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PANCREATIC CANCER IN 31 YEARS OLD PATIENT WITH NORMAL SERUM AMYLASE LEVEL (Kanker Pankreas di Pasien Usia 31 Tahun dengan Kadar Amilase Serum Normal) Melda F. Flora; Budiono Raharjo; Maimun Z. Arthamin
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1192

Kanker pankreas adalah keganasan sel di jaringan pankreas. kejadiannya meningkat pada usia di atas 60 tahun. Namun, sekitar20% dapat terjadi di usia muda. Patogenesis terjadinya masih belum jelas, dikemukakan bahwa mutasi genetik dan faktor eksogen sepertimerokok berhubungan dengan terjadinya keganasan sel pankreas. Kasus adalah seorang laki-laki perokok berusia 31 tahun dengankeluhan utama nyeri ulu hati menjalar ke punggung, disertai mual, muntah, nafsu makan turun. Pada pemeriksaan fisik didapatkansklera ikterik, perkusi redup dan ronkhi di paru, distensi abdomen dan asites. Pada pemeriksaan laboratorik didapatkan leukositosis,trombositopenia, peningkatan aspartate aminotransaminase (AST) lebih dari 10 kali Upper Range Limit (URL), hiperbilirubinemiadirek, peningkatan alkaline phosphatase (ALP), Gamma Glutamyl Transferase (GGT) dan lipase serum, sedangkan amilase serumnormal. Terdapat juga peningkatan kadar CA19-9. Pada computed tomography scan (CT scan) dan Magnetic Resonance Imaging (MRI)didapatkan gambaran kanker pankreas primer yang telah bermetastasis ke pleura dan hati. Kadar amilase normal di pasien dapatdisebabkan karena awal peningkatan dan penurunan kadar amilase terjadi lebih cepat dan pada saat diperiksa telah turun mencapaikadar normal. Simpulan, kanker pankreas dapat terjadi di usia muda. Amilase yang normal dapat terjadi di kanker pankreas.

HIGH FLUORESCENT LYMPHOCYTE COUNT EXAMINATION IN DENGUE HEMORRHAGIC PATIENTS WITH SYSMEX XN-1000 HEMATOLOGY ANALYZER Budiono Raharjo; Solichul Hadi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 2 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i2.1443

Sysmex XN-1000 hematology analyzer is an automated 5-part diff analyzer (eosinophils, basophils, neutrophils, lymphocytes, and monocytes). In the calculated area, the type of difference between the Sysmex hematology device and other hematology devices is Immature Granulocyte (IG), Nucleated Red Blood Cell (NRBC), and High Fluorescent Lymphocytes Count (HFLC). The cells calculated in the HFLC area are atypical lymphocytes. In patients with dengue hemorrhagic fever, it is often found atypical lymphocytes called blue plasma lymphocytes. The purpose of this study was to determine the description of HFLC in patients with dengue fever using the hematology analyzer Sysmex XN-1000. A descriptive retrospective study was conducted during April-May 2017. The subjects of the study were adult patients diagnosed with dengue hemorrhagic fever with WHO criteria. Of the 47 samples of Dengue Hemorrhagic Fever (DHF) patients, the average HFLC results were between 2.0-32.3%, which was 11.5%, while the average range of normal HFLC values was between 0.0-1.4% and was 0.3%. In cases of DHF, there is an increase in HFLC. This is likely to be attributed to atypical lymphocyte increase in dengue hemorrhagic fever. Further research with more varied samples still needs to be done.

Analisa Perbandingan Hasil Trombosit Pada Alat Hematologi Analyzer Metode Impedance dan Metode Optik Pada Kasus Anemia Hipokrom Mikrositer (Berdasarkan Indeks Eritrosit) Maulina Rosida; Budiono Raharjo; Halik Wijaya
Jurnal SainHealth Vol 7, No 1 (2023): Maret 2023
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v7i1.6848.41-46

