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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Oto Rhino Laryngologica Indonesiana MAHESA : Malahayati Health Student Journal Hang Tuah Medical Journal Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE)
LINGGAWAN, STEPHANI
Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Mometasone furoate topikal menurunkan kadar IL3, IL9-serum dan jumlah eosinofil mukosa hidung penderita rinitis alergi Agus Kurniawan; Stephani Linggawan; Endang Retnoningsih; Rus Suheryanto; Edi Handoko; Soehartono Soehartono
Oto Rhino Laryngologica Indonesiana Vol 43, No 2 (2013): Volume 43, No. 2 July - December 2013
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (92.585 KB) | DOI: 10.32637/orli.v43i2.70

Abstract

Latar belakang: Rinitis alergi merupakan inflamasi kronis mukosa hidung yang diperantarai oleh IgE, sering berhubungan dengan banyak ko-morbid dan berdampak pada kualitas hidup. Interleukin (IL)3 dan IL9 berperan dalam proses pembentukan eosinofil, sedangkan eosinofil diketahui berperan penting dalam menyebabkan keluhan hidung buntu dan kerusakan epitel mukosa hidung penderita rinitis alergi. Mometasone furoate merupakan kortikosteroid topikal generasi terbaru yang jarang menyebabkan efek samping.Tujuan: Penelitian ini bertujuan mengetahui perubahan kadar IL3, IL9-serum, dan jumlah eosinofil mukosa hidung sesudah pemberian semprot hidung mometasone furoate pada penderita rinitis alergi. Metode: Penelitian observasional analitik ini melibatkan 38 penderita rinitis alergi yang diberi semprot hidung mometasone furoate selama 2 minggu dengan dosis 200 µg/hari. Kadar IL3, IL9-serum, dan jumlah eosinofil mukosa hidung diukur sebelum dan sesudah perlakuan. Hasil: Data dianalisis dengan uji t-berpasangan dan uji Wilcoxon. Kadar IL3, IL9-serum, dan jumlah eosinofil mukosa hidung menurun secara bermakna (p <0,001) sesudah pemberian mometasone furoate topikal selama 2 minggu. Kesimpulan: Mometasone furoate semprot hidung terbukti berpengaruh terhadap penurunan kadar IL3, IL9-serum, dan jumlah eosinofil mukosa hidung pada penderita rinitis alergi. Penelitian lebih lanjut diperlukan untuk mengetahui pengaruh mometasone furoate topikal terhadap sitokin lain yang berperan pada rinitis alergi, pengukuran kadar IL3 dan IL9-mukosa hidung, dan hubungan kadar IL3 dan IL9-mukosa hidung dengan IL3 dan IL9-serum.Kata kunci: Rinitis alergi, IL3, IL9, eosinofil, mometasone furoate.
Midline Granuloma Stephani Linggawan
HANG TUAH MEDICAL JOURNAL Vol 15 No 1 (2017): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v15i1.24

Abstract

Midline granuloma atau nasal type extranodal T/NK-cell non-Hodgkin’s lymphoma sering menimbulkan berbagai permasalahan. Tumor ini merupakan kelainan bagian tengah wajah dengan ciri khas destruksi dan ulserasi yang progresif, meliputi hidung, sinus paranasal, palatum, mata, serta jaringan lunak wajah. Etiologi dan patofisiologi belum jelas antara reaksi radang dan tumor. Midline granuloma termasuk dalam penyakit granuloma hidung berdasarkan pemeriksaan biopsi, sedangkan The Revised European American Lymphoma (REAL) / World Health Organization (WHO) mengelompokkan midline granuloma dalam extranodal T/NK-cellnon-Hodgkin’s lymphoma berdasarkan pemeriksaan imunohistologi. Infeksi virus Epstein-Barr (EBV) 90-100% terlibat dalam proses pembentukan tumor. Diagnosis sulit dan diagnosis banding luas, sehingga diperlukan anamnesis dan pemeriksaan yang lengkap, terutama biopsi, imunohistologi, dan sitogenetik didapatkan gambaran nekrosis disertai destruksi dan ulserasi pembuluh darah, radang dengan infiltrat sel pleomorfik, CD56+, CD3+, protein sitotoksik+, dan EBV+. Penatalaksanaan dengan radioterapi, kemoterapi, transplantasi sumsum tulang, dan imunoterapi. Komplikasi dapat terjadi lokal maupun sistemik dengan penyebaran ke sirkulasi darah tepi, jaringan lunak, paru-paru, hati, kulit, saluran pencernaan, testis, saraf pusat, dan sumsum tulang. Prognosis buruk, hanya kurang dari 50% penderita yang berespon lengkap setelah kemoterapi dan radioterapi. Prognosis dapat dinilai dengan International Prognostic Index (IPI). Simpulan: Diagnosis Midline granuloma sulit, penatalaksanaan sering terlambat, sedangkan sifatnya yang progresif menimbulkan berbagai komplikasi, sehingga semakin memperburuk prognosis.
Epistaxis as The Initial Presentation of Primary Sjögren Syndrome: A Case Report Stephani Linggawan; Eric Satrio Adi Prabowo; Catherine Keiko Gunawan; Budiono Raharjo; Anton Sumarpo
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4249

