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All Journal Jurnal Biologi Tropis Mandala of Health : A Scientific Journal
Ramadhania, Yasmin Najla
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Public Health

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PROTECTIVE ROLE OF HUMAN BREAST MILK AGAINST NECROTIZING ENTEROCOLITIS IN PRETERM INFANTS Putri, Dyah Arista; Patandianan, Firdaus Kamma; Latifa, Nindy Citra; Ramadhania, Yasmin Najla; Rofilah, Alita Khainur; Maharani, Baiq Syarifaturrayyan; Yassa, I Wayan Radityakara Wirasena; Arigi, Lalu Ahmad Gamal
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17753

Abstract

Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal disease that predominantly affects preterm infants, with high rates of morbidity and mortality. Human breast milk (HBM) has long been recognized as the most effective nutritional intervention for preventing NEC due to its unique bioactive components such as immunoglobulins, lactoferrin, glutamine, vitamins, and human milk oligosaccharides (HMOs), which act through mechanisms including strengthening the intestinal barrier, modulating immune responses, and regulating the gut microbiota. This narrative review aims to synthesize recent evidence on the protective role of HBM against NEC, with particular emphasis on the function of HMOs, probiotics, and complementary nutritional interventions designed to replicate or enhance HBM’s bioactivity. The methods applied in this review followed a narrative literature search in PubMed, Scopus, and Google Scholar for studies published between 2015 and 2025 on the effects of breastfeeding on NEC risk in preterm infants, using predefined eligibility criteria. The findings indicate that HBM significantly reduces NEC incidence, while supplemental interventions such as prebiotics and probiotics may serve as complementary strategies, particularly when the availability of mother’s own milk is limited. Overall, HBM remains the primary protective factor against NEC, and optimizing its provision in neonatal care is critical for improving outcomes among preterm infants.
Association between WASH Related Risk Factors and Stunting Among 6-24 Month Children at Puyung Health Center Ramadhania, Yasmin Najla; Nurbaiti, Lina; Hasby, Amelia Ramdani
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10307

Abstract

A condition known as stunting happens when linear development falls short of its full potential, especially if it happens within the first 1000 days of life. Stunting prevalence in Indonesia was 21.5% in 2023, with a rate of 17.5% in Lombok Tengah District, West Nusa Tenggara Province. This study explores the relationship between WASH-related risk factors and stunting among children 6-24 months in Puyung Health Center area, Lombok Tengah District. This study is an observasional analytical research with a cross-sectional design. The research subjects included of 90 mothers or caregivers of children aged 6-24 month in Puyung Health Center are, Lombok Tengah Disctrict. Sampling was conducted through stratified random sampling. Data were collected using the KIA and a modified SSGI questionnaire 2022. The chi-square test was used for a bivariate data analysis. According to the statistical analysis of 90 respondents, 46 respondents (51.1%) were categorized as having no WASH-related hazards, while 49 infants (54.5%) suffered from stunting. A p-value of 0.821 (p>0.05) was achieved following a bivariate analysis using the chi-square test. These findings suggest that the prevalence of stunting in babies aged 6 to 24 months and in the Puyung Health Center region of the Central Lombok District do not significantly correlate with WASH risk factors. In the Puyung Health Center region of the Central Lombok District, there is no discernible link between stunting and WASH risk factors in children aged 6 to 24 months.
Co-Authors Arigi, Lalu Ahmad Gamal Hasby, Amelia Ramdani Latifa, Nindy Citra Lina Nurbaiti, Lina Maharani, Baiq Syarifaturrayyan Patandianan, Firdaus Kamma Putri, Dyah Arista Rofilah, Alita Khainur Yassa, I Wayan Radityakara Wirasena