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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Lumbung Farmasi : Jurnal Ilmu Kefarmasian Keluwih: Jurnal Kesehatan dan Kedokteran Journal of Economics, Management, Business And Accounting (JEMBA)
Nurul Damayanti
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Glucocorticoid Tapering: a Literature Review Damayanti, Nurul; Sumarno, Sumarno
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.8704

Abstract

Glucocorticoids (GCs), a class of corticosteroids that widely used a variety of diseases, associated physiological processes in the body [1,2]. It has structurally and pharmacologically similar to the endogenous hormone cortisol with various beneficial functions like anti-inflammatory, immunosuppressive, anti-proliferative, and vasoconstrictive effects. As an anti-inflammatory and immunosuppressive effect, corticosteroids through a combination of both inhibition upregulation of gene transcription [3-5]. Despite beneficial effects, they also have side effects that depend on the dose, type of steroid and length of treatments [6]. Short courses of high-dose GCs usually are safe and reasonably well-tolerated, but they do have numerous potential adverse effects [7]. Many of the severe complications occur in long-term use at doses greater than 20 mg of prednisone per day for three weeks or more causes tertiary adrenal insufficiency due to the HPA-axis (Hypothalamic Pituitary Adrenal Axis) suppression by endogenous GCs [8-10]. In this article, we’ll discuss how to manage GCs tapering and when is the right time to use GCs.
PENERAPAN STRATEGI PEMASARAN DALAM MENINGKATKAN OMZET PENJUALAN PADA USAHA KAFE ARAKEL Budi, Mutiara Setia; Ramadhan, Ramadhan; Damayanti, Nurul; Kesumah, Priatna
JEMBA Vol 3 No 2 (2023): Journal of Economics, Management, Business and Accounting
Publisher : Fakultas Ekonomi dan Bisnis Universitas Komputer Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34010/jemba.v3i2.11811

Abstract

Meningkatkan penjualan produk merupakan salah satu cara UMKM menggunakan strategi pemasaran yang efektif. Tujuan dari penelitian di kafe Arakel ini adalah untuk mengetahui bagaimana perusahaan dapat meningkatkan omset penjualan dan teknik pemasaran apa yang digunakan untuk melakukannya. selain itu untuk mempelajari bagaimana kafe Arakel dapat pulih dari kemundurannya. Penelitian ini menggunakan pendekatan deskriptif dengan menggunakan strategi kualitatif. Dengan menggunakan metode observasi dan wawancara yang relevan dengan strategi pemasaran, data dikumpulkan. Temuan penelitian ini menunjukkan bahwa kafe Arakel menghadapi sejumlah masalah, termasuk pelanggan yang sporadis, keharusan merelokasi dan memulai kembali, penjualan yang tidak konsisten, dan biaya produksi yang tidak menentu. Rencana pemasaran yang efektif diperlukan untuk mengatasi hal ini, memastikan aliran pengunjung yang stabil dan peningkatan omset penjualan. Strategi pemasaran kafe Arakel melibatkan penerapan rencana bauran pemasaran sebagai hasil penelitian dan inspeksi di tempat.
A Case Report Capecitabine-Induce Grade II Hand and Foot Syndrome Nurul Damayanti; Putri Ramadhani; Khusnul Fitri Hamidah; Husin Thamrin
Keluwih: Jurnal Kesehatan dan Kedokteran Vol. 6 No. 2 (2025): Keluwih: Jurnal Kesehatan dan Kedokteran (June)
Publisher : Direktorat Penerbitan dan Publikasi Ilmiah, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/kesdok.V6i2.7305

