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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Ilmu Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) MAHESA : Malahayati Health Student Journal Indonesian Journal of Life Sciences
Anton Sumarpo
Maranatha Christian University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Reference Value Evaluation of Urine Sediment in Indonesian Adult Population Using Automated Urine Analyzer Eirene Jaquelene Tomatala; Anton Sumarpo; Hani Susanti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 28, No 3 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i3.1859

Abstract

Locally established clinical laboratory reference value are required to interpret laboratory test results for screening, diagnosis, prognosis, determining retest criteria or as microscopic confirmation. The objective of this study is to establish urine sediments reference value by using automated urine flow cytometry, investigating erythrocyte, leukocyte, epithelial cells, types of epithelial cells, bacteria, casts, pathologic casts, crystals, yeast, sperm, and mucus in Indonesian population using Sysmex UF-4000. A cross sectional study was conducted in October 2018 – April 2019 at R. Said Sukanto National Police Hospital in Jakarta. The study involved 240 participants comprised of clinically healthy 120 males and 120 females aged 18-65, with normal urine chemistry, hematology, blood glucose, liver function (AST, ALT), and renal function (urea, creatinine). The reference value was reported in microliter (μL) or in High Performance Field (HPF) or Low Performance Field (LPF). Mann-Whitney test through MedCalc software was used to test significant differences with p value <0.05. This study observed significant differences between males and females in erythrocyte, epithelial cells, epithelial cell variety, bacteria, pathologic casts, and yeast—which are evidently higher in female patients. However, the mucus in LPF levels is found to be higher in male patients instead of the female, disparate than current reference value. Therefore, the reference value results were separated between the two groups in those aspects, whereas the results of other urine sediment characteristics studied were combined. As most reference value obtained are still within range of existing references, reference value established with Sysmex UF-4000 can be useful.
Reference Value Evaluation of Urine Sediment in Indonesian Adult Population Using Automated Urine Analyzer Eirene Jaquelene Tomatala; Anton Sumarpo; Hani Susanti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 3 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i3.1859

Abstract

Locally established clinical laboratory reference value are required to interpret laboratory test results for screening, diagnosis, prognosis, determining retest criteria or as microscopic confirmation. The objective of this study is to establish urine sediments reference value by using automated urine flow cytometry, investigating erythrocyte, leukocyte, epithelial cells, types of epithelial cells, bacteria, casts, pathologic casts, crystals, yeast, sperm, and mucus in Indonesian population using Sysmex UF-4000. A cross sectional study was conducted in October 2018 – April 2019 at R. Said Sukanto National Police Hospital in Jakarta. The study involved 240 participants comprised of clinically healthy 120 males and 120 females aged 18-65, with normal urine chemistry, hematology, blood glucose, liver function (AST, ALT), and renal function (urea, creatinine). The reference value was reported in microliter (μL) or in High Performance Field (HPF) or Low Performance Field (LPF). Mann-Whitney test through MedCalc software was used to test significant differences with p value <0.05. This study observed significant differences between males and females in erythrocyte, epithelial cells, epithelial cell variety, bacteria, pathologic casts, and yeast”which are evidently higher in female patients. However, the mucus in LPF levels is found to be higher in male patients instead of the female, disparate than current reference value. Therefore, the reference value results were separated between the two groups in those aspects, whereas the results of other urine sediment characteristics studied were combined. As most reference value obtained are still within range of existing references, reference value established with Sysmex UF-4000 can be useful.
Synergistic Antibacterial Activities of Ginger and Lemongrass Essential Oils as an Alternative Prevention to Food-Borne Disease Sahamastuti, Agnes Anania Triavika; Andre, Andre; Foustine, Shania; Sumarpo, Anton; Hartiadi, Leonny Yulita
Indonesian Journal of Life Sciences 2019: IJLS Vol 01 No .02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (433.341 KB) | DOI: 10.54250/ijls.v1i2.25

