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All Journal Majalah Kedokteran Bandung Jurnal Biomedika dan Kesehatan
Anshary, Suci Noviyanah
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Efektivitas Pemberian Probiotik Bifidobacterium longum Terhadap Pertumbuhan Pseudomonas aeruginosa Pada Mencit (Mus musculus) Adrian, Adrian; Wiriansya, Edward Pandu; Ikram, Dzul; Muchtar, Amrizal; Anshary, Suci Noviyanah; Karim, Marzelina; Fazdlurrahman, Fazdlurrahman; Ahmad, Izhar Fitrah; Faisal, M. Fathir; Usman, Muh. Muflih; Ilham, Muhammad
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.64-72

Abstract

Background Pseudomonas aeruginosa is an opportunistic, Gram-negative bacterium that can cause infections both acutely and chronically. Antibiotics are essential for treating acute bacterial infections. The use of probiotics is one effort to reduce the number of resistant antibiotics. One of the probiotics derived from microorganisms is Bifidobacterium longum. This study was conducted to determine the effectiveness of Bifidobacterium longum on the growth of Pseudomonas aeruginosa in mice (Mus musculus). Methods This study was conducted using the True Experimental Post-test method. The population used was 3- to 4-month-old mice, with a body weight of 20 to 40 grams, as determined by the Federer formula. The mice were fed standard food and given sterile distilled water. A total of 30 mice were tested and divided into five treatment groups. The test carried out is a test of the distribution of the number of colonies. Results Of the five groups studied, the administration of Bifidobacterium longum combined with the antibiotic ceftriaxone in the probiotic intervention group yielded an effective result (p < 0.05), as did the group that received only Bifidobacterium longum probiotics (p < 0.05). at the same time, the other group did not show an effective result (p >0.05). Conclusions Based on the study, it was explained that the administration of Bifidobacterium longum was effective as a supportive and curative group, but not as a preventive measure against the growth of Pseudomonas aeruginosa in mice.
Effectiveness of Red Ginger (Zingiber Officinale Var. Rubrum) Hydrogel Extract as a Fever Reducer in Mice (Mus Musculus) Panna, Syafril S.; Kartika, Irna Diyana; Irwan, Andi Alamanda; Ardiansar, Abdul Mubdi; Anshary, Suci Noviyanah
Majalah Kedokteran Bandung Vol 57, No 4 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Fever is a common physiological response to infection, and its management is crucial to prevent complications such as dehydration and organ damage. While pharmacological treatments like antipyretics are commonly used, there is a growing interest in exploring natural alternatives. Red ginger (Zingiber officinale var. rubrum) has shown potentials as a natural antipyretic due to its active compound, gingerol, which inhibits prostaglandin synthesis and reduces inflammation. This study aimed to evaluate the efficacy of red ginger-based hydrogel formulations in managing fever. Male albino mice were used as test subjects, with fever induced via subcutaneous injection of peptone solution. Three concentrations of red ginger extract (3%, 5%, and 10%) in hydrogel form were tested. Temperature changes were recorded at 15-minute intervals for 60 minutes post-treatment. Results showed that the 5% red ginger hydrogel formulation demonstrated the most significant temperature reduction, with an average decrease of 8.2°C when compared to 4.65°C in the 3% formulation and 4.45°C in the 10% formulation. The 5% formulation also displayed optimal physical properties, including viscosity and pH stability, ensuring efficient absorption of the active compounds. The 10% formulation showed reduced effectiveness due to its high viscosity, which impaired absorption. In conclusion, the 5% red ginger hydrogel formulation is the most effective concentration to reduce fever, highlighting its potential as a natural, affordable, and accessible alternative to conventional antipyretic treatments. Future studies should further explore its clinical applications and scalability in diverse healthcare settings
Co-Authors Adrian Adrian Ahmad, Izhar Fitrah Amrizal Muchtar Ardiansar, Abdul Mubdi Faisal, M. Fathir Fazdlurrahman, Fazdlurrahman Ikram, Dzul Irna Diyana Kartika Irwan, Andi Alamanda Karim, Marzelina Muhammad Ilham Panna, Syafril S. Usman, Muh. Muflih Wiriansya, Edward Pandu