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All Journal Biomedical Journal of Indonesia Health and Medical Journal Nusantara Hasana Journal
Jaslindo, Lieka Nugrahi
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Cellular Mechanisms of Spatial Memory Recovery via Hyperbaric Oxygen Therapy in Experimental TBI: A Review Jaslindo, Lieka Nugrahi; Ibrahim, Nurhadi
Biomedical Journal of Indonesia Vol. 11 No. 3 (2025): Vol 11, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i3.267

Abstract

Traumatic Brain Injury (TBI) impairs spatial memory, affects individuals' quality of life, and increases disability and mortality rates. Hyperbaric Oxygen Therapy (HBOT), which delivers nearly 100% oxygen in a pressurised environment, has a potential intervention to ameliorate these cognitive deficits. This narrative review presents evidence from animal studies demonstrating the efficacy of HBOT in enhancing spatial memory in rats with TBI. Specifically, we present evidence that HBOT increases levels of Brain-Derived Neurotrophic Factor (BDNF) and activates the Hypoxia-Inducible Factor 1-alpha (HIF-1α) pathway. These molecular changes foster neuroplasticity and reduce oxidative stress, thereby promoting the repair and growth of dendritic spines and decreasing Reactive Oxygen Species (ROS) levels to prevent neuronal death. By elucidating these mechanisms, this review shows how HBOT contributes to spatial memory recovery in TBI, suggesting a promising therapeutic avenue that need further clinical exploration to refine treatment protocols and evaluate its applicability in human TBI recovery.
DIFFERENCES BETWEEN FOREHEAD AND BACK OF THE HAND TEMPERATURE MEASUREMENTS USING NON-CONTACT INFRARED THERMOMETERS IN HEALTHY YOUNG ADULTS Hansah, Rendri Bayu; Dimas, Gusti Muhammad; Handayani, Kurnia Maidarmi; Sari, Widia; Maribeth, Annisa Lidra; Jaslindo, Lieka Nugrahi
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1848

Abstract

The COVID-19 pandemic necessitated the implementation of rapid, safe, and non-invasive body temperature screening methods to facilitate early identification of potentially infectious individuals. Non-contact infrared thermometers have therefore been widely adopted for this purpose. However, concerns have been raised regarding the accuracy of temperature measurements obtained from different anatomical sites, particularly in the context of increased reliance on alternative measurement locations such as the back of the hand (dorsum manus regio). This study aimed to compare body temperature measurements obtained from the forehead and dorsum manus using a non-contact infrared thermometer, with axillary temperature measured by a digital thermometer as a reference. An analytical observational study with repeated measures was conducted among 70 third-year medical students at Universitas Baiturrahmah. Temperature measurements were performed at the forehead, dorsum manus, and axilla, and participants were divided into control and intervention groups based on environmental measurement conditions. Repeated measures ANOVA revealed significant differences between forehead temperature and both dorsum manus and axillary temperatures, while no significant difference was observed between dorsum manus and axillary measurements. Independent t-tests showed no significant differences between control and intervention groups. These findings suggest that dorsum manus temperature measurements may approximate axillary values under stable conditions in healthy young adults, although caution is required when generalizing to other populations or clinical settings.
Vitamin D and Traumatic Brain Injury: A Systematic Review of Preclinical Evidence Jaslindo, Lieka Nugrahi; Sari, Widia; Dhuha, Alief; Handayani, Kurnia Maidarmi; Khudri, Ghaniyyatul Nugrahi; Maribeth, Annisa Lidra
Health and Medical Journal Vol. 8 No. 1 (2026): HEME January 2026
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v8i1.2096

Abstract

Traumativ Brain Injury (TBI) triggers multiple secondary injury processes, such as inflammation, oxidative stress, apoptosis, BBB disruption, and impaired autophagy. These mechanisms contribute to progressive neuronal damage and functional decline. Vitamin D has emerged as a potential multi-target neuroprotective agent due to its regulatory roles in immune signaling, oxidative balance, neuronal survival, and autophagy pathways. This systematic review synthesized preclinical evidence evaluating the effects of Vitamin D supplementation in animal models of TBI. A comprehensive search of PubMed, OVID, and ProQuest identified six eligible studies. Across diverse dosing regimens and formulations, Vitamin D consistently improved key TBI outcomes. Reported benefits included reduced apoptosis, decreased neuroinflammation, attenuation of oxidative stress, preservation of BBB integrity, restoration of autophagy flux, and enhanced cognitive performance. Mechanistically, Vitamin D influenced several pathways, including Nrf2 activation, TLR4/MyD88/NF-κB suppression, mTOR and TRPM2 normalization, and improved microglial polarization. Although methodological quality varied, most studies demonstrated moderate rigor and supported the neuroprotective actions of Vitamin D. Heterogeneity in injury models, dosing strategies, and outcome measures limits direct comparison and highlights the need for standardized experimental approaches. Overall, current preclinical evidence indicates that Vitamin D confers robust neuroprotection following TBI. Further studies examining its mechanistic pathways, optimal therapeutic windows, and translational potential are warranted to inform future clinical applications.
Co-Authors Dhuha, Alief Dimas, Gusti Muhammad Hansah, Rendri Bayu Khudri, Ghaniyyatul Nugrahi Kurnia Maidarmi Handayani Maribeth, Annisa Lidra Nurhadi Ibrahim Sari, Widia