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All Journal Jurnal Biologi Tropis Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Indonesian Journal of Health and Medical Education
Muliana, Atriska Citra
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Literature Study: Primary Immunodeficiency Rahmadinna, Sandia Anggun; Yuar, Alana Akmal; Musyafa, Aulia Putri; Hardiant, Excell Defry; Putri, Baiq Ghefira Rojwani; Muliana, Atriska Citra; Salsabila, Septy Rianty Putri; Ningrum, Sania Tresna; Narendra, Ahmad Wahyu; Ramadhania, Yasmine Najla; Habib, Philip
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10168

Abstract

Abnormalities in immune system development and function result in increased susceptibility to infection and reactivation of latent infections. Other immunodeficiencies can result in mild infections and may first be detected in adulthood. This literature review aims to discuss primary immunodeficiencies, including their definition, causes, treatment, and examples of the diseases they cause. This literature review was compiled through a literature search method by reviewing various scientific journals obtained from databases such as PubMed, Google Scholar, and ScienceDirect. The results Primary immunodeficiency disease (PID) results from immune system defects caused by mutations in the genetic code that codes for components of the body's immune system. PID is broadly classified as either a disorder of adaptive immunity (T-cell, B-cell, or combined immune deficiencies) or innate immunity (phagocyte and complement deficiencies). Patients with PID may experience a variety of lung problems, including recurrent lower respiratory tract infections, lung parenchymal abnormalities, asthma, ventilation abnormalities, and bronchiectasis (BE). In conclusion, primary immunodeficiency disease (PID) refers to a large, heterogeneous group of disorders characterized by abnormalities in the development and/or function of the immune system. These conditions result from immune system defects caused by mutations in the genetic code that codes for components of the body's immune system.
Understanding Precocious Puberty: When Childhood Ends Too Soon Muliana, Atriska Citra; Putri, Imey Pinasty Harianto; Prasetya, Rangga Cahya; Indratama, I Nyoman Yudayana; Athalia, Ihza Namira; Shafitri, Shira Shalsabina; Mertasari, Baiq Merna; Josafat, Gantha Narendra; Ilmiah, Janiya Abdila; As Shiddiq, Muhammad Hilmy; Aulia, Rashieka Salma; Ajmala, Indana Eva
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10337

Abstract

Precocious puberty is an endocrine disorder characterized by the premature development of secondary sexual characteristics, defined as occurring before the age of 8 in girls and 9 in boys. This literature review aims to understand precocious puberty: when childhood ends too soon. The article was compiled using a literature review method. Data were obtained through a search of various scientific sources, including international and national journals, textbooks, and clinical guidelines from the Indonesian Pediatrician Association (IDAI). Central precocious puberty, most often idiopathic in girls but associated with underlying pathology in boys, is caused by premature activation of the hypothalamic-pituitary-gonadal axis, while the peripheral form is caused by excess sex steroid production independent of gonadotropin stimulation. Clinical manifestations include early breast development, testicular enlargement, rapid linear growth, acne, and the early appearance of pubic or axillary hair. Diagnosis relies on a combination of careful history taking, physical examination, hormonal testing, bone age assessment, and imaging studies such as pelvic ultrasound or cranial MRI when indicated. Management strategies vary based on etiology, with gonadotropin-releasing hormone (GnRH) agonists being the standard treatment for central precocious puberty, while surgical or medical therapy is used for peripheral causes. In conclusion, precocious puberty is a childhood health issue of increasing concern due to its increasing global incidence. This condition not only impacts accelerated bone maturation and potential short stature in adulthood, but also impacts the child's psychological well-being and causes emotional distress to the family.
Case Study of Bilateral Ureteral Stones Complicated by Acute Kidney Injury in a 52-Year-Old Female Patient Ilmiah, Janiya Abdila; Putri, Imey Pinasty Harianto; Muliana, Atriska Citra; Athalia, Ihza Namira; Shafitri, Shira Shalsabina; Sari, Baiq Merna Merta; Aulia, Rashieka Salma; Prasetya, Rangga Cahya; Indratama, I Nyoman Yudayana; Shiddiq, Muhammad Hilmy As; Josafat, Gantha Narendra
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10344