Platelets have an important role in hemostasis, namely the formation and stabilization of platelet plugs. There are several methods in the counting of platelets. They can be carried out in a direct and an indirect manner. The direct method can be carried out in an automatic and automatic way. The automatic method uses an hematology analyzer which functions to measure and examine blood cells in blood samples. Counting the number of platelets is done automatically by two methods, namely optical and impedance which have different principles. The optical method is based on cell size and morphology, while impedance is based on cell size only. Hypochrome is a condition where the Hb concentration is less than normal so that the central achromia widens (> 1/3 of the cell) and there is a decrease in the color of the erythrocytes, namely an increase in the diameter of the central pallor above normal so that it looks paler. Microcyte is a condition where the cell size is smaller than normal. The purpose of this study was to determine the difference in the number of platelets in the hematology analyzer using the impedance method and the optical method in the case of microcytic hypochromic anemia (based on erythrocyte index) with a descriptive analytical research design. The test used is the paired t-test with a total sample of 30 samples. The results of platelets using the impedance method have an average of 339.37 * 103 / uL with a standard deviation of 120.294. The results of platelets using the optical method have an average of 314.70 * 103 / uL with a standard deviation of 113.569. A significant value of 0.000 significant value of (sig. < 0.05) can be concluded that there is a difference between the results of platelets on the hematology analyzer using the impedance method and the optical method in cases of microcytic hypochromic anemia (based on erythrocyte index).Â Keywords : Trombosit, Hipokrom Mikrositer, Hematology analyzer, Impedance, Optik.

Analisa Perbandingan Hasil Trombosit Pada Alat Hematologi Analyzer Metode Impedance dan Metode Optik Pada Kasus Anemia Hipokrom Mikrositer (Berdasarkan Indeks Eritrosit) Maulina Rosida; Budiono Raharjo; Halik Wijaya
Jurnal SainHealth Vol. 7 No. 1 (2023): Maret 2023
Publisher : Faculty of Health Sciences Universitas Maarif Hasyim Latif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51804/jsh.v7i1.6848.41-46

Platelets have an important role in hemostasis, namely the formation and stabilization of platelet plugs. There are several methods in the counting of platelets. They can be carried out in a direct and an indirect manner. The direct method can be carried out in an automatic and automatic way. The automatic method uses an hematology analyzer which functions to measure and examine blood cells in blood samples. Counting the number of platelets is done automatically by two methods, namely optical and impedance which have different principles. The optical method is based on cell size and morphology, while impedance is based on cell size only. Hypochrome is a condition where the Hb concentration is less than normal so that the central achromia widens (> 1/3 of the cell) and there is a decrease in the color of the erythrocytes, namely an increase in the diameter of the central pallor above normal so that it looks paler. Microcyte is a condition where the cell size is smaller than normal. The purpose of this study was to determine the difference in the number of platelets in the hematology analyzer using the impedance method and the optical method in the case of microcytic hypochromic anemia (based on erythrocyte index) with a descriptive analytical research design. The test used is the paired t-test with a total sample of 30 samples. The results of platelets using the impedance method have an average of 339.37 * 103 / uL with a standard deviation of 120.294. The results of platelets using the optical method have an average of 314.70 * 103 / uL with a standard deviation of 113.569. A significant value of 0.000 significant value of (sig. < 0.05) can be concluded that there is a difference between the results of platelets on the hematology analyzer using the impedance method and the optical method in cases of microcytic hypochromic anemia (based on erythrocyte index). Keywords : Trombosit, Hipokrom Mikrositer, Hematology analyzer, Impedance, Optik.

Analisis Kejadian Adverse Drug Reaction Obat Anti-Tuberkulosis dengan Faktor Risiko pada Penderita Tuberkulosis Multi-Drug Resistant : Systematic Review Andili, Agshal Almachzumi; Setiawan, Budhi; Ama, Fuad; Raharjo, Budiono
Calvaria Medical Journal Vol 2 No 1 (2024): Edisi Juni 2024 (available online Juli 2024)
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v2i1.35

Introduction: Tuberculosis patients must adhere to a six-month uninterrupted course of medication. The DOTS method is crucial in preventing resistance to anti-TB drugs, which can lead to stronger MDR-TB strains resistant to rifampicin and isoniazid. ADRs from these drugs include gastrointestinal disturbances, hepatotoxicity, dermatological and serious neurological disorders, prompting patients to discontinue treatment. Non-adherence can hinder tuberculosis recovery as patients tend to stop treatment. Patient compliance is pivotal in their decision to continue treatment. Therefore, further research is needed to explore the relationship between ADRs to anti-TB drugs and risk factors in active MDR-TB patients. Method: This qualitative study conducted a literature review using databases from 2014 to 2023 and keywords relevant to the study's title. Fifteen relevant journals were identified, comprising 11 international and 4 national journals. Results: The literature review found that the most influential factors in adverse drug reactions to OAT in outpatient MDR-TB patients were treatment history and medication adherence. Regarding individual factors such as age and gender, most journals indicated they are not significant risk factors for MDR-TB. Conclusion: Based on the literature review, it can be concluded that the most dominant factors affecting adverse drug reactions to OAT in outpatient MDR-TB patients are treatment history and medication adherence. As for individual factors like age and gender, nearly all journals indicate they are not significant risk factors for MDR-TB.

