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Kurnia Maidarmi Handayani
Bagian Biokimia, Fakultas Kedokteran, Universitas Baiturrahmah, Padang, Indonesia
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Hubungan Asupan Energi Sarapan terhadap Tingkat Konsentrasi pada Siswa-Siswi Kelas XII SMA Negeri 1 Padang Tahun Ajaran 2013/2014 Kurnia Maidarmi Handayani; Masrul Masrul; Adrial Adrial
Jurnal Kesehatan Andalas Vol 3, No 3 (2014)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v3i3.156

Abstract

AbstrakIndonesia menduduki peringkat terakhir dalam cognitive skills dan pencapaian pendidikan menurut penelitian yang dilakukan oleh Economist Intelligence Unit. Cognitive skills memerlukan fungsi otak yang adekuat yang dipertahankan oleh nutrisi berupa konsumsi pangan yang baik dan beragam, terutama sarapan. Penelitian di Amerika Serikat pada anak usia sekolah remaja (15-18 tahun) menunjukkan bahwa sebesar 30% remaja tidak biasa sarapan. Penelitian ini bertujuan untuk mengetahui hubungan antara asupan energi sarapan dan tingkat konsentrasi pada siswa SMAN 1 Padang. Studi dilakukan di SMAN 1 Padang pada bulan November 2013 terhadap 116 siswa kelas XII. Desain penelitian bersifat analitik dengan desain cross sectional. Pengolahan data dilakukan dengan uji chi-square menggunakan sistem komputerisasi. Hasil penelitian menunjukkan terdapat perbedaan tingkat konsentrasi menggunakan digit symbol test antara siswa dengan asupan energi sarapan baik, kurang, dan sangat kurang (p=0,001) dan tidak terdapat perbedaan tingkat konsentrasi menggunakan digit span test antara siswa dengan asupan energi sarapan baik, kurang, dan sangat kurang (p=0,345). Terdapat hubungan yang bermakna antara asupan energi sarapan dengan tingkat konsentrasi menggunakan digit symbol test (p<0,05).Kata kunci: sarapan, asupan energi, konsentrasi, digit symbol test, digit span testAbstractIndonesia was ranked last in the cognitive skills and educational attainment according to research conducted by the Economist Intelligence Unit.Cognitive skills require brain function is maintained by adequate intake of nutrients such as good and varied food, especially breakfast. Research in the United States in children of school age youth (15-18 years) showed that 30% of teenagers are not usually did breakfast.This study aimed to determine the relationship between energy intake at breakfast and the level of concentration of students of SMAN 1 Padang. The study was conducted at SMAN 1 Padang in November 2013 to 116 students of class XII. The research was an analytical study with cross-sectional design.Data processing is performed by the chi-square test using a computerized system. The results showed there were differences in the level of concentration using the digit symbol test between students with a good breakfast energy intake,less,and much less (p = 0.001) and there was no difference in the level of concentration using the digit span test between students with a good breakfast energy intake, less, and very less (p = 0.345). There is a significant relationship between breakfast energy intake with the level of concentration using digit symbol test (p < 0.05).Keywords: breakfast, energy intake, concentration, digit symbol test, digit span test
Evasion of the Immune System by Mycobacterium tuberculosis: A Special Review on Macrophages Kurnia Maidarmi Handayani; Febriana Catur Iswanti
Health and Medical Journal Vol 6, No 2 (2024): HEME May 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i2.1452

Abstract

Mycobacterium tuberculosis, the bacterium that caused tuberculosis, is estimated to affect 10 million people worldwide in 2019. This bacterium is an intracellular pathogen that is spread through the inhalation of bacterial aerosol particles. The innate immune system in the lungs is prepared to phagocytize these bacteria, particularly macrophages, dendritic cells, monocytes, and neutrophils. M. tuberculosis can evade attacks by the host immune system and has developed strategies to infect successfully, especially macrophages. This intracellular bacterium can inhibit phagolysosome fusion, which is associated with lipoarabinomannan (LAM) in the bacterial cell wall. M. tuberculosis also can persist in phagolysosomes by inhibiting acidification and also inhibiting the action of NOX2 from producing ROS. This ability also allows these bacteria to avoid autophagy within macrophages. Knowledge of the power of these bacteria to manipulate and evade the immune system, especially macrophages, is beneficial in developing medicines and vaccines in the future.
KEGIATAN EDUKASI BAHAYA NAPZA BAGI KESEHATAN DAN PERKEMBANGAN INTELEKTUAL ANAK USIA SEKOLAH Kurnia Maidarmi Handayani; Widia Sari; Ghaniyyatul Khudri; Annisa Lidra Maribeth
Jurnal Abdi Insani Vol 11 No 2 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i2.1632