Abstract

Background: Primary Sjögren syndrome is chronic systemic autoimmune disorder characterized by lymphocytic infiltration of the exocrine glands, most commonly presenting with dryness of the mouth and eyes. This case is very rare, which the antibody in the Sjogren's syndrome case concerns platelets. Objective: This case report emphasizes the occurrence of epistaxis in Sjögren Syndrome. Case Presentation: This case describes a 30-year-old male presenting with recurrent epistaxis as the initial clinical manifestation. Further clinical evaluation revealed hypertensive crisis and dryness in the mouth and nasal mucosa. The clinical presentation raised suspicion of an underlying autoimmune condition, prompting further testing, which confirmed the presence of anti -Sjögren’s syndrome type B (SSB) antibodies on an antinuclear antibody (ANA) profile.  Result: The criteria for Sjogren's syndrome are based on the criteria if eye and mouth symptoms, eye and mouth clinical signs, and one of autoantibodies are found Anti-Ro (SSA), Anti-La (SSB), Antinuclear antibodies (ANA), Rheumatoid factor (RF). From this case has found symptoms of mouth and antibodies SSB. Conclusion: This case highlights that epistaxis can be caused by autoimmune cases, for epistaxis it is better to do screening for autoimmune examination test, emphasizing the need for further research to elucidate the diverse clinical manifestation, progression and prognosis factor.
Analisis Rasio Monosit terhadap Limfosit pada Penderita Osteoartritis di Surabaya Efawati, Susi; Ngibad, Khoirul; Raharjo, Budiono; Linggawan, Stephani; Sumarpo, Anton
MAHESA : Malahayati Health Student Journal Vol 5, No 5 (2025): Volume 5 Nomor 5 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i5.17922

