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All Journal Jurnal Biologi Tropis Jurnal Abdi Insani Mandala of Health : A Scientific Journal
Patandianan, Firdaus Kamma
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Public Health

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PROTECTIVE ROLE OF HUMAN BREAST MILK AGAINST NECROTIZING ENTEROCOLITIS IN PRETERM INFANTS Putri, Dyah Arista; Patandianan, Firdaus Kamma; Latifa, Nindy Citra; Ramadhania, Yasmin Najla; Rofilah, Alita Khainur; Maharani, Baiq Syarifaturrayyan; Yassa, I Wayan Radityakara Wirasena; Arigi, Lalu Ahmad Gamal
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17753

Abstract

Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal disease that predominantly affects preterm infants, with high rates of morbidity and mortality. Human breast milk (HBM) has long been recognized as the most effective nutritional intervention for preventing NEC due to its unique bioactive components such as immunoglobulins, lactoferrin, glutamine, vitamins, and human milk oligosaccharides (HMOs), which act through mechanisms including strengthening the intestinal barrier, modulating immune responses, and regulating the gut microbiota. This narrative review aims to synthesize recent evidence on the protective role of HBM against NEC, with particular emphasis on the function of HMOs, probiotics, and complementary nutritional interventions designed to replicate or enhance HBM’s bioactivity. The methods applied in this review followed a narrative literature search in PubMed, Scopus, and Google Scholar for studies published between 2015 and 2025 on the effects of breastfeeding on NEC risk in preterm infants, using predefined eligibility criteria. The findings indicate that HBM significantly reduces NEC incidence, while supplemental interventions such as prebiotics and probiotics may serve as complementary strategies, particularly when the availability of mother’s own milk is limited. Overall, HBM remains the primary protective factor against NEC, and optimizing its provision in neonatal care is critical for improving outcomes among preterm infants.
Chronic Myeloid Leukemia: Etiology, Risk Factors, Pathophysiology, Diagnosis, Management, and Prognosis Patandianan, Firdaus Kamma; Hasanah, Mielosita; Mikaila, Romy Healthy; Athalia, Ihza Namira; Nitzana, Lale Nubya; Hairy, Fathinah Salsabila
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10589

Abstract

The Philadelphia chromosome is a hallmark of Chronic Myeloid Leukemia (CML), a hematopoietic stem cell disease caused by the reciprocal translocation t(9;22)(q34;q11) that creates the oncogenic fusion gene BCR-ABL1, which persistently activates tyrosine kinase and encourages unchecked myeloid cell proliferation. This literature review aims to describe the pathophysiology, clinical manifestations, diagnosis, treatment, and prognosis of CML based on recent studies. Literature searches were conducted through PubMed, Google Scholar, and official institutional websites using the keywords “Chronic Myeloid Leukemia,” “Philadelphia chromosome,” and “BCR-ABL1.” CML accounts for approximately 15–20% of all leukemia cases and progresses through three phases: chronic, accelerated, and blast crisis. The BCR-ABL1 fusion gene constitutively activates multiple oncogenic pathways, including JAK/STAT, PI3K/AKT, and RAS/RAF, leading to enhanced proliferation and resistance to apoptosis. Diagnosis is established through hematologic examination and molecular testing using PCR or FISH for BCR-ABL1 detection. The mainstay treatments include tyrosine kinase inhibitors such as imatinib, dasatinib, and nilotinib, with stem cell transplantation reserved for advanced cases. With early diagnosis and appropriate therapy, overall survival exceeds 80% at eight years. In conclusion, CML is a chronic hematologic malignancy driven by BCR-ABL1, and advances in molecular-targeted therapy have transformed it into a manageable chronic disease with significantly improved patient outcomes.
EDUKASI POLA MAKAN SEHAT DAN AKTIVITAS FISIK MENGGUNAKAN BOARD GAME DI PANTI ASUHAN DHARMA LAKSANA KOTA MATARAM Sari, Dian Puspita; Abdiman, I Made Tobias; Maringka, Kezia Michella Yusak; Manafe, Winda; Patandianan, Firdaus Kamma
Jurnal Abdi Insani Vol 11 No 3 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i3.1898

Abstract

The prevalence of obesity among children and adolescents is rising globally, leading to short- and long-term health issues such as type 2 diabetes (Type 2 DM). While obesity has multiple causes, modifiable lifestyle factors like diet and physical activity can reduce the risk Indonesian children are exposed to high-sugar, low-nutrient foods and engage in limited physical activity, increasing their risk for obesity and Type 2 DM. Although children depend on adults for food, they must learn to make healthy choices early on. This community service activity aimed to improve knowledge and promote healthy eating and physical activity among foster children at the Dharma Laksana Orphanage in Mataram City. A brief survey found that 33-60% of the children chose high-sugar foods over healthier options. Education was delivered through presentations and a custom-developed board game, "Pilah Pilih" (Select and Choose), which included a storybook and guide. Forty children and two caregivers participated. Post-activity evaluations showed 60% of children scored above 70 in knowledge assessments, with a highest score of 85. Feedback on the game indicated positive engagement and enthusiasm for replay. The "Pilah Pilih" board game shows potential as an effective educational tool to encourage behavioral change through repeated play.
Co-Authors Abdiman, I Made Tobias Arigi, Lalu Ahmad Gamal Athalia, Ihza Namira Dian Puspita Sari Hairy, Fathinah Salsabila Hasanah, Mielosita Latifa, Nindy Citra Maharani, Baiq Syarifaturrayyan Manafe, Winda Maringka, Kezia Michella Yusak Mikaila, Romy Healthy Nitzana, Lale Nubya Putri, Dyah Arista Ramadhania, Yasmin Najla Rofilah, Alita Khainur Yassa, I Wayan Radityakara Wirasena