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Muliana, Atriska Citra
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Literature Study: Primary Immunodeficiency Rahmadinna, Sandia Anggun; Yuar, Alana Akmal; Musyafa, Aulia Putri; Hardiant, Excell Defry; Putri, Baiq Ghefira Rojwani; Muliana, Atriska Citra; Salsabila, Septy Rianty Putri; Ningrum, Sania Tresna; Narendra, Ahmad Wahyu; Ramadhania, Yasmine Najla; Habib, Philip
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10168

Abstract

Abnormalities in immune system development and function result in increased susceptibility to infection and reactivation of latent infections. Other immunodeficiencies can result in mild infections and may first be detected in adulthood. This literature review aims to discuss primary immunodeficiencies, including their definition, causes, treatment, and examples of the diseases they cause. This literature review was compiled through a literature search method by reviewing various scientific journals obtained from databases such as PubMed, Google Scholar, and ScienceDirect. The results Primary immunodeficiency disease (PID) results from immune system defects caused by mutations in the genetic code that codes for components of the body's immune system. PID is broadly classified as either a disorder of adaptive immunity (T-cell, B-cell, or combined immune deficiencies) or innate immunity (phagocyte and complement deficiencies). Patients with PID may experience a variety of lung problems, including recurrent lower respiratory tract infections, lung parenchymal abnormalities, asthma, ventilation abnormalities, and bronchiectasis (BE). In conclusion, primary immunodeficiency disease (PID) refers to a large, heterogeneous group of disorders characterized by abnormalities in the development and/or function of the immune system. These conditions result from immune system defects caused by mutations in the genetic code that codes for components of the body's immune system.
Understanding Precocious Puberty: When Childhood Ends Too Soon Muliana, Atriska Citra; Putri, Imey Pinasty Harianto; Prasetya, Rangga Cahya; Indratama, I Nyoman Yudayana; Athalia, Ihza Namira; Shafitri, Shira Shalsabina; Mertasari, Baiq Merna; Josafat, Gantha Narendra; Ilmiah, Janiya Abdila; As Shiddiq, Muhammad Hilmy; Aulia, Rashieka Salma; Ajmala, Indana Eva
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10337

Abstract

Precocious puberty is an endocrine disorder characterized by the premature development of secondary sexual characteristics, defined as occurring before the age of 8 in girls and 9 in boys. This literature review aims to understand precocious puberty: when childhood ends too soon. The article was compiled using a literature review method. Data were obtained through a search of various scientific sources, including international and national journals, textbooks, and clinical guidelines from the Indonesian Pediatrician Association (IDAI). Central precocious puberty, most often idiopathic in girls but associated with underlying pathology in boys, is caused by premature activation of the hypothalamic-pituitary-gonadal axis, while the peripheral form is caused by excess sex steroid production independent of gonadotropin stimulation. Clinical manifestations include early breast development, testicular enlargement, rapid linear growth, acne, and the early appearance of pubic or axillary hair. Diagnosis relies on a combination of careful history taking, physical examination, hormonal testing, bone age assessment, and imaging studies such as pelvic ultrasound or cranial MRI when indicated. Management strategies vary based on etiology, with gonadotropin-releasing hormone (GnRH) agonists being the standard treatment for central precocious puberty, while surgical or medical therapy is used for peripheral causes. In conclusion, precocious puberty is a childhood health issue of increasing concern due to its increasing global incidence. This condition not only impacts accelerated bone maturation and potential short stature in adulthood, but also impacts the child's psychological well-being and causes emotional distress to the family.
Case Study of Bilateral Ureteral Stones Complicated by Acute Kidney Injury in a 52-Year-Old Female Patient Ilmiah, Janiya Abdila; Putri, Imey Pinasty Harianto; Muliana, Atriska Citra; Athalia, Ihza Namira; Shafitri, Shira Shalsabina; Sari, Baiq Merna Merta; Aulia, Rashieka Salma; Prasetya, Rangga Cahya; Indratama, I Nyoman Yudayana; Shiddiq, Muhammad Hilmy As; Josafat, Gantha Narendra
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10344

Abstract

Bilateral ureteral stones are a rare clinical manifestation of renal colic, obstructing urine flow, and can cause severe acute kidney injury (AKI) within hours. This case study aims to provide information regarding the diagnosis and management of bilateral ureteral stones causing acute kidney injury in a 52-year-old female patient. This case study uses a descriptive method to describe the current situation, for further analysis and interpretation. Based on anamnesis and physical examination, the patient was diagnosed with Acute Kidney Injury (AKI) stage 3 with a differential diagnosis of Advanced Chronic Kidney Disease (ACKD) stage 4. This condition is caused by urinary tract obstruction due to bilateral ureterolithiasis (stones in both ureters) and proximal right ureteral stenosis, which inhibits urine flow and worsens kidney function acutely and chronically. Complaints of right and left abdominal pain, as well as a history of urinary tract infections (UTIs) and hypertension, support the formation of stones in the urinary tract. The conclusion is that the patient Wirni/P/52 years old/AKI stage 3 dd ACKD stage 4 dt obstructive uropathy + ureterolithiasis infection + normocytic normochromic anemia dt chronic disease + bilateral ureteral stones + right proximal ureteral stenosis.
Co-Authors Ajmala, Indana Eva As Shiddiq, Muhammad Hilmy Athalia, Ihza Namira Aulia, Rashieka Salma Habib, Philip Hardiant, Excell Defry Ilmiah, Janiya Abdila Indratama, I Nyoman Yudayana Josafat, Gantha Narendra Mertasari, Baiq Merna Musyafa, Aulia Putri Narendra, Ahmad Wahyu Ningrum, Sania Tresna Prasetya, Rangga Cahya Putri, Baiq Ghefira Rojwani Putri, Imey Pinasty Harianto Rahmadinna, Sandia Anggun Ramadhania, Yasmine Najla Salsabila, Septy Rianty Putri Sari, Baiq Merna Merta Shafitri, Shira Shalsabina Shiddiq, Muhammad Hilmy As Yuar, Alana Akmal