Abstract

Drug abuse poses a significant threat to the future of the younger generation, encompassing narcotics, alcohol, psychotropic substances, and other addictive substances collectively referred to as NAPZA. Recent data from the United Nations Office on Drugs and Crime (UNODC) World Drug Report for 2023 indicates a consistent rise in drug abuse cases globally, with approximately 5.8% of individuals aged 15 to 64 reported to be involved in drug abuse. According to data from Badan Narkotika Nasional (BNN) in 2021, the village of Korong Gadang, situated in the Kuranji District of Padang City, West Sumatra, is classified as an area characterized by a drug abuse alert status. Addressing this issue is paramount, necessitating effective solutions to prevent drug abuse in this locality. One method to accomplish this is by conducting campaigns with groups of school-aged children, the nation's future, regarding drugs and their dangers.The objective of this project is to impart knowledge and educate children of school age concerning drugs and its dangers. Counseling is conducted via lecture by distributing educational materials pertaining to substances and their associated risks. In addition, pre-tests and post-tests were given prior and following to the lecture. The outcomes of this activity demonstrated that the counseling given could increase participants' awareness of drugs and their risks. As a result, counseling can be used as a viable strategy to prevent the distribution of narcotics, particularly among children of school age.
Profile Of Childhood Measles Patients At Rsi Siti Rahmah Padang 2020-2022 Zeffira, Laura; Yulfienti, Elfi; Yulika, Villya; Handayani, Kurnia Maidarmi; Sari, Widia; Khudri, Ghaniyyatul
MSJ : Majority Science Journal Vol. 2 No. 2 (2024): MSJ-May
Publisher : PT. Hafasy Dwi Nawasena

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61942/msj.v2i2.171

Abstract

Measles (morbilli), caused by the Morbillivirus, is a highly contagious disease primarily affecting children under 15 years of age. The incidence of measles in Indonesia, particularly in West Sumatra, has been increasing due to declining vaccination coverage. This study provides a descriptive analysis of pediatric measles cases at RSI Siti Rahmah Hospital in Padang, using secondary data from medical records between March 2020 and August 2022. A total of 57 pediatric measles patients were identified. The majority of these patients were aged 5-9 years and predominantly female. Diagnoses were primarily made through anamnesis and physical examination. Most patients had a history of measles vaccination, and more than 50% had good nutritional status. Importantly, 71% of patients with complications had not received measles vaccination. These findings suggest that measles vaccination is likely effective in reducing the severity and complications of the disease in children, highlighting the critical need for maintaining high vaccination coverage to mitigate the impact of measles outbreaks.
HUBUNGAN RIWAYAT KEBIASAAN MEROKOK DENGAN KEJADIAN BRONKITIS DI PUSKESMAS MUARASIPONGI TAHUN 2019-2020 Nilas Warlem; Irwan Triansyah; Ghaniyyatul Khudri; Kurnia Maidarmi Handayani; Siti Halimah
Nusantara Hasana Journal Vol. 3 No. 4 (2023): Nusantara Hasana Journal, September 2023
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i4.1282

Abstract

One of the diseases of the lungs is bronchitis. Bronchitis arises as a result of exposure to infectious and non-infectious agents (especially tobacco cigarettes). Smoking is one of the main causes of bronchitis. The increased risk of mortality due to bronchitis is almost directly proportional to the number of cigarettes smoked daily. Data on smoking incidents in Indonesia is quite high. Riskesdas Data in 2018, the proportion of smoking in the population aged ≥10 as much as 24.3%. The highest proportion in Lampung province is 28.1% and the lowest in Papua Province is 18.8%. Province of North Sumatra has a proportion of i22.4%. This research to knowing the relationship of smoking habit with bronchitis incidence in Muarasipongi Health Center Mandailing Natal Regency in 2019-2020. The scope of this research is the science of pulmonary disease. The research was conducted at Muarasipongi Health Center from September 2020 to July 2021. This type of research is descriptive analytics with a Cross Sectional design approach. The affordable population in this study was patients diagnosed with Bronchitis at Muarasipongi Health Center in 2019-2020 with 66 samples using simple random sampling techniques and data analysis using fisher exact test with spss version 24 program. The most gender in bronchitis patients was male at 38 people (57.6%), the age in bronchitis patients was the most late adolescents and seniors were 13 people each (19.7%), smoking history in bronchitis patients most smoking is 40 people (60.6%), there is a relationship of smoking habit with the incidence of bronchitis in Muarasipongi Health Center Mandailing Natal Regency in 2019-2020 the value of p = 0.000. There is a relationship between smoking habit and bronchitis in Muarasipongi Health Center in Mandailing Natal Regency in 2019-2020.
UPAYA PENCEGAHAN ANEMIA MELALUI EDUKASI ASUPAN NUTRISI DAN SUPLEMENTASI TABLET TAMBAH DARAH PADA REMAJA PEREMPUAN Maribeth, Annisa Lidra; Sari, Widia; Hamda, Rialta; Khudri, Ghaniyyatul; Handayani, Kurnia Maidarmi
Jurnal Pengabdian Pendidikan Masyarakat (JPPM) Vol 6 No 1 (2025): Jurnal Pengabdian Pendidikan Masyarakat (JPPM), Vol 6 No 1 (Maret 2025)
Publisher : LPPM UNIVERSITAS MUHAMMADIYAH MUARA BUNGO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52060/jppm.v6i1.2704