Abstract

Bilateral ureteral stones are a rare clinical manifestation of renal colic, obstructing urine flow, and can cause severe acute kidney injury (AKI) within hours. This case study aims to provide information regarding the diagnosis and management of bilateral ureteral stones causing acute kidney injury in a 52-year-old female patient. This case study uses a descriptive method to describe the current situation, for further analysis and interpretation. Based on anamnesis and physical examination, the patient was diagnosed with Acute Kidney Injury (AKI) stage 3 with a differential diagnosis of Advanced Chronic Kidney Disease (ACKD) stage 4. This condition is caused by urinary tract obstruction due to bilateral ureterolithiasis (stones in both ureters) and proximal right ureteral stenosis, which inhibits urine flow and worsens kidney function acutely and chronically. Complaints of right and left abdominal pain, as well as a history of urinary tract infections (UTIs) and hypertension, support the formation of stones in the urinary tract. The conclusion is that the patient Wirni/P/52 years old/AKI stage 3 dd ACKD stage 4 dt obstructive uropathy + ureterolithiasis infection + normocytic normochromic anemia dt chronic disease + bilateral ureteral stones + right proximal ureteral stenosis.
Tumor Embrionik Sistem Saraf Pusat Ilmiah, Janiya Abdilla; Sari, Baiq Merna Merta; Muliana, Atriska Citra
Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Vol 6, No 4 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i4.834

Abstract

Penelitian ini bertujuan untuk mengkaji tentang Central Nervous System Embryonal Tumors dalam perkembangan sumber literatur dan temuan penelitian yang sedang dilakukan. Metode penelitian yang digunakan adalah penelitian dengan tinjauan studi literatur yang ada di berbagai sumber referensi data primer dan sekunder. Analisis data yang dilakukan dengan memperdalam temuan analisis data pada sumber -sumber literatur yang ada. Hasil penelitian menunjukkan bahwa Tumor embrional sistem saraf pusat (SSP) adalah neoplasma agresif yang umum terjadi pada anak-anak, dengan jenis paling sering seperti medulloblastoma, pineoblastoma, dan ETMR. Tumor ini berasal dari sel embrional yang belum matang dan berkembang cepat, sering menyebar dalam SSP. Faktor genetik, seperti mutasi TP53, NF2, dan MYC, serta jalur molekuler seperti Hedgehog, berperan besar dalam perkembangan tumor ini. Paparan radiasi juga bisa menjadi faktor risiko. Penanganan meliputi pembedahan, radioterapi, kemoterapi, terapi target, dan imunoterapi. Namun, terapi pada anak-anak masih menimbulkan tantangan karena efek samping jangka panjang, sehingga dibutuhkan pendekatan yang lebih efektif dan spesifik.
PATHOPHYSIOLOGY OF SKIN AGING: ROLE OF OXIDATIVE STRESS, INFLAMMATION, AND DERMAL REMODELING Sari, Baiq Merna Merta; Putri, Imey Pinasty Harianto; Muliana, Atriska Citra; Shafitri, Shira Shalsabina; Ilmiah, Janiya Abdila; Athalia, Ihza Namira; Aulia, Rashieka Salma; Josafat, Gantha Narendra; Shiddiq, Muhammad Hilmy As; Indratama, I Nyoman Yudayana; Prasetya, Rangga Cahya; Nurhidayati, Nurhidayati
Indonesian Journal of Health and Medical Education Vol. 1 No. 1 (2026): Edisi Januari-Juni 2026
Publisher : Indonesian Publication Center