Abstract

ABSTRACT Osteoarthritis is a degenerative joint disease characterized by progressive erosion of articular cartilage components. The known pathogenesis of osteoarthritis mainly includes immunological, bone metabolism, and biomechanical factors. Lymphocytes and monocytes are key regulatory cells for innate and acquired immunity, and monocyte-to-lymphocyte ratio may describe the immune status in osteoarthritis patients. This study aims to analyze the monocyte-to-lymphocyte ratio in osteoarthritis patients in Surabaya. This is an analytical observational research with a cross-sectional approach. The study was conducted in March - June 2024. The population in this study were osteoarthritis patients at Mitra Keluarga Hospital, Surabaya. The number of samples taken using the purposive sampling technique for this study was 31 people. The results showed that the average monocyte-to-lymphocyte ratio in osteoarthritis patients was 2.04. Meanwhile, the average monocyte-to-lymphocyte ratio in control subjects was 0.22. There was a significant difference in the monocyte-to-lymphocyte ratio between osteoarthritis patients compared to the control group. Keywords: Monocyte-To-Lymphocyte Ratio, Osteoarthritis, Joints  ABSTRAK Osteoartritis merupakan salah satu penyakit degeneratif pada sendi yang ditandai dengan erosi komponen kartilago artikular secara progresif. Patogenesis osteoartritis yang diketahui terutama mencakup faktor imunologi, metabolisme tulang, dan biomekanik. Limfosit dan monosit adalah sel kunci untuk imunitas bawaan dan didapat, dan rasio monosit terhadap limfosit menggambarkan status imunitas pada penderita osteoartritis. Penelitian ini bertujuan untuk menganalisis rasio monosit terhadap limfosit pada penderita osteoartritis di Surabaya. Penelitian ini dilakukan dengan metode analitik observasional dengan pendekatan cross-sectional. Penelitian dilakukan pada bulan Maret - Juni 2024. Populasi dalam penelitian ini adalah seluruh pasien osteoartritis di Rumah Sakit Mitra Keluarga, Surabaya. Jumlah sampel yang diambil dengan teknik purposive sampling untuk penelitian ini adalah sebanyak 31 orang. Hasil penelitian didapatkan rata-rata rasio monosit terhadap limfosit penderita osteoartritis sebesar 2,04 sedangkan rata-rata rasio monosit limfosit pasien kontrol adalah sebesar 0,22. Terdapat perbedaan yang signifikan pada rasio monosit terhadap limfosit antara penderita osteoarthritis dibandingkan dengan populasi kontrol. Kata Kunci: Rasio Monosit Terhadap Limfosit, Osteoartritis, Sendi
Hubungan Karakteristik Kanker Kolorektal dan Jenis Terapinya dengan Masa Survival Pasien di Rumah Sakit Umum Daerah Nganjuk Fitrianto, Muhammad Rizki; Hernanda, PratikaYuhyi; Sugeng, Maria Widjianti; Raharjo, Budiono; Linggawan, Stephani; Sumarpo, Anton
MAHESA : Malahayati Health Student Journal Vol 5, No 6 (2025): Volume 5 Nomor 6 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i6.18564

Abstract

ABSTRACT Colorectal cancer survival refers to the prognosis of patients following a diagnosis of the disease. Various factors contribute to the survival outcomes of individuals diagnosed with colorectal cancer, including tumor characteristics—such as the tumor's location and stage—as well as the type of therapeutic interventions administered. This study aims to investigate the relationship between the characteristics of colorectal cancer, the therapeutic approaches employed, and patient survival rates at Nganjuk General Hospital. This study employed a retrospective design with a cross-sectional approach, focusing on patients diagnosed with colorectal cancer at Nganjuk General Hospital in Surabaya over the period from 2019 to 2024. The analysis of the associations among colorectal cancer metastasis, tumor location, and chemotherapy type with patient survival duration revealed the following p-values: 0.122 for the relationship between metastasis and survival period, 0.268 for the association between tumor location and survival, and 0.210 for the correlation between chemotherapy type and survival time. Our findings indicate that there is no significant association between the characteristics of colorectal cancer, the type of therapy administered, and the survival duration of patients treated at RSUD Nganjuk. Keywords: Colorectal Cancer, Patient Survival, Therapeutic Intervention  ABSTRAK Keberlangsungan hidup (survival) pada pasien dengan kanker kolorektal berkaitan erat dengan prognosis pasien dan waktu saat terdiagnosis (time-to-diagnosis). Berbagai faktor berkontribusi terhadap hasil kelangsungan hidup individu yang didiagnosis dengan kanker kolorektal, termasuk karakteristik tumor—seperti lokasi dan stadium tumor—serta jenis intervensi terapeutik yang diberikan. Penelitian ini bertujuan untuk menyelidiki hubungan antara karakteristik kanker kolorektal, pendekatan terapeutik yang digunakan, dan tingkat kelangsungan hidup pasien di Rumah Sakit Umum Daerah (RSUD) Nganjuk. Penelitian ini menggunakan desain retrospektif dengan pendekatan cross-sectional. Subjek penelitian yang digunakan adalah pasien yang didiagnosis dengan kanker kolorektal di RSUD Nganjuk di Surabaya selama periode 2019 hingga 2024. Hubungan antara metastasis kanker kolorektal, lokasi tumor, dan jenis kemoterapi terhadap durasi kelangsungan hidup pasien menunjukkan nilai p sebagai berikut: 0,122 untuk hubungan antara metastasis dan periode kelangsungan hidup, 0,268 untuk asosiasi antara lokasi tumor dan kelangsungan hidup, serta 0,210 untuk korelasi antara jenis kemoterapi dan waktu kelangsungan hidup. Penelitian kami menunjukkan bahwa tidak ada asosiasi yang signifikan antara karakteristik kanker kolorektal, jenis terapi yang diberikan, dan durasi kelangsungan hidup pasien yang dirawat di RSUD Nganjuk. Kata Kunci: Kanker Kolorektal, Keberlangsungan Hidup, Intervensi Terapeutik
The Assessment of Neutrophil-to-Lymphocyte Ratio in Obesity: A Descriptive Study on University Students in Surabaya, Indonesia Damayanti, Inggit; Raharjo, Budiono; Setiawan, Heru; Herawaty, Wike; Linggawan, Stephani; Sumarpo, Anton; Bintoro, Siprianus Ugroseno Yudho
MAHESA : Malahayati Health Student Journal Vol 5, No 5 (2025): Volume 5 Nomor 5 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i5.17939