Abstract

Background: Lemongrass and ginger are traditional food ingredients in Asian countries, including Indonesia, Thailand, India, and Malaysia. Although their single essential oil has been assessed for its antibacterial activities, no report has been done for their combination. Material and methods: Our study evaluated single and combination of these herbs for their antibacterial properties against food-borne bacteria E. coli (NEB® catalog No. C2989K), B. subtilis (ATCC 6633), S. typhi (ATCC 14028) and S. aureus (InaCC B4). Essential oil of lemongrass and ginger were obtained by steam distillation and their antimicrobial were evaluated using disk diffusion assay with chloramphenicol as the standard antibiotic. Synergistic activity was assessed using the combination of materials at two or four-fold dilution from their respected MIC value. Results: We confirmed that single lemongrass and ginger essential oils inhibited the bacteria growth with MIC value of about 1-5% and 2.5-5%, respectively. Moreover, their synergism activities were observed when both were mixed at two-fold dilution from their respective MIC. Conclusion: We conclude that the combination of the ginger essential oils and lemongrass essential oils may have potential as a natural preservative to prevent food-borne diseases.
Hubungan Karakteristik Faktor Sosioekonomi Dengan Masa Survival Pasien Kanker Kolorektal Di Rumah Sakit Umum Daerah Nganjuk, Jawa Timur Husodo, Muhammad Imam Lebdo; Raharjo, Budiono; Hernanda, Pratika Yuhyi; Sugeng, Maria Widijanti; Erny, Erny; Sumarpo, Anton
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 2 (2025): Volume 12 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i2.17987

Abstract

Kanker kolorektal merupakan suatu kegansan yang bermula dari jaringan mukosa usus besar, yang secara struktur terdiri dari kolon dan/atau rectum. Hingga saat ini, insiden kanker kolorektal menduduki urutan ketiga dari seluruh jenis kanker di dunia. Penelitian ini bertujuan untuk mencari hubungan dan memberikan gambaran mengenai factor sosioekonomi meliputi variable status perkawinan, status bekerja, status pendidikan, dan masa survival pada pasien kanker kolorektal di Rumah Sakit Umum Daerah (RSUD) Nganjuk. Penelitian ini menggunakan desain penelitian deskriptif analitik. Data dikumpulkan dari rekam medis pasien kanker kolorektal yang dirawat di RSUD Nganjuk. Analisis dilakukan menggunakan uji statistik Kaplan-Meier dan log-rank test untuk menganalisa gambaran factor sosioekonomi dengan masa survival pasien kanker kolorektal di RSUD Nganjuk. Terdapat gambaran masa survival yang cenderung lebih baik pada pasien berstatus menikah, bekerja, dan berpendidikan di bawah SLTA. Meskipun hasil penelitian menunjukkan hubungan yang tidak signifikan, didapatkan gambaran masa survival yang lebih baik pada variabel pasien dengan kategori menikah, bekerja, dan pendidikan di bawah SLTA.
Epistaxis as The Initial Presentation of Primary Sjögren Syndrome: A Case Report Stephani Linggawan; Eric Satrio Adi Prabowo; Catherine Keiko Gunawan; Budiono Raharjo; Anton Sumarpo
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4249

