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All Journal Jurnal Biomedika dan Kesehatan Jurnal Respirasi (JR)
Ahmad, Izhar Fitrah
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Effectiveness of Lactobacillus rhamnosus Administration on the Growth of Klebsiella pneumoniae in Mice (Mus musculus) Ahmad, Izhar Fitrah; Wiriansya, Edward Pandu; Anggita, Dwi; Basri, Rezky Pratiwi Lambang; Sodiqah, Yani; Nurmadilla, Nesyana
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.147-152

Abstract

Introduction: Klebsiella pneumoniae is a bacterium from the Enterobacteriaceae family and is considered one of the most dangerous pathogens. Antibiotics are crucial for treating acute bacterial infections. Using probiotics has become one of the supportive and curative efforts in managing the growth of K. pneumoniae. One probiotic derived from microorganisms is Lactobacillus rhamnosus. This study aimed to determine the effectiveness of L. rhamnosus on the growth of K. pneumoniae in mice (Mus musculus). Methods: This was an experimental post-test study. The study population consisted of mice aged 3 to 4 months, weighing 20 to 40 grams, determined using Federer’s formula. Mice were given standard feed and sterile distilled water. A total of 30 mice were tested and divided into five treatment groups. The distribution colony count test was used for evaluation. Results: Among the five groups studied, probiotic intervention in the group receiving a combination of L. rhamnosus and the antibiotic ceftriaxone showed effective results (p<0.05), as did the group given only the probiotic L. rhamnosus (p<0.05). In contrast, the other groups did not show effective results (p>0.05). Conclusion: The administration of L. rhamnosus is effective as a supportive and curative treatment, but it is not effective as a preventive measure against the growth of K. pneumoniae in mice.
Efektivitas Pemberian Probiotik Bifidobacterium longum Terhadap Pertumbuhan Pseudomonas aeruginosa Pada Mencit (Mus musculus) Adrian, Adrian; Wiriansya, Edward Pandu; Ikram, Dzul; Muchtar, Amrizal; Anshary, Suci Noviyanah; Karim, Marzelina; Fazdlurrahman, Fazdlurrahman; Ahmad, Izhar Fitrah; Faisal, M. Fathir; Usman, Muh. Muflih; Ilham, Muhammad
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.64-72

Abstract

Background Pseudomonas aeruginosa is an opportunistic, Gram-negative bacterium that can cause infections both acutely and chronically. Antibiotics are essential for treating acute bacterial infections. The use of probiotics is one effort to reduce the number of resistant antibiotics. One of the probiotics derived from microorganisms is Bifidobacterium longum. This study was conducted to determine the effectiveness of Bifidobacterium longum on the growth of Pseudomonas aeruginosa in mice (Mus musculus). Methods This study was conducted using the True Experimental Post-test method. The population used was 3- to 4-month-old mice, with a body weight of 20 to 40 grams, as determined by the Federer formula. The mice were fed standard food and given sterile distilled water. A total of 30 mice were tested and divided into five treatment groups. The test carried out is a test of the distribution of the number of colonies. Results Of the five groups studied, the administration of Bifidobacterium longum combined with the antibiotic ceftriaxone in the probiotic intervention group yielded an effective result (p < 0.05), as did the group that received only Bifidobacterium longum probiotics (p < 0.05). at the same time, the other group did not show an effective result (p >0.05). Conclusions Based on the study, it was explained that the administration of Bifidobacterium longum was effective as a supportive and curative group, but not as a preventive measure against the growth of Pseudomonas aeruginosa in mice.
Co-Authors Adrian Adrian Amrizal Muchtar Anggita, Dwi Anshary, Suci Noviyanah Basri, Rezky Pratiwi Lambang Faisal, M. Fathir Fazdlurrahman, Fazdlurrahman Ikram, Dzul Karim, Marzelina Muhammad Ilham Nurmadilla, Nesyana Sodiqah, Yani Usman, Muh. Muflih Wiriansya, Edward Pandu