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All Journal Jurnal Ilmu Kedokteran dan Kesehatan Holistik Jurnal Kesehatan
Gunawan, Catherine Keiko
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Effectiveness And Safety Of Erdosteinie In Management Of Chronic Obstructive Pulmonary Disease (COPD): A Systematic And Meta-Analysis Yolanda, Lorensia; Gunawan, Catherine Keiko; Sumarpo, Anton; Sahamastuti, Agnes Anania Triavika; Cokro, Fonny
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 9 (2025): Volume 12 Nomor 9
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i9.20524

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that cause limitation in the airflow and chronic inflammation. Erdosteine has been proposed as a potential therapeutic option for COPD management, based on its antioxidant activity and anti-inflammatory properties. The purpose of this systematic review and meta-analysis is to evaluate the effectiveness and safety of erdosteine in COPD patients. Multiple databases have been involved in the literature study following PRISMA guidelines, identifying randomized controlled trials (RCTs) that compared erdosteine with placebo. A total of seven studies were included in the qualitative analysis, and nine were analyzed quantitatively. Meta-analysis results indicated that erdosteine significantly improved forced expiratory volume in one second (FEV1), reduced reactive oxygen species (ROS) and 8-isoprostan levels, and lowered interleukin-8 (IL-8) concentrations. Subgroup analyses demonstrated greater benefits in patients with moderate to severe COPD (stage II/III). Safety analysis revealed that erdosteine was generally well-tolerated, with only mild adverse effects reported. However, study limitations included high heterogeneity and potential bias in some trials. Overall, the findings suggest that erdosteine is an effective and safe adjunct therapy for COPD.
Keterkaitan ASI eksklusif dan vaksinasi terhadap kejadian infeksi saluran pernapasan akut pada balita usia 12-48 bulan Dewi, Ni Luh Arisda Satya Cahya; Rahmawati, Febtarini; Linggawan, Stephani; Raharjo, Budiono; Anggono, Susan Jocelyn; Tjokro, Vanessa Susanto; Gunawan, Catherine Keiko; Sumarpo, Anton
Holistik Jurnal Kesehatan Vol. 19 No. 10 (2025): Volume 19 Nomor 10
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v19i10.1624

Abstract

Background: Breast milk contains compounds that strengthen and stimulate the immune system. Previous research has shown a correlation between exclusive breastfeeding, complete immunization, and the incidence of acute respiratory infections in children. Purpose: To analyze the relationship between exclusive breastfeeding and immunization on the incidence of acute respiratory infections in toddlers aged 12-48 months. Method: This quantitative study used a cross-sectional approach with a sample of 40 infants who met the inclusion criteria. Univariate and bivariate data were analyzed using the chi-square test. Results: The analysis showed a p-value of 0.540 (α<0.05) between exclusive breastfeeding and the incidence of ARI, and a p-value of 0.006 (α<0.05) between complete immunization and the incidence of acute respiratory infections. Conclusion: There was no statistically significant relationship between exclusive breastfeeding and the incidence of acute respiratory infections. However, a significant relationship was found between the level of complete immunization and the incidence of acute respiratory infections. Suggestion: Future research should use a larger sample size to increase the power of the study and expand the study by including other risk factors to more accurately determine their influence.   Keywords: Acute Respiratory Tract Infection; Breastfeeding; Exclusive breastfeeding; Toddlers; Vaccination.   Pendahuluan: Air susu ibu (ASI) mengandung komposisi yang memperkuat dan merangsang sistem kekebalan tubuh. Penelitian sebelumnya telah menunjukkan adanya korelasi antara pemberian ASI eksklusif, vaksinasi lengkap, dan kejadian infeksi saluran pernapasan akut (ISPA) pada anak. Tujuan: Untuk menganalisis keterkaitan ASI eksklusif dan vaksinasi terhadap kejadian infeksi saluran pernapasan akut pada balita usia 12-48 bulan. Metode: Penelitian kuantitatif dengan pendekatan cross-sectional menggunakan sampel sebanyak 40 bayi yang memenuhi kriteria inklusi. Analisis data univariat dan bivariat menggunakan uji chi-square. Hasil: Analisis menunjukan nilai p=0.540 (α<0.05) antara variabel pembeian ASI eksklusif dengan kejadian ISPA, dan nilai p=0.006 (α<0.05) antara variabel kelengkapan vaksinasi dengan kejadian ISPA. Simpulan: Tidak adanya hubungan yang signifikan secara statistik antara pemberian ASI eksklusif dengan kejadian ISPA. Namun, ditemukan hubungan yang signifikan antara tingkat kelengkapan vaksinasi dengan kejadian ISPA. Saran: Penelitian selanjutnya dapat menggunakan ukuran sampel yang lebih besar untuk meningkatkan kekuatan studi dan memperluas penelitian dengan memasukkan faktor risiko lain untuk menentukan pengaruhnya secara lebih akurat.   Kata Kunci: ASI Eksklusif; Balita; Infeksi Saluran Pernapasan Akut (ISPA); Menyusui; Vaksinasi.
Co-Authors Agnes Anania Triavika Sahamastuti Anggono, Susan Jocelyn Anton Sumarpo Cokro, Fonny Dewi, Ni Luh Arisda Satya Cahya Febtarini Rahmawati LINGGAWAN, STEPHANI RAHARJO, BUDIONO Tjokro, Vanessa Susanto Yolanda, Lorensia