Hubungan Karakteristik Faktor Sosioekonomi Dengan Masa Survival Pasien Kanker Kolorektal Di Rumah Sakit Umum Daerah Nganjuk, Jawa Timur Husodo, Muhammad Imam Lebdo; Raharjo, Budiono; Hernanda, Pratika Yuhyi; Sugeng, Maria Widijanti; Erny, Erny; Sumarpo, Anton
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 2 (2025): Volume 12 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i2.17987

Kanker kolorektal merupakan suatu kegansan yang bermula dari jaringan mukosa usus besar, yang secara struktur terdiri dari kolon dan/atau rectum. Hingga saat ini, insiden kanker kolorektal menduduki urutan ketiga dari seluruh jenis kanker di dunia. Penelitian ini bertujuan untuk mencari hubungan dan memberikan gambaran mengenai factor sosioekonomi meliputi variable status perkawinan, status bekerja, status pendidikan, dan masa survival pada pasien kanker kolorektal di Rumah Sakit Umum Daerah (RSUD) Nganjuk. Penelitian ini menggunakan desain penelitian deskriptif analitik. Data dikumpulkan dari rekam medis pasien kanker kolorektal yang dirawat di RSUD Nganjuk. Analisis dilakukan menggunakan uji statistik Kaplan-Meier dan log-rank test untuk menganalisa gambaran factor sosioekonomi dengan masa survival pasien kanker kolorektal di RSUD Nganjuk. Terdapat gambaran masa survival yang cenderung lebih baik pada pasien berstatus menikah, bekerja, dan berpendidikan di bawah SLTA. Meskipun hasil penelitian menunjukkan hubungan yang tidak signifikan, didapatkan gambaran masa survival yang lebih baik pada variabel pasien dengan kategori menikah, bekerja, dan pendidikan di bawah SLTA.

Epistaxis as The Initial Presentation of Primary Sjögren Syndrome: A Case Report Stephani Linggawan; Eric Satrio Adi Prabowo; Catherine Keiko Gunawan; Budiono Raharjo; Anton Sumarpo
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 14, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.4249

Background: Primary Sjögren syndrome is chronic systemic autoimmune disorder characterized by lymphocytic infiltration of the exocrine glands, most commonly presenting with dryness of the mouth and eyes. This case is very rare, which the antibody in the Sjogren's syndrome case concerns platelets. Objective: This case report emphasizes the occurrence of epistaxis in Sjögren Syndrome. Case Presentation: This case describes a 30-year-old male presenting with recurrent epistaxis as the initial clinical manifestation. Further clinical evaluation revealed hypertensive crisis and dryness in the mouth and nasal mucosa. The clinical presentation raised suspicion of an underlying autoimmune condition, prompting further testing, which confirmed the presence of anti -Sjögren’s syndrome type B (SSB) antibodies on an antinuclear antibody (ANA) profile. Result: The criteria for Sjogren's syndrome are based on the criteria if eye and mouth symptoms, eye and mouth clinical signs, and one of autoantibodies are found Anti-Ro (SSA), Anti-La (SSB), Antinuclear antibodies (ANA), Rheumatoid factor (RF). From this case has found symptoms of mouth and antibodies SSB. Conclusion: This case highlights that epistaxis can be caused by autoimmune cases, for epistaxis it is better to do screening for autoimmune examination test, emphasizing the need for further research to elucidate the diverse clinical manifestation, progression and prognosis factor.

Analisis Rasio Monosit terhadap Limfosit pada Penderita Osteoartritis di Surabaya Efawati, Susi; Ngibad, Khoirul; Raharjo, Budiono; Linggawan, Stephani; Sumarpo, Anton
MAHESA : Malahayati Health Student Journal Vol 5, No 5 (2025): Volume 5 Nomor 5 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i5.17922