Abstract

Background: Primary Sjögren syndrome is chronic systemic autoimmune disorder characterized by lymphocytic infiltration of the exocrine glands, most commonly presenting with dryness of the mouth and eyes. This case is very rare, which the antibody in the Sjogren's syndrome case concerns platelets. Objective: This case report emphasizes the occurrence of epistaxis in Sjögren Syndrome. Case Presentation: This case describes a 30-year-old male presenting with recurrent epistaxis as the initial clinical manifestation. Further clinical evaluation revealed hypertensive crisis and dryness in the mouth and nasal mucosa. The clinical presentation raised suspicion of an underlying autoimmune condition, prompting further testing, which confirmed the presence of anti -Sjögren’s syndrome type B (SSB) antibodies on an antinuclear antibody (ANA) profile.  Result: The criteria for Sjogren's syndrome are based on the criteria if eye and mouth symptoms, eye and mouth clinical signs, and one of autoantibodies are found Anti-Ro (SSA), Anti-La (SSB), Antinuclear antibodies (ANA), Rheumatoid factor (RF). From this case has found symptoms of mouth and antibodies SSB. Conclusion: This case highlights that epistaxis can be caused by autoimmune cases, for epistaxis it is better to do screening for autoimmune examination test, emphasizing the need for further research to elucidate the diverse clinical manifestation, progression and prognosis factor.
Analisis Rasio Monosit terhadap Limfosit pada Penderita Osteoartritis di Surabaya Efawati, Susi; Ngibad, Khoirul; Raharjo, Budiono; Linggawan, Stephani; Sumarpo, Anton
MAHESA : Malahayati Health Student Journal Vol 5, No 5 (2025): Volume 5 Nomor 5 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i5.17922

Abstract

ABSTRACT Osteoarthritis is a degenerative joint disease characterized by progressive erosion of articular cartilage components. The known pathogenesis of osteoarthritis mainly includes immunological, bone metabolism, and biomechanical factors. Lymphocytes and monocytes are key regulatory cells for innate and acquired immunity, and monocyte-to-lymphocyte ratio may describe the immune status in osteoarthritis patients. This study aims to analyze the monocyte-to-lymphocyte ratio in osteoarthritis patients in Surabaya. This is an analytical observational research with a cross-sectional approach. The study was conducted in March - June 2024. The population in this study were osteoarthritis patients at Mitra Keluarga Hospital, Surabaya. The number of samples taken using the purposive sampling technique for this study was 31 people. The results showed that the average monocyte-to-lymphocyte ratio in osteoarthritis patients was 2.04. Meanwhile, the average monocyte-to-lymphocyte ratio in control subjects was 0.22. There was a significant difference in the monocyte-to-lymphocyte ratio between osteoarthritis patients compared to the control group. Keywords: Monocyte-To-Lymphocyte Ratio, Osteoarthritis, Joints  ABSTRAK Osteoartritis merupakan salah satu penyakit degeneratif pada sendi yang ditandai dengan erosi komponen kartilago artikular secara progresif. Patogenesis osteoartritis yang diketahui terutama mencakup faktor imunologi, metabolisme tulang, dan biomekanik. Limfosit dan monosit adalah sel kunci untuk imunitas bawaan dan didapat, dan rasio monosit terhadap limfosit menggambarkan status imunitas pada penderita osteoartritis. Penelitian ini bertujuan untuk menganalisis rasio monosit terhadap limfosit pada penderita osteoartritis di Surabaya. Penelitian ini dilakukan dengan metode analitik observasional dengan pendekatan cross-sectional. Penelitian dilakukan pada bulan Maret - Juni 2024. Populasi dalam penelitian ini adalah seluruh pasien osteoartritis di Rumah Sakit Mitra Keluarga, Surabaya. Jumlah sampel yang diambil dengan teknik purposive sampling untuk penelitian ini adalah sebanyak 31 orang. Hasil penelitian didapatkan rata-rata rasio monosit terhadap limfosit penderita osteoartritis sebesar 2,04 sedangkan rata-rata rasio monosit limfosit pasien kontrol adalah sebesar 0,22. Terdapat perbedaan yang signifikan pada rasio monosit terhadap limfosit antara penderita osteoarthritis dibandingkan dengan populasi kontrol. Kata Kunci: Rasio Monosit Terhadap Limfosit, Osteoartritis, Sendi
Hubungan Karakteristik Kanker Kolorektal dan Jenis Terapinya dengan Masa Survival Pasien di Rumah Sakit Umum Daerah Nganjuk Fitrianto, Muhammad Rizki; Hernanda, PratikaYuhyi; Sugeng, Maria Widjianti; Raharjo, Budiono; Linggawan, Stephani; Sumarpo, Anton
MAHESA : Malahayati Health Student Journal Vol 5, No 6 (2025): Volume 5 Nomor 6 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i6.18564

