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All Journal International Journal of Integrated Health Sciences Health and Medical Journal Nusantara Hasana Journal Scientific Journal BULLET : Jurnal Multidisiplin Ilmu AMMA : Jurnal Pengabdian Masyarakat Jurnal Abdimas Kesehatan
Dhuha, Alief
Universitas Baiturrahmah
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Amyotrophic Lateral Sclerosis: First Case Report in Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran, Bandung Ahmad Faried; Priandana Adya Eka Saputra; Alief Dhuha; Muhammad Zafrullah Arifin
International Journal of Integrated Health Sciences Vol 7, No 1 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.846 KB) | DOI: 10.15850/ijihs.v7n1.1237

Abstract

Objective: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that is incurable and results in paralysis of the muscles. Electromyography (EMG) is used to diagnosis amyotrophic lateral sclerosis. Although recently there is no cure for ALS, knowledge has increased significantly in the past several years and is helping those who are newly diagnosed.Methods: This study reported for the first time in Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung a 58-year old man who was presented in the institution with a history of weakness of both lower extremities for four months preceded by weakness of both upper extremities since the previous month. There was no history of any medical illness or any chronic medication. The patient then underwent EMG studies, followed by muscle biopsy.Result: Electromyography and histopathological results confirmed a diagnosis of ALS.Conclusion: This case was so exceptional, since ALS occurrence in Neurosurgery Centre is extremely rare, and the diagnosis can only be established through EMG and histopathological of muscle biopsy studies.Keywords: The fist reported of ALS in Neurosurgery Bandung, electromyography studies 
Skrining Status Gizi Pada Remaja Rifkind Malik; Ruhsyahadati Ajisman; Alief Dhuha; Annisa Lidra Maribeth; Rahma Triyana; Muhammad Rizki Saputra
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 10 : November (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

Non-communicable diseases are one of the causes of disability and death in the world which are often found in developing countries, one of the factors is a change in diet that is high in fat, processed meat, high in salt and sugar but low in fiber. The aim of this social empowerment project is to screen the nutritional status of teenagers. The method is carried out sequentially starting from registration, then continuing with measuring height and weight. The results of this social empowerment project are that the majority are female, the majority are 18 years old and the majority's nutritional status is normal. During this screening, nutritional imbalances were also found to be high, so it is necessary to increase education and outreach regarding good and balanced nutrition to avoid various non-communicable diseases in the future.
Edukasi Kanker Serviks dan Efektivitas Vaksin HPV Sejak Dini di SMAN 2 Pekanbaru Muhammad Faisal; Alief Dhuha; Mega Pratiwi Irawan; Sellia Juwita; Putri Wulandini
Jurnal Abdimas Kesehatan (JAK) Vol 4, No 2 (2022): Juni
Publisher : Sekolah Tinggi Ilmu Kesehatan Baiturrahim Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jak.v4i2.359

Abstract

In 2013, the number of cervical cancer cases in Riau Province reached 894 cases. In 2020, RSUD Arifin Achmad Riau Province reported the cervical cancer was the third rank below breast and ovarian cancer. Cervical cancer has major risk factor named by HPV virus. HPV vaccine has been reported to adequate to eliminate HPV viruses. The Indonesian government has provided the health facilities to decrease cervical cancer sufferers by providing HPV vaccines. However, vulnerable women are not ready to be vaccinated.  Education level is one of the factors. Hence, we try to intervene the mind of SMAN 2 Pekanbaru female students by offer early knowledge regarding the risk factors of cervical cancer, how to prevent as well as socialize HPV vaccine effectivity and safety. Educational and outreach activities were carried out by material presentation method by a direct meeting which interactive and educative. Feedback data collection from the activities was given through the Google Form platform. This activity was held on Monday, 22nd November 2021 at 09.00 – 10.35 West Indonesian Time, joined by 20 female students of SMAN 2 Pekanbaru which included three grade levels, X, XI, and XII class. According to the results of the questionnaire, we obtained the improvement of cervical cancer and HPV vaccine information. Moreover, this activity upgraded the awareness of cervical cancer prevention, by as much as 25% (N=12). We may conclude that education on cervical cancer is tremendously important to young women as our effort to decrease cervical cancer cases in the future.
Hubungan Tingkat Stres Dan Indek Massa Tubuh Pada Mahasiswa Tingkat Akhir Fakultas Kedokteran Universitas Baiturrahmah Zahara, Ayuni; Malik, Rifkind; Nani Jelmila, Sri; Rizki Saputra, Muhammad; Dhuha, Alief
BULLET : Jurnal Multidisiplin Ilmu Vol. 3 No. 6 (2024): BULLET : Jurnal Multidisiplin Ilmu
Publisher : CV. Multi Kreasi Media

