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All Journal Jurnal Biomedika dan Kesehatan MAHESA : Malahayati Health Student Journal
Fazdlurrahman, Fazdlurrahman
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Efektivitas Pemberian Probiotik Bifidobacterium longum Terhadap Pertumbuhan Pseudomonas aeruginosa Pada Mencit (Mus musculus) Adrian, Adrian; Wiriansya, Edward Pandu; Ikram, Dzul; Muchtar, Amrizal; Anshary, Suci Noviyanah; Karim, Marzelina; Fazdlurrahman, Fazdlurrahman; Ahmad, Izhar Fitrah; Faisal, M. Fathir; Usman, Muh. Muflih; Ilham, Muhammad
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.64-72

Abstract

Background Pseudomonas aeruginosa is an opportunistic, Gram-negative bacterium that can cause infections both acutely and chronically. Antibiotics are essential for treating acute bacterial infections. The use of probiotics is one effort to reduce the number of resistant antibiotics. One of the probiotics derived from microorganisms is Bifidobacterium longum. This study was conducted to determine the effectiveness of Bifidobacterium longum on the growth of Pseudomonas aeruginosa in mice (Mus musculus). Methods This study was conducted using the True Experimental Post-test method. The population used was 3- to 4-month-old mice, with a body weight of 20 to 40 grams, as determined by the Federer formula. The mice were fed standard food and given sterile distilled water. A total of 30 mice were tested and divided into five treatment groups. The test carried out is a test of the distribution of the number of colonies. Results Of the five groups studied, the administration of Bifidobacterium longum combined with the antibiotic ceftriaxone in the probiotic intervention group yielded an effective result (p < 0.05), as did the group that received only Bifidobacterium longum probiotics (p < 0.05). at the same time, the other group did not show an effective result (p >0.05). Conclusions Based on the study, it was explained that the administration of Bifidobacterium longum was effective as a supportive and curative group, but not as a preventive measure against the growth of Pseudomonas aeruginosa in mice.
Efektivitas Pemberian Madu Hutan (Apis Dorsata) dalam Mengatasi Infeksi Klebsiella Pneumoniae pada Mencit ( Mus Musculus) Musa, Muh. Muflih Usman; Wiriansya, Edward Pandu; Dwimartyono, Fendy; Mangarengi, Yusriani; Khalid, Nurfadhillah; Ahmad, Izhar Fitrah; Adrian, Adrian; Faisal, Fathir; Fazdlurrahman, Fazdlurrahman; Ilham, Muhammad
MAHESA : Malahayati Health Student Journal Vol 5, No 11 (2025): Volume 5 Nomor 11 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i11.19657

Abstract

ABSTRACT Nosocomial infections, especially those caused by Klebsiella pneumoniae bacteria, are a significant global health problem. The increasing antibiotic resistance encourages the search for alternative therapies, one of which is through the use of natural ingredients such as honey. Honey, especially Apis dorsata wild honey, is known to have antibacterial properties that can inhibit bacterial growth. To evaluate the effectiveness of giving forest honey (Apis dorsata) based on preventive, curative and supportive groups in treating Klebsiella pneumoniae infections in mice. This research uses a quasi experimental post-test method. A total of 30 mice were divided into 5 treatment groups. The test carried out was the Colony Number Distribution Test, then the Normality Test, after finding that the samples were not normally distributed, we chose the Kruskal Wallis Non-Parametric Test and the Mann-Whitney Test.Of the five groups studied, the intervention in the group given forest honey (Apis dorsata) combined with the antibiotic ceftriaxone as well as in the group given first forest honey (Apis dorsata) showed effective results (P<0.05) while the other groups did not show results. effective (P>0.05). Based on research, it was explained that giving forest honey (Apis dorsata) was effective as a preventive and supportive group, but was not effective as a curative group in treating Klebsiella pneumoniae infections in mice. Keywords: Forest Honey (Apis Dorsata), Klebsiella Pneumoniae Infection, Mice (Mus Musculus).  ABSTRAK Infeksi nosokomial, terutama yang disebabkan oleh bakteri Klebsiella pneumoniae, merupakan masalah kesehatan global yang signifikan. Meningkatnya resistensi antibiotik mendorong pencarian alternatif terapi, salah satunya melalui penggunaan bahan alami seperti madu. Madu, khususnya madu hutan Apis dorsata, diketahui memiliki sifat antibakteri yang dapat menghambat pertumbuhan bakteri. Untuk mengevaluasi efektivitas pemberian madu hutan (Apis dorsata) berdasarkan kelompok upaya preventif, kuratif serta supportif dalam mengatasi infeksi Klebsiella pneumoniae pada mencit. Penelitian ini menggunakan metode quasi experimental post-test. Sebanyak 30 ekor mencit dibagi menjadi 5 kelompok perlakuan. Pengujian yang dilakukan adalah Uji Distribusi Jumlah Koloni, lalu kemudian Uji Normalitas, setelah didapatkan sampel tidak terdistribusi normal sehingga kami memilih Uji Non Parametrik Kruskal Wallis serta Uji  Mann-Whitney. Dari lima kelompok yang diteliti, intervensi pada kelompok pemberian madu hutan (Apis dorsata) yang dikombinasi dengan antibiotik ceftriaxone juga pada kelompok yang diberikan terlebih dahulu madu hutan (Apis dorsata) menunjukkan hasil yang efektif (P<0.05) sedangkan kelompok yang lain tidak menunjukkan hasil yang efektif (P>0.05). Berdasarkan penelitian, dijelaskan bahwa pemberian madu hutan (Apis dorsata) efektif sebagai kelompok preventif dan  supportif, namun tidak efektif sebagai kelompok kuratif dalam mengatasi infeksi Klebsiella pneumoniae pada mencit. Kata Kunci: Madu Hutan (Apis Dorsata), Infeksi Klebsiella Pneumoniae, Mencit (Mus Musculus).
Co-Authors Adrian Adrian Ahmad, Izhar Fitrah Amrizal Muchtar Anshary, Suci Noviyanah Faisal, Fathir Faisal, M. Fathir Fendy Dwimartyono Ikram, Dzul Karim, Marzelina Khalid, Nurfadhillah Mangarengi, Yusriani Muhammad Ilham Musa, Muh. Muflih Usman Usman, Muh. Muflih Wiriansya, Edward Pandu