Abstract

ABSTRACT Colorectal cancer survival refers to the prognosis of patients following a diagnosis of the disease. Various factors contribute to the survival outcomes of individuals diagnosed with colorectal cancer, including tumor characteristics—such as the tumor's location and stage—as well as the type of therapeutic interventions administered. This study aims to investigate the relationship between the characteristics of colorectal cancer, the therapeutic approaches employed, and patient survival rates at Nganjuk General Hospital. This study employed a retrospective design with a cross-sectional approach, focusing on patients diagnosed with colorectal cancer at Nganjuk General Hospital in Surabaya over the period from 2019 to 2024. The analysis of the associations among colorectal cancer metastasis, tumor location, and chemotherapy type with patient survival duration revealed the following p-values: 0.122 for the relationship between metastasis and survival period, 0.268 for the association between tumor location and survival, and 0.210 for the correlation between chemotherapy type and survival time. Our findings indicate that there is no significant association between the characteristics of colorectal cancer, the type of therapy administered, and the survival duration of patients treated at RSUD Nganjuk. Keywords: Colorectal Cancer, Patient Survival, Therapeutic Intervention  ABSTRAK Keberlangsungan hidup (survival) pada pasien dengan kanker kolorektal berkaitan erat dengan prognosis pasien dan waktu saat terdiagnosis (time-to-diagnosis). Berbagai faktor berkontribusi terhadap hasil kelangsungan hidup individu yang didiagnosis dengan kanker kolorektal, termasuk karakteristik tumor—seperti lokasi dan stadium tumor—serta jenis intervensi terapeutik yang diberikan. Penelitian ini bertujuan untuk menyelidiki hubungan antara karakteristik kanker kolorektal, pendekatan terapeutik yang digunakan, dan tingkat kelangsungan hidup pasien di Rumah Sakit Umum Daerah (RSUD) Nganjuk. Penelitian ini menggunakan desain retrospektif dengan pendekatan cross-sectional. Subjek penelitian yang digunakan adalah pasien yang didiagnosis dengan kanker kolorektal di RSUD Nganjuk di Surabaya selama periode 2019 hingga 2024. Hubungan antara metastasis kanker kolorektal, lokasi tumor, dan jenis kemoterapi terhadap durasi kelangsungan hidup pasien menunjukkan nilai p sebagai berikut: 0,122 untuk hubungan antara metastasis dan periode kelangsungan hidup, 0,268 untuk asosiasi antara lokasi tumor dan kelangsungan hidup, serta 0,210 untuk korelasi antara jenis kemoterapi dan waktu kelangsungan hidup. Penelitian kami menunjukkan bahwa tidak ada asosiasi yang signifikan antara karakteristik kanker kolorektal, jenis terapi yang diberikan, dan durasi kelangsungan hidup pasien yang dirawat di RSUD Nganjuk. Kata Kunci: Kanker Kolorektal, Keberlangsungan Hidup, Intervensi Terapeutik
Effectiveness And Safety Of Erdosteinie In Management Of Chronic Obstructive Pulmonary Disease (COPD): A Systematic And Meta-Analysis Yolanda, Lorensia; Gunawan, Catherine Keiko; Sumarpo, Anton; Sahamastuti, Agnes Anania Triavika; Cokro, Fonny
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 9 (2025): Volume 12 Nomor 9
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i9.20524