Abstract

Anemia is a common health problem worldwide, particularly among adolescent girls. This group is at high risk of anemia due to menstruation during adolescence, which leads to blood loss. Additionally, the increased need for iron in adolescent girls contributes to their vulnerability to anemia. Education about anemia and its prevention, as well as supplementation with iron tablets, is one solution to prevent and reduce the prevalence of anemia in females. Pesisir Selatan, a district in West Sumatra Province, recorded an increase in anemia prevalence in 2019. Based on this, it is necessary to provide education on anemia and its prevention to adolescent girls in the region. This counseling activity aimed to improve the knowledge and attitudes of adolescent girls regarding anemia. The activity consisted of pre-tests, counseling sessions, and post-tests. Counseling was conducted using lecture methods and interactive discussions with participants. Based on the evaluation of pre-test and post-test results, it was found that the counseling method was effective in increasing participants' knowledge. This was evidenced by a significant increase in participants' knowledge about anemia (p=0.004). The number of participants with good knowledge increased from 3 individuals (13.6%) to 7 individuals (31.8%), and none of the participants had poor knowledge after the counseling session. However, it was found that the counseling method did not significantly improve participants' attitudes towards anemia. In conclusion, although it did not affect participants' attitudes, the counseling method effectively enhanced their knowledge about anemia and is expected to help prevent anemia among adolescent girls
Penyuluhan dan Skrining Tuberkulosis pada Anak di Panti Asuhan Ashabil Rayan Zeffira, Laura; Handayani, Kurnia Maidarmi; Eldrian, Febianne; Amonica, Mutiara
Abdika Sciena Vol 3 No 1 (2025): JURABDIKES Volume 3 No 1, Juni 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/jurabdikes.v3i1.235

Abstract

Tuberkulosis (TB) adalah penyakit menular yang masih menjadi masalah kesehatan global. Penyakit ini dapat ditemukan di semua usia termasuk anak. Indonesia menduduki peringkat kedua kasus TB terbanyak di dunia dengan perkiraan  1.060.000 kasus TB, dan sebanyak 110.881 kasus anak usia < 15 th pada tahun 2022. Kegiatan skrining sangat berguna untuk mendeteksi kasus TB secara dini serta mengurangi masalah penularan infeksi TB. Tujuan pengabdian masyarakat ini adalah untuk mendeteksi penularan TB anak terutama di wilayah panti asuhan Ashabil Rayan dengan sasaran seluruh anak yang bertempat tinggal di panti asuhan ashabil rayan dengan usia 5-14 tahun. Mengingat tingginya resiko penularan TB pada anak di asrama,  maka dilakukanlah penyuluhan serta skrining TB pada anak di wilayah panti asuhan Ashabil Rayan agar penyakit tuberkulosis dapat terdeteksi dan teratasi sejak dini.
Effect of Vitamin D Supplementation During Pregnancy on Birth Weight: An Experimental Study in Rats Sari, Widia; Khudri, Ghaniyyatul; Zeffira, Laura; Handayani, Kurnia Maidarmi
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.247