Abstract

ABSTRACT The incidence of obesity worldwide is rapidly increasing, both in developed and developing countries. Obesity, particularly central obesity, is an inflammatory condition occurring within the body. The neutrophil-to-lymphocyte ratio (NLR) is a simple biomarker used to indicate the inflammatory response. This study aims to determine the profile of the neutrophil-to-lymphocyte ratio in students with obesity at the Faculty of Medicine, Universitas Wijaya Kusuma Surabaya.  This study employs a descriptive-analytic method with a cross-sectional approach. The study population comprises students from the Faculty of Medicine, Universitas Wijaya Kusuma Surabaya; 47 individuals, with 30 obese individuals and 17 individuals with a normal BMI. The results showed that the average neutrophil-to-lymphocyte ratio (NLR) for individuals with a normal BMI is 1,95. In contrast, the average NLR for obese individuals is 2,09. There is an increase in the average neutrophil-to-lymphocyte ratio (NLR) among obese students at the Faculty of Medicine, Universitas Wijaya Kusuma Surabaya. Keywords: Obesity, Neutrophil, Lymphocyte, Neutrophil-To-Lymphocyte Ratio
Epistaxis as The Initial Presentation of Primary Sjögren Syndrome: A Case Report Linggawan, Stephani; Prabowo, Eric Satrio Adi; Gunawan, Catherine Keiko; Raharjo, Budiono; Sumarpo, Anton
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 14 No. 1 (2025): MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4249

Abstract

Background: Primary Sjögren syndrome is chronic systemic autoimmune disorder characterized by lymphocytic infiltration of the exocrine glands, most commonly presenting with dryness of the mouth and eyes. This case is very rare, which the antibody in the Sjogren's syndrome case concerns platelets. Objective: This case report emphasizes the occurrence of epistaxis in Sjögren Syndrome. Case Presentation: This case describes a 30-year-old male presenting with recurrent epistaxis as the initial clinical manifestation. Further clinical evaluation revealed hypertensive crisis and dryness in the mouth and nasal mucosa. The clinical presentation raised suspicion of an underlying autoimmune condition, prompting further testing, which confirmed the presence of anti -Sjögren’s syndrome type B (SSB) antibodies on an antinuclear antibody (ANA) profile.  Result: The criteria for Sjogren's syndrome are based on the criteria if eye and mouth symptoms, eye and mouth clinical signs, and one of autoantibodies are found Anti-Ro (SSA), Anti-La (SSB), Antinuclear antibodies (ANA), Rheumatoid factor (RF). From this case has found symptoms of mouth and antibodies SSB. Conclusion: This case highlights that epistaxis can be caused by autoimmune cases, for epistaxis it is better to do screening for autoimmune examination test, emphasizing the need for further research to elucidate the diverse clinical manifestation, progression and prognosis factor.
Membranous Tonsilitis as a Clinical Presentation of Acute Monocytic Leukemia: A Rare Case Report Linggawan, Stephani; Wibowo, Eric Satrio Adi; Gunawan, Catherine Keiko; Raharjo, Budiono; Sumarpo, Anton; Raharjo, Yohanes Timothy; Dwijayanti, Ni Made Intan; Yudho Bintoro, Siprianus Ugroseno
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 14 No. 2 (2025): SEPTEMBER 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i2.4290