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that cause limitation in the airflow and chronic inflammation. Erdosteine has been proposed as a potential therapeutic option for COPD management, based on its antioxidant activity and anti-inflammatory properties. The purpose of this systematic review and meta-analysis is to evaluate the effectiveness and safety of erdosteine in COPD patients. Multiple databases have been involved in the literature study following PRISMA guidelines, identifying randomized controlled trials (RCTs) that compared erdosteine with placebo. A total of seven studies were included in the qualitative analysis, and nine were analyzed quantitatively. Meta-analysis results indicated that erdosteine significantly improved forced expiratory volume in one second (FEV1), reduced reactive oxygen species (ROS) and 8-isoprostan levels, and lowered interleukin-8 (IL-8) concentrations. Subgroup analyses demonstrated greater benefits in patients with moderate to severe COPD (stage II/III). Safety analysis revealed that erdosteine was generally well-tolerated, with only mild adverse effects reported. However, study limitations included high heterogeneity and potential bias in some trials. Overall, the findings suggest that erdosteine is an effective and safe adjunct therapy for COPD.
Kajian Pustaka: Hipertensi Renovaskuler Sumarpo, Anton; Fenny, Fenny; Suraya, Nida
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 1 (2025): Volume 12 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i1.17867

Abstract

Hipertensi renovaskuler adalah salah penyebab paling sering timbulnya hipertensi sekunder dengan proses perkembangan penyakit yang gradual dan berhubungan erat dengan sistem renin-angiotensin-aldosteron. Hipertensi renovaskuler yang telat terdeteksi dan tertangani dengan tepat berpotensi menyebabkan hipoksia dan hilangnya fungsi ginjal. Oleh karena itu, identifikasi individu dengan penurunan perfusi ginjal adalah langkah awal yang penting. Tinjauan pustaka ini akan membahas secara menyeluruh mengenai epidemiologi, etiologi, patofisiologi, manifestasi klinis, hingga pemeriksaan penunjang dan manajemen terapi untuk hipertensi renovaskuler.
KAJIAN PUSTAKA: METODE IDENTIFIKASI PENANDA BIOLOGIS FESES PADA KANKER KOLOREKTAL Sumarpo, Anton; Martioso, Penny Setyawati; Fenny, Fenny
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 1 (2024): Volume 11 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i1.13265

Abstract

Abstrak: Metode Identifikasi Penanda Biologis Feses Pada Kanker Kolorektal. Kanker kolorektal adalah salah satu penyebab kematian utama akibat kanker di seluruh dunia. Kanker kolorektal adalah jenis keganasan dengan tingkat kelangsungan hidup yang berkaitan erat dengan momentum penegakan diagnosis. Temuan klinis yang ditunjang dengan hasil pemeriksaan laboratorium dapat mengawali dugaan akan kanker kolorektal dan mencetus saran untuk pemeriksaan lanjutan, sehingga identifikasi penanda biologis untuk deteksi awal yang tepat menjadi penting. Tinjauan pustaka ini akan membahas mengenai berbagai metode dan tahapan penelitian untuk mengindentifikasi kandidat penanda biologis feses untuk kanker kolorektal. 
Co-Authors Agnes Anania Triavika Sahamastuti Andre Andre, Andre Bintoro, Siprianus Ugroseno Yudho Catherine Keiko Gunawan Damayanti, Inggit Dwijayanti, Ni Made Intan Efawati, Susi Eirene Jaquelene Tomatala Eric Satrio Adi Prabowo Erny Erny, Erny Fenny Fenny Fitrianto, Muhammad Rizki Fonny Cokro Foustine, Shania Gunawan, Catherine Keiko Hani Susanti Hernanda, PratikaYuhyi Heru Setiawan Husodo, Muhammad Imam Lebdo Leonny Yulita Hartiadi LINGGAWAN, STEPHANI Maria Widijanti Sugeng Ngibad, Khoirul Nida Suraya Penny Setyawati Martioso Prabowo, Eric Satrio Adi Pratika Yuhyi Hernanda RAHARJO, BUDIONO Raharjo, Yohanes Timothy Sugeng, Maria Widjianti Wibowo, Eric Satrio Adi Wike Herawaty Yolanda, Lorensia Yudho Bintoro, Siprianus Ugroseno