Abstract

Abstract—Capecitabine has a common side effect of hand and foot syndrome (HFS). It is cutaneous capecitabine’s adverse effect, which generally occurs within 11 to 360 days. In this case report assesses the delayed onset of capecitabine because HFS did not occur within 11-360 days but rather took longer, specifically 720 days. A female patient of 82 years old with a history of breast cancer was diagnosed four years ago. She did not undergo radiation and surgery, only capecitabine tablets as neoadjuvant therapy since April 2021. In August 2023, the patient complained of pain, dryness, and blood in both legs. Analysis of side effects of the drug was carried out using the Naranjo Probability Scale. Therapy management during hospitalization involves stopping capecitabine and performing wound care by applying fusidic acid cream and the patient's complaints improved on the eleventh day of therapy. Capecitabine discontinuation is the most effective strategy to minimize the effect of HFS. Further research is to determine the effectiveness of emollient application as a prevention for HFS. Keywords: adverse effects, capecitabine, hand and foot syndrome Abstrak—Sindrom tangan dan kaki efek samping yang sering terjadi pada penggunaan kapesitabine. Efek samping ini merupakan efek samping pada kulit yang terjadi dalam jangka waktu 11 hingga 360 hari. Pada case report ini efek samping tidak terjadi dalam jangka waktu 11-360 hari, terjadi keterlambatan reaksi yang berlangsung pada 720 hari setelah penggunaan kapesitabin. Seorang pasien perempuan berusia 82 tahun dengan riwayat kanker payudara didiagnosis empat tahun lalu. Pasien tidak menjalani radiasi dan operasi, hanya mengonsumsi tablet kapesitabin sebagai terapi neoadjuvan sejak April 2021. Pada Agustus 2023, pasien mengeluhkan nyeri, kulit kering, dan berdarah pada kedua kakinya. Analisis efek samping obat dilakukan dengan menggunakan Skala Probabilitas Naranjo. Penatalaksanaan terapi selama rawat inap meliputi penghentian kapesitabin dan perawatan luka dengan krim asam fusidat dan keluhan pasien membaik di hari ke-11 terapi. Penghentian kapesitabin merupakan strategi yang paling efektif untuk meminimalkan efek HFS. Penelitian selanjutnya adalah untuk menentukan efektivitas pemberian emolien sebagai pencegahan HFS. Kata kunci: efek samping, kapesitabin, sindrom kaki dan tangan
PREVENTION OF DENTAL CARIES THROUGH DENTAL HEALTH EDUCATION AND UTILIZATION OF MARINE PRODUCTS AT ELEMENTARY SCHOOL MUHAMMADIYAH 9 SURABAYA Pinasti, Restika Anindya; Pangabdian, Fani; Damayanti, Nurul
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol. 9 No. 3 (2025): SEPTEMBER
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/abdidos.v9i3.3032

Abstract

Muhammadiyah 9 Elementary School, Surabaya, is geographically located on the coast, so it is often referred to as Bahari Muhammadiyah 9 Elementary School. Based on preliminary survey results, Muhammadiyah 9 Elementary School students frequently consume cariogenic foods, resulting in a high caries index of 4.6. From an educational perspective, the learning method is still relatively conventional and does not align with the "Merdeka Belajar" curriculum, resulting in hampered learning and a lack of student knowledge about maintaining health, especially dental and oral health. Furthermore, the implementation of school dental health activities has not been optimal. Community service methods are carried out through several stages: outreach, training, mentoring and evaluation, and a desire program. The participation of the university community in helping solve the problems facing the community in such environments is essential by providing education and regular dental and oral health checks to reduce the caries index, as well as providing snacks such as sea cucumber jelly candy and anchovy cookies made from seafood, which have anti-cariosis properties. The use of seafood as an alternative to prevent dental caries shows very promising potential. Program Pengabdian kepada Masyarakat Bima 2025: This program has succeeded in raising student awareness of the importance of maintaining dental hygiene and introducing innovative and natural ways to prevent caries.
Kajian Polifarmasi dan Potensi Interaksi Obat Pada Pasien HIV/AIDS di Puskesmas Seberang Padang Kota Padang Ramadhani, Putri; Sakinah, Sakinah; Adriani, Syifa; Damayanti, Nurul; Hijriani, Nursela
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 1 (2026): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i1.37320

Abstract

Sistem imun, dan khususnya sel darah putih, merupakan target dari Human Immunodeficiency Virus (HIV). Acquired immunodeficiency syndrome (AIDS)," merupakan sekumpulan gejala dan indikator penyakit yang terkait dengan melemahnya sistem imun yang disebabkan oleh infeksi HIV. Obat antiretroviral sangat penting untuk pengobatan HIV/AIDS. Namun demikian, interaksi obat dapat terjadi jika banyak obat dikonsumsi secara bersamaan. Tujuan penelitian ini adalah untuk menyelidiki kemungkinan interaksi obat di antara pasien HIV/AIDS di Puskesmas Seberang Padang, Kota Padang, dan untuk mengetahui apakah terdapat hubungan antara frekuensi penggunaan obat dan frekuensi interaksi obat di antara pasien tersebut. Metode penelitian menggunakan desain cross-sectional, pengumpulan data prospektif, dan strategi pengambilan sampel terbatas waktu, penelitian ini memberikan hasil analitis tanpa melakukan eksperimen. Berdasarkan data yang diperoleh, jenis interaksi yang paling umum adalah farmakokinetik, dan insiden interaksi tertinggi berada pada kategori sedang yaitu 96,92%. Dalam penelitian ini, 119 pasien HIV/AIDS memiliki 26,37% kejadian yang berpotensi menyebabkan interaksi obat. Di Puskesmas Seberang Padang, terdapat hubungan linier positif yang signifikan (r=0,618) antara jumlah interaksi obat dan jumlah penggunaan obat oleh pasien HIV/AIDS, menurut analisis statistik. Nilai p 0,000, kurang dari tingkat sig. 0,05.
Probable Neonatal Sepsis : A Retrospective Cross-Sectional Study In Indonesia Nurul Damayanti; Lendy Nugroho; Monique Noorvitrry; Nursela Hijriani; Irsan Fahmi A
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44124