Abstract

Introduction. Vitamin D deficiency, commonly observed during pregnancy, can affect fetal growth, which can be evaluated by birth weight. Vitamin D supplementation during pregnancy is anticipated to beneficially affect birth weight, a crucial factor for neonatal health and long-term health outcomes. Methods. This research was conducted using an in vivo experimental design on Rattus norvegicus rats as animal models. This study involved 24 rat pups from four groups of pregnant rats, each provided with standard feed and varying doses of vitamin D supplementation: Group A received 62 IU/kgBW, Group B received 415 IU/kgBW, Group C received 663 IU/kgBW, and Group D received no vitamin D supplementation. Vitamin D supplementation was provided through oral gavage from the first day of gestation until parturition. At the time of delivery, six pups from each group were randomly chosen to measure their birth weights. Results. The finding from this research indicated that vitamin D supplementation during pregnancy positively influenced birth weight (p<0.001). The birth weights of pups in Group C were significantly higher compared to those in group D (p<0.001) and Group A (p<0.001). Pups in Group B also had significantly higher birth weights compared to Group D (p=0.002) and Group A (p=0.006). Conclusion. Based on these findings it can be concluded that vitamin D supplementation at doses 415 IU/kgBW and 663 IU/kgBW can increase birth weight.
The Role of Vitamin D in Immune Balance and Inflammation Handayani, Kurnia Maidarmi; Sari, Widia; Khudri, Ghaniyyatul; Dhuha, Alief
Health and Medical Journal Vol 7, No 2 (2025): HEME May 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i2.1699

Abstract

Vitamin D, traditionally known for its role in bone health, is increasingly recognized as a crucial regulator of immune balance and inflammation. This review explores the mechanisms by which vitamin D influences both innate and adaptive immune responses, with a focus on immune cells like macrophages, dendritic cells, T cells, and B cells. Vitamin D, through its active form, calcitriol, modulates immune cell function by binding to the Vitamin D receptor (VDR), which impacts cytokine production and inflammatory pathways. Notably, vitamin D promotes anti-inflammatory effects by shifting immune responses towards a regulatory phenotype, reducing pro-inflammatory cytokines while enhancing anti-inflammatory signals. This regulatory potential highlight vitamin D’s therapeutic value for inflammatory and autoimmune diseases. Further research is essential to determine optimal vitamin D dosing and its implications across diverse populations.
Effects of Vitamin D Supplementation on Blood Glucose Levels in Streptozotocin-Induced Diabetic Rats Hansah, Rendri Bayu; Dhuha, Alief; Susanti, Melya; Sari, Widia; Khudri, Ghaniyyatul; Handayani, Kurnia Maidarmi
Health and Medical Journal Vol 7, No 2 (2025): HEME May 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i2.1717

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin secretion, insulin resistance, or both. Poor glycemic control in DM leads to complications such as cardiovascular disease and nephropathy. Vitamin D has been suggested to influence glucose metabolism by improving insulin secretion and sensitivity thorugh mechanisms involving pancreatic β-cells and anti-inflammatory pathways. This study evaluates the effect of vitamin D supplementation on blood glucose levels in diabetic rats. An experimental study was conducted using 25 males Sprague Dawley rats, divided into five groups: Group A (negative control), Group B (non-DM + 415 IU/kgBW vitamin D), Group C (DM without vitamin D), Group D (DM + 415 IU/kgBW vitamin D), and Group E (DM + 1100 IU/kgBW vitamin D). Diabetes was induced using streptozotocin (50 mg/kg BW), and rats with random blood glucose levels >200 mg/dL were considered diabetic. Vitamin D supplementation was given via gavage for 30 days. Serum vitamin D and random blood glucose levels were measured 30 days after supplementation. Statistical analyses included ANOVA and Pearson correlation tests. Vitamin D supplementation significantly increased serum vitamin D levels in diabetic rats, especially in Group E (DM + 1100 IU/kgBW vitamin D; (p < 0.05). Random blood glucose levels decreased significantly in diabetic groups and Group E showed the largest glucose reduction (p < 0.001). A moderate negative correlation (r = -0.47, p = 0.017) between vitamin D levels and glucose changes was observed. Vitamin D supplementation reduces blood glucose levels in diabetic rats, with higher doses showing greater efficacy. These findings highlight vitamin D’s potential as an adjunctive therapy for diabetes management. Further research is needed to explore underlying mechanisms.
Co-Authors Adrial Adrial Amonica, Mutiara Annisa Lidra Maribeth Dhuha, Alief Febianne Eldrian, Febianne Febriana Catur Iswanti Ghaniyyatul Khudri Hamda, Rialta Hansah, Rendri Bayu Irwan Triansyah Maribeth, Annisa Lidra Masrul Melya Susanti Nilas Warlem Sari, Widia Siti Halimah Widia Sari Yulfienti, Elfi Yulika, Villya Zeffira, Laura