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Abstract

Academic stress is one of the challenges faced by students. Final year students, who are in the process of writing their theses, experience higher levels of stress compared to those who have not yet started. The stress encountered by these final year students can stem from both external and internal sources. Objective: To determine the relationship between stress levels and body fat composition among final year medical students at Universitas Baiturrahmah in the year 2019. Methods: The scope of this research encompasses Psychiatry and Nutrition Science. The study was conducted from March 2021 to March 2022. It is an observational analytic study. The accessible population for this study was all final year undergraduate medical students at Universitas Baiturrahmah from the 2019 cohort, totaling 99 samples, using a simple random sampling technique. Univariate data analysis was presented in frequency distribution, bivariate analysis used the Kolmogorov-Smirnov test, and data processing utilized the IBM SPSS software. Results: The most common stress level was normal, affecting 62 individuals (62.6%), and the most prevalent body fat composition was obesity, affecting 66 individuals (66.7%). There was no relationship found between stress levels and body fat composition among final year medical students at Universitas Baiturrahmah in 2019 (p=0.586). Conclusion: The predominant stress level among the students was normal, obesity was the most common body fat composition, and there was no correlation found between stress levels and body fat composition in final year medical students at Universitas Baiturrahmah for the year 2019.
DIAGNOSTIC HISTOPATHOLOGY OF JUVENILE GRANULOSA CELL TUMOR: HALLMARK MORPHOLOGICAL AND CYTOLOGICAL FINDINGS Liana, Nana; Ruhsyahadati, Ruhsyahadati; Triyana, Rahma; Helmizar, Roland; Dhuha, Alief; Malik, Rifkind; Saputra, Muhammad Rizki
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1417

Abstract

Juvenile granulosa cell tumour (JGCT) is a subtype of granulosa cell tumour that predominantly affects young females, particularly those who are premenarchal, with a mean age at diagnosis of 13 years. Although rare, this tumour can occur across a wide age range, from 10 months to 67 years. Histologically, JGCT resembles the adult-type granulosa cell tumour but presents with distinct features, including aggressive growth and the absence of FOXL2 mutations. Common clinical manifestations include an abdominal mass, abdominal pain, precocious puberty in prepubertal girls due to estrogen secretion, and menorrhagia or amenorrhea in premenopausal women. Macroscopically, the tumour typically exhibits a dominant solid component, frequently accompanied by hemorrhagic and necrotic areas. High mitotic activity and variable degrees of cytological atypia are characteristic findings. The diagnosis is supported by positive immunoreactivity for inhibin, calretinin, and CD99. In early-stage disease, the primary treatment is unilateral oophorectomy with fertility preservation. In contrast, advanced stages often require total hysterectomy and adjuvant chemotherapy. Prognosis is highly dependent on disease stage; patients with stage I disease have a survival rate of up to 97%, whereas advanced-stage disease is associated with a poorer outcome. This review aims to provide a comprehensive overview of the epidemiology, pathogenesis, clinical manifestations, diagnostic approaches, and management strategies of Juvenile Granulosa Cell Tumour (JGCT). It also underscores the importance of early detection and the development of more effective therapeutic options to enhance clinical outcomes.
The Role of Vitamin D in Immune Balance and Inflammation Handayani, Kurnia Maidarmi; Sari, Widia; Khudri, Ghaniyyatul; Dhuha, Alief
Health and Medical Journal Vol 7, No 2 (2025): HEME May 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i2.1699

Abstract

Vitamin D, traditionally known for its role in bone health, is increasingly recognized as a crucial regulator of immune balance and inflammation. This review explores the mechanisms by which vitamin D influences both innate and adaptive immune responses, with a focus on immune cells like macrophages, dendritic cells, T cells, and B cells. Vitamin D, through its active form, calcitriol, modulates immune cell function by binding to the Vitamin D receptor (VDR), which impacts cytokine production and inflammatory pathways. Notably, vitamin D promotes anti-inflammatory effects by shifting immune responses towards a regulatory phenotype, reducing pro-inflammatory cytokines while enhancing anti-inflammatory signals. This regulatory potential highlight vitamin D’s therapeutic value for inflammatory and autoimmune diseases. Further research is essential to determine optimal vitamin D dosing and its implications across diverse populations.
Effects of Vitamin D Supplementation on Blood Glucose Levels in Streptozotocin-Induced Diabetic Rats Hansah, Rendri Bayu; Dhuha, Alief; Susanti, Melya; Sari, Widia; Khudri, Ghaniyyatul; Handayani, Kurnia Maidarmi
Health and Medical Journal Vol 7, No 2 (2025): HEME May 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i2.1717

