortality rates from TB are still high, the disease is curable with proper treatment. The success of TB therapy can be influenced by various factors such as patient compliance, knowledge about TB, patient motivation, family support, education level, socioeconomic conditions, access to health facilities, the role of health workers, drug side effects, and comorbidities. This study aims to analyze the factors that influence the successful treatment of TB patients at Puskesmas Sentosa Baru. This study used a qualitative method with a cross-sectional descriptive approach, this study involved 15 TB patients who were interviewed in depth until the data reached the point of saturation, as well as observation and documentation. From the results of the research conducted, it was found that the factors that influence the success of patient treatment at Sentosa Baru Health Center are the level of patient compliance, level of knowledge, and patient motivation. Patients who have a better understanding of the disease tend to be more disciplined in undergoing therapy, while family support is a strong driver in improving patient adherence to treatment. Therefore, increased education, monitoring of adherence, and more intensive social support are needed so that patients can complete treatment optimally and break the chain of TB transmission.