Abstract

Background: Neonates have an immature immune system, making them highly susceptible to infections that can rapidly progress to sepsis and death if not promptly treated. Empiric antibiotics play a critical role in the initial management of neonatal sepsis. However, there is limited local evidence regarding the evaluation of empiric antibiotic therapy in probable neonatal sepsis; 2) Methods: an analytic cross-sectional design collected retrospectively from medical record data from July 2023 to December 2024; 3) Results: A total of 30 neonates with probable sepsis met the inclusion criteria. Most cases were classified as early-onset sepsis (86.67%). Sepsis was more frequently observed in neonates with normal birth weight (53.3%), term gestational age, and those delivered by cesarean section (60.0%). No significant association was found between maternal age, gestational age, or method of delivery and sepsis classification. However, birth weight was significantly associated with sepsis classification (p < 0.05). The most commonly used empiric antibiotic regimen was ampicillin–sulbactam combined with gentamicin (60.6%). No significant association was found between empiric antibiotic use and clinical outcomes (p = 0.76; OR = 1.55; 95% CI: 0.09–27.36) or length of hospital stay (p = 0.71; OR = 1.43; 95% CI: 0.22–9.38) 4) Conclusions: Penicillin–aminoglycoside was the most commonly used empiric regimen and was generally appropriate based on the Gyssens criteria. However, no significant association was found between empiric antibiotic use and clinical outcomes.
Effect of Atorvastatin on Lipoprotein Lipase and Lipid Profile in Children with Refractory Nephrotic Syndrome and Hyperlipidemia Damayanti, Nurul; Yulistiani; Ninik Asmaningsih Soemyarso; Mariyatul Qibtiyah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 13 No. 1 (2026): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v13i12026.84-91

Abstract

Background: Statin are Food and Drug Administration (FDA)-approved for hyperlipidemia but remain controversial in children. This study provides novel evidence of the molecular effects of atorvastatin on lipoprotein lipase (LPL) in children with refractory nephrotic syndrome, a population in which such data are limited. Objectives: This study aims to evaluate the effects of atorvastatin on serum lipoprotein lipase (LPL) levels and lipid profile parameters in children with refractory nephrotic syndrome. Methods: Randomized controlled trial (RCT) double-blind study of 31 children with hyperlipidemia and refractory nephrotic syndrome, included pre- and post-test groups. A placebo was given to the first group (n = 18 patients), while atorvastatin was administered to the treatment group (n = 13 patients). Results: Total cholesterol and Low-Density Lipoprotein (LDL) levels decreased significantly after treatment in both groups (p<0.05). In the atorvastatin group, LDL reduction was more pronounced compared to baseline. High-Density Lipoprotein (HDL) and Triglyceride (TG) levels showed no significant changes in either group (p>0.05). Lipoprotein Lipase (LPL) levels increased in the atorvastatin group and decreased in the control group; however, these changes were not statistically significant. No significant differences were observed between the atorvastatin and control groups in terms of changes in lipid profile parameters and LPL levels (p>0.05). Conclusions: Atorvastatin reduced cholesterol and LDL levels within the treatment group, although no significant differences were observed compared to the control group.
Co-Authors Adriani, Syifa Budi, Mutiara Setia Fani Pangabdian, Fani Irsan Fahmi A kesumah, priatna Khusnul Fitri Hamidah Lendy Nugroho M. Yogi Riyantama Isjoni Mariyatul Qibtiyah Monique Noorvitrry Ninik Asmaningsih Soemyarso NURSELA HIJRIANI Pinasti, Restika Anindya Putri Ramadhani Putri Ramadhani, Putri Sakinah Sakinah Sumarno . Thamrin, Husin Yulistiani