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin secretion, insulin resistance, or both. Poor glycemic control in DM leads to complications such as cardiovascular disease and nephropathy. Vitamin D has been suggested to influence glucose metabolism by improving insulin secretion and sensitivity thorugh mechanisms involving pancreatic β-cells and anti-inflammatory pathways. This study evaluates the effect of vitamin D supplementation on blood glucose levels in diabetic rats. An experimental study was conducted using 25 males Sprague Dawley rats, divided into five groups: Group A (negative control), Group B (non-DM + 415 IU/kgBW vitamin D), Group C (DM without vitamin D), Group D (DM + 415 IU/kgBW vitamin D), and Group E (DM + 1100 IU/kgBW vitamin D). Diabetes was induced using streptozotocin (50 mg/kg BW), and rats with random blood glucose levels >200 mg/dL were considered diabetic. Vitamin D supplementation was given via gavage for 30 days. Serum vitamin D and random blood glucose levels were measured 30 days after supplementation. Statistical analyses included ANOVA and Pearson correlation tests. Vitamin D supplementation significantly increased serum vitamin D levels in diabetic rats, especially in Group E (DM + 1100 IU/kgBW vitamin D; (p < 0.05). Random blood glucose levels decreased significantly in diabetic groups and Group E showed the largest glucose reduction (p < 0.001). A moderate negative correlation (r = -0.47, p = 0.017) between vitamin D levels and glucose changes was observed. Vitamin D supplementation reduces blood glucose levels in diabetic rats, with higher doses showing greater efficacy. These findings highlight vitamin D’s potential as an adjunctive therapy for diabetes management. Further research is needed to explore underlying mechanisms.
Correlation Between Body Mass Index and Cardiovascular Fitness in Medical Student Dhuha, Alief; Rahmadhoni, Berry; Sari, Lovea Ajeng; Puspita, Dian; Akbar, Resti Rahmadika; Sari, Widia
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.254

Abstract

Introduction: Cardiovascular fitness is one of the components that can be used to evaluate health-related physical fitness. Body mass index (BMI) is a factor that can influence cardiovascular fitness. This is due to the strong correlation between BMI and cardiovascular fitness. Aims: To assess the correlation between BMI and cardiovascular fitness among medical students at Universitas Baiturrahmah. Method: The research was conducted at the Physiology Laboratory, Faculty of Medicine, Universitas Baiturrahmah. We assessed each subjects’s BMI and evaluated their cardiovascular fitness using the Harvard Step Test. The data were processed using Spearman rho correlation analysis. Results: Among the 50 subjects who participated in this study the mean BMI was 23.66±0.67 kg/m2, with approximately 68% (34) of subjects categorized in the normal BMI group. Out of the total number of subjects, around 34% (17) subjects had good cardiovascular fitness, with a mean value around 75.48±2.17. The results showed a significant correlation between BMI and cardiovascular fitness (r = -0.436, p<0.05), indicating that a higher BMI is related to lower levels of cardiovascular fitness. Conclusion: The results of this study indicate a significant negative correlation between BMI and cardiovascular fitness among medical students at Universitas Baiturrahmah.
Co-Authors Ahmad Faried Akbar, Resti Rahmadika Annisa Lidra Maribeth Dian Puspita Ghaniyyatul Khudri Hansah, Rendri Bayu Helmizar, Roland Kurnia Maidarmi Handayani liana, nana Malik, Rifkind Mega Pratiwi Irawan, Mega Pratiwi Melya Susanti Muhammad Faisal Muhammad Rizki Saputra Muhammad Rizki Saputra, Muhammad Rizki Muhammad Zafrullah Arifin Nani Jelmila, Sri Priandana Adya Eka Saputra Putri Wulandini Rahma Triyana Rahmadhoni, Berry Rizki Saputra, Muhammad Ruhsyahadati Ajisman Ruhsyahadati, Ruhsyahadati Sari, Lovea Ajeng Sari, Widia Sellia Juwita Triyana, Rahma Zahara, Ayuni