Abstract

Background: Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the clonal proliferation of immature myeloid precursor cells in the bone marrow and peripheral circulation. Hematologic manifestations such as anemia, thrombocytopenia, and leukocytosis are welldocumented, its association with oral involvement, particularly tonsillitis, is a rare presenting feature. Objective: This case report emphasizes membranous tonsilitis as the primary presenting feature in acute monocytic leukemia (AML-M5). The aim of writing this case study is to provide an illustration that the causes of membranous tonsillitis, beside from the infection, can also be caused by infiltration of leukemia cells. Case Presentation: We report a case of a 27-year-old female presented with fever and was found to have a fluctuating mass on the right side of the neck along with gingival swelling and hyperemic, hypertrophic tonsils with a membranous exudate. The diagnosis from bone marrow aspiration and immunophenotyping revealed as acute monocytic leukemia (AML-M5). Bacterial and fungal infections were excluded through gram staining, potassium hydroxide (KOH) examination, and throat swab culture. The patient was initially stabilized with hydroxyurea, with subsequent clinical improvement, before being referred to a tertiary center for definitive management. Result: This diagnostic workup altogether from all the clinicians leads to the diagnosis of acute myeloid leukemia (AML-M5). Conclusion: This case highlights primary tonsilitis as the primary presenting feature of acute myeloid leukemia (AML-M5), emphasizing the need for continued monitoring and regular follow-up assessment to detect potential relapses and ensure optimal disease management
Hubungan Antara Kepatuhan Kontrol dan Minum Obat Pasien Diabates Melitus Tipe II dengan Kejadian Komplikasi di Rumah Sakit Aura Syifa Kediri Jordanio Viari Palallo; Febtarini Rahmawati; Stephani Linggawan
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 2 (2026): Agustus: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i2.9845

Abstract

Type 2 diabetes mellitus is a chronic disease characterized by impaired glucose metabolism resulting from insulin resistance or relative insulin deficiency. It is one of the major global health problems and can lead to various serious complications if not managed properly. Complications such as neuropathy, nephropathy, retinopathy, and diabetic ulcers frequently occur as a consequence of inadequate blood glucose control, which is strongly influenced by patients' adherence to medication and routine follow-up visits. This study aimed to determine the relationship between medication adherence, follow-up adherence, and the occurrence of complications among patients with type 2 diabetes mellitus at Aura Syifa Hospital, Kediri. This study employed an analytical observational design with a cross-sectional approach. A total of 35 patients were selected using purposive sampling. Data were collected from medical records and analyzed using Fisher's Exact Test. The results revealed a significant relationship between medication adherence and the occurrence of complications (p < 0.002), as well as between follow-up adherence and complications (p = 0.027). These findings indicate that patients who are non-adherent to medication and routine follow-up are at a higher risk of developing complications. Therefore, strengthening patient education, supervision, and adherence monitoring systems is essential in healthcare services to prevent disease progression and reduce the incidence of complications. This study is expected to serve as a basis for developing educational interventions and primary healthcare policies aimed at improving the management of patients with type 2 diabetes mellitus.
Co-Authors Agus Kurniawan Agus Kurniawan Anton Sumarpo Bintoro, Siprianus Ugroseno Yudho Catherine Keiko Gunawan Damayanti, Inggit Dwijayanti, Ni Made Intan Edi Handoko Efawati, Susi Endang Retnoningsih Eric Satrio Adi Prabowo Febtarini Rahmawati Fitrianto, Muhammad Rizki Gunawan, Catherine Keiko Hernanda, PratikaYuhyi Heru Setiawan Jordanio Viari Palallo Ngibad, Khoirul Prabowo, Eric Satrio Adi RAHARJO, BUDIONO Raharjo, Yohanes Timothy Rus Suheryanto Soehartono Soehartono Sugeng, Maria Widjianti Wibowo, Eric Satrio Adi Wike Herawaty Yudho Bintoro, Siprianus Ugroseno