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The skin, as the largest organ of the human body, plays a vital role in protecting the internal systems from external environments. As age increases, the skin undergoes two types of aging: intrinsic, caused by genetic and hormonal factors, and extrinsic, due to environmental factors such as ultraviolet (UV) radiation and pollution. The aging process is characterized by a decrease in fibroblasts, which are responsible for producing collagen and elastin, leading to a reduction in skin strength and elasticity. Oxidative stress resulting from the accumulation of reactive oxygen species (ROS) contributes to DNA damage and triggers inflammatory responses that accelerate aging, manifesting as wrinkles and sagging skin. Chronic inflammation, induced by ROS, further supports premature aging by increasing inflammatory substances that cause redness and irritation of the skin. Additionally, dermal remodeling is a physiological process essential for maintaining healthy skin. Still, it can become pathological if there is an imbalance between synthesis and degradation of the extracellular matrix, thereby hastening signs of aging such as wrinkles and sagging skin. In efforts to combat skin aging, several pharmacological aspects, such as topical therapies using sunscreens, retinoids, and alpha hydroxy acids (AHAs), have proven effective. Furthermore, systemic antioxidant supplementation also contributes to skin condition improvement. This comprehensive review provides valuable insights into the mechanisms of skin aging, the importance of skincare, and therapeutic strategies to counteract premature aging.
GUNSTOCK DEFORMITY OF THE ELBOW: CLINICAL FEATURES, BIOMECHANICS, AND CURRENT TREATMENT STRATEGIES: A LITERATURE REVIEW Athalia, Ihza Namira; Putri, Imey Pinasty Harianto; Muliana, Atriska Citra; Shafitri, Shira Shalsabina; Ilmiah, Janiya Abdila; Sari, Baiq Merna Merta; Aulia, Rashieka Salma; Josafat, Gantha Narendra; Shiddiq, Muhammad Hilmy As; Indratama, I Nyoman Yudayana; Prasetya, Rangga Cahya; Nurhidayati, Nurhidayati
Indonesian Journal of Health and Medical Education Vol. 1 No. 1 (2026): Edisi Januari-Juni 2026
Publisher : Indonesian Publication Center

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Abstract

Gunstock deformity, also known as cubitus varus, is a common complication that arises after supracondylar humerus fractures in children, primarily due to malunion of the bone. This condition results in an inward deviation of the forearm when the elbow is in full extension, creating a pronounced change in contour that can significantly impact biomechanical function and the quality of life of the patient. Common clinical symptoms include pain on the lateral side of the elbow, limited range of motion, and joint instability, particularly associated with ulnar neuropathy. Diagnosis is established through physical examination and radiological imaging to identify the angle of deviation and malalignment. Management of this deformity varies based on severity, ranging from observation in mild cases to surgical interventions like osteotomy in more severe cases. Common corrective techniques include lateral closing wedge osteotomy and dome osteotomy, aimed at restoring anatomical alignment and preventing long-term complications. Postoperative rehabilitation is crucial for regaining joint function and muscle strength. Long-term prognosis is generally good; however, it requires appropriate management to avoid complications like joint stiffness and ulnar neuropathy. A comprehensive approach encompassing diagnosis, deformity correction, and rehabilitation is essential for achieving optimal functional outcomes.
Co-Authors Ajmala, Indana Eva As Shiddiq, Muhammad Hilmy Athalia, Ihza Namira Aulia, Rashieka Salma Habib, Philip Hardiant, Excell Defry Ilmiah, Janiya Abdila Ilmiah, Janiya Abdilla Indratama, I Nyoman Yudayana Josafat, Gantha Narendra Mertasari, Baiq Merna Musyafa, Aulia Putri Narendra, Ahmad Wahyu Ningrum, Sania Tresna Nurhidayati Nurhidayati Prasetya, Rangga Cahya Putri, Baiq Ghefira Rojwani Putri, Imey Pinasty Harianto Rahmadinna, Sandia Anggun Ramadhania, Yasmine Najla Salsabila, Septy Rianty Putri Sari, Baiq Merna Merta Shafitri, Shira Shalsabina Yuar, Alana Akmal