ABSTRACT Osteoarthritis is a degenerative joint disease characterized by progressive erosion of articular cartilage components. The known pathogenesis of osteoarthritis mainly includes immunological, bone metabolism, and biomechanical factors. Lymphocytes and monocytes are key regulatory cells for innate and acquired immunity, and monocyte-to-lymphocyte ratio may describe the immune status in osteoarthritis patients. This study aims to analyze the monocyte-to-lymphocyte ratio in osteoarthritis patients in Surabaya. This is an analytical observational research with a cross-sectional approach. The study was conducted in March - June 2024. The population in this study were osteoarthritis patients at Mitra Keluarga Hospital, Surabaya. The number of samples taken using the purposive sampling technique for this study was 31 people. The results showed that the average monocyte-to-lymphocyte ratio in osteoarthritis patients was 2.04. Meanwhile, the average monocyte-to-lymphocyte ratio in control subjects was 0.22. There was a significant difference in the monocyte-to-lymphocyte ratio between osteoarthritis patients compared to the control group. Keywords: Monocyte-To-Lymphocyte Ratio, Osteoarthritis, Joints ABSTRAK Osteoartritis merupakan salah satu penyakit degeneratif pada sendi yang ditandai dengan erosi komponen kartilago artikular secara progresif. Patogenesis osteoartritis yang diketahui terutama mencakup faktor imunologi, metabolisme tulang, dan biomekanik. Limfosit dan monosit adalah sel kunci untuk imunitas bawaan dan didapat, dan rasio monosit terhadap limfosit menggambarkan status imunitas pada penderita osteoartritis. Penelitian ini bertujuan untuk menganalisis rasio monosit terhadap limfosit pada penderita osteoartritis di Surabaya. Penelitian ini dilakukan dengan metode analitik observasional dengan pendekatan cross-sectional. Penelitian dilakukan pada bulan Maret - Juni 2024. Populasi dalam penelitian ini adalah seluruh pasien osteoartritis di Rumah Sakit Mitra Keluarga, Surabaya. Jumlah sampel yang diambil dengan teknik purposive sampling untuk penelitian ini adalah sebanyak 31 orang. Hasil penelitian didapatkan rata-rata rasio monosit terhadap limfosit penderita osteoartritis sebesar 2,04 sedangkan rata-rata rasio monosit limfosit pasien kontrol adalah sebesar 0,22. Terdapat perbedaan yang signifikan pada rasio monosit terhadap limfosit antara penderita osteoarthritis dibandingkan dengan populasi kontrol. Kata Kunci: Rasio Monosit Terhadap Limfosit, Osteoartritis, Sendi

Hubungan Karakteristik Kanker Kolorektal dan Jenis Terapinya dengan Masa Survival Pasien di Rumah Sakit Umum Daerah Nganjuk Fitrianto, Muhammad Rizki; Hernanda, PratikaYuhyi; Sugeng, Maria Widjianti; Raharjo, Budiono; Linggawan, Stephani; Sumarpo, Anton
MAHESA : Malahayati Health Student Journal Vol 5, No 6 (2025): Volume 5 Nomor 6 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i6.18564

ABSTRACT Colorectal cancer survival refers to the prognosis of patients following a diagnosis of the disease. Various factors contribute to the survival outcomes of individuals diagnosed with colorectal cancer, including tumor characteristics—such as the tumor's location and stage—as well as the type of therapeutic interventions administered. This study aims to investigate the relationship between the characteristics of colorectal cancer, the therapeutic approaches employed, and patient survival rates at Nganjuk General Hospital. This study employed a retrospective design with a cross-sectional approach, focusing on patients diagnosed with colorectal cancer at Nganjuk General Hospital in Surabaya over the period from 2019 to 2024. The analysis of the associations among colorectal cancer metastasis, tumor location, and chemotherapy type with patient survival duration revealed the following p-values: 0.122 for the relationship between metastasis and survival period, 0.268 for the association between tumor location and survival, and 0.210 for the correlation between chemotherapy type and survival time. Our findings indicate that there is no significant association between the characteristics of colorectal cancer, the type of therapy administered, and the survival duration of patients treated at RSUD Nganjuk. Keywords: Colorectal Cancer, Patient Survival, Therapeutic Intervention ABSTRAK Keberlangsungan hidup (survival) pada pasien dengan kanker kolorektal berkaitan erat dengan prognosis pasien dan waktu saat terdiagnosis (time-to-diagnosis). Berbagai faktor berkontribusi terhadap hasil kelangsungan hidup individu yang didiagnosis dengan kanker kolorektal, termasuk karakteristik tumor—seperti lokasi dan stadium tumor—serta jenis intervensi terapeutik yang diberikan. Penelitian ini bertujuan untuk menyelidiki hubungan antara karakteristik kanker kolorektal, pendekatan terapeutik yang digunakan, dan tingkat kelangsungan hidup pasien di Rumah Sakit Umum Daerah (RSUD) Nganjuk. Penelitian ini menggunakan desain retrospektif dengan pendekatan cross-sectional. Subjek penelitian yang digunakan adalah pasien yang didiagnosis dengan kanker kolorektal di RSUD Nganjuk di Surabaya selama periode 2019 hingga 2024. Hubungan antara metastasis kanker kolorektal, lokasi tumor, dan jenis kemoterapi terhadap durasi kelangsungan hidup pasien menunjukkan nilai p sebagai berikut: 0,122 untuk hubungan antara metastasis dan periode kelangsungan hidup, 0,268 untuk asosiasi antara lokasi tumor dan kelangsungan hidup, serta 0,210 untuk korelasi antara jenis kemoterapi dan waktu kelangsungan hidup. Penelitian kami menunjukkan bahwa tidak ada asosiasi yang signifikan antara karakteristik kanker kolorektal, jenis terapi yang diberikan, dan durasi kelangsungan hidup pasien yang dirawat di RSUD Nganjuk. Kata Kunci: Kanker Kolorektal, Keberlangsungan Hidup, Intervensi Terapeutik

Hubungan rasio monosit/high density lipoprotein (HDL) dengan indeks massa tubuh pada pasien dengan penyakit jantung koroner Raharjo, Budiono; Kurniawati, Renny; Wijayanti, Christina Destri Wiwis; Linggawan, Stephani; Sumarpo, Anton; Bintoro, Siprianus Ugroseno Yudho
Holistik Jurnal Kesehatan Vol. 19 No. 2 (2025): Volume 19 Nomor 2
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v19i2.651

Background: The incidence of coronary heart disease continues to increase every year. The monocyte/high density lipoprotein (HDL) ratio has recently been proposed as a new predictor and prognostic indicator in cardiovascular disease. Obesity is one of the risk factors for coronary heart disease that can be measured using body mass index (BMI). Purpose: To determine the relationship between the monocyte/high density lipoprotein (HDL) ratio and body mass index (BMI) in patients with coronary heart disease. Method: This observational analytical study with a cross-sectional approach used research subjects with coronary heart disease at Mitra Keluarga Hospital, Waru during the period of January 2023 - January 2024. The sample in this study was taken by purposive sampling. The correlation test of the monocyte/high density lipoprotein (HDL) ratio with body mass index (BMI) was carried out using SPSS software version 29. Results: Body mass index in coronary heart patients was found that most patients were included in the type I obesity category as many as 9 people (30%). The monocyte/HDL ratio in coronary heart patients was found to be an average of 20.28. Conclusion: There is no significant relationship between the monocyte/HDL ratio and BMI in coronary heart patients. Suggestion: Further researchers can conduct similar research in hospital institutions with a larger sample size. Keywords: Body Mass Index; High Density Lipoprotein; Monocyte. Pendahuluan: Penyakit jantung koroner terus mengalami peningkatan setiap tahunnya. Rasio monosit/high density lipoprotein (HDL), baru-baru ini diusulkan sebagai prediktor dan indikator prognosis baru pada penyakit kardiovaskular. Obesitas merupakan salah satu faktor resiko penyakit jantung koroner yang dapat diukur menggunakan indeks massa tubuh (IMT). Tujuan: Untuk mengetahui hubungan rasio monosit/high density lipoprotein (HDL) dengan indeks massa tubuh (IMT) pada pasien dengan penyakit jantung koroner. Metode: Penelitian analitik observasional dengan pendekatan cross sectional ini menggunakan subjek penelitian dengan penyakit jantung koroner di Rumah Sakit Mitra Keluarga, Waru selama rentang waktu bulan Januari 2023 – Januari 2024. Sampel dalam penelitian ini diambil secara purposive sampling. Uji korelasi rasio monosit/high density lipoprotein (HDL) dengan indeks massa tubuh (IMT) dilakukan dengan piranti lunak SPSS versi 29. Hasil: Indeks massa tubuh pada pasien jantung koroner didapatkan sebagian besar pasien termasuk dalam kategori obesitas tipe I sebanyak 9 orang (30%). Rasio monosit/HDL pada pasien jantung koroner didapatkan rata-rata sebesar 20.28. Simpulan: Tidak ditemukan adanya hubungan yang signifikan antara rasio monosit/HDL dengan IMT pasien jantung koroner. Saran: Peneliti selanjutnya dapat melakukan penelitian serupa pada instansi rumah sakit dengan jumlah sampel yang lebih besar. Kata Kunci: High Density Lipoprotein; Indeks Massa Tubuh; Monosit.

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